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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 3 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 4 | microRNAs in cancer management显示文摘 | Yi W Kong David Ferland-McCollough Thomas J Jackson Martin Bushell | 2012 | Lancet Oncology2012，，6： | 3 |
| 5 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 6 | Corrosion resistance of tannic acid,d-limonene and nano-ZrO_(2)modified epoxy coatings in acid corrosion environments显示文摘The protection of rusted carbon steel in acid corrosion environments is of great significance for equipment to keep safe operation.In this work,we presented a method to protect the rusted steel by ru st conversion treatment and epoxy coating.Tannic acid was selected as rust conversion agent.Tannic acid,D-limonene and nano-ZrO_(2)were used to improve the corrosion resistance of epoxy coatings.The Raman spectra,Xray diffraction and 3 D confocal images were used to characterize the rust conversion reaction.Ad hesion test showed that the loss of wet adhesion of the optimal coating was relatively low due to the addition of tannic acid,limonene and nano-ZrO(2).The corrosion resistance of five different coatings was investigated by scanning electron microscopy(SEM)and electrochemical analysis.Results show that after 264 h acid immersion,the low frequency resistance of the optimal coating consisting of rust conversion treatment and additives is 10^(7)Ωcm^(2),three orders magnitude higher than that of the pristine coating.Moreover,SEM indicates that the optimal coating possesses a smooth surface and an unbroken interface between substrate and coating.Accordingly,the corrosion-resistant mechanism of the hybrid coating is proposed. | Junwei Chang Zhenyu W ang En-hou Han Xinlei Liang Gang Wang Zuyao Yi Na Li | 2021 | Journal of Materials Science & Technology2021，，6： | 3 |
| 7 | Comparative study of predictive methods for woven fabric composite elastic properties 显示文摘 | Tabiei A Yi W T | 2002 | Composite Structures2002，58，1： | 1 |
| 8 | ATP-induced changes in energy status and membrane integrity of harvested litchi fruit and its relation to pathogen resistance 显示文摘 | YI C QU H X JIANG Y M SHI J DUAN X W JOYCE D C LI Y B | 2008 | Journal of Phytopathology2008，156，： | 1 |
| 9 | Numerical modeling of arc root transfer during contact opening in a low voltage air circuit breaker 显示文摘 | YI W RONG M Z YANG F | 2008 | IEEE Transactions2008，，： | 1 |
| 10 | A novel titanium-supported Ag/Ti electrode for the electro-oxidation of hydrazine 显示文摘 | Yi Q F Li L Yu W Q | 2008 | Journal of Molecular Catalysis A: Chemical2008，295，： | 1 |
| 11 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 12 | A new and simple method for concentration of enteric viruses from water显示文摘 | LI J W WANG X W Qi Yi Rui | 1998 | Journal of Virological Methods1998，，74： | 1 |
| 13 | Hydrogen sulfide poisoning and recovery of PEMFC Pt-anodes 显示文摘 | SHI W YI B HOU M | 2007 | J Power Sources2007，165，： | 1 |
| 14 | Ant Colony Optimization for Disaster Relief Operations 显示文摘 | Yi W Kumar A | 2007 | Transportation Research Part E (S1366-5545)2007，43，6： | 1 |
| 15 | Long-term carbon dioxide fluxes from a very tall tower in a northern forest:flux measurement method,ology显示文摘 | BERGER B W DAVIS K J YI C | 2001 | Atmos Ocean Technol2001，18，： | 1 |
| 16 | Microfluidics technology for manipulation and analysis of biological cells 显示文摘 | YI C Q LI C W JI S L | 2006 | Analytica Chimica Acta2006，560，12： | 1 |
| 17 | Experimental study on progressive col- lapse-resistant behavior of reinforced concrete frame structures 显示文摘 | Yi W He Q Xiao Y | 2008 | ACI Structural Journal2008，105，43： | 1 |
| 18 | TGFβ signaling plays a critical role in promoting alternative macrophage activation显示文摘 | Gong D Shi W Yi SJ | 2012 | BMC Immunol2012，13，： | 1 |
| 19 | A dynamic logistics coordination model for evacuation and support in disaster response activities显示文摘 | Yi W zdamar L | 2007 | European Journal of Operational Research2007，179，： | 1 |
| 20 | Dynamic characteristics and wind- induced response of a super-tall building during typhoons 显示文摘 | Yi J Zhang J W Li Q S | 2013 | Journal of Wind Engineering and Industrial Aerodynamics2013，，7： | 1 |
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