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| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial显示文摘Objective:To explore the effect of electro-acupuncture(EA)on glucose and lipid metabolism in unmarried patients with polycystic ovary syndrome(PCOS).Methods:Fifty-four PCOS patients were equally randomized into true acupuncture group and sham acupuncture group(control)for totally 16 weeks of treatment by random method with a computerized randomization program.Patients in true acupuncture group accepted traditional acupuncture methods with EA and two sets of acupoint groups were used alternatively.The first set consisted of Zhongji(CV 3),Qihai(CV 6),Guilai(ST 29),Sanyinjiao(SP 6),Yinlingquan(SP 9),Hegu(LI4)and Baihui(GV 20),and the second set consisted of Tianshu(ST 25),ST 29,CV 3,CV 6,SP 6,Taichong(LR 3),Neiguan(PC)6 and GV 20.Patients in the sham acupuncture group accepted shallow acupuncture methods through EA without electricity at 4 non-meridian points in each shoulder and upper arm.Outcome measures included body mass index(BMI),waist-hip-ratio(WHR),oral glucose tolerance test(OGTT),insulin release test,glucose and lipid metabolism indicators such as total cholesterol(TC),triglycerides,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol,adiponectin,leptin,visfatin,resistin,and interleukin(IL-6).Results:Twenty-six subjects in the true acupuncture group and 20 subjects in the sham group completed the clinical trial.After 16 weeks of treatment,no significant difference in the outcome measures were observed between the two groups(P>0.05).However,as compared with baseline data,a reduction in weight,BMI,hipline,WHR,fasting glucose,homeostatic model assessment of insulin sensitivity,visfatin and HDL-C,and an increase in resistin and IL-6 were observed in the true acupuncture group(P<0.05).In addition,a reduction in visfatin and an increase in TC were also observed in the sham group(P<0.05).Conclusions:Acupuncture may have a beneficial effect in the treatment of PCOS by improving glucose and lipid metabolism.Moreover,the sham acupuncture may be not completely ineffective.Sham acupuncture may improve some of the aspects of the glucose and lipid metabolism of PCOS patients through a placebo effect.(Registration Nos.ChiCTR-TRC-12002529 and NCT01812161) | DONG Hao-xu WANG Qing WANG Zhi WU Xiao-ke CHENG Ling ZHOU Zhong-ming YANG Li Yl Ping HUANG Dong-mei | 2021 | Chinese Journal of Integrative Medicine2021，27，10： | 4 |
| 3 | Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells 显示文摘 | Ma YL Xu YS Xiao ZF Yang W Zhang C Song E | 2005 | Stem Cells2005，24，2： | 1 |
| 4 | Physical association between STAT1 and the interferon-inducible protein kinase PKR and implica- tions for interferon and double-stranded RNA signaling pathways 显示文摘 | Wong AH Tam NW Yang YL | 1997 | EMBO J1997，16，6： | 1 |
| 5 | Down-regulation of glucocorticoid receptor and its relationship to the induction of rat liver tyrosine aminotransferase显示文摘 | Yang YL Tan JX Xu RB | 1989 | Steroid Biochem1989，，32： | 1 |
| 6 | Reversal of multidrug resistance to epirubicin by cyclosporine A in liposomes or intralipid显示文摘 | Lo YL Liu FI Yang JM | 2001 | Anticancer Res2001，21，1： | 1 |
| 7 | Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer显示文摘 | Liu YL Yang YM Xu H | 2010 | J Gastroenterol Hepatol2010，25，11： | 1 |
| 8 | The total flavones from Semen cuscutae reverse the reduction of testosterone level and the expression of androgen receptor gene in kidney - yang deficient mice显示文摘 | Yang JX Wang YL Bao Y | 2008 | J Ethnopharmaco12008，119，1： | 1 |
| 9 | Penoscrotal extramammary Paget′s disease:a review of 33 cases in a 20-year experience显示文摘 | Lai YL Yang WG Tsay PK et a1 | 2003 | Plast Reconstr Surg2003，112，4： | 1 |
| 10 | Increased Golgi pro- tein73 expressing in hepatocellular carcinoma tissue correlates with tumoraggression but not survival 显示文摘 | Sun YL Yang HY Mao YL et ai | 2011 | J Gastroenterol Hepatol2011，26，7： | 1 |
| 11 | The prognostic role of the class Ⅲ beta-tubulin in non-small cell lung cancer (NSCLC) pa- tients receiving the taxane/vinorebine-based chemotherapy: a meta- analysis 显示文摘 | Yang YL Luo XP Xian L | 2014 | PLoS One2014，9，93： | 1 |
| 12 | Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer显示文摘 | Liu YL Yang YM Xu H | 2011 | J Surg Oncol2011，103，3： | 1 |
| 13 | Safflower extract: a novel renal fibrosis antagonist that functions by suppressing autoerine TGF-Beta 显示文摘 | Yang YL Chang SY Teng HC | 2008 | J Cellular Biochemistry2008，104，3： | 1 |
| 14 | Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats 显示文摘 | Yang DL Zhang HG Xu YL | 2010 | Clin Exp Pharmacol Physiol2010，37，2： | 1 |
| 15 | Characterization of yeasts colo- nlzing in healthy individuals显示文摘 | Yang YL Leaw SN Wang AH etal | 2011 | Med Mycol2011，49，1： | 1 |
| 16 | Expression of IL-23/Thl 7 pathway in a murine model of Coxsackie virus B3-induced viral myocarditis 显示文摘 | Yang F Wu WF Yah YL | 2011 | Virol J2011，8，： | 1 |
| 17 | Reactive oxygen species activate HIV long terminal repeat via post-translational control of NF-kappaB 显示文摘 | Pyo CW Yang YL Yoo | 2008 | Biochem Biophys Res Commun2008，376，1： | 1 |
| 18 | Tne FK506- binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1显示文摘 | Yao YL Seto E | 2001 | EMBO J2001，20，17： | 1 |
| 19 | C-shaped root canals in mandibular second molars in Chinese population显示文摘 | Yang ZP Yang SF Lin YL | 1988 | Endod Dent Traumatol1988，4，16： | 1 |
| 20 | Electroacupuncture reduces rat's neuronal ischemic injury and enhances the expression of basic fibroblast growth factor显示文摘 | Yang WO Huang YL | 1999 | Acupunct Electrother Res1999，24，： | 1 |
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