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| 1 | Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats显示文摘Voltage-dependent anion channel 1(VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2–5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4(TLR4). Intrathecal injection of minocycline, an inhibitor of microglia, also attenuated the pain hypersensitivity of rat models of bone cancer pain.These results suggest that VDAC1 plays a significant role in the development of complicated cancer pain, possibly by regulating the expression of TLR4. | Xiangpeng Kong Jinrong Wei Diyu Wang Xiaoju Zhu Youlang Zhou Shusheng Wang Guang-Yin Xu Guo-Qin Jiang | 2017 | Neuroscience Bulletin2017，33，6： | 4 |
| 2 | Heinrich layer in Antarctic marine sediments and its significance to global changes显示文摘Results of grain size analysis and rock magnetic measurements of core NP95-1 from Prydz Bay, Antarctica revealed two series of ice-rafted detritus layers, which correspond to cold climatic events, Younger Dryas and Heinrich event 1, occurring at about 11.7-10.3 and 14.3-13.6 kaB.P. respectively. Studies also show that the sequence of paleoclimatic changes in Antarctica can be correlated with that in other parts of the world, and that the millennial climate of the earth could change synchronously and globally. In addition, magnetic fabric analysis also shows a close relationship between paleoclimatic change and ocean circulation re-assemblage. | Hongrning Hou Youlang Luo Honghan Zheng Baogui Wang Xianzan Tang | 1998 | Chinese Science Bulletin1998，43，21： | 3 |
| 3 | Nanoparticle mediated controlled delivery of dual growth factors显示文摘Peripheral nerve functional recovery after nerve injury generally requires multiple growth factors by synergistic effect.However,the optical combination of multiple synergistic growth factors for axonal regeneration has been scarcely considered up to now.Meanwhile,the use of growth factors in promoting nerve regeneration was limited by its short biological half-life in vivo,its vulnerability to structure disruption or hydrolyzation,leading to loss of bioactivity.Herein,a novel polymeric nanoparticle delivery system composed of heparin andε-poly-L-lysine(PL)was prepared for control release of nerve growth factor(NGF)and basic fibroblast growth factor(bFGF).The nanoparticles were synthesized by polyelectrolyte complexation in aqueous solution at room temperature,followed by cross-linking with biological genipin.The obtained nanoparticles had a spherical shape,with a mean diameter of about 246 nm,and high growth factors encapsulation efficiency as well as good stability.NGF and bFGF were encapsulated in the nanoparticles and showed a continuous and slow release behavior in vitro.The bioactivities of the released growth factors were evaluated,and exhibited the synergistic effect.The controlled release of the dual synergistic growth factors would improve the treatment of peripheral nerve injury to mimic the natural cellular microenvironments. | ZHANG LuZhong ZHOU YouLang LI GuiCai ZHAO YaHong GU XiaoSong YANG YuMin | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 4 | Spheroid body-forming cells in the human gastric cancer cell line MKN-45possess cancer stem cell properties显示文摘 | Jianming Liu Lilin Ma Junfei Xu Chun Liu Jianguo Zhang Jie Liu Ruixin Chen Youlang Zhou | 2013 | International Journal of Oncology2013，，2： | 1 |
| 5 | Ru implementation of domain decomposition method based parallel finite element method in geotechnical engineering显示文摘 | Zhang Youlang Feng Xiating Jiang Annan | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，41，3： | 1 |
| 6 | Fractal study of Mesozoic hydrothermal deposits in Zhejiang Province,China显示文摘 | LI Changjiang JIANG Xuliang XU Youlang | 1996 | Scientia Geologica Sinica1996，31，3： | 1 |
| 7 | Sensitization of sodium channels by cystathionine β-synthetase activation in colon sensory neurons in adult rats with neonatal maternal deprivation显示文摘 | Shufen Hu Weiyuan Xu Xiuhua Miao Yanping Gao Liyan Zhu Youlang Zhou Ying Xiao Guang-Yin Xu | 2013 | Experimental Neurology2013，，： | 1 |
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