|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemic transition of environmental health risk during China's urbanization显示文摘China has experienced rapid urbanization in recent decades along with dramatic economic growth.Previous studies have shown that urbanization has both positive and negative effects on health.However, there is a lack of research on the overall effects of urbanization on the epidemic transition of environmental health risks considering various pathways in China. In the present study, we studied the contributions of different aspects of urbanization in China to epidemic transitions using provincial and multi-year(1995, 2000, 2005, and 2010) panel data. Statistical models with fixed and random effects were developed to explore the impacts of different urbanization indicators on the overall epidemic transition of environmental health(general model) and the changes in cause-specific mortality rates of typical diseases(cause-specific models). The results show that the impacts of non-communicable diseases continue to grow during the urbanization process in China. The ratio of communicable disease-related mortality to non-communicable disease-related mortality continues to decrease over time. The general model shows that the improved medical conditions(coefficient = 0.0011, P = 0.037), the improved urban infrastructure(e.g., tap water supply)(coefficient = 0.00065, P < 0.001), and the rise in income(coefficient = 0.00027, P = 0.047) during the urbanization process are important factors that promote this overall epidemic transition. The cause-specific models show that the mechanisms behind the general model are complicated. More attention should be paid to non-communicable diseases in urban health management. Specific health policies for different diseases should incorporate the considerations of different impact pathways of urbanization. | Miaomiao Liu Xingyu Liu Yining Huang Zongwei Ma Jun Bi | 2017 | Science Bulletin2017，62，2： | 9 |
| 2 | Preparation of microstructure-controllable superhydrophobic polytetrafluoroethylene porous thin film by vacuum thermal-evaporation显示文摘 | Na YI Shanhu BAO Huaijuan ZHOU Yunchuan XIN Aibin HUANG Yining MA Rong LI PingJIN | 2016 | Frontiers of Materials Science2016，10，3： | 2 |
| 3 | Optical Properties and Source Analysis of Aerosols over a Desert Area in Dunhuang,Northwest China显示文摘Aerosol observational data for 2012 obtained from Dunhuang Station of CARE-China(Campaign on Atmospheric Aerosol Research Network of China) were analyzed to achieve in-depth knowledge of aerosol optical properties over Dunhuang region. The results showed that the annual average aerosol optical depth(AOD) at 500 nm was 0.32 ± 0.06, and the ?ngstr?m exponent(α) was 0.73 ± 0.27. Aerosol optical properties revealed significant seasonal characteristics. Frequent sandstorms in MAM(March–April–May) resulted in the seasonal maximum AOD, 0.41 ± 0.04, and a relatively smaller αvalue, 0.44 ± 0.04. The tourism seasons, JJA(June–July–August) and SON(September–October–November) coincide with serious emissions of small anthropogenic aerosols. While in DJF(December–January–February), the composition of the atmosphere was a mixture of dust particles and polluted aerosols released by domestic heating; the average AOD and αwere 0.29 ± 0.02 and 0.66 ± 0.17, respectively. Different air masses exhibited different degrees of influence on the aerosol concentration over Dunhuang in different seasons. During MAM, ranges of AOD(0.11–1.18) and α(0.06–0.82) were the largest under the dust influence of northwest-short-distance air mass in the four trajectories. Urban aerosols transported by northwest-short-distance air mass accounted for a very large proportion in JJA and the mixed aerosols observed in SON were mainly conveyed by air masses from the west. In DJF, the similar ranges of AOD and α under the three air mass demonstrated the analogous diffusion effects on regional pollutants over Dunhuang. | Yongjing MA Jinyuan XIN Yining MA Lingbin KONG Kequan ZHANG Wenyu ZHANG Yuesi WANG Xiuqin WANG Yongfeng ZHU | 2017 | Advances in Atmospheric Sciences2017，34，8： | 2 |
| 4 | Summary for Wireless SensorNetwork 显示文摘 | Ma Zuchang Sun Yining Mei Fao | 2004 | Journal of China Instilule of Communications2004，25，4： | 1 |
| 5 | FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway显示文摘CDK4/6 inhibitors are routinely recommended agents for the treatment of advanced HR+HER2-breast cancer.However,their therapeutic effectiveness in triple-negative breast cancer(TNBC)remains controversial.Here,we observed that the expression level of fibrous sheath interacting protein 1(FSIP1)could predict the treatment response of TNBC to CDK4/6 inhibitors.High FSIP1 expression level was related to a poor prognosis in TNBC,which was associated with the ability of FSIP1 to promote tumor cell proliferation.FSIP1 downregulation led to slowed tumor growth and reduced lung metastasis in TNBC.FSIP1knockout caused cell cycle arrest at the G0/G1 phase and reduced treatment sensitivity to CDK4/6 inhibitors by inactivating the Nanog/CCND1/CDK4/6 pathway.FSIP1 could form a complex with Nanog,protecting it from ubiquitination and degradation,which may facilitate the rapid cell cycle transition from G0/G1 to S phase and exhibit enhanced sensitivity to CDK4/6 inhibitors.Our findings suggest that TNBC patients with high FSIP1 expression levels may be suitable candidates for CDK4/6 inhibitor treatment. | Guanglei Chen Lisha Sun Xi Gu Liping Ai Jie Yang Zhan Zhang Pengjie Hou Yining Wang Xunyan Ou Xiaofan Jiang Xinbo Qiao Qingtian Ma Nan Niu Jinqi Xue Hao Zhang Yongliang Yang Caigang Liu | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 6 | Kinetics Modeling of Fischer-Tropsch Synthesis over an Industrial Fe-Cu-K catalyst 显示文摘 | Yining Wang Wenping Ma Yijun Lu | 2003 | Fuel2003，，82： | 1 |
| 7 | A Poriferous Nanoflake-Assembled Flower-Like Ni_(5)P_(4) Anode forHigh-Performance Sodium-Ion Batteries显示文摘Sodium-ion batteries(SIBs)have been regarded as one of the most competitive alternatives for lithium-ion batteries(LIBs)due to the abundance of sodium and comparable electrochemical characteristics of sodium to that of lithium.However,while highly desired,developing stable anode materials remains a critical challenge.In this work,the development of a stable anode for SIBs is reported,a poriferous nanoflake-assembled flower-like nickel tetraphosphide(PNAF-NP)with high surface area and typical mesoporous property.Due to the unique structure,the PANF-NP anode exhibits excellent reversible capacity of 648.34mAhg^(-1) at 0.2Ag^(-1) with a Coulombic efficiency of 98.67%,and superior cycling stability at 0.2Ag^(-1) with high retention capacity of 456.34 mAhg^(-1) and average Coulombic efficiency of 99.19%after 300 cycles.Moreover,the high reversible capacity of 614.43,589.49,512.66,and 432.23mAhg^(-1) is achieved at 0.5,1,2,and 5Ag^(-1),respectively,indicating the superior rate capability of the PNAF-NP anode.This work represents a great advancement in the field of SIBs by reporting a high-performance anode material. | Ruihan Zhang Vidhur Raveendran Yining He Andy Yau Austin Chang Cheng Chi Sungyool Bong Feng Cheng Weigang Ma Jun Chen | 2021 | Energy Material Advances2021，，1： | 1 |
| 8 | Hydrogel-Based Stimuli-Responsive Micromotors for Biomedicine显示文摘The rapid development of medical micromotors draws a beautiful blueprint for the noninvasive or minimally invasive diagnosis and therapy.By combining stimuli-sensitive hydrogel materials,micromotors are bestowed with new characteristics such as stimuli-responsive shape transformation/morphing.excellent biocompatibility and biodegradability,and drug loading ability.Actuated by chemical fuels or external fields(eg,magnetic field,ultrasound,light,and electric field),hydrogel-based stimuli-responsive(HBSR)micromotors can be utilized to load therapeutic agents into the hydrogel networks or directly grip the target cargos(eg.,drug-loaded partides,cells,and thrombus),transport them to sites of interest(e.g.,tumor area and diseased tissues),and unload the cargos or execute a specific task(e.g.,cell capture,targeted sampling,and removal of blood dots)in response to a stimulus(eg.,change of temperature,pH,ion strength,and chemicals)in the physiological environment.The high flexibility,adaptive capacity,and shape morphing property enable the H BSR micromotors to complete specific medical tasks in complex physiological scenarios,especially in confined,hard to-reach tissues,and vessels of the body.Herein,this review summarizes the current progress in hydrogel-based medical micromotors with stimuli responsiveness.The thermo-responsive,photothermal-responsive,magnetocaloric-responsive,pH-responsive,ionic strength-responsive,and chemoresponsive micromotors are discussed in detail.Finally,curent challenges and future perspectives for the development of HBSR micromotors in the biomedical field are discussed. | Huaijuan Zhou Guozhao Dong Ge Gao Ran Du Xiaoying Tang Yining Ma Jinhua Li | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
| 9 | Advances in Research of Extraction Processes and Anti-aging Effect of Flavonoids in Traditional Chinese Medicines显示文摘Flavonoids are secondary metabolites in plants and possess extensive pharmacological activities.Flavonoids have remarkable effect in prevent anti-tumor and cancer,but flavonoids can't be synthesized directly in the body.According to the different properties and structures of flavonoids in Traditional Chinese medicines,different extraction methods should be selected.Besides,flavonoids have good anti-aging effects.Based on three theories of modern aging,the anti-aging effect of flavonoids was discussed.It is expected to provide a beneficial reference for further development and utilization of natural flavonoid resources. | Yining MA Liwei BI | 2022 | Medicinal Plant2022，13，2： | 0 |
| 10 | LncRNA ZFAS1 regulates cardiomyocyte differentiation of human embryonic stem cells显示文摘Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent. | YANG CAO YINING LIU YANG YU XIAOFEI GUO XIUXIU WANG WENYA MA HANJING LI ZHONGYU REN XINLU GAO SIJIA LI HAOYU JI HONGYANG CHEN HONG YAN YANAN TIAN XIN WANG BENZHI CAI | 2023 | BIOCELL2023，47，6： | 0 |
| 11 | Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy显示文摘To achieve highly selective synergistic chemotherapy attractive for clinical translation,the precise polymeric nano-prodrugs(PPD-NPs)were successfully constructed via the facile crosslinking reaction between p H-sensitive poly(ortho ester)s and reduction-sensitive small molecule synergistic prodrug(Pt(IV)-1).PPD-NPs endowed the defined structure and high drug loading of cisplatin and demethylcantharidin(DMC).Moreover,PPD-NPs exhibited steady long-term storage and circulation via the crosslinked structure,suitable negative potentials and low critical micelle concentration(CMC),improved selective tumour accumulation and cellular internalization via dynamic size transition and surficial amino protonation at tumoural extracellular p H,promoted efficient disintegration and drug release at tumoural intracellular p H/glutathione,and enhanced cytotoxicity via the synergistic effect between cisplatin and DMC with the feed ratio of 1:2,achieving significant tumour suppression while decreasing the side effects.Thus,the dynamic crosslinked polymeric nano-prodrugs exhibit tremendous potential for clinically targeted synergistic cancer therapy. | Shi Wang Yining Song Jingge Ma Xinyang Chen Yuanhui Guan Hui Peng Guoqing Yan Rupei Tang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
| 12 | Palladium membrane electro-hydrogenation显示文摘Palladium(Pd)plays a significant role in substantial catalytic reactions.On account of the strong affinity for hydrogen,various Pd-based nanostructures with different shapes and sizes have been extensively utilized in hydrogenation reactions.In particular,Pd reveals extraordinary properties while interacting with hydrogen,including strong adsorption,barrier-less dissociation,and large storage of hydrogen under ambient temperatures and pressures. | Yining Ma Run Shi Tierui Zhang | 2022 | The Innovation2022，3，6： | 0 |
| 13 | Genetic and histological relationship between pheromone-secreting tissues of the musk gland and skin of juvenile Chinese forest musk deer(Moschus berezovskii Flerov,1929)显示文摘Background The musk glands of adult male Chinese forest musk deer(Moschus berezovskii Flerov,1929)(FMD),which are considered as special skin glands,secrete a mixture of sebum,lipids,and proteins into the musk pod.Together,these components form musk,which plays an important role in attracting females during the breeding season.However,the relationship between the musk glands and skin of Chinese FMD remains undiscovered.Here,the musk gland and skin of Chinese FMD were examined using histological analysis and RNA sequencing(RNA-seq),and the expression of key regulatory genes was evaluated to determine whether the musk gland is derived from the skin.Methods A comparative analysis of musk gland anatomy between juvenile and adult Chinese FMD was conducted.Then,based on the anatomical structure of the musk gland,skin tissues from the abdomen and back as well as musk gland tissues were obtained from three juvenile FMD.These tissues were used for RNA-seq,hematoxylin-eosin(HE)staining,immunohistochemistry(IHC),western blot(WB),and quantitative real-time polymerase chain reaction(qRT-PCR)experiments.Results Anatomical analysis showed that only adult male FMD had a complete glandular organ and musk pod,while juvenile FMD did not have any well-developed musk pods.Transcriptomic data revealed that 88.24%of genes were co-expressed in the skin and musk gland tissues.Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathway analysis found that the genes co-expressed in the abdomen skin,back skin,and musk gland were enriched in biological development,endocrine system,lipid metabolism,and other pathways.Gene Ontology(GO)enrichment analysis indicated that the genes expressed in these tissues were enriched in biological processes such as multicellular development and cell division.Moreover,the Metascape predictive analysis tool demonstrated that genes expressed in musk glands were skin tissue-specific.qRT-PCR and WB revealed that sex-determining region Y-box protein 9(Sox9),Caveolin-1(Cav-1),and androgen receptor(AR)were expressed in all three tissues,although the expression levels differed among the tissues.According to the IHC results,Sox9 and AR were expressed in the nuclei of sebaceous gland,hair follicle,and musk gland cells,whereas Cav-1 was expressed in the cell membrane.Conclusions The musk gland of Chinese FMD may be a derivative of skin tissue,and Sox9,Cav-1,and AR may play significant roles in musk gland development. | Long LI Heran CAO Jinmeng YANG Tianqi JIN Yuxuan MA Yang WANG Zhenpeng LI Yining CHEN Huihui GAO Chao ZHU Tianhao YANG Yalong DENG Fangxia YANG Wuzi DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，9： | 0 |
| 14 | Optical,Radiative and Chemical Characteristics of Aerosol in Changsha City,Central China显示文摘Industrial pollution has a significant effect on aerosol properties in Changsha City,a typical city of central China.Therefore,year-round measurements of aerosol optical,radiative and chemical properties from 2012 to 2014 at an urban site in Changsha were analyzed.During the observation period,the energy structure was continuously optimized,which was characterized by the reduction of coal combustion.The aerosol properties have obvious seasonal variations.The seasonal average aerosol optical depth(AOD)at 500 nm ranged from 0.49 to 1.00,single scattering albedo(SSA)ranged from 0.93 to 0.97,and aerosol radiative forcing at the top of the atmosphere(TOA)ranged from−24.0 to 3.8 W m^−2.The chemical components also showed seasonal variations.Meanwhile,the scattering aerosol,such as organic carbon,SO42−,NO3−,and NH4+showed a decrease,and elemental carbon increased.Compared with observation in winter 2012,AOD and TOA decreased by 0.14 and−1.49 W m^−2 in winter 2014.The scattering components,SO42−,NO3−and NH4+,decreased by 12.8μg m^−3(56.8%),9.2μg m^−3(48.8%)and 6.4μg m^−3(45.2%),respectively.The atmospheric visibility and pollution diffusion conditions improved.The extinction and radiative forcing of aerosol were significantly controlled by the scattering aerosol.The results indicate that Changsha is an industrial city with strong scattering aerosol.The energy structure optimization had a marked effect on controlling pollution,especially in winter(strong scattering aerosol). | Xiaoyan WU Jinyuan XIN Wenyu ZHANG Chongshui GONG Yining MA Yongjing MA Tianxue WEN Zirui LIU Shili TIAN Yuesi WANG Fangkun WU | 2020 | Advances in Atmospheric Sciences2020，37，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员