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| 1 | Hardy spaces H^p over non-homogeneous metric measure spaces and their applications显示文摘Let(X,d,)be a metric measure space satisfying both the geometrically doubling and the upper doubling conditions.Let ρ∈(1,∞),0 | FU Xing LIN Hai Bo YANG Da Chun YANG Dong Yong | 2015 | Science China Mathematics2015，58，2： | 32 |
| 2 | A Survey of 16 Rare Earth Elements in the Major Foods in China显示文摘Objective The aim of this survey was to inves gate the level of contamina on of the most consumed foods in China with 16 rare earth elements (REEs),and to provide the basic data for establishing and revising food safety standards for REEs.Methods Sixteen REEs in foods were measured by induc vely coupled plasma-mass spectrometry (ICP-MS) in the labs of the Centers for Disease Control and Preven on of four provinces and two municipali es,during 2009-2010.Results 1 231 samples were analyzed and 19 121 concentra on data of 16 REEs were collected.The REEs levels in the inves gated foods varied significantly.The concentra ons of cerium (Ce),dysprosium (Dy),y rium (Y),lanthanum (La),and neodymium (Nd) were rela vely high,while the remaining eleven REEs were at low levels.The mean values of total rare earth element oxides (REOs) in cereals,fresh vegetables,fresh aqua c products,fresh meats and eggs varied from 0.052 mg/kg to 0.337 mg/kg.Conclusion 16 REEs in the major foods were at very low contamina on levels in the inves gated regions. | JIANG Ding Guo YANG Jie ZHANG Shuo YANG Da Jin | 2012 | Biomedical and Environmental Sciences2012，25，3： | 28 |
| 3 | The biomass and aboveground net primary productivity of Schima superba-Castanopsis carlesii forests in east China显示文摘The biomass and productivity of Schima superba-Castanopsis carlesii forests in Tiantong,Zhejiang Province,were determined using overlapping quadrants and stem analyses.The total community biomass was(225.3±30.1) t hm-2,of which the aboveground parts accounted for 72.0% and the underground parts accounted for 28.0%.About 87.2% of biomass existed in the tree layer.The resprouting biomass was small,of which over 95.0% occurred in the shrub layer.The productivity of the aboveground parts of the community was(386.8±98.9) g m-2a-1,in which more than 96.0% was present at the tree level.The trunk's contribution to productivity was the greatest,while that of leaves was the smallest.In China,the community biomass of subtropical evergreen broadleaved forests differs significantly with the age of the forest.The community biomass of the 52-year-old S.superba-C.carlesii forests in this study was lower than the average biomass of subtropical evergreen broadleaved forests in China,and was lower than the biomass of other subtropical evergreen broadleaved forests elsewhere in the world.Moreover,its productivity was lower than the model estimate,indicating that without disturbance,this community has great developmental potential in terms of community biomass and productivity. | YANG TongHui1,2,SONG Kun1,DA LiangJun1*,LI XiuPeng3 & WU JianPing1 1School of Resources and Environment Science,East China Normal University,Shanghai 200062,China 2Ningbo Academy of Agricultural Science,Ningbo 315040,China 3Ningbo Technology Extension Center for Forestry and Specialty Forest Products,Ningbo 315012,China | 2010 | Science China(Life Sciences)2010，53，7： | 23 |
| 4 | Efficacy and Safety of Quxie Capsule(祛邪胶囊) in Metastatic Colorectal Cancer:A Double-Blind Randomized Placebo Controlled Trial显示文摘Objective:To verify the efficacy and safety of Quxie Capsule(祛邪胶囊) in patients with metastatic colorectal cancer(mC RC).Methods:The present study was a randomized,double-blind,placebo-controlled trial.Sixty patients with mC RC were randomized into two groups at a 1:1 ratio by sealed envelope.The treatment group received conventional therapy combined with Quxie Capsule for 3 months.The control group was treated with conventional therapy combined with placebo for 3 months.Main outcome measures were overall survival(OS) and progression-free survival(PFS).Subgroup analysis was performed according to age,right or left-sided disease,and second-line therapy to determine the differences in PFS and OS between the two groups.Patients were followed up every 3 months until Dec 31 st 2016.Results:The median OS was 23 months in the treatment group [95% confidence interval(CI):15–not calculated] vs.14 months in the control group(95% CI:11–22,P=0.060).The OS of the treatment group tended to be longer than that of the control group(P>0.05).In the subgroups of patients <65 years old,left-sided colon,and 2 nd-line therapy,the treatment group showed a significant survival benefit compared with the control group(P=0.006,0.038,0.013,respectively).There were no significant differences between the two groups in PFS(P>0.05).Safety analysis showed no severe hematological toxicity or liver and renal function injury in the treatment group.Conclusions:Quxie Capsule showed good safety and efficacy,and could prolong the OS of patients with mC RC. | ZHANG Tong YANG Yu-fei HE Bin YI Dan-hui HAO Jie ZHANG Da | 2018 | Chinese Journal of Integrative Medicine2018，24，3： | 20 |
| 5 | A Review on Graphene-Based Gas/Vapor Sensors with Unique Properties and Potential Applications显示文摘Graphene-based gas/vapor sensors have attracted much attention in recent years due to their variety of structures, unique sensing performances, room-temperature working conditions, and tremendous application prospects, etc.Herein, we summarize recent advantages in graphene preparation, sensor construction, and sensing properties of various graphene-based gas/vapor sensors, such as NH_3, NO_2, H_2, CO, SO_2, H_2S, as well as vapor of volatile organic compounds.The detection mechanisms pertaining to various gases are also discussed. In conclusion part, some existing problems which may hinder the sensor applications are presented. Several possible methods to solve these problems are proposed, for example, conceived solutions, hybrid nanostructures, multiple sensor arrays, and new recognition algorithm. | Tao Wang Da Huang Zhi Yang Shusheng Xu Guili He Xiaolin Li Nantao Hu Guilin Yin Dannong He Liying Zhang | 2016 | Nano-Micro Letters2016，8，2： | 18 |
| 6 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 7 | On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B显示文摘BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs. | Xiu-Juan Chang Chao Sun Yan Chen Xiao-Dong Li Zu-Jiang Yu Zheng Dong Wen-Lin Bai Xiao-Dong Wang Zhi-Qin Li Da Chen Wen-Juan Du Hao Liao Qi-Yu Jiang Li-Jun Sun Yin-Yin Li Cui-Hong Zhang Dong-Ping Xu Yong-Ping Chen Qin Li Yong-Ping Yang | 2019 | World Journal of Gastroenterology2019，25，32： | 12 |
| 8 | Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis:a multi-center,single-blind,randomized controlled trial显示文摘PURPOSE: To observe the efficacy and safety of Shaoyang Xibi decoction(SYXBD) in patients with knee osteoarthritis(KOA), and to verify that the theory of 'Shaoyang dominating bone' in Traditional Chinese Medicine(TCM) can be applied to KOA treatment.METHODS: Participants were randomly allocated to two groups: SYXBD(treatment group, n = 66)and Meloxicam(control group, n = 66). Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and 36-Item Short Form Health Survey(SF-36) were used to assess efficacy before the treatment and 8 weeks after the treatment.RESULTS: Baseline data before the treatment between the two groups were similar. The WOMAC scores significantly decreased and the SF-36 scores significantly increased after 8-week treatment in both groups compared with before the treatment(P < 0.05). SYXBD significantly decreased pain scores(P < 0.001), physical function scores(P <0.001) and the total scores(P < 0.001) in WOMAC compared to Meloxicam. SYXBD significantly improved physical function(P = 0.021), bodily pain(P = 0.002) and general health(P = 0.014), with no significant difference in role emotional(P = 0.053),role physical(P = 0.517), vitality(P = 0.241), social function(P = 0.712) and mental health(P = 0.800)in SF-36 compared to Meloxicam. No adverse events were reported in the treatment group while13 adverse events happened in the control group during the study.CONCLUSION: SYXBD, prepared based on the theory of 'Shaoyang dominating bone', has a better curative efficay and safety in patients with KOA compared with Meloxicam. The TCM theory of 'Shaoyang dominating bone' may be useful in KOA treatment. | Si Yuhao Ma Yong Guo Yang Pan Yalan Zheng Suyang Xu Guihua Da Weiwei Xu Lili | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 11 |
| 9 | Passive-source ocean bottom seismograph(OBS) array experiment in South China Sea and data quality analyses显示文摘Long-term passive source ocean bottom seismograph(OBS) observatory is challenging due to various technical difficulties. In order to gain experience in this field, and to reveal the lithospheric structure beneath the extinct ridge in the central South China Sea(SCS), we carried out a passive source OBS array experiment, which includes 18 OBSs, in the deep portion of SCS. Here we present the instrumentation, the OBS deployment and recovery of this experiment, and more importantly, the data quality evaluated by a number of approaches. Through processing and inspecting waveforms from global, regional and local earthquakes, we find that most of recovered OBSs have good data quality with discernible main phases. The ambient noise analyses of OBS recordings show that their noise is higher than the global average, and the horizontal component is noisier than the vertical, indicating current impacts on horizontal components are more severe. In the period range of 5–10 s, there is a noise notch for the SCS OBSs, and noise levels of horizontal components are comparable to the vertical. This feature, which is not seen at OBS stations in open ocean, suggests the distant sources for double frequency microseism in this marginal sea are not significant. In addition, we successfully determined the orientations for 7 OBSs by investigating their Rayleigh wave polarizations; and we demonstrated the dispersion feature of Rayleigh waves through the frequency-time analysis. Finally, we summarized lessons learned from this experiment regarding the passive source OBS investigations in SCS. | Chenguang Liu Qingfeng Hua Yanliang Pei Ting Yang Shaohong Xia Mei Xue Ba Manh Le Da Huo Fang Liu Haibo Huang | 2014 | Chinese Science Bulletin2014，59，33： | 11 |
| 10 | Association between fifteen risk factors and progressing ischemic stroke in the Han population of northeast China显示文摘与进行的 ischemic 联系的死亡和残疾摸的背景比一般 ischemic 击高得多。这研究被进行决定为进行的 ischemic 的因素在有在 24 个小时以内的 ischemic 击的 2511 个病人的一个总数承认了到神经病学的部门的东北 China.Methods 的汉人口摸的风险,哈尔滨医药大学的首先隶属于的医院被学习,从 2007 年 11 月到 2009 年 5 月。所有病人被分类进根据斯堪的纳维亚的神经病学的击规模的分数进行或非进行的组。十五个通常认为的风险因素被评估。为进行的 ischemic 击的风险因素的影响与简单逻辑分析,多重逻辑分析,和逐步的逻辑回归模型被分析。所有统计分析被 SAS 9.1 .Results 完全执行 359 (14.3%) 病人们为进行的 ischemic 满足了标准击。逻辑分析显示出那年龄,家庭中风历史,吸烟历史,录取上的高血压,在在到医院的录取以后的血压的落下,录取上的高浆液葡萄糖,并且发烧与在有这些因素的 ischemic 中风的东北 China.Conclusion 人的汉人口的进行的 ischemic 击有关是更可能的发展进行 ischemic 击。 | YANG Shan-shan TENG Da YOU Ding-yun SU Zhi-qiang LI Fang ZHAO Ji-yang | 2010 | Chinese Medical Journal2010，，11： | 11 |
| 11 | Key nodes of a micro RNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer显示文摘Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas(TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This 'paradox' can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating m RNA and micro RNA(mi RNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major mi RNAs and 214 m RNAs. Among the 8 mi RNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 mi RNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer. | Yan Sun Fei Guo Marina Bagnoli Feng-Xia Xue Bao-Cun Sun Ilya Shmulevich Delia Mezzanzanica Ke-Xin Chen Anil K. Sood Da Yang Wei Zhang | 2015 | Chinese Journal of Cancer2015，34，1： | 10 |
| 12 | mi R-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1显示文摘AIM To evaluate the levels of mi R-192-5 p in non-alcoholic fatty liver disease(NAFLD) models and demonstrate the role of mi R-192-5 p in lipid accumulation. METHODS Thirty Sprague Dawley rats were randomly divided into three groups, which were given a standard diet, a high-fat diet(HFD), and an HFD with injection of liraglutide. At the end of 16 weeks, hepatic mi R-192-5 p and stearoyl-Co A desaturase 1(SCD-1) levels were measured. Mi R-192-5 p mimic and inhibitor and SCD-1 si RNA were transfected into Huh7 cells exposed to palmitic acid(PA). Lipid accumulation was evaluated by oil red O staining and triglyceride assays. Direct interaction was validated by dual-luciferase reporter gene assays.RESULTS The HFD rats showed a 0.46-fold decrease and a 3.5-fold increase in hepatic mi R-192-5 p and SCD-1 protein levels compared with controls, respectively, which could be reversed after disease remission by liraglutide injection(P < 0.01). The Huh7 cells exposed to PA also showed down-regulation and up-regulation of mi R-192-5 p and SCD-1 protein levels, respectively(P < 0.01). Transfection with mi R-192-5 p mimic and inhibitor in Huh7 cells induced dramatic repression and promotion of SCD-1 protein levels, respectively(P < 0.01). Luciferase activity was suppressed and enhanced by mi R-192-5 p mimic and inhibitor, respectively, in wild-type SCD-1(P < 0.01) but not in mutant SCD-1. Mi R-192-5 p overexpression reduced lipid accumulation significantly in PA-treated Huh7 cells, and SCD-1 si RNA transfection abrogated the lipid deposition aggravated by mi R-192-5 p inhibitor(P < 0.01).CONCLUSION This study demonstrates that mi R-192-5 p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1. | Xiao-Lin Liu Hai-Xia Cao Bao-Can Wang Feng-Zhi Xin Rui-Nan Zhang Da Zhou Rui-Xu Yang Ze-Hua Zhao Qin Pan Jian-Gao Fan | 2017 | World Journal of Gastroenterology2017，23，46： | 10 |
| 13 | A Novel Semiconductor CIGS Photovoltaic Material and Thin-Film ED Technology显示文摘In order to achieve low cost high efficiency thin film solar cells,a novel Semiconductor Photovoltaic (PV) active material CuIn 1-x Ga x Se 2 (CIGS) and thin film Electro Deposition (ED) technology is explored.Firstly,the PV materials and technologies is investigated,then the detailed experimental processes of CIGS/Mo/glass structure by using the novel ED technology and the results are reported.These results shows that high quality CIGS polycrystalline thin films can be obtained by the ED method,in which the polycrystalline CIGS is definitely identified by the (112),(204,220) characteristic peaks of the tetragonal structure,the continuous CIGS thin film layers with particle average size of about 2μm of length and around 1 6μm of thickness.The thickness and solar grade quality of CIGS thin films can be produced with good repeatability.Discussion and analysis on the ED technique,CIGS energy band and sodium (Na) impurity properties,were also performed.The alloy CIGS exhibits not only increasing band gap with increasing x ,but also a change in material properties that is relevant to the device operation.The beneficial impurity Na originating from the low cost soda lime glass substrate becomes one prerequisite for high quality CIGS films.These novel material and technology are very useful for low cost high efficiency thin film solar cells and other devices. | ZHENG Guang fu 1,YANG Hong xing 1,MAN Cheuk ho 1,WONG Wing lok 2, AN Da wei 1 and John BURNETT 1(1 Centre for Development of Solar Energy Technology,Department of Building Services Engineering, The Hong Kong Polytechnic University,Hong Kong,C | 2001 | Journal of Semiconductors2001，22，11： | 10 |
| 14 | Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film显示文摘一个新奇电气化学的脱氧核糖核酸生物传感器基于氧化锌(ZnO ) ,为脱氧核糖核酸固定和提高的杂交察觉的 nanoparticles 和多围的碳 nanotubes (MWNT ) 被介绍。MWNTs/nano ZnO/chitosan 合成电影修改了玻璃化炭黑电极(MWNTs/ZnO/CHIT/GCE ) 被制作,脱氧核糖核酸探针在电极表面上被使不能调动。杂交事件被微分脉搏 voltammetry (DPV ) 作为指示物用亚甲蓝(MB ) 监视。传感器能有效地区别不同脱氧核糖核酸序列与有关在转基因的玉米轻拍基因,与 2.8 ×的检测极限 10 ? 目标顺序的 12 mol/L。 | Wei Zhang Tao Yang Da Ming Huang Kui Jiao | 2008 | Chinese Chemical Letters2008，19，5： | 8 |
| 15 | Boundedness of Some Maximal Commutators in Hardy-type Spaces with Non-doubling Measures显示文摘让μ是满足一些仅仅生长条件的 R^d 上的一项非否定的氡措施。在这个假设下面,在一些强壮类型的空格的围住的海角为是 Calderon-Zygmund 操作符和 RBMO 产生的平常的最大的整流器的变体的最大的 Calderon-Zygmund 操作符和最大的整流器的一个类被建立(μ)函数,在强壮类型的空格是一些的地方,拨出潜水艇空格,与考虑 RBMO 联系了(μ)函数,强壮的空格 H^1 ( Tolsa 的μ)。 | Guo En HU Yan MENG Da Chun YANG | 2007 | Acta Mathematica Sinica,English Series2007，23，6： | 8 |
| 16 | Diagnosis and treatment of inflammatory myofibroblastoma in children and adolescents显示文摘To the Editor:Inflammatory myofibroblastoma (IMT) is a rare type of intermediate tumor with malignant potential that often affects children and young adults.Although IMT can arise from various organs,most originate in the lungs,abdomen/pelvis or retroperitoneum.These tumors are thought to arise via a benign inflammatory process,although some exhibit malignant behavior or undergo a malignant transformation. | Yi Ding He-Ying Yang Da Zhang Fei Guo Jia-Xiang Wang Ya-Ping Li Yan-An Li | 2019 | Chinese Medical Journal2019，，9： | 8 |
| 17 | Germplasm resources and genetic breeding of Paeonia:a systematic review显示文摘Members of the genus Paeonia,which consists of globally renowned ornamentals and traditional medicinal plants with a rich history spanning over 1500 years,are widely distributed throughout the Northern Hemisphere.Since 1900,over 2200 new horticultural Paeonia cultivars have been created by the discovery and breeding of wild species.However,information pertaining to Paeonia breeding is considerably fragmented,with fundamental gaps in knowledge,creating a bottleneck in effective breeding strategies.This review systematically introduces Paeonia germplasm resources,including wild species and cultivars,summarizes the breeding strategy and results of each Paeonia cultivar group,and focuses on recent progress in the isolation and functional characterization of structural and regulatory genes related to important horticultural traits.Perspectives pertaining to the resource protection and utilization,breeding and industrialization of Paeonia in the future are also briefly discussed. | Yong Yang Miao Sun Shanshan Li Qihang Chen Jaime A.Teixeira da Silva Ajing Wang Xiaonan Yu Liangsheng Wang | 2020 | Horticulture Research2020，7，1： | 8 |
| 18 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 19 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 20 | Flow stress equation for multipass hot-rolling of aluminum alloys显示文摘A series of simple axisymmetric compression tests were carried out on the computer servo controlled Gleeble 1 500 machine when strain rates ranged between 0.05 25 s -1 and deformation temperature 300 500 ℃. The results show that flow stress is related to the Zener Hollonom parameter Z and strain, as well as the static recrystallization fraction between passes during multipass hot deformation of 5182 aluminum alloy. Hence, a modified exponential flow stress equation was presented by considering the values of ln A and β as functions of strain, and by using the uniform softening method and incorporating the static recrystallization fraction between passes to consider the effects of residual strain during multipass hot rolling of 5182 aluminum alloy. The validity of the equation was examined by a typical non isothermal multipass deformation test. | ZHANG Hui,PENG Da shu,YANG Li bin,MENG Li ping (Department of Materials Science and Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，1： | 7 |
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