|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | Gene expression profiling and endothelin in acute experimental pancreatitis显示文摘AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy. | Helieh S Oz Ying Lu Louis P Vera-Portocarrero Pei Ge Ada Silos-Santiago Karin N Westlund | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 4 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 5 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 6 | Numerical study on the dynamics of a driven disordered vortex lattice 显示文摘 | Cao Y G Jiao Z K Ying H P | 2000 | Phys Rev B2000，62，： | 1 |
| 7 | Effect of oxide vscale ontemperature-dependent interfacial heat transfer in hotstamping process显示文摘 | Hua P Ying L Li Y | 2013 | Journal of Materials ProcessingTechnology2013，213，9： | 1 |
| 8 | Sensitized luminescence from sol-gel-derived SrAl2O4 co-doped with Cu^2+ and Dy^3+ 显示文摘 | YING P LU M K XU D | 2003 | Materials Science and Engineering2003，64，： | 1 |
| 9 | Preparation of Mo2C/HZSM-5 and its catalytic performance for the conversion of n-butane into aromatics显示文摘 | YUAN S DERANOUE-ABD HAMIDB S B LI Y YING P XIN Q DEROUANE E G LI C | 2002 | J Mol Catal A2002，184，12： | 1 |
| 10 | An investigation of dynamic subcarrier allocation in MIMO-OFDMA systems 显示文摘 | PENG Ying ARMOUR S M D McGEEHAN J P | 2007 | IEEE Trans on Vehicular Technology2007，56，5： | 1 |
| 11 | A Potential Causal Association Mining Algorithm for Screening Adverse Drug Reactions in Postmarketing Surveillance显示文摘 | Ji Y Ying H Dews P | 2011 | IEEE transactions on information technology in biomedicine2011，15，3： | 1 |
| 12 | Epidemiology and outcomes of health-care-associated pneumonia from a large vs database of culture-positive pneumonia 显示文摘 | MARIN H K ANDREW S YING P | 2005 | Am J Respir Crit Care Med2005，171，2： | 1 |
| 13 | DNA and RNA-based vaccines: principles, progress and prospects显示文摘 | Leitner W W Ying H Restifo N P | 2000 | Vaccines2000，18，910： | 1 |
| 14 | Ah receptor signals cross-talk with multiple developmental pathways显示文摘 | Alvaro P Craig R T Ying X | 2005 | Biochemical Pharmac2005，69，2： | 1 |
| 15 | Relationship between circadian oscillations of Hev-erbo expression and intracellular levels of its ligand, heme显示文摘 | ROGERS P M YING L BURRIS T P | 2008 | Biochemical and Biophysical Research Communications2008，368，4： | 1 |
| 16 | The promotional effect of NO on N2 O decomposition over the bi-nuclear Fe sites in Fe /ZSM-5显示文摘 | XIA H SUN K LIU Z FENG Z YING P LI C | 2010 | J Catal2010，270，1： | 1 |
| 17 | 显示文摘 | Luo M Ying P | 2003 | Appl Catal A2003，246，： | 1 |
| 18 | Study of the mechanism for poly (p-phenylene) benzoxazole polymerization-A remarkable reaction pathway to make rigid-rod polymers显示文摘 | Ying H S Jerry P H Bruce B | 1998 | Macromolecules1998，31，： | 1 |
| 19 | Synthesis, characteriza- tion and spectroscopic studies of copolymer of styrene with 4-oxe4 (P-hydroxyl phenylamino ) but-2-enoic acid and corresponding fluorescent macromolecular lanthanide (Ⅲ) complexes 显示文摘 | Liang X Jia X Q Ying Y Hou L P | 2010 | Eu- ropean Polymer Journal2010，46，： | 1 |
| 20 | Phase transformation in the surface region of zirconia detected by UV raman spectroscopy显示文摘 | LI M FENG Z XIONG G XIONG G YING P XIN Q LI C | 2001 | J Phys Chem B2001，105，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员