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| 1 | Efficacy and safety of icotinib in Chinese patients with advanced non-small cell lung cancer after failure of chemotherapy显示文摘 | Shao Lan Zhang Beibei He Chunxiao Lin Baochai Song Zhengbo Lou Guangyuan Yu Xinmin Zhang Yiping | 2014 | Chinese Medical Journal2014，，2： | 12 |
| 2 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 3 | Efficacy and advantages of modified Traditional Chinese Medicine treatments based on'kidney reinforcing'for chronic aplastic ane-mia:a randomized controlled clinical trial显示文摘OBJECTIVE:To compare the efficacy of modified treatments based on 'kidney reinforcing' in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),'kidney reinforcing and Qi tonifying'(KQ),and 'kidney reinforcing and blood circulation invigorating'(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery. | Wu Dijiong Shen Yiping Ye Baodong Fang Bingmu Lin Shengyun Chen Zhilu Jiang Huifang Feng Changwei He Lüyuan Gao Yanting Liu Yonglin Liu Yonghua Zhu Jiajia Wu Liqiang Shao Keding Zhou Yuhong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 6 |
| 4 | Evaluation of genotoxicity of combined soil pollution by cadmium and imidacloprid显示文摘Cadmium (Cd) is one of the important pollutants of soil and the genotoxicity of Cd-contaminated soil was studied in combination with imidacloprid. The single cell gel electrophoresis or comet assay was used to quantify DNA strand breaks as a measure of DNA damage induced by Cd and imidacloprid contamination in soil. The soil was artificially contaminated by Cd 2 h at 25℃ and were used in the comet assay. DNA damage was measured as the values of percentage of nuclei with tails, tail length, tail DNA, tail moment (TM), and Olive tail moment (OTM). DNA damages of root tips of Vicia faba increased after Cd treatment and there were dose-related increases in DNA damage measured as these parameters. However, the addition of imidacloprid further increased the DNA damage. These data confirmed the genotoxic effect of Cd to plants, and that the combined pollution with imidacloprid can enhance the genotoxicity of Cd. | LIN Aijun ZHU Yongguan TONG Yiping | 2005 | Science China(Life Sciences)2005，48，z1： | 6 |
| 5 | Liquid modified photonic crystal fiber for simultaneous temperature and strain measurement显示文摘A liquid modified photonic crystal fiber(PCF)integrated with an embedded directional coupler and multi-mode interferometer is fabricated by infiltrating three adjacent air holes of the innermost layer with standard 1.48 refractive index liquids.The refractive index of the filled liquid is higher than that of background silica,which can not only support the transmitting rod modes but also the'liquid modified core'modes propagating between the PCF core and the liquid rods.Hence,the light propagating in the liquid modified core can be efficiently coupled into the satellite waveguides under the phase-matching conditions,resulting in a dramatic decrease of the resonant wavelength intensity.Furthermore,there is a multi-mode interference produced by modified core modes and rod modes.Such a compact(~0.91 cm)device integrated with an embedded coupler and interferometer is demonstrated for high-sensitivity simultaneous temperature(~14.72 nm∕℃)and strain(~13.01 pm∕με)measurement. | CHUPAO LIN YING WANG YIJIAN HUANG CHANGRUI LIAO ZHIYONG BAI MAOXIANG HOU ZHENGYONG LI YIPING WANG | 2017 | Photonics Research2017，5，2： | 3 |
| 6 | Undoped semi-insulating indium phosphide (InP) and its applications显示文摘 | DONG Hongwei, ZHAO Youwen, JIAO Jinghua, ZENG Yiping, LI Jimin & LIN Lanying Materials Science Center, Institute of Semiconductors, Chinese Acad-emy of Sciences, Beijing 100083, China Correspondence should be addressed to Dong Hongwei | 2003 | Chinese Science Bulletin2003，48，4： | 3 |
| 7 | Entropy as a selection rule for crystal growth in undercooled binary eutectic melts显示文摘A solution entropy model was developed for the undercooled binary eutectic alloy systems. As an ex-tension of Taylor and Fidler et al.'s model, the present model considered the change of phase compo-sition with the increase of undercooling. Furthermore, the sub-regular solution model and the interac-tion parameter (IAB) were also introduced. In this paper, the extended model is used to calculate the solution entropy for binary eutectic phases under the undercooled condition, and the application scope of the model is also extended. Not only the growth manner of eutectic phases, but also the transition of morphologies may be predicted and explained by calculating the solution entropy of eutectic phases under the non-equilibrium condition with the developed model. Experimental results show that the developed model is valid for the undercooled Ni-Si and Ni-Sn eutectic alloy systems. | LU YiPing XI ZengZhe YANG GenCang LIN Xin ZHOU YaoHe | 2009 | Chinese Science Bulletin2009，54，6： | 2 |
| 8 | On applying stochastic network calculus显示文摘性能评估在网络系统的设计起一个关键作用。包括排队理论,有效带宽和网络演算,许多理论工具被建议了到 providemodeling 机制和结果。当这些理论广泛地为表演评估被采用了时,各个有它的自己的限制。与那个网络,系统变得更复杂、更难在很多无常和随意存在的地方,描述,到使如此的系统的表演评估易控制,某妥协经常必要、有用。随机的网络演算(SNC ) 是如此的一个理论工具。当 SNC 是一个相对新的理论时,它正在增加增加兴趣和流行。在当前的 SNC 文学,许多注意自己在理论的发展被给予了。另外,研究人员们也开始了在最近的年里把 SNC 用于系统的各种各样的类型的性能分析。这份报纸的目的是在新理论工具上提供一本教程。明确地,各种各样的 SNC 交通模型和 SNC 服务者模型被考察。焦点在怎么使用 SNC 上它,四关键步被形式化并且讨论。另外, SNC 申请话题 / 区域的一张表可以在那里存在巨大的研究潜力,被介绍。 | Chuang LIN Yiping DENG Yuming JIANG | 2013 | Frontiers of Computer Science2013，7，6： | 2 |
| 9 | THE HOPF BIFURCATION DIRECTION OF A FOUR DIMENSIONAL ELECTRONIC NEURAL NETWORK SYSTEM显示文摘In this paper we give an applicable parameter formula about the bifurcationand stability of periodic solution for a four-dimensional differential system. By using thisresult in a simple electronic neural network system, we obtain a strict condition of theexistence of periodic solution. | LIN Yiping LI Jibin(Institute of Applied Mathematics of Yunnan Province, Kunming University of Science and Technology, Kunming 650093, China)CAO Jinde(College of Adult Education, Yunnan University, Kunming 650091, China) | 1997 | Systems Science and Mathematical Sciences1997，10，4： | 2 |
| 10 | Deep level defects in high temperature annealed InP显示文摘b Deep level defects in high temperature annealed semi-condctng InP have been studied by deep level transient spectroscopy (DLTS). There is obvious difference in the deep defects between as-grown InP InP annealed in phosphorusambient and iron phosphide ambient, as far as their quantity and coneentration are concerned. Only two defects at 0.24 and 0.64 eV can be detected in InP annealed in iron phosphide amibent, while defects at 0.24,0.42,0.54 and 0.64 eV have been detected in InP annealed in phosphorus ambient, in contrast to two defects at 0.49 and 0.64 eV or one defect at 0.13 eV in as-grown InP. A defect suppression phenomenon related to iron diffusion process has been observed. The formation mechanism and the nature of the defects have been discussed. | DONG Zhiyuan ZHAO Youwen ZENG Yiping DUAN Manlong LIN Lanying | 2004 | Science China(Technological Sciences)2004，47，3： | 2 |
| 11 | A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1αin pancreatic cancer显示文摘Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer(PC).Both the long non-coding RNA(lncRNA)plasmacytoma variant translocation 1(PVT1)and hypoxic inducible factor-1α(HIF-1α)are highly expressed in PC patients and play a crucial role in disease progression.Reciprocal regulation involving PVT1 and HIF-1αin PC,however,is poorly understood.Here,we report that PVT1 binds to the HIF-1αpromoter and activates its transcription.In addition,we found that PVT1 could bind to HIF-1αand increases HIF-1αpost-translationally.Our findings suggest that the PVTl-HIF-1αpositive feedback loop is a potential therapeutic target in the treatment of PC. | Yiping Zhu Fang Wu Weiwei Gui Nan Zhang Erik Matro Linghua Zhu Daniel Turunen Eserberg Xihua Lin | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 12 | Two Ultraviolet Radiation Datasets that Cover China显示文摘Ultraviolet(UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to observe the UV radiation, with an accuracy of 5%, which meets the World Meteorology Organization's measurement standards. The extremum method was used to control the quality of the measured datasets. The other dataset contains daily cumulative UV radiation estimates that were calculated using an all-sky estimation model combined with a hybrid model. The reconstructed daily UV radiation data span from 1961 to 2014. The mean absolute bias error and root-mean-square error are smaller than 30% at most stations, and most of the mean bias error values are negative, which indicates underestimation of the UV radiation intensity. These datasets can improve our basic knowledge of the spatial and temporal variations in UV radiation. Additionally, these datasets can be used in studies of potential ozone formation and atmospheric oxidation, as well as simulations of ecological processes. | Hui LIU Bo HU Yuesi WANG Guangren LIU Liqin TANG Dongsheng JI Yongfei BAI Weikai BAO Xin CHEN Yunming CHEN Weixin DING Xiaozeng HAN Fei HE Hui HUANG Zhenying HUANG Xinrong LI Yan LI Wenzhao LIU Luxiang LIN Zhu OUYANG Boqiang QIN Weijun SHEN Yanjun SHEN Hongxin SU Changchun SONG Bo SUN Song SUN Anzhi WANG Genxu WANG Huimin WANG Silong WANG Youshao WANG Wenxue WEI Ping XIE Zongqiang XIE Xiaoyuan YAN Fanjiang ZENG Fawei ZHANG Yangjian ZHANG Yiping ZHANG Chengyi ZHAO Wenzhi ZHAO Xueyong ZHAO Guoyi ZHOU Bo ZHU | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 13 | Spatiotemporal analysis of drought variability based on the standardized precipitation evapotranspiration index in the Koshi River Basin, Nepal显示文摘Drought is an inevitable condition with negative impacts in the agricultural and climatic sectors,especially in developing countries.This study attempts to examine the spatial and temporal characteristics of drought and its trends in the Koshi River Basin(KRB)in Nepal,using the standardized precipitation evapotranspiration index(SPEI)over the period from 1987 to 2017.The Mann-Kendall test was used to explore the trends of the SPEI values.The study illustrated the increasing annual and seasonal drought trends in the KRB over the study period.Spatially,the hill region of the KRB showed substantial increasing drought trends at the annual and seasonal scales,especially in summer and winter.The mountain region also showed a significant increasing drought trend in winter.The drought characteristic analysis indicated that the maximum duration,intensity,and severity of drought events were observed in the KRB after 2000.The Terai region presented the highest drought frequency and intensity,while the hill region presented the longest maximum drought duration.Moreover,the spatial extent of drought showed a significant increasing trend in the hill region at the monthly(drought station proportion of 7.6%/10 a in August),seasonal(drought station proportion of 7.2%/10 a in summer),and annual(drought station proportion of 6.7%/10 a)scales.The findings of this study can assist local governments,planners,and project implementers in understanding drought and developing appropriate mitigation strategies to cope with its impacts. | Nirmal M DAHAL XIONG Donghong Nilhari NEUPANE Belayneh YIGEZ ZHANG Baojun YUAN Yong Saroj KOIRALA LIU Lin FANG Yiping | 2021 | Journal of Arid Land2021，13，5： | 1 |
| 14 | Stability and Hopf bifurcation for an epidemic disease model with delay 显示文摘 | Chengjun Sun Yiping Lin Maoan Han | 2006 | Chaos Solitons and Fractals2006，30，： | 1 |
| 15 | Identification of WSB1 gene as an important regulator in the development of zebrafish embryo during midblastula transition显示文摘为了揭开,新奇基因潜在地在胚胎包含了开发,特别在中间的胞胚转变(MBT ) 在斑马鱼的发展中的胚胎的阶段, Affymetrix 斑马鱼 GeneChip 微数组分析在 14,900 个基因抄本的表达式上被执行。分析的结果证明 360 基因清楚地是起来调整的, 119 基因是显著地下面调整的。许多这些基因涉及转录因子活动, nucleic 绑定,和房间生长。现在的学习证明在抄本丰富的重要变化发生在 MBT 阶段期间。这 479 基因中的八个的表达式被反向的抄写聚合酶链反应分析识别,证实微数组结果。WSB1 基因,发现由微数组和反向的抄写聚合酶链反应分析下面调整,为进一步的学习被选择。WSB1 基因的顺序分析证明它与 75% 身份编码蛋白质到相应活跃人的 orthologs。另外, WSB1 基因表达在 4 h 柱子授精在 2 h 柱子授精并且在底层在高水平被检测,与薄片结果一致。WSB1 基因的 Overexpression 能在胚胎导致畸形的形成,由激活荧光的房间排序决定了。现在的学习不含糊地证明 WSB1 表示的出现在在斑马鱼胚胎的开发的 MBT 阶段期间是一个重要事件。 | Wenjian Lv Yunbin Zhang Zhili Wu Lin Chu S. S. Koide Yuguang Chen Yuanchang Yan Yiping Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 1 |
| 16 | The competitive model based on the demand response in the off-peak period for the taipower system显示文摘 | Chu Wenchen Chen Yiping Lin Tzuhao | 2008 | IEEE Transactions on Industry Applications2008，44，4： | 1 |
| 17 | Parametric optimization and comparative study of organic Rankine cycle (ORC) for low grade waste heat recovery 显示文摘 | Dai Yiping Wang Jiangfeng Gao Lin | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 18 | Exergy analyses and parametric optimizations for different cogeneration power plants in cement industry显示文摘 | WANG JIANGFENG DAI YIPING GAO LIN | 2009 | Applied Energy2009，86，： | 1 |
| 19 | A Triterp-noid fromKadsttra heteroclita显示文摘 | Chen Yiping Lin Zhongwen Zhang Hongjie | 1990 | Phytochemistry1990，29，10： | 1 |
| 20 | A new combined cooling, heating and power system driven by solar energy显示文摘 | Jiangfeng Wang Yiping Dai Lin Gao Shaolin Ma | 2009 | Renewable Energy2009，，12： | 1 |
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