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| 1 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 2 | Fabrication and performance evaluation of novel transparent ceramics RE:Tb_(3)Ga_(5)O_(12)(RE=Pr,Tm,Dy)toward magneto-optical application显示文摘Transparent ceramics are at the heart of modern magneto-optical materials providing promising opportunities for Faraday isolators.1.0 at%RE:Tb3Ga5O12(rare earth(RE)=Pr,Tm,Dy)transparent ceramics were successfully prepared by air sintering and sequential HIP technique using the coprecipitated powders as the raw material.All the powders have shown to be a pure cubic terbium gallium garnet(TGG)phase and exhibit good dispersion.Additionally,a change could not be observed in particle shape with the different doped ions.After the two-step sintering,all the obtained ceramics have good optical quality,and the in-line transmittances at 1070 nm are higher than 80%.Moreover,no secondary phase can be detected from the microstructures.However,the pores which remain entrapped in the ceramics can be noted.The Verdet constant of ceramic samples is optimized by RE doping,and the Verdet constant at 632.8 nm is about−143 rad·T^(−1)·m^(−1),which is about 5%higher than that of TGG ceramics.Finally,the thermo-optical properties of 1.0 at%RE:TGG transparent ceramics are compared.The annealed TGG ceramic showed the best thermo-optical properties,and the thermally induced depolarization of 1.0 at%Ce:TGG and 1.0 at%Tm:TGG was inferior to that of annealed TGG ceramic. | Xiaoying Li Ilya LSnetkov Aleksey Yakovlev Qiang Liu Xin Liu Ziyu Liu Penghui Chen Danyang Zhu Lexiang Wu Zhaoxiang Yang Tengfei Xie Haohong Chen Oleg Palashov Jiang Li | 2021 | Journal of Advanced Ceramics2021，10，2： | 3 |
| 3 | Roles of DNA frag- mentation factor and poly (ADP-ribose) polymerase in an amplifi-cation phase of tumor necrosis factor-induced apoptosis显示文摘 | Boularc HA Zoltoski AJ Yakovlev A | 2001 | J Bio Chemi2001，276，28： | 1 |
| 4 | Neclear DNA content,base comp-osition,hetero chromatin and rDNA in Picea omorika and Picea abies显示文摘 | Yakovlev S S Cerbah M Coulaud J | 2002 | Theor Appl Genet2002，104，： | 1 |
| 5 | Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury显示文摘 | Yakovlev A G Knoblach SM Fan I | 1997 | Neurosci1997，17，74： | 1 |
| 6 | High-level modeling and design of asynchronous interface logic显示文摘 | A V Yakovlev A M Koelmans L Lavagno | 1995 | IEEE Design and Test of Computers1995，1995，： | 1 |
| 7 | Determination of the ratio of diacetyl and acetaldehydein streptococcic cul- tures by gas-liquid chromatography显示文摘 | Ibragimova AZ Yakovlev DA | 1980 | Molochnaya Promyshlennost1980，2，： | 1 |
| 8 | Clockless circuits and system synthesis显示文摘 | Sokolov D Yakovlev A | 2005 | Computers and Digital Techniques2005，152，3： | 1 |
| 9 | Activation of CPP32-1ike caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury显示文摘 | Yakovlev Ag Knoblach SM Fan L | | Neurosci0，17，19： | 1 |
| 10 | Presence of DNA fragmentation and lack of neuroprotective effect in DFF45 knockout mice subjected to traumatic brain injury显示文摘 | Yakovlev AG Di X Movsesyan V | 2001 | Mol Med2001，7，3： | 1 |
| 11 | Development of new catalytic systems for upgraded bio-fuels production from bio-crude-oil and biodiesel显示文摘 | Yakovlev V A Khromova S A Sherstyuk O V | 2009 | Catalysis Today2009，144，： | 1 |
| 12 | Use of thermally expanded graphite in waterpurification and water-treat ment systems 显示文摘 | Yakovlev A V | 2004 | Environmental Problems of Chemistry and Technology2004，，11： | 1 |
| 13 | In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury显示文摘 | Di Giovanni S De Biase A Yakovlev A | 2005 | J Biol Chem2005，280，3： | 1 |
| 14 | Outcomes of percutaneous disc decompression utilizing nucleoplasty for the treatment of chronic discogenic pain 显示文摘 | Yakovlev A Tamimi MA Liang H | 2007 | Pain Physician2007，10，2： | 1 |
| 15 | SETT-subcutaneousendoscopic transaxillary tcnotomy for congenital muscular torticollis显示文摘 | Kozlov Y Yakovlev A Novogilov V | 2009 | J Laparoendosc Adv Surg Tech A2009，191，： | 1 |
| 16 | Effect of dolomite limestone powder on the compressive strength of concrete显示文摘 | MIKHAILOVA O YAKOVLEV G MAEVA I | 2013 | Procedia Engineering2013，，57： | 1 |
| 17 | In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury显示文摘 | Di Giovanni S De Biase A Yakovlev A | 2005 | J Biol Chem2005，280，3： | 1 |
| 18 | Mode locking of electron spin coherences in singly charged quantum dots显示文摘 | Greilich A Yakovlev DR Shabaev A etal | 2006 | Science2006，313，5785： | 1 |
| 19 | Transmission through stacked 2D periodic distributions of square conduc- ting patches显示文摘 | Kaipa C S R Yakovlev A B Medina F | 2012 | J Appl Phys2012，112，03： | 1 |
| 20 | The accurate FROG characterization of attosecond pulses from streaking measurements显示文摘 | J. Gagnon E. Goulielmakis V.S. Yakovlev | 2008 | Applied Physics B2008，，1： | 1 |
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