|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Urine—an untapped goldmine for biomarker discovery?显示文摘The past decade witnessed a few biomarkers discovered and validated;however,biomarker research as a whole has not been fruitful as expected.A majority of our efforts has been focused on blood,the dynamic tissue directly connecting every part of the body.Nevertheless,despite all the interest and endeavor spent on it,the blood has failed to deliver sufficient number of clinically valuable biomarkers.Is it possible that we have been barking up the wrong tree? | GAO YouHe | 2013 | Science China(Life Sciences)2013，56，12： | 31 |
| 2 | Urimem,a membrane that can store urinary proteins simply and economically,makes the large-scale storage of clinical samples possible显示文摘By nature,biomarker is the measurable change associated with a physiological or pathophysiological process.Unlike blood which has mechanisms to minimize changes and to keep the internal environment homeostatic,urine is more likely to reflect changes of the body and is a better biomarker source.Because of its potential in biomarker discovery,urinary proteins should be preserved comprehensively as the duration of the patients’corresponding medical records.Here,we propose a method to adsorb urinary proteins onto a membrane we named Urimem.This simple and inexpensive method requires minimal sample handling,uses no organic solvents,and is environmentally friendly.Urine samples were filtered through the membrane,and urinary proteins were adsorbed onto the membrane.The proteins on the membrane were dried and stored in a vacuum bag,which keeps the protein pattern faithfully preserved.The membrane may even permit storage at room temperature for weeks.Using this simple and inexpensive method,it is possible to begin preserving urine samples from all consenting people.Thus,medical research especially biomarker research can be conducted more economically.Even more objective large-scale prospective studies will be possible.This method has the potential to change the landscape of medical research and medical practice. | JIA LuLu LIU XueJiao LIU Liu LI MingXi GAO YouHe | 2014 | Science China(Life Sciences)2014，57，3： | 19 |
| 3 | Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma显示文摘The most fundamental property of biomarkers is change.But changes are hard to maintain in plasma since it is strictly controlled by homeostatic mechanisms of the body.There is no homeostatic mechanism for urine.Besides,urine is partly a filtration of blood,and systematic information can be reflected in urine.We hypothesize that change of blood can be reflected in urine more sensitively.Here we introduce the interference into the blood by two anticoagulants heparin or argatroban.Plasma and urine proteins were profiled by LC-MS/MS and then validated by Western blot in totally six SD female rats before and after the drug treatments.In argatroban treated group,with exactly the same experimental procedure and the same cutoff value for both plasma and urine proteins,62 proteins changed in urine,only one of which changed in plasma.In heparin treated group,27 proteins changed in urine but only three other proteins changed in plasma.Both LC-MS/MS and Western blot analyses demonstrated drug-induced increases in transferrin and hemopexin levels in urine but not in plasma.Our data indicates that urine may serve as a source for more sensitive detection of protein biomarkers than plasma. | LI MengLin ZHAO MinDi GAO YouHe | 2014 | Science China(Life Sciences)2014，57，7： | 18 |
| 4 | Applications of urinary proteomics in biomarker discovery显示文摘Urine is an important source of biomarkers.This article reviews current advances,major challenges,and future prospects in the field of urinary proteomics.Because the practical clinical problem is to distinguish diseases with similar symptoms,merely comparing samples from patients of a particular disease to those of healthy individuals is inadequate for finding biomarkers with sufficient diagnostic power.In addition,the variation of expression levels of urinary proteins among healthy individuals and individuals under different physiological conditions adds to the difficulty in identifying biomarkers.We propose that establishing the natural variation in urinary protein expression among a healthy population can serve as a reference to help identify protein abundance changes that are caused by disease,not by individual variations or physiological changes.We also discuss that comparing protein expression levels between urine and plasma may reveal the physiological function of the kidney and that may facilitate biomarker discovery.Finally,we propose that establishing a data-sharing platform for data collection and integrating results from all urinary biomarker studies will help promote the development of urinary proteomics. | SHAO Chen WANG Yan GAO YouHe | 2011 | Science China(Life Sciences)2011，54，5： | 15 |
| 5 | Urinary Biomarkers of Brain Diseases显示文摘Biomarkers are the measurable changes associated with a physiological or pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clinical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood,there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome. | Manxia An Youhe Gao | 2015 | Genomics, Proteomics & Bioinformatics2015，13，6： | 9 |
| 6 | Particle dynamics in dense shear granular flow显示文摘粒子动力学在一环形砍小粒的流动用包装部分的分离元素方法,和影响被学习,砍率和磨擦系数被分析。我们证明批评收拾行李部分的存在在 shear 存在小粒的流动。当收拾行李的部分比这批评价值低时,吝啬的正切的速度侧面展出一个率无关的特征。然而,当收拾行李的部分超过这批评价值时,正切的速度侧面成为率依赖者并且逐渐地变化从对线性与增加非线性砍率。而且,我们从 unjammed 国家发现连续转变到堵塞国家在一 shear 收拾行李的部分增加的小粒的流动。在这转变进程,力量分发清楚地变化,接触力量网络也展出不同特征。关键词砍小粒的流动 - 正切的速度侧面 - 批评收拾行李部分 - 力量分发 - 堵塞状态工程被国家天赋的关键工程支持中国(10532040 ) 和大学(IRT 0628 ) 里的 Changjiang 学者和创新研究队的计划的科学基础。 | Dengming Wang Youhe Zhou | 2010 | Acta Mechanica Sinica2010，26，1： | 8 |
| 7 | Statistics of contact force network in dense granular matter显示文摘We investigate the distribution of contact forces in a static granular system and in annular shear granular flow, using the discrete element method, and considering the influences of both packing fraction and friction coefficient. We find the existence of a critical packing fraction. If the packing fraction is lower than this critical value, all contact forces in granular system vanish. For shear granular flow, the critical packing fraction is significantly smaller than that for static granular system. The distribution of the contact forces also exhibits different forms, especially at lower packing fraction. We also investigate the spatial configuration of contact network using the angular distribution of contact forces. In static granular systems, the contact force network is approximately isotropic, while in shear granular flow, it exhibits a distinct anisotropy along the shear direction. | DengmingWang Youhe Zhou | 2010 | Particuology2010，8，2： | 6 |
| 8 | Discrete element simulation of localized deformation in stochastic distributed granular materials显示文摘The deformation in granular material under loading conditions is a problem of great interest currently. In this paper,the micro-mechanism of the localized deformations in stochastically distributed granular materials is investigated based on the modi-fied distinct element method under the plane strain conditions,and the influences of the confining pressure,the initial void ratio and the friction coefficient on the localized deformation and the stability of granular materials are also studied. It is concluded,based on the numerical simulation testing,that two crossed shear sliding planes may occur inside the granular assembly,and deformation patterns vary with the increasing of transverse strain. These conclusions are in good agreement with the present experimental results. By tangential velocity profiles along the direction normal to the two shear sliding planes,it can be found that there are two different shear deformation patterns: one is the fluid-like shear mode and the other is the solid-like shear mode. At last,the influences of various material parameters or factors on localized deformation features and patterns of granular materials are discussed in detail. | WANG DengMing ZHOU YouHe | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，9： | 6 |
| 9 | PERTURBATION ANALYSIS FOR MAGNETO-PLASTIC INSTABILITY OF FERROMAGNETIC BEAM-PLATES WITH GEOMETRIC IMPERFECTION显示文摘The magneto-plastic instability of a ferromagnetic beam-type plate with simple supports and small initial imperfection is analytically investigated in this paper for that the plastic deformation of the plate with a linear-strain hardening relation is considered when the plate is located in a strong uniformly distributed magnetic ?eld. After the distribution of magnetic ?elds related to the de?ected con?guration of plate is imaginably divided into two parts, i.e., one is related to the ?at plate and the other dependent on the perturbation of magnetic ?elds for which the plate con?guration changes from the ?at into the deformed state, the perturbation technique is employed to analyze the distribution of the perturbation magnetic ?elds in and out-of the magnetic medium of the ferromagnetic structure in a transverse magnetic ?eld, which leads to some analytical formulae/solutions for the magnetic ?elds and the resulting magnetic force exerted on the plate. Based on them, the magneto-plastic buckling and snapping of the plate in a transverse magnetic ?eld is discussed, and the critical magnetic ?eld is analytically formulated in terms of the parameters of geometry and material of the plate employed by solving the governing equation of the magneto-plastic plate in the applied magnetic ?eld. Further, the sensitivity of the initial imperfection on the magneto-plastic instability, expressed by an ampli?cation function, is obtained by solving the dynamic equation of de?ection of the plate after the inertial force in the transverse direction is taken into account. The results obtained show that the critical magnetic ?eld is sensitive to the plastic characteristic, e.g., hardening coe?cient, and the instability mode and de?ection of the plate are dependent on the geometrical imperfection as well. | Zhou Youhe Gao Yuanwen Zheng Xiaojing | 2004 | Acta Mechanica Solida Sinica2004，17，4： | 6 |
| 10 | SINGULAR BEHAVIORS OF INTERFACIAL CRACKS IN 2D MAGNETOELECTROELASTIC BIMATERIALS显示文摘The singular characteristics of stress,electric displacement and magnetic induction fields near the tip of impermeable interfacial cracks in two-dimensional magnetoelectroelastic bimaterials are studied using the generalized Stroh formalism.Two types of singularities are ob-tained:one is the oscillating singularity 1/2±iε,the other is the non-oscillating singularity 1/2±κ.It is found that the non-zero parameters ε and κ cannot coexist for one transversely isotropic MEE bimaterial,a similar result is obtained for transversely isotropic piezoelectric bimaterials. | Cuiying Fan Youhe Zhou Han Wang Minghao Zhao | 2009 | Acta Mechanica Solida Sinica2009，22，3： | 5 |
| 11 | Numerical analysis of magnetization AC losses in high-temperature superconducting slabs subjected to uniform strains显示文摘High-temperature superconductors in superconductor apparatuses are subjected to mechanical strains under operating conditions.These strains cause the degradation of the critical current densities and influence AC losses in the superconductors.Based on the dynamic process of thermomagnetic interaction,we report the results of numerical analysis of AC losses in an infinite high-temperature superconducting slab subjected to a uniform in-plane strain in an alternating external magnetic field parallel to the sample surface.The numerical analysis shows the details of electromagnetic phenomena in the slab and the dependences of AC loss on various external parameters including the uniform strain in the slab and the amplitude and frequency of the external magnetic field.In this paper,we find that whether the magnetic field fully penetrates the superconductor is the key factor that influences the features of AC loss.When the magnetic field cannot fully penetrate the superconductor,the loss rises with increasing strain or decreasing frequency.When the magnetic field can fully penetrate the superconductor,the feature is just opposite.We also analyze the effects of periodic strain on AC loss.It is interesting to find that when the periodic strain frequency equals the external magnetic field frequency,the AC loss reaches the maximum,regardless if the magnetic field fully penetrates the superconductor or not. | XIA Jing ZHOU YouHe | 2014 | Science China(Technological Sciences)2014，57，4： | 5 |
| 12 | Methane dry reforming on Ni/La_2Zr_2O_7 treated by plasma in different atmospheres显示文摘A series of Ni/La2Zr2O7 pyrochlore catalysts prepared by impregnation method and treated by dielectric barrier discharge(DBD) plasma in different atmospheres and varied sequences were prepared and applied for dry reforming of methane(DRM). It is found that all of the plasma treated catalysts show evidently improved activity and coke resistance in comparison with the non-plasma treated one. The best performance is achieved on Ni/La2Zr2O7–H2P–C,a catalyst treated in H2 plasma before calcination. TGA-DSC and SEM demonstrate that carbon deposition is significantly suppressed on all of the plasma treated samples. Moreover,XRD and TEM results testify that both Ni O and Ni sizes on the calcined and reduced samples treated by plasma are also decreased,which results in higher Ni metal dispersion on the reduced and used catalysts and enhances the interactions between Ni sites and the support. It is believed that these are the inherent reasons accounting for the promotional effects of plasma treatment on the reaction performance of the Ni/La2Zr2O7 pyrochlore catalysts. | Honggen Peng Youhe Ma Wenming Liu Xianglan Xu Xiuzhong Fang Jie Lian Xiang Wang Changqing Li Wufeng Zhou Ping Yuan | 2015 | Journal of Energy Chemistry2015，24，4： | 4 |
| 13 | Now is the time to test early urinary biomarkers in large-scale human samples显示文摘Although blood is the most common source for biomarkers,urine has not been completely ignored. There have been some urinary biomarker studies with clinical samples.However, most-if not all-biomarker researchers lack confidence in urine as a good biomarker source. Many researchers think that good results from urine are a statistical accident. To demonstrate the validity of urinary biomarkers,large-scale studies are needed. Until such convincing evidence exists, what funding agent could support research in this field? | Youhe Gao | 2019 | Science China(Life Sciences)2019，62，6： | 4 |
| 14 | Collection and preservation of urinary proteins, using a fluff pulp diaper显示文摘Change is the most fundamental property of a biomarker. In contrast to the blood, which is under homeostatic controls, urine reflects changes in the body earlier and is more sensitive, thus making it a better biomarker source. Moreover, drawing blood from infants and toddlers is difficult and not tolerated well. For patients limited by language, communicating their chief complaint is difficult. Thus, monitoring biomarkers in urine can provide valuable clues for the diagnosis of diseases, especially pediatric diseases. Collecting urine from young children and some adult patients is more challenging than collecting it from healthy adults.Here, we propose a method that uses a fluff pulp diaper to collect urine. Urinary proteins are then eluted and adsorbed onto a piece of nitrocellulose membrane, which can be dried and stored in a vacuum bag. SDS-PAGE and LC-MS/MS analysis indicated that this method is reproducible, and similar proteins were identified as those obtained by an acetone precipitation method. With this simple and economical method, it is possible to collect and preserve urine samples from infants, toddlers, and patients with special needs, even for large-scale biomarker studies. | Weiwei Qin Zhenhuan Du Youhe Gao | 2018 | Science China(Life Sciences)2018，61，6： | 4 |
| 15 | Wavelet solutions of Burgers' equation with high Reynolds numbers显示文摘A wavelet method is proposed to solve the Burgers’equation.Following this method,this nonlinear partial differential equation is first transformed into a system of ordinary differential equations using the modified wavelet Galerkin method recently developed by the authors.Then,the classical fourth-order explicit Runge–Kutta method is employed to solve the resulting system of ordinary differential equations.Such a wavelet-based solution procedure has been justified by solving two test examples:results demonstrate that the proposed method has a much better accuracy and efficiency than many other existing numerical methods,and whose order of convergence can go up to 5.Most importantly,our results also indicate that the present wavelet method can readily deal with those fluid dynamics problems with high Reynolds numbers. | LIU XiaoJing ZHOU YouHe ZHANG Lei WANG JiZeng | 2014 | Science China(Technological Sciences)2014，57，7： | 4 |
| 16 | A theoretical model of collision between soft-spheres with Hertz elastic loading and nonlinear plastic unloading显示文摘This paper presents a theoretical model on the normal(head-on) collision between soft-spheres on the basis of elastic loading of the Hertz contact for compression process and a nonlinear plastic unloading for restitution one,in which the parameters all are determined in terms of the material and geometric ones of the spheres,and the behaviors of perfect elastic,inelastic,and perfect plastic collisions appeared in the classical mechanics are fully described once a value of coefficient of restitution is specified in the region of 0 ≤ε≤ 1.After an empirical formula of the coefficient of restitution dependent on the impact velocity is suggested to fit the existing experimental measurements by means of the least square method,the predictions of the dependency and the collision duration are in well quantitative agreement with their experimental measurements.It is found that the measurable quantities are dependent on both the impact velocity and the parameters of spheres.Following this model,finally,an approach to determine the spring coefficient in the linear viscoelastic model of the collision is also displayed.These results obtained here will be significantly beneficial for the applications where a collision model is requested in the simulations of relevant grain flows and impact dynamics etc.. | Youhe Zhou 1,2,a) 1) Key Laboratory of Mechanics on Disaster and Environment in Western China,the Ministry of Education of China 2)Department of Mechanics and Engineering Science,College of Civil Engineering and Mechanics,Lanzhou University,Lanzhou 730000,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，4： | 4 |
| 17 | Early candidate biomarkers found from urine of glioblastoma multiforme rat before changes in MRI显示文摘Dear Editor,Gliomas are the most frequent primary tumors of the central nervous system,accounting for more than 60%of all brain tumors(Wang and Bettegowda,2015).Among them,glioblastoma multiforme(GBM)is the most common aggressive glioma,and the average survival rate remains low(Chen et al.,2015).The standard combination of surgery and radiotherapy or chemotherapy can only extend the progressionfree survival time for 12–18 months,with a high risk of recurrence(Li et al.,2008).In addition,the incidence of | Yanying Ni Fanshuang Zhang Manxia An Wei Yin Youhe Gao | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 18 | APPLICATIONS OF WAVELET GALERKIN FEM TO BENDING OF PLATE STRUCTURE显示文摘A kind of calculating method for high order differentials expanded by the wavelet scal-ing functions and the integral of their product used in Galerkin FEM is proposed,so that we can usethe wavelet Galerkin FEM to solve boundary-value differential equations with orders higher than two.To combine this method with the Generalized Gaussian integral method in wavelet theory,we can findthat this method has many merits in solving mechanical problems,such as the bending of plates andthose with variable thickness.The numerical results show that this method is accurate. | Zhou Youhe Wang Jizeng Zheng Xiaojing | 1999 | Acta Mechanica Solida Sinica1999，12，2： | 4 |
| 19 | Frictional Behavior of a Micro-sized Superconducting Fiber in a Low-Temperature Medium: Experimental and Computational Analysis显示文摘 | Shiren La Jun Wang Xingyi Zhang Youhe Zhou | 2018 | Acta Mechanica Solida Sinica2018，31，4： | 3 |
| 20 | Effects of charged sand on electromagnetic wave propagation and its scattering field显示文摘Based on the Rayleigh’s scattering theory, the effects of sandstorms on the propagation of electromagnetic wave with different visibilities are presented by solving the scattering field of charged sand particles. Because of the electric charges on the sand surface, the theoretical attenuation will be large enough to match the measured value under certain conditions. And the results show that the effect of sand with electric charges all over its surface on electromagnetic wave attenuation is the same as that of sand without charge, which proves that electric charges distribute on partial surface of the sand in fact. | HE Qinshu ZHOU Youhe ZHENG Xiaojing | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员