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| 1 | Procyanidins from grape seeds protect against phorbol ester-induced oxidative cellular and genotoxic damage显示文摘AIM: To evaluate the inhibitory effects of Vitis vinifera procyanidins (PAs) on carcinogen-induced oxidative stress. METHODS: The single cell gel electrophoresis technique (comet assay) was employed to detect DNA damage induced by the carcinogen phorbol-12-myristate-13-acetate (PMA), The release of hydrogen peroxidase from polymorphonuclear leukocytes (PMNs) was assayed by the horseradish peroxidase-mediated oxidation of phenol red. The microplate assay was used to detect the presence of oxidative products by means of 2',7'-dichlorofluorescindiacetate (DCFH-DA). The superoxide dismutase (SOD) activity of liver mitochondria was assayed, based on the ability of SOD to inhibit the generation of superoxidate anions by the xanthine-xanthine oxidase system. The malondialdehyde (MDA) level was determined by the thiobarbituric acid (TBA) assay. RESULTS: DNA of NIH3T3 cells was significantly damaged after addition of PMA. The length of the comet tail was observed ,while in normal cells the comet tail could not be observed. PAs showed significant protective effects on carcinogen PMA-induced DNA damage. Through assessment of DCFH-DA oxidation, PAs were shown to inhibit the PMA-induced release of hydrogen peroxide by PMNs, and to inhibit respiratory burst activity in NIH3T3 mouse fibroblasts. Ex vivo study showed that serum from rats administered with PAs displayed similar effects in a dose-dependent manner. In addition, PAs suppressed liver mitochondrial lipid peroxidation induced by PMA. PAs protected the activity of SOD and decreased the level of MDA in liver mitochondria damaged by PMA. CONCLUSION: Dietary PAs from grape seeds protect against carcinogen-induced oxidative cellular and genotoxic damage, | YinLU Wan-zhouZHAO ZaiCHANG Wen-xingCHEN LinLI | 2004 | Acta Pharmacologica Sinica2004，25，8： | 10 |
| 2 | Use of suppression subtractive hybridization strategy for cloning and identifying specifically expressed genes of renal cell carcinoma显示文摘Using suppression subtractive hybridization, a renal cell carcinoma (RCC) cDNA subtractive library which only contains differently expressed cDNAs between human RCC and normal kidney has been constructed. 200 clones were picked out randomly to perform enzyme digest analysis, a part of them underwent sequence analysis and Northern blot to identify RCC specially expressed genes. Results showed that 190 clones contain 50-400 bp inserts respectively. Sequence analysis was performed in 10 clones. All the 10 sequences were unknown before and derived from 6 unique novel genes among which the cDNA insert RCC18 has five copies. Northern blot analysis showed that RCC18 cDNA expressed highly in RCC, but there was no signal detected in normal kidney, and the full length of RCC18 was about 2.5 kb. The constructed cDNA subtractive library of human RCC is a highly efficient one and lays the solid foundation for large-scale screening and cloning new and specific oncogenes or tumor suppressor genes of RCC. The novel | ZHANG Qiang ZHANG Zhiwen GONG Kan XIN Dianqi NA Yanqun GUO Yinlu | 2001 | Chinese Science Bulletin2001，46，3： | 8 |
| 3 | Helium-3 global optical model potential with energies below 250 MeV显示文摘A new set of global phenomenological optical model potential parameters has been obtained for helium-3 projectile,by simultaneously fitting the experimental data of helium-3 total reaction cross sections and elastic scattering angular distributions in the mass range of target nuclei 20 A 209 at incident energies below 250 MeV.A comparison has been made between the extracted helium-3 global optical model potential parameters and the existing ones.The calculated results of total reaction cross sections and elastic scattering angular distributions are also compared with experimental data with their satisfactory agreement. | XU YongLi GUO HaiRui HAN YinLu SHEN QingBiao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 4 |
| 4 | Globally Exponential Stability of Memristive Neural Networks With Time-varying Delays and Synchronous Switching显示文摘 | Yinlu Jiang Chuandong Li | 2017 | 自动化学报2017，43，8： | 3 |
| 5 | RIPL – Reference Input Parameter Library for Calculation of Nuclear Reactions and Nuclear Data Evaluations显示文摘 | R. Capote M. Herman P. Oblo?insky P.G. Young S. Goriely T. Belgya A.V. Ignatyuk A.J. Koning S. Hilaire V.A. Plujko M. Avrigeanu O. Bersillon M.B. Chadwick T. Fukahori Zhigang Ge Yinlu Han S. Kailas J. Kopecky V.M. Maslov G. Reffo M. Sin E.Sh. Soukhovitski | 2009 | Nuclear Data Sheets2009，，12： | 2 |
| 6 | Engineered biocontainable RNA virus vectors for non-transgenic genome editing across crop species and genotypes显示文摘CRISPR/Cas genome-editing tools provide unprecedented opportunities for basic plant biology research and crop breeding.However,the lack of robust delivery methods has limited the widespread adoption of these revolutionary technologies in plant science.Here,we report an efficient,non-transgenic CRISPR/Cas delivery platform based on the engineered tomato spotted wilt virus(TSWV),an RNA virus with a host range of over 1000 plant species.We eliminated viral elements essential for insect transmission to liberate genome space for accommodating large genetic cargoes without sacrificing the ability to infect plant hosts.The resulting non-insect-transmissible viral vectors enabled effective and stable in planta delivery of Cas12a and Cas9 nucleases as well as adenine and cytosine base editors.In systemically infected plant tissues,the deconstructed TSWV-derived vectors induced efficient somatic gene mutations and base conversions in multiple crop species with little genotype dependency.Plants with heritable,bi-allelic mutations could be readily regenerated by culturing the virus-infected tissues in vitro without antibiotic selection.Moreover,we showed that antiviral treatment with ribavirin during tissue culture cleared the viral vectors in 100%of regenerated plants and further augmented the recovery of heritable mutations.Because many plants are recalcitrant to stable transformation,the viral delivery system developed in this work provides a promising tool to overcome gene delivery bottlenecks for genome editing in various crop species and elite varieties. | Qian Liu Chenglu Zhao Kai Sun Yinlu Deng Zhenghe Li | 2023 | Molecular Plant2023，16，3： | 2 |
| 7 | High-efficiency Extraction of Bitumen from Oil Sands Using Mixture of Ionic Liquid [Emim][BF_(4)] and Dichloromethane显示文摘An ionic liquid(IL),1-ethyl-3-methyl imidazolium tetrafluoroborate([Emim][BF_(4)]),was used to enhance bitumen recovery from oil sands by dichloromethane solvent extraction.A multiphase system could be formed by simply mixing the components at ambient temperature,consisting of sands and clays,mixtures of ionic liquid and dichloromethane,and concentrated bitumen layer.The results demonstrated that[Emim][BF_(4)]increased the bitumen recovery up to 92%.Much less clay fines were found in the recovered bitumen than those formed by using dichloromethane solvent extraction alone,and the dichloromethane residue was not detected in the spent sands.We proposed that[Emim][BF_(4)]had an ability to reduce the adhesion of bitumen to sand,resulting in an improved separation efficiency.Furthermore,[Emim][BF_(4)]could facilitate the transfer of the extracted bitumen to the surface interface,and then the bitumen was auto-partitioned to a separate immiscible phase for ease of harvesting.This technology circumvented the issue of high consumption of distillation energy due to separation of bitumen phase and low boiling point of dichloromethane.[Emim][BF_(4)]and dichloromethane could be readily recycled through the system and used repeatedly.After ten cycles,the bitumen recovery remained above 88%.Initial scale-up work suggested that this approach would form the basis for a viable large-scale process. | Sun Yinlu Sun Yizhuo Jia Yushan Yuan Wei Song Ximing | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，2： | 2 |
| 8 | Zaprinast stimulates extracelluiaradenosine accumulation in rat pontine slices显示文摘 | YinLu MinouLe YaLi | 2004 | NeuroscJ Lett2004，，： | 1 |
| 9 | 显示文摘 | YINLu—Qiao(殷桥) YANGWei—Qiao(杨卫桥) LIShu—Zhi(李抒智) eta1 | 2011 | 光学学报2011，31，5： | 1 |
| 10 | Deuteron global optical model potential for energies up to 200 MeV显示文摘 | Han Yinlu Shi Yuyang Shen Qingbiao | 2006 | Phys Rev2006，74，04： | 1 |
| 11 | Helium-3 microscopic optical model potential based on the Skyrme interaction显示文摘 | Guo Hairui Zhang Yue Han Yinlu | 2009 | Phys Rev2009，79，06： | 1 |
| 12 | PKB negatively modulates TGF-β responsiveness in prostate carcinoma PC-3 cells through its interaction with Smad3显示文摘Most prostate cancers are insensitive to growth-inhibitory effect of TGF-β, while PI3K-PKB signaling is highly activated in prostate cancers. We investigated whether the PI3K-PKB signaling con- tributes to TGF-β insensitivity in PTEN-null prostate cancer PC-3 cells. Cell growth analysis showed that inhibition of PI3K-PKB pathway by LY294002 en- hanced growth inhibition and cell cycle arrest induced by TGF-β. Furthermore, activation of PI3K-PKB pathway by insulin or overexpression of PKB de- creased the transcriptional activity of TGF-β, as measured by the TGF-β/Smad3-responsive CAGA- luciferase reporter, while inhibition of PI3K-PKB pathway by introducing PTEN, inactive PKB mutant or using LY294002 promoted TGF-β-induced expres- sion of CAGA-luciferase. Co-immunoprecipitation studies further demonstrated that Smad3 interacted with PKB through its linker region and MH2 domain. This interaction was facilitated by insulin and disrupted by TGF-β signaling activation. Our results suggest that the PI3K-PKB pathway may play an important role in rendering cell resistance to the antiproliferative effect of TGF-β and regulating cell response to TGF-β. | LI Wei, XIN Dianqi & GUO Yinlu Department of Urology, the First Hospital of Peking University the Urological Research Institute, Peking University, Beijing 100034, China | 2006 | Chinese Science Bulletin2006，51，13： | 1 |
| 13 | Deuteron global optical model potential for ener- gies up to 200 MeV显示文摘 | HAN Yinlu SHI Yuyang SHEN Qingbiao | 2006 | Physical Review C2006，74，4： | 1 |
| 14 | Properties of Hot Nuclear and Neutron Matter In a Relativistic Hartree-Fock Theory | Han, Yinlu Shen, Qingbiao Zhuo, Yizhong | 1995 | Chinese journal of nuclear physics1995，，2： | 1 |
| 15 | Exponential stability of memristor-based synchronous switching neural networks with time delays显示文摘 | Yinlu Jiang Chuandong Li | 2016 | International Journal of Biomathematics2016，9，1： | 0 |
| 16 | Calculation of Nuclear Data for Proton Induced Reactions on ^(56)Fe and ^(57)Fe | Xu Xiaoping Han Yinlu Zhuang Youxiang China Institute of Atomic Energy,P.O.Box 275(41),Beijing 102413 | 1997 | Chinese journal of nuclear physics1997，，4： | 0 |
| 17 | Lingual flange protrusion:diagnostic marker for metastatic liver cancer显示文摘OBJECTIVE: To investigate the diagnostic significance of lingual flange protrusion for liver metastasis of patients with malignant neoplasia.METHODS: The data of 191 patients with malignant neoplasia were analyzed. All photos of patients' tongue image were recorded and lingual flange protrusion was the positive standard. χ~2 test for paired data and Kappa test were used to determine the diagnostic value of lingual flange protrusion for metastatic liver cancer. Mann-Whitney U test was used to compare the levels of liver serolog-ical markers. The area under receiver operating characteristic curve(ROC) and logistic regression model were used to analyze the predictive values of lingual flange protrusion, alkaline phosphatase(ALP), and lactate dehydrogenase(LDH) levels.RESULTS: Patients with lingual flange protrusion had a higher risk of liver metastasis than those without it(P < 0.001). There was no significant difference in diagnosis of liver metastasis between lingual flange protrusion and traditional diagnostic criteria(P = 0.541). Kappa was 0.738(P < 0.001). Lingual flange protrusion was significantly correlated with increased serum ALP and LDH levels(P < 0.01).Comparison of ROC curves showed that the diagnostic value of lingual flange protrusion is better than ALP, LDH and the combination of ALP and LDH(P < 0.01). Furthermore, the combined diagnostic values of lingual flange protrusion and ALP,lingual flange protrusion and LDH, and lingual flange protrusion, ALP and LDH are not better than lingual flange protrusion alone(P > 0.05).CONCLUSION: Lingual flange protrusion is a potential diagnostic marker for liver metastasis of patients with malignant neoplasia. | Ma Yinlu Yang Xue Zhu Cuihong Cao Rui Wu Xiongzhi | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 0 |
| 18 | Global Phenomenological Optical Model Potential for 9~Be and (8,10,11)~B Projectile显示文摘The optical model is one of the most fundamental theoretical models in nuclear reaction theory.The key point of the optical model is how to give the optical model potential.The global phenomenological optical model potential for 9Be projectile is obtained by simultaneously fitting the experimental data of the reaction cross sections and elastic scattering angular distributions in the mass range of the target nuclei 9≤A≤209at incident projectile energy below 200 MeV.These results are compared with the corresponding experimental data.The performance shows that the global phenomenological optical model potential can give a satisfactory description for elastic scattering angular distributions and reaction cross sections. | HAN Yinlu XU Yongli LIANG Haiying WU Zhendong GUO Hairui CAI Chonghai SHEN Qingbiao | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 19 | Theoretical Analysis and Evaluation for Neutron-induced Reaction on 93Nb and 239Pu显示文摘The neutron-induced reaction data is an important basic data for nuclear science and engineering,and is one of the key data in nuclear astrophysics.High-quality nuclear data for neutron-induced reactions on 93Nb n and 239Pu are required.Based on existing experimental data for total,nonelastic cross sections and elastic scatter- | HAN Yinlu HU Jiaqi LIANG Haiying WU Zhendong JIAO Xuesheng GUO Hairui YE Tao SUN Weili CAI Chonghai | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 20 | Global Phenomenological Optical Model Potential for 6,7,8Li Projectiles显示文摘The optical model is one of the most fundamental theoretical models in nuclear reaction theory.The key point of the optical model is how to give the optical model potential.The global phenomenological optical model potential for ~6Li,~7Li,~8Li projectiles are obtained by simultaneously fitting the experimental data of the reaction cross sections and elastic | HAN Yinlu HU Jiaqi XU Yongli SU Xinwu LIANG Haiying WU Zhendong GUO Hairui CAI Chonghai | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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