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| 1 | Role of H3K27 methylation in the regulation of IncRNA expression显示文摘 | Susan C Wu | 2010 | Cell Research2010，20，10： | 22 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 4 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 5 | AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function显示文摘LSD1 (在新名称下面的 KDM1 ) 是属于黄素依赖者胺 oxidase 家庭的首先识别的离氨酸特定的 histone demethylase。这里,我们报导那 AOF1 (在新名称下面的 KDM1B ) ,与 LSD1 有关的哺乳动物的蛋白质,也为 H3K4me1 和 H3K4me2 与特性拥有 histone demethylase 活动。象 LSD1 一样,高度保存的 SWIRM 领域为它的酶的活动被要求。然而, AOF1 在几个方面不同于 LSD1。首先, AOF1 不看起来形成包含 histone deacetylases 的稳定的蛋白质建筑群。第二, AOF1 被发现在房间周期的有丝分裂的阶段期间本地化到染色体,而 LSD1 不做。第三, AOF1 镇压抄写什么时候拴住到 DNA 和这项压抑活动,独立于它的 demethylase 活动。结构、功能的分析为 demethylase 作为必要识别了它的唯一的 N 终端 Zf-CW 领域活动无关的压抑功能。一起,我们的学习在黄素依赖者胺 oxidases 的家庭作为第二 histone demethylase 识别 AOF1 并且揭示 AOF1 的 demethylase 独立的压抑功能。 | Ze Yang Jun Jiang David M Stewart Shankang Qi Kenichi Yamane Jiwen Li Yi Zhang Jiemin Wong | 2010 | Cell Research2010，20，3： | 6 |
| 6 | 急性大动脉闭塞患者机械取栓术后管理:美国神经介入外科学会指南显示文摘近年来,数项大型试验已证实急性大动脉闭塞(emergent large vessel occlusions,ELVOs)所致的卒中患者能够从血管内治疗中获益。对ELVO患者术前、术中和术后的管理问题备受关注。遗憾的是,目前很多与机械取栓相关卒中治疗的措施仍存在争议。本指南综合分析现有的最佳证据,以制定机械取栓术后患者管理的指导建议。 | Leslie-Mazwi T Chen M Yi J 赵文博 蒋芳 李传辉 吴川杰 陈健 吉训明 | 2018 | 中国脑血管病杂志2018，15，6： | 5 |
| 7 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 8 | 斯图加特市图书馆显示文摘此项目选址在市中心一个略带坡度的区域,位于斯图加特欧洲区总规划图划定区域的中心地带。这个位于城市盆地内的区域南起斯图加特火车总站,北至北部边境的海尔布隆大街。建成之后,位于Mailander Platz的斯图加特市图书馆由于其独有的设计与规模将会带动周边的发展,未来新的市中心将在此形成规模。它全新的面貌,以浅灰色清水混凝土结构的外墙和边长达45米的立方体磨砂玻璃砖特点呈现,无不向人们宣告了它的存在。 | Eun Young Yi Stefan Müller Günther Marsch 谢作标 | 2013 | 现代装饰2013，，2： | 3 |
| 9 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 10 | Huperzine H, a New Lycopodium Alkaloid from Huperzia serrata显示文摘A new lycopodium alkaloid with a novel skeleton was isolated from Huperzia serrata.Its structure was determined on the basis of spectral evidences. | Wen Yun GAO Yi M lug LI Bac De WANG Da Yuan ZHU(State Key Laboratory of New Drug Research. Shanghai Institute of Materia Medica. ChineseAcademy of Sciences, Shanghai 200031) | 1999 | Chinese Chemical Letters1999，10，6： | 2 |
| 11 | Electrical anisotropy in single crystals of Bi-layer structured ferroelectrics 显示文摘 | MIYAYAMA M YI I S | 2000 | Ceram Int2000，26，： | 2 |
| 12 | Effects of Preheating Temperature, Moisture and Sodium Metabisulfite Content on Property of Maize Flour Dough显示文摘Processing temperature, maze flour particle size, and level of water and sodium metabisulfite were varied during the preparation of maize noodles. Preheated to 90—95 ℃ a mixture of maize flour or meal, water(43%—45% moisture) and salt enabled the preparation of noodles using a pasta extruder. Maize flour with smaller particle size yielded better noodles than did maize meal. The addition of sodium metabisulfite enabled the production of noodles at lower processing temperatures; however, cooking losses increased. Processing maize flour with higher water absorption yielded noodles that required longer cooking time but with decreased losses. The functionalities of starch and protein in raw ingredients and in products were determined. Starch gelatinized and retorgraded during processing maize noodles, as indicated by changes in pasting viscosity curves. Maize proteins contributed to the increased viscosity of dough above 40 ℃. The increased integrity of cooked maize noodles, however, corresponded to the increased amounts of gelatinized and retrograded starch. | TONG Yi 1, Waniska Ralph D. 2 and LI Wei 1** (1. College of Life Science, Jilin University, Changchun, 130023 2. Cereal Quality Laboratory, Department of Soil & Crop Sciences, Texas A & M University, College Station, Texas, 77843 24474) | 2000 | Chemical Research in Chinese Universities2000，16，3： | 2 |
| 13 | CpG motifs in bacterial DNA trigger direct B-cell activation 显示文摘 | Krieg A M Yi A K Matson S | 1995 | Nature1995，374，： | 2 |
| 14 | Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats显示文摘现在的实验被设计与 aging.Methods 在内皮细胞层依赖者收缩学习变化: 老鼠有或没有内皮细胞层的 20 星期、 1 岁的老鼠的大腿骨的动脉在机关房间被推迟记录等轴的紧张。在内皮细胞层的导出氧的自由基的生产用共焦的显微镜学与 2',7'-dichlorodihydrofluorescein 乙酰乙酸盐(DCF ) 被测量。蛋白质存在被西方的 blotting.Results 决定:在从1岁的老鼠的动脉,到 A23187 的内皮细胞层依赖者松驰被减少,但是内皮细胞层依赖者收缩到 A23187 (面对N^(终止) -nitro-L-arginine 甲基酉旨水疗院氯化物[L名字;氮的氧化物 synthase 的一个禁止者])有老化的被扩充的、示威内皮机能障碍。消炎痛使回答正常化,建议那一个 cyclooxygenase (艇长) 依赖者收缩在老化是突出的。内皮细胞层依赖者收缩被 terutroban (一块 thromboxane-prostanoid 受体) 也阻止,证实脉管的光滑的 muscle.Valeryl 水杨酸盐上的 thromboxane-prostanoid 受体的激活,显示 COX-1 和 COX-2 被包含并且 NS-398 (COX-1 和 COX-2 的优先的禁止者,分别地) 部分减少了反应。西方的弄污证实了起来在 1 岁的老鼠的动脉的两 isoforms 的规定。面对 L 名字, A23187 在内皮细胞层增加了 DCF 荧光,证明导出氧的自由基的生产贡献内皮细胞层依赖者收缩。过氧化氢酶的活动与 1 岁的老鼠的内皮细胞层在动脉被减少,显示那过氧化氢是在变老的 endothelium.Conclusion 的增加的氧化应力的可能的调停人: 内皮细胞层依赖者收缩与老化被扩充。氧化应力加强反应,和 COX-1 和 COX-2 被包含。 | Yi SHI Ricky YK MAN Paul M VANHOUTTE | 2008 | Acta Pharmacologica Sinica2008，29，2： | 2 |
| 15 | The Surgical Treatment and Outcome of Nonmetastatic Extremity Osteosarcoma with Pathological Fractures显示文摘 | Zhi-Ping Deng Yi Ding Ajay Puri Edward H M Wang Ashish Gulia Claire Durban Xiao-Hui Niu | 2015 | Chinese Medical Journal2015，，19： | 2 |
| 16 | Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up显示文摘·AIM: To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a2 y period. To compare the success rates between primary angle-closure glaucoma(PACG) and primary open angle glaucoma(POAG). Lastly, to identify factors associated with success of bleb needling.·METHODS: This was a retrospective review of 227 patients who underwent bleb needling between June2009 and June 2011 in Singapore National Eye Centre.The 5-fluorouracil(5-FU) augmented bleb needling was performed either at the slit lamp or in the operating theatre. Repeat bleb needlings were performed as necessary. Complete success was defined as maintenance of intraocular pressure(IOP) ≥6 mm Hg and ≤21 mm Hg, in the absence of further surgery or use of antiglaucoma medication. Qualified success met the above criteria with or without use of antiglaucoma medications.· RESULTS: One hundred and seventy-five eyes completed the two-year follow up. Sixty-nine percent of participants had POAG and 31% had PACG. The mean interval between filtering surgery and bleb needling was299.9 ±616.4d for POAG and 167.1 ±272.2d for PACG.Mean needling attempts were 1.9±1.4 and 2±1.6 for POAG and PACG respectively. In general, there was a statistically significant reduction of IOP ranging from21.9% to 26.8% from month 1 through to month 24. The complete success rates at month 6 were 70.0% for POAG and 65.7% for PACG. At month 12, this decreased to62.2% for POAG and PACG and at month 24, 57.9% for POAG and 63.0% for PACG respectively. The qualified success rates at month 6 for POAG and PACG were23.8% and 29.9% respectively, 32.2% and 29.2% at month12, and 34.7% and 29.6% at month 24. The success ratesbetween POAG and PACG were not significantly different(P >0.05 for complete and qualified success at months 6,12 and 24). An increased number of needlings and higher pre-needling IOP were associated with failure.·CONCLUSION: The 5-FU augmented bleb needling within one year of trabeculectomy in Asian eyes can provide clinically significant IOP lowering of more than20% for 2y. POAG and PACG had similar complete success rates(58% and 63% respectively). Factors associated with greater risk of procedure failure included increased number of needlings and higher pre-needling IOP. Asian eyes have a greater propensity for scarring but bleb needling, if performed in a timely manner can rescue bleb function. | Andrew S.H.Tsai Pui Yi Boey Hla M Htoon Tina T Wong | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 2 |
| 17 | Effects of short-term N2 treatments on ripening of banana fruit显示文摘 | Yi C Jiang Y M Sun J | 2006 | Journal of Horticultural Science and Biotechnology2006，4，： | 1 |
| 18 | A fundamental understanding to the failure of cement concrete pavement based on the concept of fracture mechanics显示文摘 | YI Z J YANG Q G TANG B M | 2002 | International Journal of Road Material and Pavement Design2002，3，3： | 1 |
| 19 | An acetic/water based Sol-Gel PZT process I : Modification of Zr and Ti alkoxides with acetic acid 显示文摘 | Yi G H Sayer M | 1996 | J Sol-Gel Sci Technol1996，6，1： | 1 |
| 20 | Two-dimensional simulation of underground seepage in a dangerous piping zone of the Jingjiang Great Levee,the middle reach of the Yangtze River显示文摘 | C Yi B Wang M Jin | 2007 | Quarterly Journal of Engineering Geology and Hydrogeology2007，40，1： | 1 |
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