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| 1 | Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population显示文摘AIM:To identify if methylene tetra-hydrofolatereductase(MTHFR)C677T polymorphisms are associated with oesophageal adenocarcnomas in a Caucasian population and to test whether folic acid and homocysteine levels are linked with cancer risk.METHODS:A case control study comprising of 58 non cancer and 48 cancer patients,MTHFR C667T genotyping was made and serum folate,homocysteine and vitamin B12 levels were made.Tumour stage,differentiation and survival was recorded.A P value of less than0.05 was taken to be significant.Theχ2 used to compare discrete variables and the Mantel-Cox was used to compare survival.A P value less than 0.05 was deemed to be significant.RESULTS:MTHFR polymorphisms is associated with an increased risk of several cancers.A link between MTHFR C677T polymorphisms and oesophageal squamous cell carcinoma and gastric cardia adenocarcinoma has been demonstrated in at risk Chinese populations.In a Western European population the role of the MTHFR gene has not previously been investigated in the setting of oesophageal adenocarcinoma.No association between folic acid levels and cancer patients was found.The unstable MTHFR 667 TT genotype occurred in 11%cancers and 7%controls,but statistical significance was not reached,homocysteine levels and folic acid levels were not affected,cancer patients with TT genotype displayed a trend for a shorter survival 7 mo vs 20 mo.Serum vitamin B12 levels were higher in the cancer group.The MTHFR 667 TT genotype is much lower than previous population studies.CONCLUSION:We conclude that serum folic acid and MTHFR polymorphisms are not associated with an increased risk of oesophageal adenocarcinoma,although cancers with unstable TT genotype may indicate a more aggressive disease course. | Richard Keld Manyi Thian Chia Hau Jamil Sajid Narveen Kumar Yeng Ang | 2014 | World Journal of Gastroenterology2014，20，34： | 8 |
| 2 | Effects of feeding whole linseed on ruminal fatty acid composition and microbial population in goats显示文摘The objective of the present study was to evaluate the effect of feeding different levels of whole linseed,as a source of n-3 polyunsaturated fatty acids(PUFA), on ruminal fatty acid composition and microbial population in the goat. Twenty-four crossbred Boer goats were assigned to 3 dietary treatments: LO(control), L10 and L20 containing 0,10%, or 20% whole linseed, respectively. The ruminal pH and concentration of total volatile fatty acids(VFA) were not affected by dietary treatments. The feeding of L10 and L20 diets produced higher(P < 0.05) molar proportions of acetate and lower(P < 0.05) molar proportions of butyrate and valerate than the LO diet. Molar proportions of myristic acid(C14:0) and palmitic acid(C16:0) were lower(P < 0.05) in the rumen of goats offered L10 and L20 diets than the control diet. However, stearic acid(C18:0), vaccenic acid(C18:1 trans-11), conjugated linoleic acid(CLA,C18:2 trans-10, cis-12) and a-lenolenic acid(C18:3 n-3) were higher(P < 0.05) in the rumen of goats fed L10 and L20 than L0. Both inclusion levels of linseed in the diet(L10 and L20) reduced the ruminal total bacteria, methanogens, and protozoa compared with LO(P < 0.05). The effect of the dietary treatments on cellulolytic bacteria, varied between the individual species. Both inclusion levels of linseed resulted in a significant decrease(P < 0.05) in the population of Fibrobacter succinogenes, and Rumunococus flavefaciens compared with LO, with no significant difference between the groups fed linseed diets. The population of Rumunococus albus was not affected by the different dietary treatments. It was concluded that inclusion of whole linseed in the diet of goats could increase the concentration of PUFA in the rumen, and decrease the population of F. succinogenes, R. flavefaciens, methanogens and protozoa in rumen liquid of goats. | Kamaleldin Abuelfatah Abu B.Zuki Yeng M.Goh Awis Q.Sazili Abdelrahim Abubakr | 2016 | Animal Nutrition2016，，4： | 7 |
| 3 | Targeting key signalling pathways in oesophageal adenocarcinoma:A reality for personalised medicine?显示文摘Cancer treatments are rapidly changing.Curative treatment for oesophageal adenocarcinoma currently involves surgery and cytotoxic chemotherapy or chemoradiotherapy.Outcomes for both regimes are generally poor as a result of tumor recurrence.We have reviewed the key signalling pathways associated with oesophageal adenocarcinomas and discussed the recent trials of novel agents that attempt to target these pathways.There are many trials underway with the aim of improving survival in oesophageal cancer.Currently,phase 2 and 3 trials are focused on MAP kinase inhibition,either through inhibition of growth factor receptors or signal transducer proteins.In order to avoid tumor resistance,it appears to be clear that targeted therapy will be needed to combat the multiple signalling pathways that are in operation in oesophageal adenocarcinomas.This may be achievable in the future with the advent of gene signatures and a combinatorial approach. | Richard R Keld Yeng S Ang | 2011 | World Journal of Gastroenterology2011，17，23： | 6 |
| 4 | Targeting the cell cycle in esophageal adenocarcinoma:An adjunct to anticancer treatment显示文摘Esophageal adenocarcinoma is a major cause of cancer death in men in the developed world.Continuing poor outcomes with conventional therapies that predominantly target apoptosis pathways have lead to increasing interest in treatments that target the cell cycle.A large international effort has led to the development of a large number of inhibitors,which target cell cycle kinases,including cyclin-dependent kinases,Aurora kinases and polo-like kinase.Initial phase Ⅰ/Ⅱ trials in solid tumors have often demonstrated only modest clinical benefits of monotherapy.This may relate in part to a failure to identify the patient populations that will gain the most clinical benefit.Newer compounds lacking the side effect profile of first-generation compounds may show utility as adjunctive treatments targeted to an individual's predicted response to treatment. | Martyn Dibb Yeng S Ang | 2011 | World Journal of Gastroenterology2011，17，16： | 6 |
| 5 | Risk factors for neoplastic progression in Barrett's esophagus显示文摘Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a 'metaplasia-dysplasia-carcinoma' (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available. | Elizabeth F Wiseman Yeng S Ang | 2011 | World Journal of Gastroenterology2011，17，32： | 5 |
| 6 | Gastric endoscopic submucosal dissection as a treatment for early neoplasia and for accurate staging of early cancers in a United Kingdom Caucasian population显示文摘AIM To investigate the efficacy of endoscopic submucosal dissection(ESD) at diagnosing and treating superficial neoplastic lesions of the stomach in a United Kingdom Caucasian population.METHODS Data of patients treated with or considered for ESD at a tertiary referral center in the United Kingdom were retrieved for a period of 2 years(May 2015 to June 2017) from the electronic patient records of the hospital. Only Caucasian patients were included. Primary outcomes were curative resection(CR) and were defined as ESD resections with clear horizontal and vertical margin and an absence of lympho-vascular invasion, poor differentiation and submucosal involvement on histological evaluation of the resected specimen. Secondary end-points were reversal of dysplasia at 12 mo endoscopic follow-up and/or at the latest follow up. Change in histological diagnosis pre and post ESD was also analysed.RESULTS Twenty-four patients were initially identified with intention to treat. 19 patients were eligible after mapping gastroscopy and ESD was attempted on a total of 25 ESD lesions, 4 of which failed and had to be aborted mid-procedure. Out of 21 ESD performed, en-bloc resection was achieved in 71.4% of cases. Resection was considered complete on endoscopy in 90.5% of cases compared to only 38.1% on histology. A total of 6 resections were considered curative(28%), 5 noncurative(24%) and 10 indefinite for CR or non-CR(24%). ESD changed the histological diagnosis in 66.6% of cases post ESD. Endoscopic follow-up in the 'indefinite' group and CR group showed that 50% and 80% of patients were clear of dysplasia at the latest follow-up respectively; 2 cases of recurrence were observed in the 'indefinite'group. Survival rate for the entire cohort was 91.7%.CONCLUSION This study provides early evidence for the efficacy of ESD as a therapeutic and diagnostic intervention in Caucasian populations and supports its application in the United Kingdom. | Aisha Sooltangos Matthew Davenport Stephen McGrath Jonathan Vickers Siba Senapati Kurshid Akhtar Regi George Yeng Ang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，12： | 3 |
| 7 | Long-Range Balanced Electron- and Hole-Transport Lengths in Organic-Inorganic CH3NH3PbI3显示文摘 | Guichuan Xing Nripan Mathews Shuangyong Sun Swee Sien Lim Yeng Ming Lam Michael Gr?tzel Subodh Mhaisalkar Tze Chien Sum | 2013 | 2013 (6156)2013，，6156： | 3 |
| 8 | Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7cell line model using comet assay显示文摘Objective:To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta(E.hirta)in MCF-7 cell line model using comet assay.Methods:The cytotoxicity of E.hirta extract was investigated by employing brine shrimp lethality assay and the genotoxicity of E.hirta was assessed by using Comet assay.Results:Both toxicity tests exhibited significant toxicity result.In the comet assay,the E.hirta extract exhibited genotoxicity effects against MCF-7 DNA in a time-dependent manner by increasing mean percentage of DNA damage.The extract of E.hirta showed significant toxicity against brine shrimp with an LC_(50)value of 620.382μg/mL(24 h).Comparison with positive control potassium dichroniate signifies that cytotoxicity exhibited by the methanol extract might have moderate activity.Conclusion:The present work confirmed the cytotoxicity and genotoxicity of E.hirta.However,the observed toxicity of E.hta extracts needs to be confirmed in additional studies. | Kwan Yuet Ping Ibrahim Darah Yeng Chen Sreenivasan Sasidharan | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 2 |
| 9 | Reliable guaranteed cost control for uncertain nonlinear systems显示文摘 | YANG G H WANG J L YENG C S | 2000 | IEEE Trans on Automatic Control2000，45，11： | 1 |
| 10 | Anmiotic fuid interphaseo zation (FISH) for detection of aneuploidy :experiences in 130 prenatal cases显示文摘 | Lim HJ Kim YJ Yeng JH fluorescenoe in situ hybridi | 2002 | J Korean Med Sci2002，17，： | 1 |
| 11 | Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression显示文摘 | Yeng YM Fang AL Zhou CJ | 2011 | Cancer Sci2011，102，7： | 1 |
| 12 | The Effect of Calcination Temperature on the Crystallinity of TiO2 Nanopowders显示文摘 | CHEN Yung-fang LEE Chi-young YENG Ming-yu | 2003 | J Crystal Growth2003，247，： | 1 |
| 13 | Ant colony optimization for the nonlinear resource allocation problem 显示文摘 | Yin Peng yeng Wang Jing yu | 2006 | Applied Mathematics and Computation2006，，174： | 1 |
| 14 | A novel anti-hmnan DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death显示文摘 | Guo Y Chen C Yeng Y | 2005 | J Biol Chem2005，280，41： | 1 |
| 15 | Activation of peroxisome pro-liferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism显示文摘 | Jo SH Caemus B | 2007 | Pathol2007，170，2： | 1 |
| 16 | A lig-nan and four ter penods from Brucea javani-ca that induce differentiation with cultured HL-60 promyelcytic leukemia cells显示文摘 | Lu Yeng IL Sun N TONG HH | 1996 | Phytochemis- try1996，43，2： | 1 |
| 17 | Adaptive Kalman Filtering in Networked Systems with Random Sensor Delays, Multiple Packet Dropouts and Missing Measurements显示文摘 | Maryam M Yung F K Yeng C S | 2010 | IEEE Trans- actions on Signal Processing2010，58，3： | 1 |
| 18 | On the stability of uncertain systems with multiple time -varying delay显示文摘 | Yeng - Jen Sun Jer - Guang Hsich and Hong - Chin Yang | 1997 | IEEE Trans Auto Control1997，42，1： | 1 |
| 19 | Ensemble of Online Sequential Extreme Learning Machine显示文摘 | Yuan Lan Yeng Chai Soh Guang-Bin Huang | | 0，，13： | 1 |
| 20 | Treatment of primary pure angiosarcoma of ovary with muhiple lung metastases: a ease report显示文摘 | Twu NF Juang CM Yeng MS | 1999 | Eur J Gynaecol Oncol1999，20，56： | 1 |
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