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| 1 | Effect of removing silica in rice husk for the preparation of activated carbon for supercapacitor applications显示文摘Renewable biomass-derived activated carbons have attracted attentions for supercapacitor applications. Rice husk is a kind of abundant biomass, which has been studied for the preparation of hierarchical activated carbons. Rice husk is rich in silica. Silica in rice husk affects the formation of pore structure in the KOH activation process, which further affects the electrochemical performance of the resultant activated carbon for supercapacitors. In this paper, the effects of silica in rice husk on the activation process were investigated. When the silica in rice husk is not removed, KOH preferentially reacts with silica to produce silicate, which hinders the formation and enlargement of mesopores;the obtained activated carbon exhibits high microporous ratio, high specific area (up to 3263 m^2/g), high specific capacitance (315 F/g at 0.5 A/g), but poor rate capability (51.7%capacitance retention with increasing the current density from 0.5 A/g to 20 A/g). When the silica in rice husk is removed, the pores produced by the removal of silica are etched to mesopores in activation process;the obtained activated carbon exhibits high mesoporous ratio, relative high specific surface area of 2804 m2/g and relative high capacitance of 278 F/g at 0.5 A/g with excellent rate capability (76.6%capacitance retention with increasing the current density from 0.5 A/g to 20 A/g). | Dechen Liu Wenli Zhang Weimin Huang | 2019 | Chinese Chemical Letters2019，30，6： | 7 |
| 2 | Highly biocompatible BSA-MnO_2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy显示文摘More recently, the biomedical applications of MnO_2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However,research on a near infrared(NIR) photothermal response of MnO_2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin(BSA)-reduced and stabilized MnO_2 nanoparticles(BSA-MnO_2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO_2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent. | Yuzhen Wang Yujun Song Guixian Zhu Dechen Zhang Xuewu Liu | 2018 | Chinese Chemical Letters2018，29，11： | 5 |
| 3 | KOH Direct Activation for Preparing Activated Carbon Fiber from Polyacrylonitrile-based Pre-oxidized Fiber显示文摘 | GAO Lili LU Haiyan LIN Haibo SUN Xiuyun XU Jianling LIU Dechen LI Yang | 2014 | Chemical Research in Chinese Universities2014，30，3： | 4 |
| 4 | Open Shape Model Based on Absolute Frame in Three-dimensional Space显示文摘 | Liu Yongshan Gao Shiwei Wang Dechen | | 0，，03： | 1 |
| 5 | Nature-inspired design of droplet-synthesized polymeric nanoelectrode for photoelectrochemical microRNA sensing within single cells显示文摘Nanoelectrodes have been shown to be powerful tools for nanoscopic research on single entities,deepening the understanding of heterogeneity and stochastics for single molecules,nanoparticles and cells[1–3].However,despite their importance,current nanoelectrode preparations are highly restrained to flame/electrochemical etching,metal sputtering,electrochemical deposition,etc.[3],resulting in a limited range of materials(mainly gold,platinum and carbon)for potential-resolved detection of redox-active species(Table S1 online).The enrichment of preparation methods to introduce novel materials and mechanisms should prove significant for the development of nanoelectrodes. | Si-Yuan Yu Yi-Li Liu Zheng Li Dechen Jiang Jing-Juan Xu Hong-Yuan Chen Wei-Wei Zhao | 2024 | Science Bulletin2024，69，2： | 0 |
| 6 | Real-Time and Spatial Electroanalysis of Biomolecules in One Living Cell Using Liquid-Phase Modified Nanopipette显示文摘The well-developed solid-phase modified strategy at the electrode has enabled the preparation of biosensors for the detection of multiple analytes,even in single living cells.However,limited assay elements can be modified at the solid surface,restricting the types of molecules that can be analyzed and the sensitivity of detection.Here,a novel liquid-phase modified strategy at the tip of a nanopipette is designed to realize real-time and local analysis of biomolecules inside the cell that are barely detectable using solid-phase modified nanoelectrodes.This design utilizes the nanotip structure at a platinized carbon open nanopipette to stably retain a nanodroplet that contains the required reagents with high reactivity for the assay of the target analyte.The generated hydrogen peroxide is electrochemically quantified at the Pt layer to carry out the real-time measurement in a living cell with a spatial resolution of 70 nm.Taking advantage of highly spatial and real-time detection,uneven distribution of sphingomyelinase(SMase)in the living CT26 cell is unprecedentedly shown to exhibit the significance in the establishment of liquid-phase modified nanopipette.This new modification strategy opens up a new direction for sensor design and consequently advances the development of biosensors in the chemical and biological research. | Kang Liu Rujia Liu Dengchao Wang Rongrong Pan Hong-Yuan Chen Dechen Jiang | 2023 | CCS Chemistry2023，5，6： | 0 |
| 7 | The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior显示文摘The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal striatum(DS),which also contributes to decision-making behavior,yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear.Using mice performing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go stimulus.The choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS.By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA rate.These results demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior. | Jing Liu Dechen Liu Xiaotian Pu Kexin Zou Taorong Xie Yaping Li Haishan Yao | 2023 | Neuroscience Bulletin2023，39，10： | 0 |
| 8 | BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes显示文摘Brain-specific serine/threonine-protein kinase 2(BRSK2)plays critical roles in insulin secretion andβ-cell biology.However,whether BRSK2 is associated with human type 2 diabetes mellitus(T2DM)has not been determined.Here,we report that BRSK2 genetic variants are closely related to worsening glucose metabolism due to hyperinsulinemia and insulin resistance in the Chinese population.BRSK2 protein levels are significantly elevated inβcells from T2DM patients and high-fat diet(HFD)-fed mice due to enhanced protein stability.Mice with inducibleβ-cell-specific Brsk2 knockout(βKO)exhibit normal metabolism with a high potential for insulin secretion under chow-diet conditions.Moreover,βKO mice are protected from HFD-induced hyperinsulinemia,obesity,insulin resistance,and glucose intolerance.Conversely,gain-of-function BRSK2 in matureβcells reversibly triggers hyperglycemia due toβ-cell hypersecretion-coupled insulin resistance.Mechanistically,BRSK2 senses lipid signals and induces basal insulin secretion in a kinase-dependent manner.The enhanced basal insulin secretion drives insulin resistance andβ-cell exhaustion and thus the onset of T2DM in mice fed an HFD or with gain-of-function BRSK2 inβcells.These findings reveal that BRSK2 links hyperinsulinemia to systematic insulin resistance via interplay betweenβcells and insulin-sensitive tissues in the populations carrying human genetic variants or under nutrient-overload conditions. | Rufeng Xu Kaiyuan Wang Zhengjian Yao Yan Zhang Li Jin Jing Pang Yuncai Zhou Kai Wang Dechen Liu Yaqin Zhang Peng Sun Fuqiang Wang Xiaoai Chang Tengli Liu Shusen Wang Yalin Zhang Shuyong Lin Cheng Hu Yunxia Zhu Xiao Han | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
| 9 | 德庆玉珍:用教育传递爱与光明显示文摘35-year-old Dechen Yudron was born and raised in Lhasa.In 2006,she was admitted into the School of International Studies at Peking University(PKU)due to stellar results onhercollegeentrance exams.In2011,shewenttostudyin New York University for a Master of Arts in education and social policy. | Liu Linlin Pei Cong Dechen Yudron(Photos) | 2023 | China's Tibet2023，34，4： | 0 |
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