|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. | Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 2 | Display Method for Online Bookstore Emulating Real Bookstore by WebGL显示文摘Thanks to the spread of the Internet, opportunities to use online bookstores have been increasing in recent years. However, it is difficult for the typical customer to intuitively grasp which book sells well or which book is recommended by the shop. We have therefore developed a display system for virtual bookstores in which an image of books arranged in a bookshelf or stacked on a table is reproduced by using WebGL. Since the amount of book stock that is managed by the server side needs to be changed as orders come in from clients, we introduce a server side technology using a hypertext preprocessor(PHP). | Kazuhisa Yanaka Terumichi Iizuka | 2014 | Journal of Electronic Science and Technology2014，12，1： | 2 |
| 3 | High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection显示文摘BACKGROUND We hypothesized that thermal damage accumulation during endoscopic submucosal dissection(ESD)causes the pathogenesis of post-ESD electrocoagulation syndrome(PECS).AIM To determine the association between Joule heat and the onset of PECS.METHODS We performed a retrospective cohort study in patients who underwent colorectal ESD from May 2013 to March 2021 in Japan.We developed a novel device that measures swift coagulation time with a sensor adjacent to the electrosurgical coagulation unit foot switch,which enabled us to calculate total Joule heat.PECS was defined as localized abdominal pain(visual analogue scale≥30 mm during hospitalization or increased by≥20 mm from the baseline)and fever(temperature≥37.5 degrees or white blood cell count≥10000μ/L).Patients exposed to more or less than the median Joule heat value were assigned to the high and low Joule heat groups,respectively.Statistical analyses included Mann-Whitney U and chisquare tests and logistic regression and receiver operating characteristic curve(ROC)analyses.RESULTS We evaluated 151 patients.The PECS incidence was 10.6%(16/151 cases),and all patients were followed conservatively and discharged without severe complications.In multivariate analysis,high Joule heat was an independent PECS risk factor.The area under the ROC curve showing the correlation between PECS and total Joule heat was high[0.788(95%confidence interval:0.666-0.909)].CONCLUSION Joule heat accumulation in the gastrointestinal wall is involved in the onset of PECS.ESD-related thermal damage to the peeled mucosal surface is probably a major component of the mechanism underlying PECS. | Masanori Ochi Ryosuke Kawagoe Toshiro Kamoshida Yukako Hamano Haruka Ohkawara Atsushi Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai Akinori Yanaka Kiichiro Tsuchiya | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 4 | Immediate surgery reduces mortality in deeply comatose patients with spontaneous carebellar hemorrhage显示文摘 | Yanaka K Meguro K Fujita K | 2000 | Neurol Med Chir2000，40，6： | 1 |
| 5 | Maintenance of steel bridges on honshu-shikoku crossing 显示文摘 | Yanaka Y Kitagawa M | 2002 | Journal of Constructional Steel Research2002，58，： | 1 |
| 6 | Contribution of theflexible loop region to the function of staphylococcal enterotoxinB显示文摘 | Yanaka S Kudou M Tanaka Y | 2010 | Protein Engi Des Sel2010，23，5： | 1 |
| 7 | Stable nitroxide tempol ameliorates brain injury by inhibiting lipid pemxidation in a rat model of transient focal cerebral ischemia显示文摘 | Kato N Yanaka K Hyodo K | | 0，，1： | 1 |
| 8 | Silk protein, sericin, suppresses DMBA- TPA- induced mouse skin tumorigenesis by reducing oxidative stress, inflanunatory responses and endogenous tumor promoter TNF - alpha显示文摘 | Zhaorigetu S Yanaka N Sasaki M | 2003 | Oncol Rep2003，10，3： | 1 |
| 9 | Cervical spondylotic myelopathy: surgical results and factors affecting outcome with special reference to age differences 显示文摘 | Yamazaki T Yanaka K Sato H | 2003 | Neurosurgery2003，52，1： | 1 |
| 10 | cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles显示文摘 | Yanaka N Kurosawa Y Minami K | 2003 | Biosci Biotechnol Biochem2003，67，5： | 1 |
| 11 | Management of unruptured cerebral aneurysms in patients with polycystic kidney disease显示文摘 | Yanaka K Nagase S Asakawa H | 2004 | Surg Neurol2004，62，： | 1 |
| 12 | Repair of a tear at the base of a blister-like aneurysm with suturing and an encircling clip:technical note显示文摘 | Yanaka K Meguro K Nose T | 2002 | Neurosurgery2002，50，： | 1 |
| 13 | Combined laminoplasty with posterior lateral mass plate for unstable spondylotic cervical canal stenosis-technical note显示文摘 | Matsumura A Yanaka K Akutsu H | | 0，，10： | 1 |
| 14 | Expression of homeobox gene CDX2 precedes that of CDXI during the progression of intestinal metaptasia 显示文摘 | Eda A Osawa H Yanaka I | 2002 | J Gastroenterot2002，37，2： | 1 |
| 15 | Expression of homeobox gene Cdx2 precedes that of CDX1 during the progression of intestinal metaplasia 显示文摘 | Eda A Osawa H Yanaka I | 2002 | Gastroenterol2002，37，7： | 1 |
| 16 | Monitoring the Akashi Kaikyo bridge: first experiences 显示文摘 | Satoshi Kashima Yukikazu Yanaka Shuichi Suzuki | 2001 | Structural Engineering International2001，，2： | 1 |
| 17 | Synthetic fibronectin peptides and ischemic brain injury after transient middle cerebral artery occlusion in rats显示文摘 | Yanaka K Camarata PJ Spellman SR | 1996 | J Neurosurg1996，85，1： | 1 |
| 18 | Lysophosphatidylcholine activates extracellular signal-regulated kinases 1/2 through reactive oxygen species in rat vascular smooth muscle cell显示文摘 | Yamakawa T Tanaka S Yanaka S Kamei J Numaguchi K Motley ED | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 19 | Management of spontaneous cerebellar hematomas: a prospective treatment protocol 显示文摘 | Yanaka K Matsumaru Y Nose T | 2002 | Neurosurgery2002，51，2： | 1 |
| 20 | Small unruptured cerebral aneurysms presenting with oculomotor nerve palsy 显示文摘 | Yanaka K Matsumaru Y Mashiko R | 2003 | Neurusurgery2003，52，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员