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| 1 | 巨细胞病毒:激素难治性溃疡性结肠炎的一个可能病因显示文摘巨细胞病毒(CMV)是一种机会病原体,是多种自身免疫性疾病的触发因素。接受激素治疗的溃疡性结肠炎(UC)患者易发生CMV感染。CMV存在时,炎症将更为复杂。感染CMV的活动期UC患者常对激素治疗无应答,给予抗病毒药物则可诱导缓解。根据既往临床证据,CMV是激素难治性UC的一个可能病因。 | 薛猛 姒健敏 | 2013 | 胃肠病学2013，18，10： | 13 |
| 2 | Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status显示文摘AIM:To clarify the impact of cytomegalovirus(CMV)activation and antiviral therapy based on CMV antigen status on the long-term clinical course of ulcerative colitis(UC)patients.METHODS:UC patients with flare-up were divided into CMV-positive and-negative groups according to the CMV antigenemia assay.The main treatment strategy provided for the patients in the CMV-positive group comprised a dose reduction of corticosteroids and administration of ganciclovir.RESULTS:The median number of days to initial remission was significantly greater for the patients in the CMV-positive group(21 d vs 16 d,P=0.009).However,the relapse rate after remission and colectomy rate during more than 30 mo of observation did not differ between the two groups.Multivariate analysis revealed that administration of ganciclovir was the only independent factor for avoiding colectomy in patients of the CMV-positive group.CONCLUSION:CMV antigen status did not significantly affect the long-term prognosis in UC patients under treatment with appropriate antiviral therapy. | Toshihiro Inokuchi Jun Kato Sakiko Hiraoka Hideyuki Suzuki Asuka Nakarai Tomoko Hirakawa Mitsuhiro Akita Sakuma Takahashi Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，2： | 6 |
| 3 | 巨细胞病毒与炎症性肠病的关系显示文摘巨细胞病毒(cytomegalovirus,CMV)为机会致病性病毒,多数人呈隐性或潜伏感染,显性CMV感染常发生在免疫功能抑制者。炎症性肠病(IBD)是一种慢性、复发性的肠道炎症疾病,患者常使用激素或免疫抑制剂治疗,因而有很高的CMV易感性。近年研究表明CMV感染可能在炎症性肠病病情发展变化中起关键作用,CMV通过直接或间接作用致组织损伤,目前新发展的检测技术或联合多种检测手段可增加CMV检出的敏感性和特异性,而不少研究表明难治性IBD时应用抗CMV病毒治疗可明显改善病情。本文就CMV在IBD疾病进展中的作用和关系,以及对CMV的最新检测技术和治疗策略的研究进展作一综述。 | 姚雪洁 吴小平 | 2011 | 胃肠病学和肝病学杂志2011，20，10： | 3 |
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