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| 1 | Urinary Biomarkers of Brain Diseases显示文摘Biomarkers are the measurable changes associated with a physiological or pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clinical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood,there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome. | Manxia An Youhe Gao | 2015 | Genomics, Proteomics & Bioinformatics2015，13，6： | 9 |
| 2 | Early candidate biomarkers found from urine of glioblastoma multiforme rat before changes in MRI显示文摘Dear Editor,Gliomas are the most frequent primary tumors of the central nervous system,accounting for more than 60%of all brain tumors(Wang and Bettegowda,2015).Among them,glioblastoma multiforme(GBM)is the most common aggressive glioma,and the average survival rate remains low(Chen et al.,2015).The standard combination of surgery and radiotherapy or chemotherapy can only extend the progressionfree survival time for 12–18 months,with a high risk of recurrence(Li et al.,2008).In addition,the incidence of | Yanying Ni Fanshuang Zhang Manxia An Wei Yin Youhe Gao | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
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