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| 1 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 2 | Chloroplast phylogenomics of the New World grape species (Vitis, Vitaceae)显示文摘Vitis L。(葡萄类) 是经济地很重要的水果庄稼,葡萄和酒的来源。在类以内的种系发生的关系是高度争论的。此处,我们从整个 plastomes 采用顺序数据试图提高 Vitis 种系发生的分辨率。结果作为 monophyletic 支持新世界 Vitis 亚属 Vitis。在 clade 以内, V。californica 是到仍然保持新的姐妹世界 Vitis 亚属 Vitis。在亚属 Vitis 以内,而且,欧亚的 clade 要用体力地被支持并且是到新世界 clade 的姐妹。Vitis vinifera ssp 的 clade。vinifera 和 V。vinifera ssp。sylvestris 是到 Vitis 的核心亚洲人 clade 的姐妹。在北美洲的几普遍的种被发现例如,是在 plastome 树上的 nonmonophyletic 广泛地定义的 Vitis cinerea 和 V。aestivalis 各个需要被分成几种。可能也 nonmonophyly 某种类由于在北美的 Vitis 的杂交的普通出现。由进九个系列的 Munson 的北美的 Vitis 的分类基于种系发生的结果被讨论。分叉时间和系多样化的分析在在晚第三纪开始的北美洲支持 Vitis 的快速的放射。 | Jun Went AJ Harris Yash Kalburgi Ning Zhang Yuan Xu Wei Zheng Stefanie M. Ickert-Bondt Gabriel Johnson Elizabeth A. Zimmer | 2018 | Journal of Systematics and Evolution2018，56，4： | 14 |
| 3 | Albumin as a prognostic marker for ulcerative colitis显示文摘AIM To evaluate the role of albumin at the time of ulcerative colitis(UC) diagnosis in predicting the clinical course of disease.METHODS Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified and divided into two categories: hypoalbuminemia(i.e.,≤ 3.5 gm/dl) or normal albumin levels(i.e.,> 3.5 gm/dl) at the time of UC diagnosis. The exposure of interest was presence of hypoalbuminemia defined asalbumin level ≤ 3.5 g/dl at the time of UC diagnosis. Patients were then followed over time to identify the use of ≥ 2 courses of corticosteroids(CS),thiopurines,anti-TNF medications and requirement of colectomy for UC management. RESULTS The eligible study cohort included 802 patients,but 92(11.4%) patients did not have their albumin levels checked at the time of UC diagnosis,and they were excluded. A total of 710 patients,who had albumin levels checked at time of UC diagnosis,were included in our study. Amongst them,536 patients had a normal albumin level and 174 patients had hypoalbuminemia. Patients with hypoalbuminemia at diagnosis had a higher likelihood of ≥ 2 courses of CS use(adjusted HR = 1.7,95%CI: 1.3-2.3),higher likelihood of thiopurine or anti-TNF use(adjusted HR = 1.72,95%CI: 1.23-2.40) than patients with normal albumin level at diagnosis. There was a trend of higher likelihood of colectomy in hypoalbuminemic patients,but it was not statistically significant(Adjusted HR = 1.7,95%CI: 0.90-3.25).CONCLUSION Hypoalbuminemia at disease diagnosis can serve as a prognostic marker to predict the clinical course of UC at the time of diagnosis. | Nabeel Khan Dhruvan Patel Yash Shah Chinmay Trivedi Yu-Xiao Yang | 2017 | World Journal of Gastroenterology2017，23，45： | 6 |
| 4 | Performance analysis of deep learning CNN models for disease detection in plants using image segmentation显示文摘Food security for the 7 billion people on earth requires minimizing crop damage by timely detectionofdiseases.Most deep learningmodels forautomated detectionof diseases in plants suffer fromthe fatal flaw that once tested on independent data,their performance drops significantly.This work investigates a potential solution to this problem by using segmented image data to train the convolutional neural network(CNN)models.As compared to the F-CNN model trained using full images,S-CNN model trained using segmented imagesmore than doubles in performance to 98.6%accuracy when tested on independent data previously unseen by the models even with 10 disease classes.Not only this,by using tomato plant and target spot disease type as an example,we show that the confidence of self-classification for S-CNN model improves significantly over F-CNN model.This research work brings applicability of automated methods closer to non-experts for timely detection of diseases. | Parul Sharma Yash Paul Singh Berwal Wiqas Ghai | 2020 | Information Processing in Agriculture2020，7，4： | 5 |
| 5 | 先进蛋黄-蛋壳结构能源转化纳米反应器(英文)显示文摘蛋黄-蛋壳结构独特的纳米结构及特性,使其在很多领域中具有潜在的应用价值,因此近年来受到了广泛关注.本综述总结了使用蛋黄-蛋壳纳米结构作为纳米反应器的研究进展.从合成策略出发,主要强调最近五年合成蛋黄-蛋壳纳米结构的最新研究进展.通过光催化,甲烷重整和电催化等反应作为典型的反应过程,重点讨论蛋黄-蛋壳结构纳米反应器在催化领域的应用,并对该领域未来的发展进行了展望. | 王美文 Yash Boyjoo 潘剑 王少彬 刘健 | 2017 | Chinese Journal of Catalysis2017，38，6： | 3 |
| 6 | Excellent tribological properties of epoxy-Ti3C2 with three-dimensional nanosheets composites显示文摘As a widely used engineering polymer,epoxy resin has been successfully employed in high-performance components and setups.However,the poor thermal and friction properties of traditional epoxy resin greatly limit its application in many extreme environments.In this work,a new kind of epoxy-Ti3C2 with three-dimensional nanosheets(3DNS)composite which was designed by freeze-drying method showed up excellent thermal and friction properties.As a result,the coefficient of thermal expansion(CTE)of epoxy-Ti3C23DNS 3.0 composites was 41.9 ppm/K at 40℃,which was lower than that of the traditional epoxy resin(46.7 ppm/K),and the thermal conductivity(TC)was also improved from 0.176 to 0.262 W/(m-K).Meanwhile,epoxy-Ti3C23DNS 1.0 composites showed up the best friction property,with wear rate 76.3%lower than that of epoxy resin.This work is significant for the research of high-performance composite materials. | Fanning MENG Zhenyu ZHANG Peili GAO Ruiyang KANG Yash BOYJOO Jinhong YU Tingting LIU | 2021 | Friction2021，9，4： | 3 |
| 7 | Healthcare utilization and costs associated with gastroparesis显示文摘AIM To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis.METHODS We analyzed the National Inpatient Sample Database(NIS)for all patients in whom gastroparesis(ICD-9 code:536.3)was the principal discharge diagnosis during the period,1997-2013.The NIS is the largest publicly available all-payer inpatient care database in the United States.It contains data from approximately eight million hospital stays each year.The statistical significance of the difference in the number of hospital discharges,length of stay and hospital costs over the study period was determined by regression analysis.RESULTS In 1997,there were 3978 admissions with a principal discharge diagnosis of gastroparesis as compared to16460 in 2013(P<0.01).The mean length of stay for gastroparesis decreased by 20%between 1997 and 2013from 6.4 d to 5.1 d(P<0.001).However,during this period the mean hospital charges increased significantly by 159%from$13350(after inflation adjustment)per patient in 1997 to$34585 per patient in 2013(P<0.001).The aggregate charges(i.e.,'national bill') for gastroparesis increased exponentially by 1026%from$50456642±4662620 in 1997 to$568417666±22374060 in 2013(P<0.001).The percentage of national bill for gastroparesis discharges(national bill for gastroparesis/total national bill)has also increased over the last 16 years(0.0013%in 1997 vs 0.004%in2013).During the study period,women had a higher frequency of gastroparesis discharges when compared to men(1.39/10000 vs 0.9/10000 in 1997 and 5.8/10000vs 3/10000 in 2013).There was a 6-fold increase in the discharge diagnosis of gastroparesis amongst type 1 DM and 3.7-fold increase amongst type 2 DM patients over the study period(P<0.001).CONCLUSION The number of inpatient admissions for gastroparesis and associated costs have increased significantly over the last 16 years.Inpatient costs associated with gastroparesis contribute significantly to the national healthcare bill.Further research on cost-effective evaluation and management of gastroparesis is required. | Vaibhav Wadhwa Dhruv Mehta Yash Jobanputra Rocio Lopez Prashanthi N Thota Madhusudhan R Sanaka | 2017 | World Journal of Gastroenterology2017，23，24： | 3 |
| 8 | An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects显示文摘 | Yash M. Kolambkar Kenneth M. Dupont Joel D. Boerckel Nathaniel Huebsch David J. Mooney Dietmar W. Hutmacher Robert E. Guldberg | 2010 | Biomaterials2010，，1： | 2 |
| 9 | Behavior of Cu (I) in chloride solutions 显示文摘 | Var' yash L N Rekharskiy V I | 1981 | Geochem Intl1981，18，： | 1 |
| 10 | Fibre film contaetor显示文摘 | Yash Gupa Anil K Saroha | 2012 | Indian Institute of Chemical Engineers2012，54，2： | 1 |
| 11 | The wealth effect in empirical life-cycle aggregate consumption equations 显示文摘 | MEHRA YASH P | 2001 | Economic Quarterly2001，，2： | 1 |
| 12 | Effects of protein dose and delivery system on BMP-mediated bone regeneration显示文摘 | Joel D. Boerckel Yash M. Kolambkar Kenneth M. Dupont Brent A. Uhrig Edward A. Phelps Hazel Y. Stevens Andrés J. García Robert E. Guldberg | 2011 | Biomaterials2011，，22： | 1 |
| 13 | 查谟-克什米尔地区查谟后西瓦立克沉积中的亚洲象化石显示文摘描述了一件象属( Elephas) 的右上臼齿化石。标本产自查谟紧靠上西瓦立克亚群巨砾岩组( Boulder Conglomerate Formation) 之上的砂质、粉砂质泥岩夹砾石层中,化石地点位于查谟市南10 km,Kharian 村北约500 m 处。根据齿板数、齿脊频率、釉质层厚度、冠高指数、绝对大小和齿长/齿高指数等牙齿形态参数,暂时将之归为 Elephas cf. E. maximus indicus。还简短讨论了象属的地理分布和地质时代。 | Yash Pal KUNDAL Som Nath KUNDAL | 2011 | 古脊椎动物学报2011，49，3： | 1 |
| 14 | Atrial fibrillation and coronary artery disease:An integrative review focusing on therapeutic implications of this relationship显示文摘The incidence of both atrial fibrillation(AF)and coronary artery disease(CAD)increases with advancing age.They share common risk factors and very often coexist.Evidence points to an intricate relationship between atrial tissue excitability and neuronal remodeling with ischemia at the microcirculatory level.In this review,we delineated this complex relationship,identified a common theme between the two,and discussed how the knowledge of this relationship translates into a positive and meaningful impact in patient management.Recent research indicates a high prevalence of CAD among AF patients undergoing coronary angiography.Further,the incidence of AF is much higher in those suffering from CAD compared to age-matched adults without CAD underlying this reciprocal relationship.CAD adversely affects AF by promoting progression via re-entry and increasing excitability of atrial tissue as a result of ischemia and electrical inhomogeneity.AF in turn accelerates atherosclerosis via endothelial dysfunctional and inflammation and together with enhanced thrombogenicity and hypercoagulability contribute to micro and macrothrombi throughout cardiovascular system.In a nutshell,the two form a vicious cycle wherein one disease promotes the other.Most AF recommendations focuses on rate/rhythm control and prevention of thromboembolism.Very few studies have discussed the importance of unmasking coexistent CAD and how the treatment of underlying ischemia will impact the burden of AF in these patients.Inflammation and endothelial dysfunction remain central to both disease processes and form a handsome therapeutic target in the management of the two diseases.The relationship between AF and CAD is complex and much more than mere coincidence.The two diseases share common risk factor and pathophysiology.Hence,it is impractical to treat them in isolation.Accordingly,we share the implications of managing underlying ischemia and inflammation to positively impact and improve quality of life among AF patients. | Akash Batta Juniali Hatwal Akshey Batta Samman Verma Yash Paul Sharma | 2023 | World Journal of Cardiology2023，15，5： | 1 |
| 15 | A mesh based multi- cast routing protocol for network sender显示文摘 | Vishal Nagar Yash Pal Singh Dhubkarya D C | 2011 | Recent Advances in In- telligent Computational Systems (RAICS) IEEE2011，，： | 1 |
| 16 | Business strategy,manufacturing flexibility,and organizational performance relationships:A path analysis approach显示文摘 | Yash P | 1996 | Production and Operations Management1996，5，3： | 1 |
| 17 | The wealth effect in empirical life-cycle aggregate consumption equations显示文摘 | Mehra Yash P | 2001 | Economic Quarterly2001，87，2： | 1 |
| 18 | Sleep deprivation impairs memory,tau metabolism,and synaptic integrity of a mouse model of Alzheimer’s disease with plaques and tangles显示文摘 | Antonio DM Yash BJ Domenico P | 2014 | Neurobiology of Aging2014，35，8： | 1 |
| 19 | Is Money Exogenous in Money Demand Equations显示文摘 | Mehra Yash | 1978 | Journal of Political Economy1978，，1： | 1 |
| 20 | Area-load based pricing in DSM through ANN and heuristic scheduling显示文摘 | Kunwar N Yash K Kumar R | 2013 | IEEE Transactions on Smart Grid2013，4，3： | 1 |
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