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| 1 | Dynamic tubulation of mitochondria drives mitochondrial network formation显示文摘 | Chong Wang Wanqing Du Qian Peter Su Mingli Zhu Peiyuan Feng Ying Li Yichen Zhou Na Mi Yueyao Zhu Dong Jiang Senyan Zhang Zerui Zhang Yujie Sun Li Yu | 2015 | Cell Research2015，25，10： | 8 |
| 2 | Role of nitric oxide in the genotoxic response to chronic microcystin-LR exposure in human–hamster hybrid cells显示文摘Microcystin-LR(MC-LR) is the most abundant and toxic microcystin congener and has been classified as a potential human carcinogen(Group 2B) by the International Agency for Research on Cancer. However, the mechanisms underlying the genotoxic effects of MC-LR during chronic exposure are still poorly understood. In the present study, human–hamster hybrid(AL) cells were exposed to MC-LR for varying lengths of time to investigate the role of nitrogen radicals in MC-LR-induced genotoxicity. The mutagenic potential at the CD59 locus was more than 2-fold higher(p < 0.01) in ALcells exposed to a cytotoxic concentration(1 μmol/L) of MC-LR for 30 days than in untreated control cells, which was consistent with the formation of micronucleus. MC-LR caused a dose-dependent increase in nitric oxide(NO) production in treated cells. Moreover, this was blocked by concurrent treatment with the NO synthase inhibitor NG-methyl-L-arginine(L-NMMA), which suppressed MC-LRinduced mutations as well. The survival of mitochondrial DNA-depleted(ρ0) ALcells was markedly decreased by MC-LR treatment compared to that in ALcells, while the CD59 mutant fraction was unaltered. These results provided clear evidence that the genotoxicity associated with chronic MC-LR exposure in mammalian cells was mediated by NO and might be considered as a basis for the development of therapeutics that prevent carcinogenesis. | Xiaofei Wang Pei Huang Yun Liu Hua Du Xinan Wang Meimei Wang Yichen Wang Tom K.Hei Lijun Wu An Xu | 2015 | Journal of Environmental Sciences2015，27，3： | 6 |
| 3 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 4 | Towards win-win: weighted-Voronoi-diagram based channel quantization for security enhancement in downlink cloud-RAN with limited CSI feedback显示文摘Physical layer(PHY) security is recently proved to enable improving the security of wireless communication networks. In downlink frequency division duplex(FDD) cloud radio access network(C-RAN), the performance of PHY security highly relies on the channel state information(CSI) which is usually acquired through the codebook-quantization-based technique at the transceiver. However, the conventional quantization method aggravates the leakage of privacy information in C-RAN under the eavesdropping environment. In this paper, a novel channel quantization method is investigated to improve the secrecy-rate performance of C-RAN by exploiting the high-dimension space geometry. Based on this method, it is proved that when the statistical distribution of the channel matrices of both the legitimate user and the eavesdropper is exploited, a win-win situation can be created where secrecy-rate gains are improved without sacrificing beamforming gains from the point of view of ergodic rate. Particularly, a secrecy-oriented criterion is devised to implement the proposed method for generating codebooks. Then a weighted Voronoi diagram(WVD) is formulated on the complex Grassmann manifold and finally, a vector quantization based algorithm is proposed to build up novel quantization codebooks iteratively. Simulation results further validate the superiority of our proposed codebooks over conventional codebooks in C-RAN systems. | Dongyang XU Pinyi REN Qinghe DU Li SUN Yichen WANG | 2017 | Science China(Information Sciences)2017，60，4： | 2 |
| 5 | Sn_(4)P_(3)nanoparticles confined in multilayer graphene sheets as a high-performance anode material for potassium-ion batteries显示文摘Phosphorus-based anodes are highly promising for potassium-ion batteries(PIBs)because of their large theoretical capacities.Nevertheless,the inferior potassium storage properties caused by the poor electronic conductivity,easy self-aggregation,and huge volumetric changes upon cycling process restrain their practical applications.Now we impregnate Sn_(4)P_(3)nanoparticles within multilayer graphene sheets(Sn_(4)P_(3)/MGS)as the anode material for PIBs,greatly improving its potassium storage performance.Specifically,the graphene sheets can efficiently suppress the aggregation of Sn_(4)P_(3)nanoparticles,enhance the electronic conductivity,and sustain the structural integrity.In addition,plenty of Sn_(4)P_(3)nanoparticles impregnated in MGS offer a large accessible area for the electrolyte,which decreases the diffusion distance for K^(+)and electrons upon K^(+)insertion/extraction,resulting in an improved rate capability.Consequently,the optimized Sn_(4)P_(3)/MGS containing 80 wt%Sn_(4)P_(3)(Sn_(4)P_(3)/MGS-80)exhibits a high reversible capacity of 378.2 and 260.2 m Ah g;at 0.1 and 1 A g^(-1),respectively,and still delivers a large capacity retention of 76.6%after the 1000th cycle at 0.5 A g^(-1). | Yichen Du Zuyue Yi Bingbing Chen Jingyi Xu Zhuangzhuang Zhang Jianchun Bao Xiaosi Zhou | 2022 | Journal of Energy Chemistry2022，31，3： | 2 |
| 6 | Coupling Co_(3)[Co(CN)_(6)]_(2) nanocubes with reduced graphene oxide for high-rate and long-cycle-life potassium storage显示文摘As one of prussian blue analogues,Co_(3)[Co(CN)_(6)]_(2) has been explored as a promising anode material for potassium-ion batteries(PIBs) owing to its high potassium storage capacity.Unfortunately,Co_(3)[Co(CN)_(6)]_(2) possesses low electronic conductivity and its structure collapses easily during potassiation and depotassiation,resulting in poor rate performance and cyclic stability.To solve these problems,we develop a facile multi-step method to successfully combine uniformCo_(3)[Co(CN)_(6)]_(2) nanocubes with rGO by C-O-Co bonds.As expected,these chemcial bonds shorten the distance betweenCo_(3)[Co(CN)_(6)]_(2) and rGO to the angstrom meter level,which significantly improve the electronic conductivity ofCo_(3)[Co(CN)_(6)]_(2).Besides,the complete encapsulation ofCo_(3)[Co(CN)_(6)]_(2) nanocubes by rGO endows the structure ofCo_(3)[Co(CN)_(6)]_(2) with high stability,thus withstanding repeated insertion/extraction of potassium-ions without visible morphological and structural changes.Benefiting from the abovementioned structural advantages,the CO3 [Co(CN)6]2/rGO nanocomposite exhibits a high reversible capacity of 400.8 mAh g^(-1) at a current density of 0.1 A g^(-1),an exceptional rate capability of 115.5 mAh g^(-1) at 5 A g^(-1), and an ultralong cycle life of 231.9 mAh g^(-1) at 0.1 A g^(-1) after 1000 cycles.Additionally,the effects of different amounts of rGO and different sizes ofCo_(3)[Co(CN)_(6)]_(2) nanocubes on the potassium storage performance are also studied.This work offers an ideal route to significantly enhance the electrochemical properties of prussian blue analogues. | Yifan Xu Yichen Du Zuyue Yi Zhuangzhuang Zhang Chenling Lai Jiaying Liao Xiaosi Zhou | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 7 | A review on emulsification via microfluidic processes显示文摘Emulsion is a disperse system with two immiscible liquids,which demonstrates wide applications in diverse industries.Emulsifcation technology has advanced well with the development of microfluidic process.Compared to conventional methods,the micro-fluidics-based process can produce controllable droplet size and distribution.The droplet formation or breakup is the result of combined effects resulting from interfacial tension,viscous,and inertial forces as well as the forces generated due to hydrodynamic pressure and extermal stimuli.In the current study,typical microfluidic systems,including microchannel array,T-shape,flow-focusing,co-flowing,and membrane systems,are reviewed and the corresponding mechanisms,fow regimes,and main parameters are compared and summarized. | Yichen Liu Yongli Li Andreas Hensel Juergen JBrandner Kai Zhang Xiaoze Du Yongping Yang | 2020 | Frontiers of Chemical Science and Engineering2020，14，3： | 0 |
| 8 | UAV search-and-rescue planning using an adaptive memetic algorithm显示文摘The use of unmanned aerial vehicles(UAVs) is becoming more commonplace in search-and-rescue tasks,but UAV search planning can be very complex due to limited response time, large search area, and multiple candidate search modes. In this paper, we present a UAV search planning problem where the search area is divided into a set of subareas and each subarea has a prior probability that the target is present in it. The problem aims to determine the search sequence of the subareas and the search mode for each subarea to maximize the probability of finding the target. We propose an adaptive memetic algorithm that combines a genetic algorithm with a set of local search procedures and dynamically determines which procedure to apply based on the past performance of the procedures measured in fitness improvement and diversity improvement during problem-solving. Computational experiments show that the proposed algorithm exhibits competitive performance compared to a set of state-of-the-art global search heuristics, non-adaptive memetic algorithms, and adaptive memetic algorithms on a wide set of problem instances. | Libin HONG Yue WANG Yichen DU Xin CHEN Yujun ZHENG | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，11： | 0 |
| 9 | Adult tiger beetles Cicindela gemmata modify their foraging strategy in different hunting contexts显示文摘Predator–prey interaction has long been an interesting item in the research of animal behaviors.Given that live prey can damage their predators,predators must trade foraging efficiency for safety while hunting,but the extent of this trade-off is not yet clear.Tiger beetles display diversity in their diets and hunting strategies,and hence,they become an ideal system to address how self-security affects foraging efficiency.We addressed this question in captive adult tiger beetles Cicindela gemmata.By offering several types of arthropod and plant foods,we confirmed that C.gemmata is carnivorous.We found that C.gemmata hunt by either ambushing or chasing their prey,and that they switch between strategies based on differences in the number of prey,the prey status and encounter rate,and the number of predators.Ambushing success increased with the number of prey but decreased with prey encounter rate.Chasing success decreased as prey body size and encounter rate increased.Foraging Cicindela gemmata often gave up an attack when it was nonfatal.This active giving up of hunting may be a consequence of a trade-off between foraging efficiency and self-security.Therefore,it is an adaptive response to the risk of injury when hunting for larger live prey. | Shumin Wang Panshuai Fei Zifeng Wu Zeyi Luo Yichen Wu Ningning Sun Yujie Wang Shumei Zi Lifang Gao Bo Du | 2023 | Insect Science2023，30，6： | 0 |
| 10 | Enhancing physical-layer security via big-data-aided hybrid relay selection显示文摘The explosive growth in data trac presents new challenges to the new generation of wireless communication systems,such as computing capabilities,spectrum eciency and security.In this paper,we use the network structure,which is adaptable for the big data trac,to improve the security of wireless networks.Speci cally,a big-data aided hybrid relay selection scheme is designed and analyzed to enhance physical layer security.First,considering the ideal situation that an eavesdropper's CSI(Channel State Information)is known to the legal nodes,we propose an optimal hybrid relay selection scheme consisting of the optimal mode selection scheme and the optimal relay selection scheme.In this case,we analyze the upper bound of an eavesdropper's capacity in FD(Full-Duplex)mode and the secrecy outage probabilities of the optimal HD(Half-Duplex),FD,and hybrid relay selection schemes.Through the analysis of data,it is clear that the mode selection is decided by the self-interference of the FD technique.However,the instantaneous CSI of an eavesdropper is dicult to obtain due to the passive characteristic of eavesdroppers in practice.Therefore,a more practical hybrid relay selection scheme with only the channel distribution information of an eavesdropper is further studied,where a weighting factor is employed to guarantee that the hybrid mode is no worse than either the FD mode or HD mode when the self-interference grows.Finally,the simulation results show the improved security of our proposed scheme. | Hongliang He Pinyi Ren Qinghe Du Li Sun Yichen Wang | 2017 | Journal of Communications and Information Networks2017，2，1： | 0 |
| 11 | Double-Coated Fe_(2)N@TiO_(2)@C Yolk-Shell Submicrocubes as an Advanced Anode for Potassium-Ion Batteries显示文摘Main observation and conclusion Rationally designing inexpensive iron nitrides that have large conductivity,high theoretical capacity,and rapid ionic diffusion kinetics is of great importance for realizing their practical application in potassium-ion batteries. | Yichen Du Wangsuo Weng Zhuangzhuang Zhang Yanan He Jingyi Xu Tian Yang Jianchun Bao Xiaosi Zhou | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
| 12 | Spatiotemporal variation of cyanobacterial harmful algal blooms in China based on literature and media information显示文摘Cyanobacterial harmful algal blooms(CyanoHABs)in inland waters are now among the most pressing environmental issues worldwide,especially in China.Satellite remote sensing has limitations in monitoring CyanoHABs in small water bodies due to spatial and temporal resolution limitations.While literature and news media have the potential to supplement satellite remote sensing in monitoring CyanoHABs,they have currently not received sufficient attention.In this study,we combined information on the distributions of CyanoHABs from literature and media for the first time to comprehensively assess the spatiotemporal variation in CyanoHABs in China.We collected,cleaned,validated,and organized data from literature and media on CyanoHABs in China,resulting in the establishment of a comprehensive database on CyanoHABs in China's inland waters(ChinaCyanoDB)covering 198 water bodies,525 records for 1950-2021.The majority of water bodies with CyanoHABs(CyanoWaters)are located in the eastern China,mainly concentrated in the middle and lower Yangtze region,with a clear upward trend in their number over the last four decades.The ChinaCyanoDB and analytical results can provide valuable data support for monitoring and managing CyanoHABs in China while the database construction method may also be applied to other countries and regions. | Yichen Du Chen Wang Mengqiu Wang Huan Zhao Kai Yan Yunchang Mu Wenzhi Zhang Fangfang Zhang Shenglei Wanga Junsheng Li | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 13 | mRNA delivery in cancer immunotherapy显示文摘Messenger RNA(mRNA)has drawn much attention in the medical field.Through various treatment approaches including protein replacement therapies,gene editing,and cell engineering,mRNA is becoming a potential therapeutic strategy for cancers.However,delivery of mRNA into targeted organs and cells can be challenging due to the unstable nature of its naked form and the low cellular uptake.Therefore,in addition to mRNA modification,efforts have been devoted to developing nanoparticles for mRNA delivery.In this review,we introduce four categories of nanoparticle platform systems:lipid,polymer,lipid-polymer hybrid,and protein/peptide-mediated nanoparticles,together with their roles in facilitating mRNA-based cancer immunotherapies.We also highlight promising treatment regimens and their clinical translation. | Yichen Zhong Shi Du Yizhou Dong | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
| 14 | High-resolution anatomical and spatial transcriptome analyses reveal two types of meristematic cell pools within the secondary vascular tissue of poplar stem显示文摘The secondary vascular tissue emanating from meristems is central to understanding how vascular plants such as forest trees evolve,grow,and regulate secondary radial growth.However,the overall molecular characterization of meristem origins and developmental trajectories from primary to secondary vascular tissues in woody tree stems is technically challenging.In this study,we combined high-resolution anatomic analysis with a spatial transcriptome(ST)technique to define features of meristematic cells in a developmental gradient from primary to secondary vascular tissues in poplar stems.The tissue-specific gene expression of meristems and derived vascular tissue types were accordingly mapped to specific anatomical domains.Pseudotime analyses were used to track the origins and changes of meristems throughout the development from primary to secondary vascular tissues.Surprisingly,two types of meristematic-like cell pools within secondary vascular tissues were inferred based on high-resolution microscopy combined with ST,and the results were confirmed by in situ hybridization of,transgenic trees,and single-cell sequencing.The rectangle shape procambium-like(PCL)cells develop from procambium meristematic cells and are located within the phloem domain to produce phloem cells,whereas fusiform shape cambium zone(CZ)meristematic cells develop from fusiform metacambium meristematic cells and are located inside the CZ to produce xylem cells.The gene expression atlas and transcriptional networks spanning the primary transition to secondary vascular tissues generated in this work provide new resources for studying the regulation of meristem activities and the evolution of vascular plants.A web server(http://gffzza1d164964eba4dabs5k6kc6ofqpv56qko.ffgz.tsg.suse.edu.cn/stRNAPal/)was also established to facilitate the use of ST RNA-seq data. | Juan Du Yichen Wang Wenfan Chen Mingling Xu Ruhong Zhou Huixia Shou Jun Chen | 2023 | Molecular Plant2023，16，5： | 0 |
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