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| 1 | Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anti-clastogenicity of lutein from marigold flowers显示文摘 | Mingchen Wang Rong Tsao Shanfeng Zhang Ziming Dong Raymond Yang Jianhua Gong Yingxin Pei | 2006 | Food and Chemical Toxicology2006，，9： | 2 |
| 2 | A Sub-100 mg Electromagnetically Driven Insect-inspired Flapping-wing Micro Robot Capable of Liftoff and Control Torques Modulation显示文摘Inspired by the unique,agile and efficient flapping flight of insects,we present a novel sub-100 mg,electromagnetically driven,tailless,flapping-wing micro robot.This robot utilizes two optimized electromagnetic actuators placed back to back to drive two wings separately,then kinematics of each wing can be independently controlled,which gives the robot the ability to generate all three control torques of pitch,roll and yaw for steering.To quantify the performance of the robot,a simplified aerodynamic model is used to estimate the generated lift and torques,and two customized test platforms for lift and torque measurement are built for this robot.The mean lift generated by the robot is measured to be proportional to the square of the input voltage amplitude.The three control torques are measured to be respectively proportional to three decoupled parameters of the control voltages,therefore the modulation of three control torques for the robot is independent,which is helpful for the further controlled flight.All these measured results fit well with the calculated results of the aerodynamic model.Furthermore,with a total weight of 96 mg and a wingspan of 3.5 cm,this robot can generate sufficient lift to take off. | Chenyang Wang Weiping Zhang Yang Zou Ran Meng Jiaxin Zhao Mingchen Wei | 2020 | Journal of Bionic Engineering2020，17，6： | 2 |
| 3 | Blood compatibility of thermoplastic polyurethane membrane immobilized with water-soluble chitosan/dextransulfate显示文摘 | Lin Wenching Yu Daguang Yang Mingchen | 2005 | Colloids and Surfaces B: Biointerfaces2005，44，： | 1 |
| 4 | Blood compatibility of thermoplastic polyurethane membrane immobilized with water-soluble chitosan/dextran sulfate显示文摘 | Lin Wenching Yu Daguang Yang Mingchen | 2005 | Colloids and Surfaces B: Biointerfaces2005，44，23： | 1 |
| 5 | Designing hollow fiber contactors显示文摘 | Yang Mingchen Cussler E L | 1986 | AIChE J1986，32，11： | 1 |
| 6 | Designig hollow fiber contactors 显示文摘 | Yang Mingchen | 1986 | AICHE1986，32，11： | 1 |
| 7 | Molecular Mechanism of Zhizi Ganjiang Decoction in Regulating Liver Cirrhosis Based on BATMAN-TCM Platform显示文摘[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction in the treatment of liver cirrhosis based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of Zhizi Ganjiang Decoction,and the GeneCards database searched for targets related to liver cirrhosis;Cytoscape 3.5.1 software was used to construct compound-cirrhosis target interaction network and protein interaction network;then gene ontology(GO)enrichment analysis,Reactome pathway enrichment analysis,and KEGG-based biological pathway enrichment analysis were performed.[Results]The compound-disease-target network of Zhizi Ganjiang Decoction was constructed.The PPI network of Zhizi Ganjiang Decoction targets constructed based on String contained 130 nodes and 689 interaction relationships.The key nodes mainly involved nuclear hormone receptor-like domain superfamily and ligand binding domain,serpentine type 7TM GPCR chemoreceptor and chemoreceptor Srx,rhodopsin family transmembrane receptors,zinc finger NHR/GATA type nuclear hormone receptors and ligand binding domains,PI3-kinase family p85 binding domain,phosphoinositide(PI)3-kinase catalytic domain and other categories.GO enrichment analysis pathway related entries mainly involved steroid hormone receptor activity,nuclear receptor activity,transcription factor activity,direct ligands regulation sequence-specific DNA binding,G protein-coupled amine receptor activity,steroid binding,catecholamine binding,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,and oxidoreductase activity,etc.KEGG channel analysis mainly involved neuroactive ligand-receptor interaction,aldosterone regulates sodium reabsorption,regulates lipolysis in adipocytes,regulates inflammatory mediators of TRP channels,tyrosine metabolism,calcium signaling pathway,cAMP signaling pathway,and nonalcoholic fatty liver diseases.[Conclusions]The research results suggest that Zhizi Ganjiang Decoction regulates the process of liver cirrhosis mainly through aldosterone regulation of sodium reabsorption,regulation of lipolysis in adipocytes,regulation of inflammatory mediators of TRP channels,calcium signaling pathways,and nonalcoholic fatty liver diseases.This reflects the multi-target and holistic action characteristics of the Chinese herbal compounds,and is expected to provide new ideas for further research on the molecular mechanism of Zhizi Ganjiang Decoction. | Mingchen CAO Enze LI Zhiwei YANG Yanlin SHAO Fangang MENG Zenan ZHANG Wenjing LI Mengxiang FANG Yuefen LIU | 2023 | Medicinal Plant2023，14，2： | 0 |
| 8 | Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors显示文摘With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses. | Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 9 | A Pharmacological Study on Action Mechanism of Zhizi Ganjiang Decoction from Treatise on Cold Damage Diseases in Treating Sleep Disorders显示文摘[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of ZZGJD and constructed a compound-disease-target network map,and the GeneCards database was used to search for insomnia-related targets;with the aid of Cytoscape 3.5.1 software,the compound-insomnia target interaction network and protein-protein interaction(PPI)network were constructed,and gene ontology(GO)enrichment,Reactome pathway enrichment,and biological pathway enrichment analysis based on KEGG(Kyoto Encyclopedia of Genes and Enomes)was performed.[Results]The constructed PPI network of ZZGJD involves 204 nodes and 645 interaction relationships.Key nodes involve G protein-coupled receptors,rhodopsin-like adrenaline receptor families,zinc finger proteins,nuclear hormone receptor superfamilies,ligand-binding domains of hormone receptors,voltage-gated calcium(Ca^(2+))channel IQ domains,and neuropituitary hormones.The related entries of GO enrichment analysis pathway mainly involve G protein-coupled receptor activity,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,catecholamine binding,G protein-coupled serotonin receptor activity,serotonin receptor activity,and steroid hormone receptors(SHRs)activity.Reactome pathway mainly involves amine ligand binding receptors,rhodopsin-like receptors,G protein-coupled receptor ligand binding,adrenergic receptors,neuronal systems and signal transduction,etc.KEGG channel analysis mainly involves neural activity ligand-receptor interaction,calcium ion messenger pathway,cAMP signaling pathway,serotonergic synapse,dopaminergic synapse,cGMP-PKG signaling pathway,and cholinergic synapse pathway,etc.[Conclusions]The potential targets of ZZGJD in the treatment of insomnia mainly involve G protein-coupled receptors,and regulate various neural receptor pathways such as calcium ion channels,serotonin,dopamine,and adrenergic receptors.INS,IGF-1,CTNNB1,ESR1,HIF-1A,etc.may be the key targets of ZZGJD in regulating sleep disorders,reflecting the multi-target and overall function characteristics of Chinese herbal compounds.ZZGJD is of great significance in the treatment of sleep disorders caused by blood sugar abnormality in patients with diabetes and perimenopausal hormones in women.This article is expected to It provide new ideas for in-depth study of the molecular mechanism of ZZGJD. | Xiaowei XIN Xuemei LIU Xuelian LIU Zhiwei YANG Fangang MENG Wenxiao WANG Xinxin WEI Daiming ZHANG Mingchen CAO | 2022 | Medicinal Plant2022，13，6： | 0 |
| 10 | An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia显示文摘Children with severe aplastic anemia(SAA)face heterogeneous prognoses after immunosuppressive therapy(IST).There are few models that can predict the long-term outcomes of IST for these patients.The objective of this paper is to develop a more effective prediction model for SAA prognosis based on clinical electronic medical records from 203 children with newly diagnosed SAA.In the early stage,a novel model for long-term outcomes of SAA patients with IST was developed using machine-learning techniques.Among the indicators related to long-term efficacy,white blood cell count,lymphocyte count,absolute reticulocyte count,lymphocyte ratio in bone-marrow smears,C-reactive protein,and the level of IL-6,IL-8 and vitamin B12 in the early stage are strongly correlated with long-term efficacy(P<.05).Taken together,we analyzed the long-term outcomes of rabbit antithymocyte globulin and cyclosporine therapy for children with SAA through machine-learning techniques,which may shorten the observation period of therapeutic effects and reduce treatment costs and time. | Lixian Chang Mingchen Yan Jingliao Zhang Binghang Liu Li Zhang Ye Guo Jing Sun Yang Wan Meihui Yi Yang Lan Yuli Cai Yuanyuan Ren Haihui Zheng Aoli Zhang Zhenyu Li Jian Wang Yingrui Li Xiaofan Zhu | 2023 | Blood Science2023，5，3： | 0 |
| 11 | A Comparison Study on the δD Value of Polycyclic Aromatic Hydrocarbons in Hydrous Pyrolysate of Herbaceous Peat with Different Water Medium显示文摘To investigate the influence of diagenetic water media on the hydrogen isotopes of individual sedimentary aromatic compounds,a series of hydrous pyrolyses were conducted on herbaceous peat.Polycyclic aromatic hydrocarbons(PAHs)in hydrous pyrolysed samples and their hydrogen isotopic composition characteristics were studied.The aqueous medium demonstrated a significant influence on the hydrogen isotopic composition of the individual PAHs generated during pyrolysis.The results showed that the PAHs formed after pyrolysis in the presence of a saltwater medium with high δD value from a salt lake had a heavy hydrogen isotopic composition.The PAHs formed after pyrolysis in the presence of a fresh water medium with low δD value from a swamp had a light hydrogen isotopic composition.The difference in the average PAHδD value between the two hydrous experiments varied from -174‰ to -109‰,suggesting that the hydrogen isotopic composition of individual sedimentary PAHs can reflect the source of the diagenetic water medium.In addition,a comparative study found that the hydrogen isotopes of PAHs were superior to those of n-alkanes in the same sample for diagenetic water indications.The results indicated that the exchange of water-derived inorganic hydrogen and organic hydrogen was more intensive in freshwater experiments than in saltwater experiments.With an increase in the simulation temperature,the average δD value of PAHs generated in the hydrous simulation experiments showed an increasing trend,reflecting that the δD value of sedimentary PAHs formed with the participation of diagenetic water media was still closely related to the thermal maturity of organic matter.Comparative studies showed that theδD values of different types of organic compounds produced by hydrous pyrolysis of peat were in the order,PAHs>n-alkanes>methane. | DUAN Yi WU Yingzhong XING Lantian WU Yingqin ZHAO Yang LI Zhongping MA Lanhua DUAN Mingchen | 2023 | Acta Geologica Sinica(English Edition)2023，97，6： | 0 |
| 12 | CoS Nanosheets Coated with Dopamine-Derived Carbon Standing on Carbon Fiber Cloth as Binder-Free Anode for Li-ion Batteries显示文摘Cobalt sulphides attract much attention as anode materials for Li-ion batteries(LIBs).However,its poor conductivity,low initial column efficiency and large volume changes during cycling have hindered its further development.Herein,novel interlaced CoS nanosheets were firstly prepared on Carbon Fiber Cloth(CFC)by two hydrothermal reactions followed with carbon coating via carbonizing dopamine(CoS NS@C/CFC).As a freestanding anode,the nanosheet structure of CoS not only accommodates the volume variation,but also provides a large interface area to proceed the charge transfer reaction.In addition,CFC works as both a three-dimensional skeleton and an active substance which can further improve the areal capacity of the resulting electrode.Furthermore,the coated carbon combined with the CFC work as a 3D conductive network to facilitate the electron conduction.The obtained CoS NS@C/CFC,and the contrast sample prepared with the same procedure but without carbon coating(CoS NS/CFC),are characterized with XRD,SEM,TEM,XPS and electrochemical measurements.The results show that the CoS NS@C/CFC possesses much improved electrochemical performance due to the synergistic effect of nanosheet CoS,the coated carbon and the CFC substrate,exhibiting high initial columbic efficiency(~87%),high areal capacity(2.5 at 0.15 mA cm−2),excellent rate performance(1.6 at 2.73 mA cm−2)and improved cycle stability(87.5%capacity retention after 300 cycles).This work may provide a new route to explore freestanding anodes with high areal specific capacity for LIBs. | Lianyuan Ji Mingchen Shi Zengkai Feng Hui Yang | 2024 | Journal of Renewable Materials2024，12，2： | 0 |
| 13 | The Biological Significance of Multi-copy Regions and Their Impact on Variant Discovery显示文摘Identification of genetic variants via high-throughput sequencing(HTS)technologies has been essential for both fundamental and clinical studies.However,to what extent the genome sequence composition affects variant calling remains unclear.In this study,we identified 63,897 multi-copy sequences(MCSs)with a minimum length of 300 bp,each of which occurs at least twice in the human genome.The 151,749 genomic loci(multi-copy regions,or MCRs)harboring these MCSs account for 1.98% of the genome and are distributed unevenly across chromosomes.MCRs containing the same MCS tend to be located on the same chromosome.Gene Ontology(GO)analyses revealed that 3800 genes whose UTRs or exons overlap with MCRs are enriched for Golgirelated cellular component terms and various enzymatic activities in the GO biological function category.MCRs are also enriched for loci that are sensitive to neocarzinostatin-induced double-strand breaks.Moreover,genetic variants discovered by genome-wide association studies and recorded in dbSNP are significantly underrepresented in MCRs.Using simulated HTS datasets,we show that false variant discovery rates are significantly higher in MCRs than in other genomic regions.These results suggest that extra caution must be taken when identifying genetic variants in the MCRs via HTS technologies. | Jing Sun Yanfang Zhang Minhui Wang Qian Guan Xiujia Yang Jin Xia Ou Mingchen Yan Chengrui Wang Yan Zhang Zhi-Hao Li Chunhong Lan Chen Mao Hong-Wei Zhou Bingtao Hao Zhenhai Zhang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，5： | 0 |
| 14 | Clinical Observation and Network Pharmacology Study on Analgesic Effect of Qianghuo Chushi Decoction on Fasciitis显示文摘[Objectives]To observe the clinical analgesic effect of Qianghuo Chushi Decoction(QHCSD)on patients with fasciitis,and explore its possible molecular mechanism based on network pharmacology.[Methods]120 enrolled patients were randomly divided into experimental group and control group,and were separately treated with QHCSD formula granules and Diclofenac Sodium Enteric-coated Tablets for 4 weeks.The patient’s pain visual analogue scale(VAS)was used as the curative effect indicator.The molecular action mechanism of QHCSD was predicted based on network pharmacology,the active components of QHCSD were screened using TCMSP database,potential targets were predicted by PharmMapper server,compound-target network and protein interaction network were constructed,and GO-based enrichment analysis and KEGG-based biological pathway enrichment analysis were performed.[Results]After treatment,the pain scores in each group were significantly lower than those before treatment(P<0.01),the score of the experimental group was significantly lower than that of the control group(P<0.01),and the total effective rate of the experimental group was 83.33%,which was significantly higher than that of the control group(78.33%,P<0.05).Based on 108 active components in QHCSD,a compound-target network was constructed.The PPI network contained 155 nodes and 527 interaction relationships,and key nodes included FOS,ESR1,NCOA1,RELA,EGFR,MAPK8,IL-6,etc.The GO pathway mainly involved steroid hormone and its receptor activity,RNA polymerase II transcriptional regulator binding,nuclear receptor activity,protein heterodimerization activity and other pathways.KEGG metabolic pathways included PI3 K-Akt signaling pathway,Kaposi’s sarcoma-associated herpesvirus(KSHV)infection and other pathways.[Conclusions]QHCSD has a significant analgesic effect on fasciitis,and the PI3 K-Akt signaling pathway may be the key pathway for its analgesic effect. | Mingchen CAO Lei DONG Chuan WANG Wenjing LI Xinxin WEI Shasha ZHANG Hongxia YU Cheng CHENG Xue YANG | 2022 | Medicinal Plant2022，13，5： | 0 |
| 15 | Advances in Research of Mechanism of Herb-Drug Interactions显示文摘With the concurrent consumption of herbal medicines and conventional drugs,herb-drug interactions(HDIs)have become the most important clinical consequence of this practice.A general overview and the significance of pharmacokinetic and pharmacodynamic HDIs are provided,detailing basic mechanism,especially the metabolic enzymes and drug transporters,such as CYP450 and P-gp. | Mingchen CAO Chuan WANG Zhiwei YANG Zenan ZHANG Wenxiao WANG Hongxia YU Shasha ZHANG Cheng CHENG Wei REN | 2023 | Medicinal Plant2023，14，1： | 0 |
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