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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | BiVO_(4),Bi_(2)WO_(6) and Bi_(2)MoO_(6) photocatalysis:A brief review显示文摘In recent years,photocatalytic technologies have been extensively studied and diffusely used in water splitting,decomposition of organic pollutants,reduction of carbon dioxide,etc.As a type of eye-catching semiconductors,BiVO_(4),Bi_(2)WO_(6),and Bi_(2)MoO_(6) (denoted as BiaAOb)have become a hotspot in photocatalytic researches due to their crystal structure stability,high light quantum and electronic transmission efficiency,and outstanding energy utilization capacity.However,pristine BiaAOb(A=V,W,and Mo)possesses several drawbacks,such as low separation efficiency of photo-excited electron-hole pairs,low specific surface area,as well as the poor quantum utilization,which restrict their photocatalytic performance.Considerable efforts,such as nanostructure modification,surface engineering,and heterojunction/homojunction fabrication,have been conducted to solve these problems.This integrated review aims to sum up recent advances in current studies on fabrication of high efficiency BiaAOb photocatalysts to accelerate the developments of BiaAOb-based materials in the photocatalysis(PC)field.The current challenges and prospects of BiaAOb are emphasized which stretches the existing fundamental theories of PC as well as provide a promising strategy to fabricate high efficiency BiaAOb catalysts to control environmental pollution and assist the sustainable development of energy. | Xintong Liu Shaonan Gu Yanjun Zhao Guowei Zhou Wenjun Li | 2020 | Journal of Materials Science & Technology2020，56，21： | 13 |
| 3 | A method for the production and expedient screening of CRISPR/Cas9-mediated non-transgenic mutant plants显示文摘Developing CRISPR/Cas9-mediated non-transgenic mutants in asexually propagated perennial crop plants is challenging but highly desirable.Here,we report a highly useful method using an Agrobacterium-mediated transient CRISPR/Cas9 gene expression system to create non-transgenic mutant plants without the need for sexual segregation.We have also developed a rapid,cost-effective,and high-throughput mutant screening protocol based on Illumina sequencing followed by high-resolution melting(HRM)analysis.Using tetraploid tobacco as a model species and the phytoene desaturase(PDS)gene as a target,we successfully created and expediently identified mutant plants,which were verified as tetra-allelic mutants.We produced pds mutant shoots at a rate of 47.5%from tobacco leaf explants,without the use of antibiotic selection.Among these pds plants,17.2%were confirmed to be non-transgenic,for an overall non-transgenic mutation rate of 8.2%.Our method is reliable and effective in creating non-transgenic mutant plants without the need to segregate out transgenes through sexual reproduction.This method should be applicable to many economically important,heterozygous,perennial crop species that are more difficult to regenerate. | Longzheng Chen Wei Li Lorenzo Katin-Grazzini Jing Ding Xianbin Gu Yanjun Li Tingting Gu Ren Wang Xinchun Lin Ziniu Deng Richard J.McAvoy Frederick G.Gmitter Jr. Zhanao Deng Yunde Zhao Yi Li | 2018 | Horticulture Research2018，5，1： | 12 |
| 4 | Meta-Analysis:Prevalence of Food Allergy and Food Allergens—China, 2000−2021显示文摘What is already known about this topic?In recent decades,the prevalence of food allergy has increased worldwide;however,a comprehensive estimate of the prevalence of food allergy and allergens in China is not yet available.What is added by this report?By searching the English databases PubMed,Embase,Cochrane Library,and Chinese databases CNKI,Wanfang Data,and VIP Chinese epidemiological studies on food allergy,the probability of food allergy in China and related influencing factors were determined.What are the implications for public health practice?The findings of this study provide up-to-date estimates of the prevalence of food allergy rates in China in terms of age,gender,and the eight major food allergens. | Jiangzuo Luo Qiuyu Zhang Yanjun Gu Junjuan Wang Guirong Liu Tao He Huilian Che | 2022 | China CDC weekly2022，4，34： | 4 |
| 5 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 6 | Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning显示文摘Dear Editor,Myocardial injury following ischemia/reperfusion(I/R)is a common clinical scenario in patients suffering from ischemic heart disease(Hausenloy et al.,2016).The involvement of proteins and signaling pathways is well studied in myocardial I/R injury and protection(Hausenloy et al.,2016;Yang et al.,2012),however,more than 98%of the transcriptional output in mammals are noncoding RNAs(ncRNAs).These products range from short microRNAs(miRNAs)to long noncoding RNAs(lncRNAs,Das et al.,2018)and modulate critical pathophysiologic mechanisms,such as apoptosis,oxidative stress,Ca2+overload and inflammation,during myocardial I/R injury and protection(Das et al.,2018). | Jiliang Tan Shanshan Gu Yanjun Zheng Huangtian Yang | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 7 | Incidence, risk factors for amputation among patients with diabetic foot ulcer in a Chinese tertiary hospital显示文摘 | Xiang Li Ting Xiao Yuzhen Wang Hongbin Gu Zhiguo Liu Yufeng Jiang Yanjun Liu Zuqian Lu Xiaopin Yang Yin Lan Zhangrong Xu | 2011 | Diabetes Research and Clinical Practice2011，，1： | 2 |
| 8 | More efficient automatic repair of large-scale programs using weak recompilation显示文摘Automatically repairing a bug can be a time-consuming process especially for large-scale programs owing to the significant amount of time spent recompiling and reinstalling the patched program.To reduce this time overhead and speed up the repair process,in this paper we present a recompilation technique called weak recompilation.In weak recompilation,we assume that a program consists of a set of components,and for each candidate patch only the altered components are recompiled to a shared library.The original program is then dynamically updated by a function indirection mechanism.The advantage of weak recompilation is that redundant recompilation cost can be avoided,and while the reinstallation cost is completely eliminated as the original executable program is not modified at all.For maximum applicability of weak recompilation we created WAutoRepair,a scalable system for fixing bugs with high efficiency in large-scale C programs.The experiments on real bugs in widely used programs show that our repair system significantly outperforms Genprog,a wellknown approach to automatic program repair.For the wireshark program containing over 2 million lines of code,WAutoRepair is over 128 times faster in terms of recompilation cost than Genprog. | QI YuHua MAO XiaoGuang WEN YanJun DAI ZiYing GU Bin | 2012 | Science China(Information Sciences)2012，55，12： | 2 |
| 9 | Associationbe- tweenpl6 INK4apromoter methylation and non-small cell- lungcancer: ameta - analysis 显示文摘 | Jundong Gu Yanjun wen Siwei zhu | 2013 | PLoS One2013，8，60： | 1 |
| 10 | Proposed Wall Climbing Robot with Permanent Magnetic Tracks for Inspecting Oil Tanks 显示文摘 | Shen Weimin Gu Jason Shen Yanjun | 2005 | IEEE International Conference on Mechatronics and Automation2005，4，29： | 1 |
| 11 | Role for mono- aminergic systems in the antidepressant-like effect of etha- nol extracts from Hemerocallis citrina 显示文摘 | Gu Lan Liu Yanjun Wang Yaobin | 2012 | J Ethnopharma- col2012，139，3： | 1 |
| 12 | Thickness-dependent morphologies of Ag on n-layer MoS2 and its surface-enhanced Raman scattering显示文摘n 层瞬间 2 上的 Ag nanoparticles 的尺寸和密度展出 thicknessdependent 行为。分别地,这些粒子的尺寸和密度与增加 n 层瞬间 2 的层数字(n) 增加了并且减少。而且,这底层上的 Ag 的散布的提高表面的拉曼(重量的单位) 被观察。这散布的改进因素与瞬间 2 的厚度变化了。管理上述的厚度依赖的机制被建议并且讨论。 | Ya Deng Minjiang Chen Jian Zhang Zihao Wang Wenbin Huang Yun Zhao Jean PierreNshimiyimana Xiao Hu Xiannian Chi Gu Hou ,Xueyao Zhang Yanjun Guo Lianfeng Sun | 2016 | Nano Research2016，9，6： | 1 |
| 13 | The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model显示文摘 | Baocun Sun Shiwu Zhang Danfang Zhang Yanjun Gu Wenchao Zhang Xiulan Zhao | 2007 | Journal of Cancer Research and Clinical Oncology2007，，12： | 1 |
| 14 | The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model显示文摘 | Baocun Sun Shiwu Zhang Danfang Zhang Yanjun Gu Wenchao Zhang Xiulan Zhao | 2007 | Journal of Cancer Research and Clinical Oncology2007，，12： | 1 |
| 15 | Preparation and Properties of Chinese Lacquer Modified by Methylolureas显示文摘In this study,different molar of methylolureas(MMU)were used to improve the properties and drying speed of the raw lacquer(RL).The drying time,gloss,pencil hardness and impact resistance of the lacquer film were tested.The thermal behaviors and chemical structures of the lacquer membrane were also discussed by thermal gravimetric analysis(TGA),fourier infrared spectrometer(FT-IR)and nuclear magnetic resonance(NMR)analysis,respectively.The results demonstrated that lower molar ratio MMU can significantly improve the properties of lacquer.The TGA analysis showed that the modified lacquer had high thermal stability than that of the control.The FT-IR and 13C NMR analysis revealed that the structures of the modified lacquer were significantly improved by cross-linking with the hydroxymethyl groups and methylene methyl ethers of MMU.In addition,through scanning electron microscopy(SEM)characterization,it was found that the introduction of MMU can effectively improve the surface smoothness of the lacquer film. | Qiang Xiao Yanjun Cao Hailu Tan Qiaoling Feng Xinyue Gu Jianhua Lyu Hui Xiao Ming Chen Yuzhu Chen | 2023 | Journal of Renewable Materials2023，11，2： | 0 |
| 16 | Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders显示文摘The hair follicle is not only a critical penetration route in percutaneous absorption but also has been recognized to be a target for hair follicle-associated disorders,such as androgenetic alopecia(AGA)and acne vulgaris.Hair follicle-targeting drug delivery systems allow for controlled drug release and enhance therapeutic efficacywithminimal side effects,exerting a promising method for themanagement of hair follicle-associated dysfunctions.Therefore,they have obtained much attention in several fields of research in recent years.This review gives an overviewof potential follicle-targeting drug delivery formulations currently applied based on the particularities of the hair follicles,including a comprehensive assessment of their preclinical and clinical performance. | Yueting Gu Qiong Bian Yanjun Zhou Qiaoling Huang Jianqing Gao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，3： | 0 |
| 17 | In-orbit performance of ME onboard Insight-HXMT in the first 5 years显示文摘Introduction The medium-energy X-ray telescope(ME)is a collimated X-ray telescope onboard the Insight hard X-ray modulation telescope(Insight-HXMT)satellite.It has 1728 Si-PIN pixels readout using 54 low noise application-specific integrated circuits(ASICs).ME covers the energy range of 5–30 keV and has a total detection area of 952cm2.The typical energy resolution of ME at the beginning of the mission is 3 keV at 17.8 keV(full width at half maximum,FWHM),and the time resolution is 255μs.In this study,we present the in-orbit performance of ME in its first 5 years of operation.Methods The performance of ME was monitored using onboard radioactive sources and astronomical X-ray objects.ME carries six 241Am radioactive sources for onboard calibration,which can continuously illuminate the calibration pixels.The long-term performance evolution of ME can be quantified using the properties of the accumulated spectra of the calibration pixels.In addition,observations of the Crab Nebula and the pulsar were used to check the long-term evolution of the detection efficiency as a function of energy.Conclusion After 5 years of operation,742cm2 of the Si-PIN pixelswere stillworking normally.The peak positions of 241Am emission lines gradually shifted to the high-energy region,implying a slow increase in ME gain of 1.43%.A comparison of the ME spectra of the Crab Nebula and the pulsar shows that the E–C relations and the redistribution matrix file are still acceptable for most data analysis works,and there is no detectable variation in the detection efficiency. | Ying Tan Xuelei Cao Weichun Jiang Xiaobo Li Bin Meng Wanchang Zhang Sheng Yang Tao Luo Yudong Gu Liang Sun Xiaojing Liu Yuanyuan Du Jiawei Yang Yanjun Xu Jinyuan Liao Yupeng Xu Fangjun Lu Liming Song Shuangnan Zhang | 2023 | Radiation Detection Technology and Methods2023，7，1： | 0 |
| 18 | Development of plant cytosine base editors with the Cas12a system显示文摘Base editors of the Cas9 system have been widely used for precise nucleotide substitution in crops. In this study, Cas12a was applied to construct plant cytosine base editors(CBEs). The main elements of Cas12aCBEs were engineered and their efficiency was evaluated in stably transformed rice cells. An optimized ttCas12a-hyA3Bctd editor, consisting of a LbCas12a variant carrying catalytic inactive D832A and temperature-tolerance D156R double mutations, a truncated human APOBEC3B deaminase, a human RAD51 single-stranded DNA-binding domain, and double copies of UGI, outperformed other Cas12aCBEs in base editing efficiency. In T0transgenic rice plants, ttCas12a-hyA3Bctd edited an average of42.01% and a maximum of 68.75% of lines at six genomic targets. A-to-G conversions were generated in rice by an adenine base editor with a similar architecture to the optimized CBE. Our results provide preliminary evidence for the feasibility of robust and efficient plant Cas12a base editing systems, which could be useful for precise crop breeding. | Huanhuan Wang Jing Liang Like Chen Bufang Deng Dongfang Gu Xiaoshuang Liu Shan Jin Rongfang Xu Ruiying Qin Yitong Zhu Liangxia Zhao Dourong Kou Yanjun Chen Yingli Jiang Juan Li Pengcheng Wei | 2023 | The Crop Journal2023，11，5： | 0 |
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