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| 1 | Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats显示文摘AIM: To examine the effectiveness of human placental inhibitors, by injecting vitamin E to rats with transplanted Norris-5123 hepatoma, on the expression of cathepsins B and L in tumor, liver, lung and blood sera after transplantation of Norris 5123 hepatoma.METHODS: Animals were divided into 10 groups receiving three different concentrations of vitamin E and inhibitors along or in combination and compared with negative control (healthy rats) and positive control (tumor rats). Effectiveness of treatment was evaluated with regard to survival time,tumor response and determination of the activities of proteolytic enzymes and their inhibitors using flurogenic substrates.RESULTS: Cathepsins B and L activities were elevated by 16-fold in comparison with negative control tissues, and their endogenous inhibitor activity decreased by 1.2-fold before treatment. In several cases, tumors completely disappeared following vitamin E plus human placental cyteine protease inhibitor (CPI) compared with controls.The number of complete tumor responses was higher when 20 m/kg vitamin E plus 400 μg of CPI was used, i.e.7/10 rats survived more than two mo. Cathepsins B and L were expressed significantly in tumor, liver, lung tissues and sera in parallel to the increasing of the endogenous inhibitor activity compared with the controls after treatment (P<0.0001).CONCLUSION: The data indicate formation of metastasis significantly reduced in treated rats, which might provide a therapeutic basis for anti-cancer therapy. | Tadeusz Sebzda Piotr Hanczyc Yousif Saleh Bernice F Akinpelumi Maciej Siewinski Jerzy Rudnicki | 2005 | World Journal of Gastroenterology2005，11，4： | 2 |
| 2 | Principally injective rings显示文摘 | NICHOLSON W K YOUSIF M F | 1995 | J Algebra1995，174，： | 1 |
| 3 | Principally quasi-injective modules 显示文摘 | NICHOLSON W K PARK J K YOUSIF M F | 1999 | Comm Algebra1999，27，1： | 1 |
| 4 | Principally injective rings显示文摘 | Nicholson W K Yousif F M | 1995 | J Algebra1995，174，1： | 1 |
| 5 | Mininjective rings显示文摘 | NICHOLSON W K YOUSIF M F | 1997 | J Algebra1997，187，： | 1 |
| 6 | On a theorem of Camillo 显示文摘 | Nicholson W K Yousif M F | 1995 | Comm Algebra1995，23，14： | 1 |
| 7 | Modeling of corrosionrate under two phase flow in horizontal pipe usingneural network显示文摘 | KADHIM F S YOUSIF Y K | 2012 | Journal of Engineering2012，18，7： | 1 |
| 8 | FP-rings显示文摘 | NICHOLSM W K YOUSIF M F | 2001 | Comm Alg2001，29，1： | 1 |
| 9 | Multitemporal spaceborne SAR data for urban change detection in China 显示文摘 | Ban Y F Yousif O A | 2012 | IEEE Journal of Selected Topics in Applied Eearth Observations and Remote Sensing2012，5，4： | 1 |
| 10 | Role of silanized halloysite nanotubes on structural,mechanical properties and fracture toughness of thermoset nanocomposites显示文摘 | Albdiry M T Yousif B F | 2014 | Materials and Design2014，57，： | 1 |
| 11 | The Analysis of Thermal Effects in a Full Journal Bearing 显示文摘 | Mccallion H Yousif F Lloyd T | 1970 | Transactions of the ASME1970，92，： | 1 |
| 12 | Principally quasi-injective modules 显示文摘 | NICHOLSON W K PARK J K YOUSIF M F | 1999 | Comm Algebra1999，27，24： | 1 |
| 13 | Design consideration of low temperature differential double-acting Stirling engine for solar application显示文摘 | Abdullah S Yousif B F Sopian K | 2005 | Renewable Energy2005，30，11： | 1 |
| 14 | On generalizations of injective rings显示文摘 | CHEN Jian long DING Nan qing Yousif M F | 2003 | Common Algebra2003，31，10： | 1 |
| 15 | Effect of the molsidomine metabolite SIN-1 on coronary arteries and peripheral vessels of sheep with special reference to tolerance and endothelium 显示文摘 | MARIAM H YOUSIF F THUEESIUS O | 1991 | Cardiovascular Drugs Therapy1991，5，4： | 1 |
| 16 | Mininjective rings显示文摘 | Nicholson W K Yousif M F | 1999 | J Algebra1999，187，： | 1 |
| 17 | Ikeda-Nakayama Rings显示文摘 | Camillo V Yousif M F | 2000 | J Algebra2000，22，6： | 1 |
| 18 | A review on thedegradability of polymeric composites based on natural fibres 显示文摘 | AZWA Z N YOUSIF B F MANALO A C | 2013 | Materials and Design2013，47，： | 1 |
| 19 | A model for the particulate matter enrichment with toxic metals in solid fuel flames 显示文摘 | Lookwood F C Yousif S | 2000 | Fuel Processing Technology2000，，6566： | 1 |
| 20 | In State of Art : Mechanical and tribological behaviour of polymeric composites based on natural fibres显示文摘 | Shalwan A Yousif B F | 2013 | Ma- terials and Design2013，48，2： | 1 |
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