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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Efficient Photoelectrochemical Water Splitting by g-C_3N_4/TiO_2 Nanotube Array Heterostructures显示文摘Well-ordered TiO_2 nanotube arrays(TNTAs)decorated with graphitic carbon nitride(g-C_3N_4) were fabricated by anodic oxidization and calcination process.First, TNTAs were prepared via the anodic oxidation of Ti foil in glycerol solution containing fluorinion and 20%deionized water. Subsequently, g-C_3N_4 film was hydrothermally grown on TNTAs via the hydrogen-bonded cyanuric acid melamine supramolecular complex. The results showed that g-C_3N_4 was successfully decorated on the TNTAs and the g-C_3N_4/TNTAs served as an efficient and stable photoanode for photoelectrochemical water splitting. The facile deposition method enables the fabrication of efficient and low-cost photoanodes for renewable energy applications. | Changhai Liu Fang Wang Jin Zhang Ke Wang Yangyang Qiu Qian Liang Zhidong Chen | 2018 | Nano-Micro Letters2018，10，2： | 6 |
| 3 | Recent advances on deoximation: From stoichiometric reaction to catalytic reaction显示文摘Deoximation reaction is one of the most important transformations in organic synthesis and for fine chemical production.Since oximes are easily synthesized from carbonyl compounds and are stable compounds,this reaction can be used for protection-deprotection,purification,and characterization of carbonyl compounds in organic synthesis,especially for the synthesis of medicines as well as the natural products.Moreover,because many oximes can be synthesized from non-carbonyl starting materials,the deoximation reaction is also widely used in the production of many carbonyl-contained fine chemicals.Deoximation methods by using stoichiometric reagents are mature and can produce the related carbonyl products in very high yield with broad substrate application scopes.But for environment-protection consideration as well as the production cost controlling purpose in fine chemical industry,developing catalytic deoximation methods is the trend of the field and there are a series of references on this topic in recent years.This short review summarized recent advances on the development of deoximation methods from stoichiometric reaction to catalytic reaction and the mechanisms of some important transformations were discussed in detail for reader reference. | Yinghao Zheng Aiqiong Wu Yangyang Ke Hongen Cao Lei Yu | 2019 | Chinese Chemical Letters2019，30，5： | 5 |
| 4 | Using Imbalanced Triangle Synthetic Data for Machine Learning Anomaly Detection显示文摘The extreme imbalanced data problem is the core issue in anomaly detection.The amount of abnormal data is so small that we cannot get adequate information to analyze it.The mainstream methods focus on taking fully advantages of the normal data,of which the discrimination method is that the data not belonging to normal data distribution is the anomaly.From the view of data science,we concentrate on the abnormal data and generate artificial abnormal samples by machine learning method.In this kind of technologies,Synthetic Minority Over-sampling Technique and its improved algorithms are representative milestones,which generate synthetic examples randomly in selected line segments.In our work,we break the limitation of line segment and propose an Imbalanced Triangle Synthetic Data method.In theory,our method covers a wider range.In experiment with real world data,our method performs better than the SMOTE and its meliorations. | Menghua Luo Ke Wang Zhiping Cai Anfeng Liu Yangyang Li Chak Fong Cheang | 2019 | Computers, Materials & Continua2019，，1： | 4 |
| 5 | Enhanced oxygen reduction reaction performance of Co@N–C derived from metal-organic frameworks ZIF-67 via a continuous microchannel reactor显示文摘Traditional methods of preparing metal-organic frameworks(MOFs)compounds have the disadvantages such as poor dispersion,inefficient and discontinuous process.In this work,microchannel reactor is used to prepare MOFs-derived zeolite-imidazole material via flash nanoprecipitation to form ZIF-67+PEI(FNP),which reduces the MOF synthesis time down to millisecond time interval while keeping the synthesized ZIF-67+PEI(FNP)highly dispersed.The Co@N–C(FNP)catalyst obtained by flash nanoprecipitation and carbonization has a higher Co content and thus more active sites for oxygen reduction reaction than the Co@N–C(DM)catalyst prepared by direct mixing method.Electrochemical tests show that the Co@N–C(FNP)catalyst prepared by this method has excellent oxygen reduction performance,good methanol resistance and high stability.The onset potential and half-wave potential of Co@N–C(FNP)are 0.92 VRHE and 0.83 VRHE,respectively,which are higher than that of Co@N–C(DM)(Eonset=0.90 VRHEand E1/2=0.83VRHE).Moreover,the Zn-air battery assembled with Co@N–C(FNP)as the cathode catalyst has high open circuit voltage,high power density and large specific capacity.The performance of these batteries has been comparable to that of Pt/C assembled batteries.Density functional theory(DFT)calculations confirm that the Co(220)crystal plane present in Co@N–C(FNP)have stronger adsorption energy than that of Co(111)crystal plane in Co@N–C(DM),leading to better electrocatalytic performance of the former. | Chenxu Wang Huifang Yuan Feng Yu Jie Zhang Yangyang Li Wentao Bao Zhimou Wang Ke Lu Jie Yu Ge Bai Gang Wang Banghua Peng Lili Zhang | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 6 | A grain level model for deformation and failure of ultrafine-grained tungsten显示文摘Ultrafine-grained tungsten(UFG W) produced by severe plastic deformation technology has many potential applications due to its high strength and ductility. To reveal the mechanism for the high ductility of UFG W, the deformation and failure behaviors of coarse-grained tungsten(CG W) and UFG W have been compared based on a three-dimensional crystal plastic finite element method(CPFEM) simulation. Cohesive element method has been utilized to model the behavior of grain boundaries(GBs). Both plastic deformation in grain interiors and grain boundary opening have been observed in different periods of deformation in UFG W. It is concluded that the high GB density and elongated microstructure in the UFG W suppress crack propagation, decrease the stress concentration and impurity concentration on GBs, therefore enhance the ductility of the material. | REN Ke CHEN LiRong CHENG YangYang WANG JianXiang DUAN HuiLing | 2019 | Science China(Technological Sciences)2019，62，5： | 1 |
| 7 | 胆酸通过抑制NLRP3炎症小体活化控制炎症及代谢综合征的发生显示文摘免疫系统和代谢系统的相互作用彼此影响着对方生理功能的正常发挥,对于维持机体的代谢平衡和免疫稳态起着重要的调节作用。当二者的相互调控出现失衡或发生异常时,往往会导致机体相关病理性事件如代谢综合征、自身免疫性疾病、心血管疾病以及肿瘤等的发生。 | Chuansheng Guo Shujun Xie Zhexu Chi Jinhua Zhang Yangyang Liu Li Zhang Mingzhu Zheng Xue Zhang Dajing Xia Yuehai Ke Linrong Lu 王迪 | 2017 | 科学新闻2017，19，4： | 0 |
| 8 | Accurate quantification of 3'-terminal 2'-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR显示文摘The continuing discoveries of novel classes of RNA modifications in various organisms have raised the need for improving sensitive,convenient,and reliable methods for quantifying RNA modifications.In particular,a subset of small RNAs,including microRNAs(miRNAs)and Piwi-interacting RNAs(piRNAs),are modified at their 3'-terminal nucleotides via 2'-0-methylation.However,quantifying the levels of these small RNAs is difficult because 2'-0-methylation at the RNA 3'-terminus inhibits the activity of polyadenylate polymerase and T4 RNA ligase.These two enzymes are indispensable for RNA labeling or ligation in conventional miRNA quantification assays.In this study,we profiled 3'-terminal 2'-0-methyl plant miRNAs in the livers of rice-fed mice by oxidative deep sequencing and detected increasing amounts of plant miRNAs with prolonged oxidation treatment.We further compared the efficiency of stem-loop and poly(A)-tailed RT-qPCR in quantifying plant miRNAs in animal tissues and identified stem-loop RT-qPCR as the only suitable approach.Likewise,stem-loop RT-qPCR was superior to poly(A)-tailed RT-qPCR in quantifying 3'-terminal 2'-0-methyl piRNAs in human seminal plasma.In summary,this study established a standard procedure for quantifying the levels of 3'-terminal 2'-0-methyl miRNAs in plants and piRNAs.Accurate measurement of the 3'-terminal 2'-0-methylation of small RNAs has profound implications for understanding their pathophysiologic roles in biological systems. | Yan Kong Huanhuan Hu Yangyang Shan Zhen Zhou Ke Zen Yulu Sun Rong Yang Zheng Fu Xi Chen | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 9 | The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike显示文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions. | Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei Lu Zifeng Guo | 2024 | The Crop Journal2024，12，1： | 0 |
| 10 | 3-2 Dielectronic Recombination of Be-like 40Ar14+at the CSRm显示文摘The total recombination rate coefficients of Be-like 40Ar14+ions have been measured by employing the electron-ion merged-beams technique at the heavy ion storage ring CSRm at IMP.Fig.1 shows the recombination spectrum for electron energy from 0 to 58 eV in the center-of-mass frame.The resonant capture,involving the core excitation of an electron and two electrons,which is termed dielectronic recombination(DR)and trielectronic recombination(TR)individually and leads to series of peaks,have been preliminarily identified by extending downward in energy from their series limits with the Rydberg formula[1]. | Huang Zhongkui Wen Weiqiang Wang Hanbing Dou Lijun Zhu Xiaolong Xu Xin Zhu Linfan Wang Shuxing Xu Weiqing Yao ke Xu Tianheng YangYang Mao Lijun Li Jie Yang Jiancheng Yuan Youjin Ma Xinwen | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 11 | Are public‒private partnerships still an answer for social infrastructure?A systematic literature review显示文摘Social infrastructure has become an important element for measuring national economic development and social benefits that are usually financed in the form of government grants,private investment,and public‒private partnerships(PPPs).However,social infrastructure PPPs have attracted considerable public debate due to their low profitability and complex operational demands.This study aims to answer the question,“are PPPs still an answer for social infrastructure?”,from the perspectives of the body of knowledge,application status,and prospects.Initially,an iterative search and review procedure and a scientometric analysis were performed to systematically screen the literature and to structure the body of knowledge of the social infrastructure PPPs literature.Furthermore,the application status and trends were analyzed to further explore the studied countries/regions,application sectors,and research topics.Results show that PPPs still have valuable application potential for delivering social infrastructure despite their mixed results across different topics.Six main research themes and the corresponding research trends were also identified,namely,financing and economics viability,risk management,performance management,contract and relationship management,governance and regulation,and facilitating and hindering factors.These findings offer practitioners and researchers a comprehensive overview and constructive guidance on social infrastructure PPPs. | Liang MA Yangyang HU Liuying ZHU Yongjian KE | 2023 | Frontiers of Engineering Management2023，10，3： | 0 |
| 12 | Chemical Bath Co-deposited ZnS Film Prepared from Different Zinc Salts: ZnSO_4—Zn(CH_3COO)_2, Zn(NO_3)_2—Zn(CH_3COO)_2,or ZnSO_4—Zn(NO_3)_2显示文摘ZnSO_4—Zn(CH_3COO)_2, Zn(NO_3)_2—Zn(CH_3COO)_2, ZnSO_4—Zn(NO_3)_2, ZnSO_4, Zn(NO_3)_2 or Zn(CH_3COO)_2 have been used as zinc sources to prepare ZnS thin films by chemical bath deposition and co-deposition methods.Zn(NO_3)_2 or/and Zn(CH_3COO)_2 is/are favorable for cluster by cluster deposition process while ZnSO_4 favors ion by ion deposition process regardless of concentration ratios of ZnSO_4. However, Zn(NO_3)_2 affects the nucleation density of Zn S nuclei on the substrate. Zn S thin films deposited from ZnSO_4—Zn(CH_3COO)_2 are not only more homogeneous and compact, but also have higher growth rate and adhesion on to the glass substrate. The cubic ZnS films are obtained after only single deposition. The average transmission of films from S6, S7, S8, S9 and S1 for 2 and 2.5 h is greater than 85% in visible region. Compared with the film from S6(112 nm), the film from S7 is not only thicker(125 nm), but also more transparent. The band gaps of the films deposited from S6, S7, S8, S9 and S1 for 2 and 2.5 h range from 3.88 to 3.98 e V.The effects of anions from different zinc salts are discussed in detail. | Tingzhi Liu Yangyang Li Huan Ke Yuhai Qian Shuwang Duo Yanli Hong Xinyuan Sun | 2016 | Journal of Materials Science & Technology2016，32，3： | 0 |
| 13 | Dual inhibition of CDK4 and FYN leads to selective cell death in KRAS-mutant colorectal cancer显示文摘Dear Editor,Activating mutations in KRAS have been found in nearly 50%of colorectal cancers(CRCs),and patients with KRAS mutations are resistant to the anti-EGFR agent cetuximab1.Currently,though there are several strategies targeting the mutated cysteine in KRAS(G12C;http://gffzzd3f38a9638994581hcuk596uk09uq69wo.ffgz.tsg.suse.edu.cn/ct2/show/NCT03600883),the frequency of the KRAS G12C mutation is much lower in CRC than in lung adenocarcinoma2.Thus,it is urgent to increase efforts to develop a novel strategy for KRAS-mutant CRC. | Yan Wang Rongjie Lin Huan Ling Yuan Ke Yangyang Zeng Yudi Xiong Qian Zhou Fuxiang Zhou Yunfeng Zhou | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
| 14 | Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors显示文摘Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor treatment.The fact that not every patient can benefit from it highlights the importance for defining biomarkers that help predict patients’responses.As particular self-amplifying biotherapeutics,the anti-tumor effects of OVs are highly dependent on the host factors for viral infection and replication.By using weighted gene co-expression network analysis(WGCNA),we found matrix remodeling associated 8(MXRA8)is positively correlated with the oncolysis induced by oncolytic virus M1(OVM). | Deli Song Xudong Jia Xincheng Liu Linyi Hu Kaiying Lin Tong Xiao Yangyang Qiao Jiayu Zhang Jia Dan Chunwa Wong Cheng Hu Ke Sai Shoufang Gong Max Sander Runling Shen Xiaoyu Chen Xiaoting Xiao Jiehong Chen Yanming Zhang Cailv Wei Xiao Xiao Jiankai Liang Qinfen Zhang Jun Hu Wenbo Zhu Guangmei Yan Yuan Lin Jing Cai | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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