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| 1 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 2 | Cloning and expression analysis of phytoenedesaturase and g-carotene desaturase genes in Carica papaya显示文摘 | Yan P Gao X Z Shen WT | 2011 | Molecular Biology Reports2011，38，2： | 1 |
| 3 | Differentially expressed microRNAs in the serum of cervical squamous cell carcino- ma patients before and after surgery 显示文摘 | Wang WT Zhao YN Yan IX | 2014 | J Hematol On- col2014，7，： | 1 |
| 4 | Research of lead identifica- tion based on multiple-input multiple-output SVM model selec- tion 显示文摘 | MAC) WT TIAN M YAN GR | 2012 | Proceedings of the Institution of Mechanical Engi- neers Part C: Journal of Mechanical Engineers Science2012，，5： | 1 |
| 5 | Effect of inoculating lactic acid bacteria starter cultures on the nitrite concentration of fermenting Chinese paocai显示文摘 | YAN PM XUE WT TAN SS | 2008 | Food Control2008，19，1： | 1 |
| 6 | Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and aftersurgery显示文摘 | Wang WT Zhao YN Yan JX | 2014 | J Hematol Oncol2014，7，1： | 1 |
| 7 | S100A9and EGFR gene signatures predictdisease progression in muscleinvasive bladder cancer patients afterchemotherapy显示文摘 | Kim WT Kim J Yan C | 2014 | Ann Oncol2014，25，5： | 1 |
| 8 | PrimaryTreatmentofAcuteDacryocystitisby EndoscopicDacryocystorhinostomy with SiliconeIntubationGuidedbyaSoft Probe显示文摘 | Wu WC Yan WT JuliaKM | 2009 | Ophthalmology2009，116，1： | 1 |
| 9 | Prediction factors of postoperative hy- perbilirubinemia in living right lobe donor: a single-center analysis of 210 cases 显示文摘 | Lei JY Yan LN Wang WT | 2013 | Transplant Proc2013，45，1： | 1 |
| 10 | Autonomous detection of pulmonary nodules on CT images with a neural network-based fuzzy system显示文摘 | Lin DT Yan CR Chen WT | 2005 | Computerized Medical Imaging and Graphics2005，29，6： | 1 |
| 11 | Adeno-associated virusmediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy显示文摘 | Deng WT Yan Z Dinculescu A | 2005 | Hum Gene Ther2005，16，： | 1 |
| 12 | Autonomous detection of pulmonary nodules on CT images with a neural network-based fuzzy system显示文摘 | Lin DT Yan CR Chen WT | 2005 | Computerized Med Imaging Graphics2005，29，： | 1 |
| 13 | Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy显示文摘 | Deng WT Yan Z Dinculescu A | 2005 | Hum Gene Ther2005，16，11： | 1 |
| 14 | Upfront consolidation treatment with 131I-mIBG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma显示文摘Importance:131I-metaiodobenzylguanidine(131I-mIBG)has a significant targeted antitumor effect for neuroblastoma.However,currently there is a paucity of data for the use of 131I-mIBG as a'front-line'therapeutic agent in those patients with newly diagnosed high-risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy(MAC).Objective:To evaluate the feasibility of upfront consolidation treatment with 131I-mIBG plus MAC and hematopoietic stem cell transplantation(HSCT)in high-risk neuroblastoma patients.Methods:A retrospective,single-center study was conducted from 2003-2019 on newly diagnosed high-risk neuroblastoma patients without progressive disease(PD)after the completion of induction therapy.They received 131I-mIBG infusion and MAC followed by HSCT.Results:A total of 24 high-risk neuroblastoma patients were enrolled with a median age of 3.0 years at diagnosis.After receiving this sequential consolidation treatment,3 of 13 patients who were in partial response(PR)before 131I-mIBG treatment achieved either complete response(CR)(n=1)or very good partial response(VGPR)(n=2)after HSCT.With a median follow-up duration of 13.0 months after 131I-mIBG therapy,the 5-year event-free survival and overall survival rates estimated were 29%and 38%for the entire cohort,and 53%and 67%for the patients who were in CR/VGPR at the time of 131I-mIBG treatment.Interpretation:Upfront consolidation treatment with 131I-mIBG plus MAC and HSCT is feasible and tolerable in high-risk neuroblastoma patients,however the survival benefit of this 131I-mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I-mIBG treatment. | Jianhua Feng Frankie WT Cheng Alex WK Leung Vincent Lee Eva WM Yeung Hoi Ching Lam Jeanny Cheung Grace KS Lam Terry TW Chow Carol LS Yan Chi Kong Li | 2020 | Pediatric Investigation2020，4，3： | 1 |
| 15 | Autonomous detection of pulmonary nodules on CT images with a neural network-based fuzzy system 显示文摘 | Lin DT Yan CR Chen WT | 2005 | Comput Med Imaging Graph2005，29，6： | 1 |
| 16 | Potential contribution of SOCC to cerebral vasospasm after experimental subarachnoid hemorrhage in tars显示文摘 | Song JN Yan WT An JY | 2013 | BrainRes2013，1517，3： | 1 |
| 17 | MicroRNA-125b functions as a tumor suppressor in hepatocellular carcinoma cells显示文摘 | JIA HY WANG YX YAN WT | 2012 | Inter- national Journal of Molecular Sciences2012，13，7： | 1 |
| 18 | Impact of pretransplant MELD score on posttransplant outcome in orthotopic liver transplan- tation for patients with acute-on-chronic hepatitis B liver failure 显示文摘 | Wang ZX Yan LN Wang WT | 2007 | Transplant Proc2007，39，5： | 1 |
| 19 | Impact ofpretransplant MELD score on post transplant outcome in orthotopic liver transplantation for patients with acute on chronic hepatitis Bliver failure显示文摘 | Wang ZX Yan LN Wang WT | | 0，，05： | 1 |
| 20 | Hangzhou criteria for liver transplantation in hepatocellular carcinoma: a single-center experience显示文摘 | Lei JY Wang WT Yan LN | 2014 | Eur J Gastroenterol Hepatol2014，26，2： | 1 |
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