| 2 | TRP (transient receptor potential) ion channel family:structures, biological functions and therapeutic interventions for diseases显示文摘Transient receptor potential(TRP)channels are sensors for a variety of cellular and environmental signals.Mammals express a total of 28 different TRP channel proteins,which can be divided into seven subfamilies based on amino acid sequence homology:TRPA(Ankyrin),TRPC(Canonical),TRPM(Melastatin),TRPML(Mucolipin),TRPN(NO-mechano-potential,NOMP),TRPP(Polycystin),TRPV(Vanilloid).They are a class of ion channels found in numerous tissues and cell types and are permeable to a wide range of cations such as Ca^(2+),Mg^(2+),Na^(+),K^(+),and others.TRP channels are responsible for various sensory responses including heat,cold,pain,stress,vision and taste and can be activated by a number of stimuli.Their predominantly location on the cell surface,their interaction with numerous physiological signaling pathways,and the unique crystal structure of TRP channels make TRPs attractive drug targets and implicate them in the treatment of a wide range of diseases.Here,we review the history of TRP channel discovery,summarize the structures and functions of the TRP ion channel family,and highlight the current understanding of the role of TRP channels in the pathogenesis of human disease.Most importantly,we describe TRP channel-related drug discovery,therapeutic interventions for diseases and the limitations of targeting TRP channels in potential clinical applications. | Miao Zhang Yueming Ma Xianglu Ye Ning Zhang Lei Pan Bing Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 4 |
| 3 | A COLLABORATIVE SPECTRUM SENSING SCHEME USING FUZZY COMPREHENSIVE EVALUATION IN COGNITIVE RADIO显示文摘Cognitive Radio(CR) is a promising technology to solve the challenging spectrum scarcity problem.However, to implement CR, spectrum sensing is the groundwork and the precondition.In this paper, a collaborative spectrum sensing scheme using fuzzy comprehensive evaluation is proposed.The final sensing decision of the proposed scheme is based on the combination of distributed sensing results of different Secondary Users(SUs).To improve the reliability of the sensing decision, the combination procedure takes into account the credibility of each SU, which is evaluated using fuzzy comprehensive evaluation.The effect of the presence of malicious SUs and malfunctioning SUs on the performance of the proposed scheme is also investigated.The efficiency of the scheme is validated through analysis and simulation. | Yang Wendong Ye Yuhuang Cai Yueming Xu Youyun | 2009 | Journal of Electronics(China)2009，26，3： | 3 |
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