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| 1 | CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes显示文摘染色体编辑工具例如定期聚类短 palindromic 重复(CRISPR ) 联系了的 interspaced 系统(Cas ) 广泛地被用来包括动物接合子和人的房间在模型系统修改基因,并且为基本研究和临床的应用保持巨大的诺言。迄今为止,严肃的知识差距在人的早胚胎,并且在效率和在人的培植前胚胎使用象 CRISPR/Cas9 那样的技术的潜在的离开目标效果留在我们 DNA 修理机制的理解。在这份报告,我们使用了推进的接合子调查 CRISPR/Cas9-mediated 基因在人的房间编辑的 tripronuclear (3PN ) 。我们发现 CRISPR/Cas9 能有效地劈开内长的 -globin 基因(HBB ) 。然而,相应再结合的效率指导了 HBB 的修理(HDR ) 是低的,编辑胚胎是马赛克。离开目标劈开在由 T7E1 试金并且 whole-exome 定序揭示了的这些 3PN 接合子也是明显的。而且,内长的 delta-globin 基因(HBD ) 对 HBB 相应,与外长的施主 oligos 竞争了充当修理模板,导致倔强的变化。我们的数据也显示在这些胚胎的 HBB 地点的修理通过非转线路 HDR 小径优先地发生了。一起拿,我们的工作加亮紧迫的需要进一步改进 CRISPR/Cas9 平台的忠实和特性,为编辑的 CRSIPR/Cas9-mediated 的任何临床的应用程序的一个前提。 | Puping Liang Yanwen Xu Xiya Zhang Chenhui Ding Rui Huang Zhen Zhang Jie Lv Xiaowei Xie Yuxi Chen Yujing Li Ying Sun Yaofu Bai Zhou Songyang Wenbin Ma Canquan Zhou Junjiu Huang | 2015 | Protein & Cell2015，6，5： | 149 |
| 2 | Potential and challenges of tannins as an alternative to in-feed antibiotics for farm animal production显示文摘Naturally occurring plant compounds including tannins, saponins and essential oils are extensively assessed as natural alternatives to in-feed antibiotics.Tannins are a group of polyphenolic compounds that are widely present in plant region and possess various biological activities including antimicrobial,anti-parasitic, anti-viral, antioxidant, anti-inflammatory, immunomodulation, etc.Therefore, tannins are the major research subject in developing natural alternative to in-feed antibiotics.Strong protein affinity is the well-recognized property of plant tannins, which has successfully been applied to ruminant nutrition to decrease protein degradation in the rumen, and thereby improve protein utilization and animal production efficiency.Incorporations of tannin-containing forage in ruminant diets to control animal pasture bloat, intestinal parasite and pathogenic bacteria load are another 3 important applications of tannins in ruminant animals.Tannins have traditionally been regarded as 'anti-nutritional factor' for monogastric animals and poultry, but recent researches have revealed some of them, when applied in appropriate manner, improved intestinal microbial ecosystem, enhanced gut health and hence increased productive performance.The applicability of plant tannins as an alternative to in-feed antibiotics depends on many factors that contribute to the great variability in their observed efficacies. | Qianqian Huang Xiuli Liu Guoqi Zhao Tianming Hu Yuxi Wang | 2018 | Animal Nutrition2018，，2： | 54 |
| 3 | Rise of Cross-border E-commerce Exports in China显示文摘 | Shuzhong Ma Yuxi Chai Hongsheng Zhang | 2018 | China & World Economy2018，26，3： | 29 |
| 4 | One-step strategy to graphene/Ni(OH)2 composite hy- drogels as advanced three-dimensional supercapacitor electrode materials显示文摘基于 Graphene 三维(3D ) 宏观的材料最近在电气化学的精力变换和存储由他们的令人激动的潜力的优点吸引了增加的兴趣。这里,我们报导灵巧的一步舞策略准备机械地强壮、电子上传导性的 graphene/Ni (哦) 有一个互连的多孔的网络的 2 合成 hydrogels。没有增加任何另外的文件夹或传导性的添加剂,合成 hydrogels 直接被用作 3D supercapacitor 电极材料。包含 82 wt.% Ni 的优化合成 hydrogel (哦) 2 与优秀骑车在 40 mV/s (63% 电容保留) 以 5 mV/s 和 785 F/g 的扫描率展出了 1,247 F/g 的一个特定的电容稳定性。3D hydrogels 的能力极大地超过 graphene 表和 Ni 的物理混合物的(哦) 2 nanoplates (在 40 mV/s 的 309 F/g ) 。一样的策略也被使用制作 graphene 碳 nanotube/Ni (哦) 有进一步改进的特定的电容(在 5 mV/s 的 1,352 F/g ) 和率能力(在 40 mV/s 的 66% 电容保留) 的 2 第三的合成 hydrogels。这里获得的两合成 hydrogels 能交付高精力密度(43 和 47 Wh/kg,分别地) 并且力量密度(8 和 9 kW/kg,分别地) ,为 supercapacitor 应用使他们成为吸引人的电极材料。这研究打开一条新小径到功能的 3D graphene 的设计和制造合成材料,和罐头显著地包括精力存储并且在以外影响宽广区域。 | Yuxi Xu Xiaoqing Huang Zhaoyang Lin Xing Zhong Yu Huang Xiangfeng Duan | 2013 | Nano Research2013，6，1： | 28 |
| 5 | Effective gene editing by high-fidelity base editor 2 in mouse zygotes显示文摘通过相应再结合的指向的点 mutagenesis 广泛地在基因研究被使用了并且为在病人修理引起疾病的变化保持可观的诺言。然而,象 mosaicism 那样的问题和低 mutagenesis 效率继续提出挑战到如此的途径的临床的申请。最近,一个基础编辑器() 在 cytidine (C) 脱氨基酶上造的系统和 CRISPR/Cas9 技术在植物,酵母,和人的房间为指向的点 mutagenesis 作为一个其他的方法被开发。然而,基础编辑器高效地在 deamination 窗口中把 C 变换成 thymidine (T) 是否指向了在鼠标胚胎的基础编辑,仍然保持不清楚是可行的。在这份报告,我们产生了基础编辑的一个修改高保真版本 2 (HF2-BE2 ) ,并且调查了它在老鼠胚胎编辑功效的底。我们发现 HF2-BE2 能高效地把 C 变换成 T,与直到在老鼠胚胎的 100% biallelic 变化效率。不同于 BE3, HF2-BE2 能在目标和非目标海滨上把 C 变换成 T,扩展基础编辑器的编辑范围。令人惊讶地,我们发现 HF2-BE2 能也使脱去氨基对 gRNA 有约束力的区域近似的 C。一起拿,我们的工作表明由基础编辑,和下划线在鼠标产生点变化的可行性小心地优化编辑系统以便消除近似地点的 deamination 的底的需要。 | Puping Liang Hongwei Sun Ying Sun Xiya Zhang Xiaowei Xie Jinran Zhang zhen Zhang Yuxi Chen Chenhui Ding Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2017 | Protein & Cell2017，8，8： | 17 |
| 6 | Three-dimensional graphene framework with ultra-high sulfur content for a robust lithium-sulfur battery显示文摘 | Benjamin Papandrea Xu Xu Yuxi Xu Chih-Yen Chen Zhaoyang Lin Gongming Wang Yanzhu Luo Matthew Liu yu Huang Liqiang Mai Xiangfeng Duan | 2016 | Nano Research2016，9，1： | 13 |
| 7 | Preparation of hexagonal ultrathin WO3 nano-ribbons and their electrochemical performance as an anode material in lithium ion batteries显示文摘多达几测微计的 subnanometer 厚度, 25 nm 宽度,和长度的六角形的 ultrathin WO 3nano 带子(HUWNR ) 被一个 solvothermal 方法准备。同样准备的 HUWNR 成长[001 ] 方向,和主要暴露的方面是(120 ) 水晶飞机。因为他们的唯一的结构, HUWNR 在锂离子电池作为阳极材料展出好电气化学的性能。这些唯一的材料可以在许多地里被使用,这被相信。 | Chao Lian Xiaoling Xiao Zheng Chen Yuxi Liu Enyue Zhao Dingsheng Wang Chen Chen Yadong Li | 2016 | Nano Research2016，9，2： | 12 |
| 8 | 基于组学技术研究反刍动物瘤胃微生物及其代谢功能的进展显示文摘瘤胃微生物对反刍动物的生产效率和健康状况以及温室气体的排放起着至关重要的作用,而采用不同的研究方法和手段揭示瘤胃生态系统中微生物群落的结构组成和代谢功能是该研究领域的热点和重点。本文综述了采用多组学(宏基因组学、宏转录组学、宏蛋白质组学和代谢组学)技术,结合不断发展的仪器分析和生物信息技术,研究反刍动物瘤胃微生物组成、基因组功能及代谢方面的最新进展,旨在为进一步调控瘤胃微生物以提高反刍动物生产和减轻环境污染提供新的技术手段和理论基础。 | 牛化欣 常杰 胡宗福 Wang Yuxi | 2019 | 畜牧兽医学报2019，50，6： | 12 |
| 9 | Tectonic Evolution and Geological Characteristics of Hydrocarbon Reservoirs in Marine Mesozoic-Paleozoic Strata in the South Yellow Sea Basin显示文摘The South Yellow Sea Basin is the main body of the lower Yangtze area in which marine Mesozoic–Paleozoic strata are widely distributed.The latest geophysical data were used to overcome the limitation of previous poor-quality deep data.Meanwhile,the geological characteristics of hydrocarbon reservoirs in the marine Mesozoic–Paleozoic strata in the South Yellow Sea Basin were analyzed by comparing the source rocks and the reservoir and utilizing drilling and outcrop data.It is believed that the South Yellow Sea Basin roughly underwent six evolutionary stages:plate spreading,plate convergence,stable platform development,foreland basin development,faulted basin development,and depression basin development.The South Yellow Sea Basin has characteristics of a composite platform-fault depression geological structure,with a half-graben geological structure and with a ‘sandwich structure' in the vertical direction.Four sets of hydrocarbon source rocks developed – the upper Permian Longtan–Dalong formation,the lower Permian Qixia formation,the lower Silurian Gaojiabian formation,and the lower Cambrian Hetang formation/Mufushan formation,giving the South Yellow Sea Basin relatively good hydrocarbon potential.The carbonate is the main reservoir rock type in the South Yellow Sea area,and there are four carbonate reservoir types:porous dolomitic,reef-bank,weathered crust,and fractured.There are reservoir-forming horizons similar to the typical hydrocarbon reservoirs in the Yangtze land area developed in the South Yellow Sea,and there are three sets of complete source-reservoir-cap rock assemblages developed in the marine strata,with very good hydrocarbon potential. | YUAN Yong CHEN Jianwen ZHANG Yuxi LIANG Jie ZHANG Yinguo ZHANG Penghui | 2018 | Journal of Ocean University of China2018，17，5： | 11 |
| 10 | Effect of different sources and levels of iron in the diet of sows on iron status in neonatal pigs显示文摘This study was conducted to determine the effects of maternal dietary supplementation of ferrous glycine chelate(Fe-Gly) and ferrous sulfate monohydrate(FeSO_4·H_2O) on the relative organ weight, tissue iron contents, red blood cells(RBC), hemoglobin concentration(HGB) and hematocrit(HCT) in blood, as well as ferritin(Fn), serum iron(SI), and total iron binding capacity(TIBC) in serum of newborn piglets.Forty-five sows(Landrace × Large white, mean parity 3 to 4, no significant differences in BW) were randomly allotted to 9 treatments(n=5 sows/treatment): control(basal diet with no Fe supplementation), the basal diet supplemented with 50, 80, 110 or 140 mg Fe/kg as Fe-Gly, and the basal diet supplemented with 50, 80, 110 or 140 mg Fe/kg as FeSO_4·H_2O.The neonatal piglets(n=45) were used to determine the relative organ weight, tissue iron contents and blood biochemical indices.Compared with the control, the relative weight of spleen and kidney were significantly increased(P < 0.05) in the Fe-Gly groups.The iron contents in liver,spleen, kidney and femur were also found increased(P < 0.05) in the Fe-Gly groups.The RBC(d 1 and 21),HGB(d 1 and 21) and HCT(d 1 and 21) in blood and Fn(d 1) and SI(d 1 and 21) significantly increased(P < 0.05), but the TIBC(d 1 and 21) in serum decreased(P < 0.05) in the Fe-Gly groups.Moreover, the kidney relative weight, iron content in liver, spleen, kidney and femur, RBC(d 1) and HGB(d 21) in blood, and SI(d 1)in the Fe-Gly groups increased(P < 0.05) compared with the FeSO_4·H_2O treatment.Linear and quadratic responses of the kidney relative weight, the iron content in liver, spleen, kidney and femur, RBC(d 1 and 21),HGB(d 1 and 21) and HCT(d 1 and 21) in whole blood, SI(d 1) and TIBC(d 1 and 21) in the Fe-Gly groups were observed(P < 0.05).Linear responses of Fn(d 1 and 21) and SI(d 21) in the Fe-Gly groups, and spleen relative weight, HCT(d 1), Fn(d 1) and TIBC(d 1 and 21) in the FeSO_4·H_2O groups were observed(P < 0.05).These finding suggest that Fe-Gly supplemented at the level of 110 mg/kg in the diet of sows in this experiment is superior to other forms of supplementation, based on HGB concentration, the relative organ weight, tissue iron contents and blood biochemical indices of piglets. | Yan Li Weiren Yang Donghua Dong Shuzhen Jiang Zaibin Yang Yuxi Wang | 2018 | Animal Nutrition2018，，2： | 11 |
| 11 | Rare earth oxides and their supported noble metals in application of environmental catalysis显示文摘Volatile organic compounds(VOCs),methane,carbon monoxide,soot,automotive exhaust,and nitrogen oxides are harmful to the atmosphere and human health.It is urgent to strictly control their emissions.Heterogeneous catalysis is an effective pathway for the removal of these pollutants,and the critical issue is the development of novel and high-performance catalysts.In this review,we briefly summarize the preparation methods,physicochemical properties,catalytic activities,and related reaction mechanisms for the above pollutants removal of the rare earth oxides,mixed rare earth oxide,rare earth oxidesupported noble metal,and mixed rare earth oxide-supported noble metal catalysts that have been investigated by our group and other researchers.It was found that catalytic performance was associated with the factors,such as specific surface area,pore structure,particle size and dispersion,adsorbed oxygen species concentration,reducibility,reactant activation ability or interaction between metal nanoparticles and support.Furthermore,we also envision the development trend of such a topic in future work. | Zhiquan Hou Wenbo Pei Xing Zhang Kunfeng Zhang Yuxi Liu Jiguang Deng Lin Jing Hongxing Dai | 2020 | Journal of Rare Earths2020，38，8： | 10 |
| 12 | Research on FBG-Based CFRP Structural Damage Identification Using BP Neural Network显示文摘增强的塑料(CFRP ) 组织的碳纤维的一个损坏鉴定系统用纤维布拉格被调查栅栏(FBG ) 传感器和背繁殖(BP ) 神经网络。FBG 传感器被使用构造察觉到的网络检测活跃使活动产生的结构的动态反应信号。损坏鉴定模型基于 BP 神经网络被造。Fourier 变换提取的动态信号特征是输入,并且损坏状态是模型的产量。而且,损坏被把 lumped 群众交给不同重量而不是导致真实损坏模仿,它被证实由有限元素分析(FEA ) 可行。最后,损坏鉴定系统与 300 公里在一个 CFRP 盘子上被验证 ?????????? 偍 ?????????? 瀠? 偍 ??? ‰ ?慐 吗?? | Xiangyi GENG Shizeng LU Mingshun JIANG Qingmei SUI Shanshan LV Hang XIAO Yuxi JIA Lei JIA | 2018 | Photonic Sensors2018，8，2： | 9 |
| 13 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 14 | Research on Pressure Tactile Sensing Technology Based on Fiber Bragg Grating Array显示文摘一个压力触觉的传感器基于纤维布拉格栅栏(FBG ) ,数组在这篇论文,和它的有弹性的身体的数字模拟被介绍被有限元素软件(ANSYS ) 实现。根据模拟,纤维布拉格栅栏绳在灵活硅酮被植入认识到传感器制造过程,并且一个严峻的系统被造。一系列刻度测试经由高精确被做通用出版社机器。触觉的传感器数组察觉了外部压力,它被纤维栅栏解调仪器使解调,并且三尺寸的图画被规划视觉上显示位置和尺寸。同时,传感器的一个动态接触实验为模仿在未知环境遇到另外的目标的机器人被进行。试验性的结果证明传感器有好线性,重覆性,并且有动态反应的好效果,并且它的压力敏感是 0.03 nm/N。另外,传感器也有反电磁的干扰的优点,好灵活性,简单结构,低等等花费,它被期望以后在便携人工的皮肤被过去常。 | Jinxue SONG Qi JIANG Yuanyang HUANG Yibin LI Yuxi JIA Xuewen RONG Rui SONG Hongbin LIU | 2015 | Photonic Sensors2015，5，3： | 8 |
| 15 | Hydrocarbon Geological Conditions and Exploration Potential of Mesozoic–Paleozoic Marine Strata in the South Yellow Sea Basin显示文摘No substantial breakthroughs have been made in hydrocarbon exploration of the South Yellow Sea Basin.It is believed that the Mesozoic-Paleozoic marine sedimentary formation in the South Yellow Sea Basin is similar to that in the Sichuan Basin.Therefore,outcrop,drilling,and seismic data were determined and compared with the research results on petroleum geological conditions in the Yangtze land area,and the hydrocarbon geological conditions were analyzed comprehensively from multiple aspects,such as basin evolution and main source rocks,reservoir characteristics,preservation conditions,and structural traps.The results show that two main stages in the South Yellow Sea Basin(the stable evolution stage of the Mesozoic-Paleozoic marine basin and the Mesozoic-Cenozoic tectonic reformation and basin formation stage)were important for the development and evolution of four sets of main source rocks.Reservoirs dominated by carbonate rocks,three sets of capping beds with good sealing capability,relatively weak magmatic activity,and multiple types of structural traps jointly constituted relatively good hydrocarbon-reservoir-forming conditions.There were four sets of main source-reservoir-cap assemblages and three possible hydrocarbon reservoir types(primary residual-type hydrocarbon reservoir,shallow reformed-type hydrocarbon reservoir,and composite-type hydrocarbon reservoir)developed in the marine strata.It is concluded that the marine strata in the South Yellow Sea Basin have relatively good hydrocarbon potential.The Laoshan Uplift is characterized by stable structure,complete preserved source reservoir cap assemblage,and large structural traps,and thus it is the preferred prospect zone for marine Paleozoic hydrocarbon exploration in this area. | YUAN Yong CHEN Jianwen LIANG Jie XU Ming LEI Baohua ZHANG Yuxi CHENG Qingsong WANG Jianqiang | 2019 | Journal of Ocean University of China2019，18，6： | 7 |
| 16 | Concurrent catalytic removal of typical volatile organic compound mixtures over Au-Pd/α-MnO2 nanotubes显示文摘α-MnO_2 nanotubes and their supported Au-Pd alloy nanocatalysts were prepared using hydrothermal and polyvinyl alcohol-protected reduction methods, respectively. Their catalytic activity for the oxidation of toluene/m-xylene, acetone/ethyl acetate, acetone/m-xylene and ethyl acetate/m-xylene mixtures was evaluated. It was found that the interaction between Au-Pd alloy nanoparticles and α-MnO_2 nanotubes significantly improved the reactivity of lattice oxygen, and the 0.91 wt.% Au0.48 Pd/α-MnO_2 nanotube catalyst outperformed the α-MnO_2 nanotube catalyst in the oxidation of toluene, m-xylene, ethyl acetate and acetone. Over the0.91 wt.% Au0.48 Pd/α-MnO_2 nanotube catalyst,(i) toluene oxidation was greatly inhibited in the toluene/m-xylene mixture, while m-xylene oxidation was not influenced;(ii) acetone and ethyl acetate oxidation suffered a minor impact in the acetone/ethyl acetate mixture; and(iii) m-xylene oxidation was enhanced whereas the oxidation of the oxygenated VOCs(volatile organic compounds) was suppressed in the acetone/m-xylene or ethyl acetate/m-xylene mixtures. The competitive adsorption of these typical VOCs on the catalyst surface induced an inhibitive effect on their oxidation, and increasing the temperature favored the oxidation of the VOCs. The mixed VOCs could be completely oxidized into CO_2 and H_2 O below 320°C at a space velocity of 40,000 m L/(g·hr). The 0.91 wt.% Au0.48 Pd/α-MnO_2 nanotube catalyst exhibited high catalytic stability as well as good tolerance to water vapor and CO_2 in the oxidation of the VOC mixtures. Thus, the α-MnO_2 nanotube-supported noble metal alloy catalysts hold promise for the efficient elimination of VOC mixtures. | Yunsheng Xia Lu Xia Yuxi Liu Tao Yang Jiguang Deng Hongxing Dai | 2018 | Journal of Environmental Sciences2018，30，2： | 7 |
| 17 | PdAg bimetallic electrocatalyst for highly selective reduction of CO2 with low COOH^* formation energy and facile CO desorption显示文摘For electrocatalytic reduction of CO2 to CO,the stabilization of intermediate COOH^* and the desorption of CO^* are two key steps.Pd can easily stabilize COOH^*,whereas the strong CO^* binding to Pd surface results in severe poisoning,thus lowering catalytic activity and stability for CO2 reduction.On Ag surface,CO^* desorbs readily,while COOH^* requires a relatively high formation energy,leading to a high overpotential.In light of the above issues,we successfully designed the PdAg bimetallic catalyst to circumvent the drawbacks of sole Pd and Ag.The PdAg catalyst with Ag-terminated surface not only shows a much lower overpotential(-0.55 V with CO current density of 1 mA/cm^2)than Ag(−0.76 V),but also delivers a CO/H2 ratio 18 times as high as that for Pd at the potential of-0.75 V vs.RHE.The issue of CO poisoning is significantly alleviated on Ag-terminated PdAg surface,with the stability well retained after 4h electrolysis at-0.75 V vs.RHE.Density functional theory(DFT)calculations reveal that the Ag-terminated PdAg surface features a lowered formation energy for COOH^* and weakened adsorption for CO^*,which both contribute to the enhanced performance for CO2 reduction. | Rui Lin Xuelu Ma Weng-Chon Cheong Chao Zhang Wei Zhu Jiajing Pei Kaiyue Zhang Bin Wang Shiyou Liang Yuxi Liu Zhongbin Zhuang Rong Yu Hai Xiao Jun Li Dingsheng Wang Qing Peng Chen Chen Yadong Li | 2019 | Nano Research2019，12，11： | 7 |
| 18 | The precise regulation of different COR genes by individual CBF transcription factors in Arabidopsis thaliana显示文摘The transcription factors CBF1/2/3 are reported to play a dominant role in the cold responsive network of Arabidopsis by directly regulating the expression levels of cold responsive(COR) genes.In this study,we obtained CRISPR/Cas9-mediated loss-of-function mutants of cbf1$3.Over 3,000 COR genes identified by RNA-seq analysis showed a slight but significant change in their expression levels in the mutants compared to the wildtype plants after being treated at 4 °C for 12 h.The C-repeat(CRT) motif(50-CCGAC-30) was enriched in promoters of genes that were up-regulated by CBF2 and CBF3 but not in promoters of genes up-regulated by CBF1.These data suggest that CBF2 and CBF3 play a more important role in directing the cold response by regulating different sets of downstream COR genes.More than 2/3 of COR genes were co-regulated by two or three CBFs and were involved mainly in cellular signal transduction and metabolic processes;less than 1/3 of the genes were regulated by one CBF,and those genes up-regulated were enriched in cold-related abiotic stress responses.Our results indicate that CBFs play an important role in the trade-off between cold tolerance and plant growth through the precise regulation of COR genes in the complicated transcriptional network. | Yihao Shi Jiaying Huang Tianshu Sun Xuefei Wang Chenqi Zhu Yuxi Ai Hongya Gu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 7 |
| 19 | Two-Dimensional Regular Shock Reflection for the Pressure Gradient System of Conservation Laws显示文摘We establish the existence of a global solution to a regular reflection of a shock hitting a ramp forthe pressure gradient system of equations.The set-up of the reflection is the same as that of Mach's experimentfor the compressible Euler system,i.e.,a straight shock hitting a ramp.We assume that the angle of the rampis close to 90 degrees.The solution has a reflected bow shock wave,called the diffraction of the planar shock atthe compressive corner,which is mathematically regarded as a free boundary in the self-similar variable plane.The pressure gradient system of three equations is a subsystem,and an approximation,of the full Euler system,and we offer a couple of derivations. | Yuxi Zheng | 2006 | Acta Mathematicae Applicatae Sinica2006，22，2： | 7 |
| 20 | Transparency and amplification in a hybrid system of the mechanical resonator and circuit QED显示文摘We theoretically study the transparency and amplification of a weak probe field applied to the cavity in hybrid systems formed by a driven superconducting circuit QED system and a mechanical resonator,or a driven optomechanical system and a superconducting qubit.We find that both the mechanical resonator and the superconducting qubit can result in the transparency to a weak probe field in such hybrid systems when a strong driving field is applied to the cavity.We also find that the weak probe field can be amplified in some parameter regimes.We further study the statistical properties of the output field via the degrees of second-order coherence.We find that the nonclassicality of the output field strongly depends on the system parameters.Our studies show that one can control single-photon transmission in the optomechanical system via a tunable artificial atom or in the circuit QED system via a mechanical resonator. | WANG Hui SUN HuiChen ZHANG Jing LIU YuXi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 6 |
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