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| 1 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 2 | A brief of recent research progress on ionospheric disturbances显示文摘Ionospheric disturbances are the main causes of space weather events,which seriously influence accurate navigation,telecommunication,and so on.It is a fundamental issue to detect and analyze the disturbance processes of the ionosphere.Theoretically,the understanding of the mechanisms of most ionospheric disturbances depends on observational results.With the development of space observation techniques and related equipments,various eforts have been made to analyze the long-term statistical variations as well as sudden disturbances of ionospheric observation results.We briefly report some research progresses of ionospheric disturbances achieved in recent years,with regard to ground-based and satellites observations.The purpose is to provide a reference about the latest research progresses and improve the development of the future ionospheric disturbances observations and related researches. | XIAO Zuo YU ShiMei SHI Hao HAO Yong | 2013 | Science China(Information Sciences)2013，56，12： | 5 |
| 3 | Tolerance of Physocypria kraepelini (Crustacean, Ostracoda) to water-borne ammonia, phosphate and pH value显示文摘This study evaluated the median lethal concentration (LC50) and safe concentration of water-borne ammonia, phosphate and pH value on Physocypria kraepelini, a freshwater Ostracoda with a static renewal test system. The results indicated that the LC50 values of ammonia for P. kraepelini were 1026.71, 859.98, 771.79 and 583.82 mg/L at 24, 48, 72 and 96 h exposure, respectively, and the safe concentration range of ammonia for the long-term survival of P. kraepelini was less than 58.38 mg/L. The safe range of pH value for the survival of P. kraepelini was from 6.59 to 7.61. P. kraepelini has a high tolerance to ammonia, phosphate and pH value which are the main environmental factors in the serious eutrophication water. | YU Na, CHEN Shimei, LI Erchao, CHEN Jiayan, CHEN Liqiao School of Life Science, East China Normal University, Shanghai 200062, China | 2009 | Journal of Environmental Sciences2009，21，11： | 4 |
| 4 | Effects of dietary chitosan oligosaccharides and Bacillus coagulans on the growth, innate immunity and resistance of koi ( Cyprinus carpio koi )显示文摘 | Shimei Lin Shuhong Mao Yong Guan Lin Luo Li Luo Yu Pan | 2012 | Aquaculture2012，，： | 1 |
| 5 | Effects of dietary/-1,3 glucan, chitosan or raffinose on the growth, innate immunity and resistance of koi (Cyprinus carpio koi) 显示文摘 | Lin Shimei Pan Yu Luo Lin | 2011 | Fish and Shellfish Immunology2011，31，6： | 1 |
| 6 | The divergence of brassinosteroid sensitivity between rice subspecies involves natural variation conferring altered internal auto-binding of OsBSK2显示文摘Japonica/geng and indica/xian are two major rice(Oryza sativa)subspecies with multiple divergent traits,but how these traits are related and interact within each subspecies remains elusive.Brassinosteroids(BRs)are a class of steroid phytohormones that modulate many important agronomic traits in rice.Here,using different physiological assays,we revealed that japonica rice exhibits an overall lower BR sensitivity than indica.Extensive screening of BR signaling genes led to the identification of a set of genes distributed throughout the primary BR signaling pathway with divergent polymorphisms.Among these,we demonstrate that the C38/T variant in BR Signaling Kinase2(OsBSK2),causing the amino acid change P13L,plays a central role in mediating differential BR signaling in japonica and indica rice.OsBSK2in indica plays a greater role in BR signaling than OsB SK2in japonica by affecting the auto-binding and protein accumulation of OsBSK2.Finally,we determined that OsBSK2 is involved in a number of divergent traits in japonica relative to indica rice,including grain shape,tiller number,cold adaptation,and nitrogen-use efficiency.Our study suggests that the natural variation in OsB SK2 plays a key role in the divergence of BR signaling,which underlies multiple divergent traits between japonica and indica. | Wenchao Yin Lulu Li Zhikun Yu Fan Zhang Dapu Liu Hongkai Wu Mei Niu Wenjing Meng Xiaoxing Zhang Nana Dong Yanzhao Yang Jihong Liu Yongqiang Liu Guoxia Zhang Jianlong Xu Shimei Wang Chengcai Chu Qian Qian Hongning Tong | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 7 | Enterovirus 713C proteolytically processes the histone H3 N-terminal tail during infection显示文摘Dear Editor,Enterovirus 71(EV71)belongs to the genus Enterovirus,family Picornaviridae(Oberste et al.,1999).It was first isolated from patients with central nervous system diseases in California between 1969 and1974(Schmidt et al.,1974)and has spread worldwide(Solomon et al.,2010).EV71 infection usually causes mild,self-limiting hand,foot,and mouth disease in children.Acute EV71 infection may also cause severe polio-like neurological diseases and significant mortality. | Meng Miao Gang Deng Xiaobei Xiong Yang Qiu Wenda Huang Meng Yuan Fei Yu Shimei Bai Xi Zhou Xiaolu Zhao | 2022 | Virologica Sinica2022，37，2： | 0 |
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