| 2 | High quality reference genome of drumstick tree(Moringa oleifera Lam.), a potential perennial crop显示文摘The drumstick tree(Moringa oleifera Lam.) is a perennial crop that has gained popularity in certain developing countries for its high-nutrition content and adaptability to arid and semi-arid environments. Here we report a high-quality draft genome sequence of M. oleifera. This assembly represents 91.78% of the estimated genome size and contains 19,465 protein-coding genes. Comparative genomic analysis between M. oleifera and related woody plant genomes helps clarify the general evolution of this species, while the identification of several species-specific gene families and positively selected genes in M. oleifera may help identify genes related to M. oleifera's high protein content, fast-growth, heat and stress tolerance. This reference genome greatly extends the basic research on M. oleifera, and may further promote applying genomics to enhanced breeding and improvement of M. oleifera. | TIAN Yang ZENG Yan ZHANG Jing YANG Cheng Guang YAN Liang WANG XuanJun SHI ChongYing XIE Jing DAI TianYi PENG Lei ZENG HUAN Yu XU An Ni HUANG YeWei ZHANG JiaJin MA Xiao DONG Yang HAO ShuMei SHENG Jun | 2015 | Science China(Life Sciences)2015，58，7： | 10 |
| 4 | A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance显示文摘Malignant melanoma cell-intrinsic PD-1:PD-L1 interaction thrusts tumorigenesis,angiogenesis,and radioresistance via mTOR hyperactivation to aggravate circumjacent aggression.Interdicting melanoma intrinsic growth signals,including the blockade of PD-L1 and mTOR signaling concurrently,cooperative with radiotherapy may provide a vigorous repertoire to alleviate the tumor encumbrance.Thence,we design a three-pronged platinum@polymer-catechol nanobraker to deliver mTOR inhibitor TAK228 and anti-PD-L1 antibody(aPD-L1)for impeding the melanoma-PD-1-driven aggression and maximizing the melanoma eradication.The aPD-L1 collaborated with TAK228 restrains melanoma cell-intrinsic PD-1:PD-L1 tumorigenic interaction via blocking melanoma-PD-L1 ligand and the melanoma-PD-1 receptor-driven mTOR signaling;corresponding downregulation of mTOR downstream protumorigenic cellular MYC and proangiogenic hypoxia-inducible factor 1-alpha is conducive to preventing tumorigenesis and angiogenesis,respectively.Further,high-Z metal platinum sensitizing TAK228-enhanced radiotherapy confers the nanobraker on remarkable tumoricidal efficacy.Hereto,the customized three-pronged nanobrakers efficiently suppress melanoma tumorigenesis and angiogenesis concomitant with the amplification of radiotherapeutic efficacy.Such an ingenious tactic may provide substantial benefits to clinical melanoma patients. | Wenxi Li Jie Yan Hao Tian Bei Li Guohao Wang Wei Sang Zhan Zhang Xuanjun Zhang Yunlu Dai | 2023 | Bioactive Materials2023，，4： | 0 |
| 5 | Theory, Technology and Practice of Unconventional Petroleum Geology显示文摘0 INTRODUCTION The breakthroughs in unconventional petroleum have a great impact on world petroleum industry and innovation in petroleum geology(Dou et al,2022;Jia,2017;Zou et al.,2015b,2014a;Yerkin,2012;Pollastro,2007;Schmoker,1995).The exploration and development evolution from conventional petroleum to unconventional petroleum and more and more frequent industrial activities of exploring petroleum inside sources kitchen have deepened theoretical understanding of unconventional petroleum geology and promoted technical research and development(Jia et al.,2021,2017;Jin et al.,2021;Zhao W Z et al.,2020;Ma Y S et al.,2018,2012;Zou et al.,2018b,2016,2009;Dai et al.,2012).We have introduced and extended the theory of continuous hydrocarbon accumulation since 2008 and published several papers/books(in Chinese and English)with respect to unconventional petroleum geology since 2009,basically forming the theoretical framework for this discipline(Yang et al.,2022a,2021a,2019a,,2015a;Zou et al.,2019c,2017b,2014a,,2013a).In this paper,we present the background of unconventional petroleum geology,review the latest theoretical and technological progress in unconventional petroleum geology,introduce relevant thinking and practices in China,and explore the pathway of unconventional petroleum revolution and multi-energy coordinated development in super energy basins,hopefully to promote the unconventional petroleum geology and industry development. | Caineng Zou Zhi Yang Guosheng Zhang Rukai Zhu Shizhen Tao Xuanjun Yuan Lianhua Hou Dazhong Dong Qiulin Guo Yan Song Qiquan Ran Zhen Qiu Songtao Wu Feng Ma Bin Bai Lan Wang Bo Xiong Songqi Pan Hanlin Liu Xiaoni Wang | 2023 | Journal of Earth Science2023，34，4： | 0 |
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