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| 1 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Output of an Ultrasonic Wave-Driven Nanogenerator in a Confi ned Tube显示文摘The output of an ultrasonic wave-driven nanogenerator(NG)has been found to depend on the excitation conditions and geometry.Incidence angle tests indicate that the effective area of an NG determines the amount of power that can be generated.The output power of an NG is also directly related to its distance from the ultrasonic source.A sinusoidal profile of the electrical output was observed when an NG was moved inside a long tube filled with water with the ultrasonic source located at one end.This is due to the oscillation of the wave intensity inside the tube as a function of the distance from the excitation source. | Xudong Wang Yifan Gao Yaguang Wei Zhong Lin Wang | 2009 | Nano Research2009，2，3： | 3 |
| 4 | Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair显示文摘Photodynamic therapy(PDT)is an important technique to deal with drug-resistant bacterial infections in the post-antibiotic era.However,the hypoxic environment in intractable infections such as refractory keratitis and periodontitis,makes PDT more difficult.In this work,spontaneous oxygen-producing cyanobacteria were used as the carrier of photosensitizer(Ce6),and ultrasmall Cu_(5.4)O nanoparticles(Cu_(5.4)O USNPs)with catalase activity for infection and inflammation elimination and rapid tissue repair(CeCycn-Cu_(5.4)O).The loading of Ce6 and Cu_(5.4)O USNPs onto cyanobacteria surface were confirmed by transmission electron microscopy,nano particle size analyzer,scanning electron microscopy.In vitro sterilization and biofilm removal experiments demonstrated that the restriction of hypoxic environment to PDT was significantly alleviated due to the oxygen production of cyanobacteria.Under laser irradiation,the close transfer of energy photons to oxygen produced by cyanobacteria reduced more than 90% of Ce6 dosages(660 nm,200 mW/cm^(2),2 min).It is worth mentioning that both rapid sterilization through PDT and long-term oxidized free radicals elimination were achieved by adjusting the ratio of Ce6 and Cu_(5.4)O USNPs.Both periodontitis and refractory keratitis animal models proved the excellent self-oxygenation enhanced antibacterial property and promotion of tissue repair. | Bailiang Wang Liyang Zhou Yishun Guo Hanwen Guo Yiming Zhong Xiaomin Huang Yifan Ge Qingying Wang Xiaoying Chu Yingying Jin Kaiyue Lan Mei Yang Jia Qu | 2022 | Bioactive Materials2022，7，6： | 3 |
| 5 | Gut health benefit and application of postbiotics in animal production显示文摘Gut homeostasis is of importance to host health and imbalance of the gut usually leads to disorders or diseases for both human and animal.Postbiotics have been applied in manipulating of gut health,and utilization of postbiotics threads new lights into the host health.Compared with the application of probiotics,the characteristics such as stability and safety of postbiotics make it a potential alternative to probiotics.Studies have reported the beneficial effects of components derived from postbiotics,mainly through the mechanisms including inhibition of pathogens,strengthen gut barrier,and/or regulation of immunity of the host.In this review,we summarized the characteristics of postbiotics,main compounds of postbiotics,potential mechanisms in gut health,and their application in animal production. | Yifan Zhong Shanshan Wang Hanqiu Di Zhaoxi Deng Jianxin Liu Haifeng Wang | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 3 |
| 6 | Hypoxia response element-directed expression of bFGF in dental pulp stem cells improve the hypoxic environment by targeting pericytes in SCI rats显示文摘Cell-based transplantation strategies possess great potential for spinal cord injury(SCI)repair.Basic fibroblast growth factor(bFGF)has been reported to have multiple neuro-promoting effects on developing and adult nervous system of mammals and considered a promising therapy for nerve injury following SCI.Human dental pulp stem cells(DPSCs)are abundant stem cells with low immune rejection,which can be considered for cell replacement therapy.The purpose of this study was to investigate the roles of DPSCs which express bFGF under the regulation of five hypoxia-responsive elements(5HRE)using an adeno-associated virus(AAV-5HRE-bFGF-DPSCs)in SCI repairing model.In this study,DPSCs were revealed to differentiate into CD13^(+)pericytes and up-regulate N-cadherin expression to promote the re-attachment of CD13^(+)pericytes to vascular endothelial cells.The re-attachment of CD13^(+)pericytes to vascular endothelial cells subsequently increased the flow rate of blood in microvessels via the contraction of protuberance.As a result,increased numbers of red blood cells carried more oxygen to the damaged area and the local hypoxia microenvironment in SCI was improved.Thus,this study represents a step forward towards the potential use of AAV-5HRE-bFGF-DPSCs in SCI treatment in clinic. | Sipin Zhu Yibo Ying Yan He Xingxing Zhong Jiahui Ye Zhiyang Huang Min Chen Qiuji Wu Yifan Zhang Ziyue Xiang Yurong Tu Weiyang Ying Jian Xiao Xiaokun Li Qingsong Ye Zhouguang Wang | 2021 | Bioactive Materials2021，6，8： | 2 |
| 7 | Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis显示文摘The immune microenvironment induced by biomaterials played vital roles in bone regeneration.Hydroxyapatite(HA)and its ion-substituted derivates represent a large class of core inorganic materials for bone tissue engineering.Although ion substitution was proved to be a potent way to grant HA more biological functions,few studies focused on the immunomodulatory properties of ion-doped HA.Herein,to explore the potential osteoimmunomodulatory effects of ion-doped HA,zinc and strontium co-assembled into HA through a collagen template biomimetic way(ZnSr-Col-HA)was successfully achieved.It was found that ZnSr-Col-HA could induce a favorable osteo-immune microenvironment by stimulating macrophages.Furthermore,ZnSr-Col-HA demonstrated a procedural promoting effect on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.Specifically,the osteo-immune microenvironment acted as a dominant factor in promoting osteogenic gene expressions at the early stage through OSM signal pathway.Whereas the direct stimulating effects on BMSCs by Zn^(2+)/Sr^(2+) were more effectively at the later stage with Nfatc1/Maf and Wnt signals activated.In vivo study confirmed strong promoting effects of ZnSr-Col-HA on critical-sized cranial defect repair.The current study indicated that such a combined biomaterial design philosophy of dual ion-doping and biomimetic molecular co-assembly to endow HA applicable osteoimmunomodulatory characteristics might bring up a new cutting-edge concept for bone regeneration study. | Zhenyu Zhong Xiaodan Wu Yifan Wang Mengdie Li Yan Li XuLong Liu Xin Zhang Ziyang Lan Jianglin Wang Yingying Du Shengmin Zhang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 8 | Self-powered electronic paper with energy supplies and information inputs solely from mechanical motions显示文摘The electronic paper(E-paper)displays features such as flexibility,sunlight visibility,and low power consumption,which makes it ideal for Internet of Things(IoT)applications where the goal is to eliminate bulky power modules.Here,we report a unique self-powered E-paper(SPEP),where information inputs and energy supplies are all converted from mechanical motion by a triboelectric nanogenerator(TENG).The operation of an electrophoretic E-paper is first investigated,identifying the current density as a determinative parameter for driving pigment particle motion and color change.Electrical and optical responses of the E-paper driven by a slidingmode TENG are then found to be consistent with that under a current source mode.All-in-one monochromic and chromatic SPEPs integrated with a flexible transparent TENG are finally demonstrated,and a pixelated SPEP is discussed for future research.The sliding-driven mechanism of SPEP allows for a potential handwriting function,is free of an extra power supply,and promises undoubtedly a wide range of future applications. | YIFAN GU TINGTING HOU PENG CHEN JINXIN CAO CHONGXIANG PAN WEIGUO HU BO-RU YANG XIONG PU AND ZHONG LIN WANG | 2020 | Photonics Research2020，8，9： | 2 |
| 9 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 10 | Variations of the relativistic electron flux after a magnetospheric compression event显示文摘On January 21, 2015, a sharp increase of the solar wind dynamic pressure impacted the magnetosphere. The magnetopause moved inward to the region L< 8 without causing a geomagnetic storm. The flux of the relativistic electrons in the outer radiation belt decreased by half during this event based on the observations of the particle radiation monitor(PRM) of the fourth of the China-Brazil Earth Resource Satellites(CBERS-4). The flux remained low for approximately 11 d; it did not recover after a small magnetic storm on January 26 but after a small magnetic storm on February 2. The loss and recovery of the relativistic electrons during this event are investigated using the PRM data, medium-and high-energy electron observations of NOAA-15 and the Van Allen Probes, medium-energy electron observations of GOES-13, and wave observations of the Van Allen Probes. This study shows that the loss of energetic electrons in this event is related to magnetospheric compression. The chorus waves accelerate the medium-energy electrons, which causes the recovery of relativistic electrons. The Van Allen Probes detected strong chorus waves in the region L =3–6 from January 21 to February 2. However, the flux of medium-energy electrons was low in the region. This implies that the long-lasting lack of recovery of the relativistic electrons after this event is due to the lack of the medium-energy'seed' electrons. The medium-energy electrons in the outer radiation belt may be a clue to predict the recovery of relativistic electrons. | CHEN Zhe CHEN HongFei LI YiFan XIANG HongWen YU XiangQian SHI WeiHong HAO ZhiHua ZOU Hong ZOU JiQing ZHONG WeiYing | 2017 | Science China(Technological Sciences)2017，60，4： | 1 |
| 11 | Bioceramic scaffolds with triply periodic minimal surface architectures guide early-stage bone regeneration显示文摘The pore architecture of porous scaffolds is a critical factor in osteogenesis,but it is a challenge to precisely configure strut-based scaffolds because of the inevitable filament corner and pore geometry deformation.This study provides a pore architecture tailoring strategy in which a series of Mg-doped wollastonite scaffolds with fully interconnected pore networks and curved pore architectures called triply periodic minimal surfaces(TPMS),which are similar to cancellous bone,are fabricated by a digital light processing technique.The sheet-TPMS pore geometries(s-Diamond,s-Gyroid)contribute to a 3‒4-fold higher initial compressive strength and 20%-40%faster Mg-ion-release rate compared to the other-TPMS scaffolds,including Diamond,Gyroid,and the Schoen’s I-graph-Wrapped Package(IWP)in vitro.However,we found that Gyroid and Diamond pore scaffolds can significantly induce osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Analyses of rabbit experiments in vivo show that the regeneration of bone tissue in the sheet-TPMS pore geometry is delayed;on the other hand,Diamond and Gyroid pore scaffolds show notable neo-bone tissue in the center pore regions during the early stages(3-5 weeks)and the bone tissue uniformly fills the whole porous network after 7 weeks.Collectively,the design methods in this study provide an important perspective for optimizing the pore architecture design of bioceramic scaffolds to accelerate the rate of osteogenesis and promote the clinical translation of bioceramic scaffolds in the repair of bone defects. | Miaoda Shen Yifan Li Fengling Lu Yahui Gou Cheng Zhong Shukun He Chenchen Zhao Guojing Yang Lei Zhang Xianyan Yang Zhongru Gou Sanzhong Xu | 2023 | Bioactive Materials2023，，7： | 1 |
| 12 | Equilibrium Piezoelectric Potential Distribution in a Deformed ZnO Nanowire显示文摘The equilibrium piezoelectric potential distribution in a deformed ZnO semiconductive nanowire has been systematically investigated in order to reveal its dependence on the donor concentration,applied force,and geometric parameters.In particular,the donor concentration markedly affects the magnitude and distribution of the electric potential.At a donor concentration of ND>1018 cm-3,the piezopotential is almost entirely screened.Among the other parameters,a variation in the length of the nanowire does not signifi cantly affect the potential distribution. | Giulia Mantini Yifan Gao A.DʼAmico C.Falconi Zhong Lin Wang | 2009 | Nano Research2009，2，8： | 1 |
| 13 | Lomoxicam phannacokinetics in relation to cytochromeP450 2C9 genotype显示文摘 | Dafang Zhong Dayong Si | 2005 | Br J Clin Pharmacol2005，59，： | 1 |
| 14 | Surfactant-assisted doctor-blading-printed FAPbBr3 films for efficient semitransparent perovskite solar cells显示文摘Organic-inorganic hybrid perovskite solar cells have generated wide interest due to the rapid development of their photovoltaic conversion effciencies.However,the majority of the reported devices have been fabricated via spin coating with a device areaof<1 cm2.In this study,we fabricated a wide-bandgap formamidi-nium lead bromide(FAPbBr3)film using a cost-effective,high-yielding doctor-blade-coating process.The effects of different surfactants,such as I-α-phosphatidylcholine,polyoxyethylene sorbitan monooleate,sodium lauryl sulfonate,and hexadecyl trimethyl ammonium bromide,were studied during the printing process.Accompanying the optimization of the blading temperature,crystal sizes of over 10μm and large-area perovskite films of5cm×5 cm were obtained using this method.The printed FAPbBr3 solar cells exhibited a short-circuit current density of 8.22 mA/cm2,an open-circuit voltage of 1.175 V,and an efficiency of 7.29%.Subsequently,we replaced the gold with silver nanowires as the top electrode to prepare a semitransparent perovskite solar cell with an average transmittance(400-800 nm)of 25.42%,achieving a high-power efficiency of 5.11%.This study demonstrates efficient doctor-blading printing for preparing large-area FAPbBr3 films that possess high potential for applications in building integrated photovoltaics. | Hangkai YING Yifan LIU Yuxi DOU Jibo ZHANG Zhenli WU Qi ZHANG Yi-Bing CHENG Jie ZHONG | 2020 | Frontiers of Optoelectronics2020，13，3： | 1 |
| 15 | Network Performance Aware MPI Collective Communication Operations in the Cloud显示文摘 | Gong Yifan He Bingsheng Zhong Jianlang | 2013 | IEEE Transactions on Parallel Distributed Systems2013，96，1： | 1 |
| 16 | Pharmacokinetics of Loratadine and its metabolite descarboethoxyloratadine in healthy Chinese subjects显示文摘 | Zhang Yifan Chen Xiaoyan Zhong Dafang | 2003 | Acta Pharmacol Sin2003，24，7： | 1 |
| 17 | Groups-dependent phosphines as the organic redox for point defects elimination in hybrid perovskite solar cells显示文摘Lead(Pb)^(0) and iodine(I)^(0) point defects generated during perovskite solar cell(PSC)fabrication and photoconversion form deep band energy levels as the carriers’recombination centers.These defects not only deteriorate device efficiency,but also facilitate chemical degradation with ion migration,resulting in restricted device lifetime.Herein,we present a novel type of phosphines as the point defects stabilizer for hybrid perovskite solar cells with enhanced performances.Three phosphines with varied side groups of tributyl,trioctyl and triphenyl are exampled as the dopants in perovskite films.The group dependent redox properties were observed in the perovskite film,dependent on their molecular weights and steric hinderances of phosphines.The partially oxidized tributyl phosphine(TBUP)with additional tributyl phosphine oxides(TBPO)is efficient in reduction of lead(Pb)^(0) and iodine(I)^(0) concentrations during the device fabrication and operation.The device with TBUP-TBPO pair showed enhanced power conversion efficiency(PCE)to 20.48% and maintain 91.7% of their initial PCEs after 500 h at 65℃ thermal annealing.Thus,this work presents an efficient route of utilize the phosphine species to reduce point defects in the perovskite film,which promoting further development of novel phosphorous additives with defects stabilization,interface passivation and encapsulation for low-cost solution processed PSCs. | Zhengli Wu Miao Zhang Yifan Liu Yuxi Dou Yinjie Kong Lin Gao Weitao Han Guijie Liang Xiao Li Zhang Fuzhi Huang Yi-Bing Cheng Jie Zhong | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 18 | Controlled synthesis,characterization,and catalytic properties of Mn2O3and Mn3O4nanoparticles supported on mesoporous silica SBA-15显示文摘 | HAN Yifan CHEN Fengxi ZHONG Ziyi | 2006 | Journal of Physical Chemistry:B2006，110，24： | 1 |
| 19 | Controlled syn- thesis,chara- cterization, and catalytic properties of Mn2O3 and Mn3O4 nanoparticales supported on mesoporous silica SBA-15显示文摘 | Han Yifan Chen Fengxi Zhong Ziyi | 2006 | J PhyChemB2006，110，24： | 1 |
| 20 | Synthesis and characterization of MnaO4 and Mn203 nanocrystals on SBA- 15: Novel combustion catalysts at low reaction temperatures 显示文摘 | Han Yifan Chen Fengxi Zhong Ziyi | 2006 | CatalCommun2006，7，10： | 1 |
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