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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Application of magnetic particles modified with amino groups to adsorb copper ions in aqueous solution显示文摘A magnetic adsorbent can be easily recovered from treated water by magnetic force,without requiring further downstream treatment.In this research,amine-functionalized silica magnetite has been synthesized using N-[3-(trimethoxysilyl)propyl]-ethylenediamine(TPED) as a surface modification agent.The synthesized magnetic amine adsorbents were used to adsorb copper ions in an aqueous solution in a batch system,and the maximum adsorption was found to occur at pH 5.5 ± 0.1.The adsorption equilibrium data fitted the Langmuir isotherm equation reasonably well,with a maximum adsorption capacity of 10.41 mg/g.A pseudo second-order model could best describe the adsorption kinetics,and the derived activation energy was 26.92 kJ/mol.The optimum condition to desorb Cu2+ from NH2/SiO2/Fe3O4 was provided by a solution with 0.1 mol/L HNO3. | Yafen Lin Huawei Chen Kaelong Lin Boryann Chen Chyowsan Chiou | 2011 | Journal of Environmental Sciences2011，23，1： | 4 |
| 3 | Global and China temperature changes associated with the inter-decadal variations of East Asian summer monsoon advances显示文摘The modern atmospheric observation and literatural historical drought-flood records were used to extract the inter-decadal signals of dry-wet modes in eastern China and reveal the possible relationship of global and China temperature changes associated with the East Asian summer monsoon advances.A climate pattern of 'wet-north and dry-south' in eastern China and cool period in China and globe are associated with the strong summer monsoon that can advance further to the northernmost part in the East Asian monsoon region.On the contrary,a climate pattern of 'dry-north and wet-south' in eastern China and a warm period in China and globe are associated with the weaker summer monsoon that only reaches the southern part in the region.An interdecadal oscillation with the timescale about 60 years was found dominating in both the dry-wet mode index series of the East Asian summer monsoon and the global temperature series after the secular climate states and long-term trend over inter-centennial timescales have been removed. | QIAN WelHong LIN Xiang ZHU YaFen | 2012 | Chinese Science Bulletin2012，57，30： | 2 |
| 4 | Climatic regime shift and decadal anomalous events in China显示文摘 | Weihong Qian Xiang Lin Yafen Zhu Yuan Xu Jiaolan Fu | 2007 | Climatic Change2007，，2： | 1 |
| 5 | 3 efficacy of ectopic pregnancy con- servative treatment显示文摘 | Qiu Yafen Ren Lixin Qiu Lin | 2008 | J Practical Medicine2008，24，13： | 1 |
| 6 | A multi-band atomic candle with microwave-dressed Rydberg atoms显示文摘Stabilizing important physical quantities to atom-based standards lies at the heart of modern atomic,molecular and optical physics,and is widely applied to the field of precision metrology.Of particular importance is the atom-based microwave field amplitude stabilizer,the so-called atomic candle.Previous atomic candles are realized with atoms in their ground state,and hence suffer from the lack of frequency band tunability and small stabilization bandwidth,severely limiting their development and potential applications.To tackle these limitations,we employ microwave-dressed Rydberg atoms to realize a novel atomic candle that features multi-band frequency tunability and large stabilization bandwidth.We demonstrate amplitude stabilization of microwave field from C-band to Ka-band,which could be extended to quasi-DC and terahertz fields by exploring abundant Rydberg levels.Our atomic candle achieves stabilization bandwidth of 100 Hz,outperforming previous ones by more than two orders of magnitude.Our simulation indicates the stabilization bandwidth can be further increased up to 100 kHz.Our work paves a route to develop novel electric field control and applications with a noise-resilient,miniaturized,sensitive and broadband atomic candle. | Yafen Cai Shuai Shi Yijia Zhou Jianhao Yu Yali Tian Yitong Li Kuan Zhang Chenhao Du Weibin Li Lin Li | 2023 | Frontiers of physics2023，18，1： | 1 |
| 7 | Removal characteristics of TCDD/Fs by dual bag filter system of a fly ash treatment plant显示文摘 | Lin Wenyinn Wang Linchi Wang Yafen | 2008 | Journal of Hazardous Materials2008，153，： | 1 |
| 8 | Bisulfite-free mapping of DNA cytosine modifications:challenges and perspectives显示文摘The mapping of DNA cytosine modifications is crucial for understanding the dynamic landscape of epigenetic regulation.While bisulfite sequencing has been the gold standard for decades,it suffers from limitations such as DNA degradation and low library quality due to harsh chemical treatment.In recent years,bisulfite-free methods have emerged as promising alternatives for detecting and quantifying DNA cytosine modifications.These methods employ enzymatic and chemical strategies to investigate cytosine modifications without the need for bisulfite treatment.This review provides an overview of the historical context of bisulfite-based methods and presents the current landscape of bisulfite-free methods.The advantages and limitations of each approach are discussed,along with insights into their applications.Furthermore,the review explores the existing challenges in the field and presents future perspectives and potential directions for advancing bisulfite-free mapping methods.The continued progress in bisulfite-free techniques holds great promise for unraveling the intricate nature of DNA cytosine modifications and their functional implications in diverse biological processes and diseases. | Yanfang Du Ying Tang Bingqian Lin Xiaochen Xue Yafen Wang Yibin Liu | 2023 | Science China Chemistry2023，66，11： | 0 |
| 9 | Study on the Relationship Between Tableware Color and Consumers’Appetite显示文摘In order to explore the relationship between the color of tableware and appetite,random samples were selected from the network survey.The results show that the vast majority of people will pay attention to the color of tableware,and think that the color of tableware will have an impact on appetite:Most of the respondents prefer the warm color of tableware.Finally,according to the survey results,some suggestions and ideas are put forward to the catering operators:Catering operators need to improve their aesthetic artistry;pay attention to the collocation of different colors;according to the tableware function deployment tableware color;and so on. | HUANG Yafen LIN Xiaoqing | 2022 | Psychology Research2022，12，5： | 0 |
| 10 | Prognostic value of the 21-gene recurrence score in ER-positive,HER2-negative,node-positive breast cancer was similar in nodenegative diseases:a single-center study of 800 patients显示文摘Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.This study aimed to evaluate the prognostic significance of the 21-gene recurrence score(RS)in Chinese patients with pN0-l,estrogen receptor-positive(ER+),human epidermal growth factor receptor 2-negative(HER2)breast cancer.Among 800 patients recruited between 2009 and 2016,the median RS was 24(0-69),with 27.4%,46.8%,and 25.9%patients classified into low-,intermediate-,and high-risk groups.Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival(IDFS)and distant disease-free survival(DDFS)events compared with the low-risk category(IDFS:HR=2.450,95%Cl 1.017-5.902,P=0.046;DDFS:HR=2.829,95%Cl 1.013-7.901,P=0.047).No significant association between RS category and overall survival(OS)was found(intermediate vs.low:HR=1.244,95%Cl 0.292-5.297,P=0.768;high vs.low:HR=2.933,95%Cl 0.759-11.327,P=0.119).RS,as a continuous variable,was a highly significant predictor for IDFS(HR=1.028,95%Cl 1.010-1.047,P=0.002),DDFS(HR=1.030,95%Cl 1.010-1.051,P=0.003),and OS(HR=1.034,95%Cl 1.007-1.063,P=0.014).Our findings suggested that RS may predict IDFS in Chinese patients with ER+/HER2 breast cancer with NO or N1 disease. | Jiayi Wu Weiqi Gao Xiaosong Chen Chunxiao Fei Lin Lin Weiguo Chen Ou Huang Siji Zhu Jianrong He Yafen Li Li Zhu Kunwei Shen | 2021 | Frontiers of Medicine2021，15，4： | 0 |
| 11 | A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score显示文摘Objective: The indication of adjuvant chemotherapy recommendation(ACR) in breast cancer patients with intermediate recurrence score(RS) is controversial. This study investigated the relationship between routine clinicopathological indicators and ACR, and established a nomogram for predicting the probability of ACR in this subset of patients.Methods: Data for a total of 504 consecutive patients with intermediate RS from January 2014 to December2016 were retrospectively reviewed. A nomogram was constructed using a multivariate logistic regression model based on data from a training set(378 cases) and validated in an independent validation set(126 cases). A Youdenderived cut-off value was assigned to the nomogram for accuracy evaluation.Results: The multivariate logistic regression analysis identified that age, histological grade, tumor size, lymph node(LN) status, molecular subtype, and RS were independent predictors of ACR. A nomogram based on these predictors performed well. The P value of the Hosmer-Lemeshow test for the prediction model was 0.286. The area under the curve(AUC) values were 0.905 [95% confidence interval(95% CI): 0.876–0.934] and 0.883(95%CI: 0.824–0.942) in the training and validation sets, respectively. The accuracies of the nomogram for ACR were84.4% in the training set and 82.1% in the validation set.Conclusions: We developed a nomogram to predict the probability of ACR in breast cancer patients with intermediate RS. This model may aid the individual risk assessment and guide treatment decisions in clinical practice. | Feilin Qu Xiaosong Chen Xiaochun Fei Lin Lin Weiqi Gao Yu Zong Jiayi Wu Ou Huang Jianrong He Li Zhu Weiguo Chen Yafen Li Kunwei Shen | 2018 | Chinese Journal of Cancer Research2018，30，2： | 0 |
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