|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 2 | The relevance of short-range fibers to cognitive efficiency and brain activation in aging and de- mentia 显示文摘 | Gao J Cheung RT Chan YS | 2014 | PLoS One2014，9，90： | 1 |
| 3 | Laparoscopic versus open hepatectomy for liver tumours: a case control study 显示文摘 | Lee KF Cheung YS Chong CN | 2007 | Hong Kong Med J2007，13，6： | 1 |
| 4 | Elevated perioperative trans-aminase level predicts intrahepatic recurrence in hepatitis B-related hepatocellular carcinoma after curative hepatectomy显示文摘 | Cheung YS Chan HL WongJ | 2008 | Asian J Surg2008，31，2： | 1 |
| 5 | Comparison of postoperative pain between single-incision laparoscopic cholecystectomy and conventional laparoscopic cholecystectomy:prospective case-control study显示文摘 | Wong JS Cheung YS Fong KW | | 0，，： | 1 |
| 6 | Laparoseopie resection for rectal cancers显示文摘 | Ng KH Ng CK Cheung YS | 2009 | Ann Surg2009，321，249： | 1 |
| 7 | Is regular follw-up scan for giant liver haemangioma necessary? 显示文摘 | Ng WW Cheung YS Lee KF | 2007 | Hong Kong Med J2007，13，5： | 1 |
| 8 | Laparoscopic and robotic hepatectomy: experience from a single centre 显示文摘 | Lee KF Cheung YS Chong CC | 2016 | ANZ J Surg2016，86，3： | 1 |
| 9 | Hyperglycemia and the rate of lacticacid accumulation during cerebral ischemia in developing animals:in vivo proton MRSstudy显示文摘 | Young YS Petroff OA Aquila WJ Cheung A Gore JC | 1992 | Biol Neonate1992，61，4： | 1 |
| 10 | Randomized clinical t~'ial o1' open hepatectomy with or without intermittent Pringle manoeuvre 显示文摘 | Lee KF Cheung YS Wong J et a| | 2012 | BrJSurg2012，99，9： | 1 |
| 11 | Fine-needle aspiration cytology of thyroid nodules how well are we doing? 显示文摘 | Cheung YS Poon CM Mak SM | 2007 | Hong Kong MOd J2007，13，1： | 1 |
| 12 | Fine-needle aspiration cytology of Chyroid nodules-how well are we doing显示文摘 | Cheung YS pooh CM Mak SM | 2007 | Hong Kong Med J2007，13，1： | 1 |
| 13 | Is regular follow-up scan for giant liver haemangioma necessary? 显示文摘 | Wilson WC Ng YS Cheung KF Lee el al | 2007 | Hong Kong Med2007，13，5： | 1 |
| 14 | Unit responses to bidirectional off-vertical axes rotations in central vestibular and cerebellar fastigial nuclei 显示文摘 | Chan YS Cheung YM Hwang JC | 1988 | Prog Brain Res1988，76，1： | 1 |
| 15 | Laparoscopic resection for colorectal cancer in octogenarians:results in a decade显示文摘 | Hester YS Cheung FRA Chung CC | 2007 | Dis Colon Rectum2007，50，11： | 1 |
| 16 | Response characteristics of neurons in the cat vestibular nuclei during slow and constant velocity off-vertical axes rotations in the clockwise and counterclockwise directions 显示文摘 | Chan YS Cheung YM Hwang JC | 1987 | Brain Res1987，406，12： | 1 |
| 17 | Comparison of postoperative pain between single-incision laparoscopic cholecystectomy and con- ventional laparoscopic cholecystectomy: prospective case-control study显示文摘 | Wong JS Cheung YS Fong KW | 2012 | Surg Laparosc Endosc Percutan Tech2012，22，1： | 1 |
| 18 | Laparoscopic resection for rectal cancers: lessons learned from 579 cases显示文摘 | Ng KH Ng CK Cheung YS | 2009 | Annals of Surgery2009，249，1： | 1 |
| 19 | Is regular follow-up scan for giant liver haemangioma necessary?显示文摘 | Wilson WC Cheung YS Lee KF | 2007 | Hong Kong Med2007，13，5： | 1 |
| 20 | Is regular follow-up scan for giant liver haemangioma necessary 显示文摘 | Ng WW Cheung YS Lee KF | 2007 | Hong Kong Med J2007，13，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员