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| 1 | Paracrine and endocrine actions of bone——the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts显示文摘The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes,and osteoclasts exert regulation on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner. Osteoblasts secrete a range of different molecules including RANKL/OPG, M-CSF, SEMA3A, WNT5A, and WNT16 that regulate osteoclastogenesis. Osteoblasts also produce VEGFA that stimulates osteoblastogenesis and angiogenesis. Osteocytes produce sclerostin(SOST) that inhibits osteoblast differentiation and promotes osteoclast differentiation. Osteoclasts secrete factors including BMP6, CTHRC1, EFNB2, S1P, WNT10B, SEMA4D, and CT-1 that act on osteoblasts and osteocytes, and thereby influencea A osteogenesis. Osteoclast precursors produce the angiogenic factor PDGF-BB to promote the formation of Type H vessels, which then stimulate osteoblastogenesis. Besides, the evidences over the past decades show that at least three hormones or 'osteokines'from bone cells have endocrine functions. FGF23 is produced by osteoblasts and osteocytes and can regulate phosphate metabolism. Osteocalcin(OCN) secreted by osteoblasts regulates systemic glucose and energy metabolism, reproduction, and cognition. Lipocalin-2(LCN2) is secreted by osteoblasts and can influence energy metabolism by suppressing appetite in the brain.We review the recent progresses in the paracrine and endocrine functions of the secretory proteins of osteoblasts, osteocytes, and osteoclasts, revealing connections of the skeleton with other tissues and providing added insights into the pathogenesis of degenerative diseases affecting multiple organs and the drug discovery process. | Yujiao Han Xiuling You Wenhui Xing Zhong Zhang Weiguo Zou | 2018 | Bone Research2018，6，2： | 52 |
| 2 | A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood显示文摘新复合 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl )-5,6,7,8-tetrahydro-4H-chromen-4-one (1 ) 从中国沉香被孤立[Aquilaria sinensis (愁相) Gilg ] 。它的结构被阐明根据光谱数据。与 14.6 渭 g /mL 的 IC50 价值由 MTT 方法在 vitro 对人的胃的癌症房间线(SGC-7901 ) 加重 1 显示出的 cytotoxicity。 | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai | 2008 | Chinese Chemical Letters2008，19，8： | 25 |
| 3 | Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain显示文摘Objective Our previous study showed that tumor tissue-derived formaldehyde at low concentrations plays an important role in bone cancer pain through activating transient receptor potential vanilloid subfamily member 1 (TRPV1). The present study further explored whether this tumor tissue-derived endogenous formaldehyde regulates TRPV1 expression in a rat model of bone cancer pain, and if so, what the possible signal pathways are during the development of this type of pain. Methods A rat model of bone cancer pain was established by injecting living MRMT-1 tumor cells into the tibia. The formaldehyde levels were determined by high performance liquid chromatography, and the expression of TRPV1 was examined with Western blot and RT-PCR. In primary cultured dorsal root ganglion (DRG) neurons, the expression of TRPV1 was assessed after treatment with 100 μmol/L formaldehyde with or without pre-addition of PD98059 [an inhibitor for extracellular signal-regulated kinase], SB203580 (a p38 inhibitor), SP600125 [an inhibitor for c-Jun N-terminal kinase], BIM [a protein kinase C (PKC) inhibitor] or LY294002 [a phosphatidylinositol 3-kinase (PI3K) inhibitor]. Results In the rat model of bone cancer pain, formaldehyde concentration increased in blood plasma, bone marrow and the spinal cord. TRPV1 protein expression was also increased in the DRG. In primary cultured DRG neurons, 100 μmol/L formaldehyde significantly increased the TRPV1 expression level. Pre-incubation with PD98059, SB203580, SP600125 or LY294002, but not BIM, inhibited the formaldehyde-induced increase of TRPV1 expression. Conclusion Formaldehyde at a very low concentration up-regulates TRPV1 expression through mitogen-activated protein kinase and PI3K, but not PKC, signaling pathways. These results further support our previous finding that TRPV1 in peripheral afferents plays a role in bone cancer pain. | Ying Han Yan Li Xlng Xlao Jia Liu Xiang-Ling Meng Feng-Yu Liu Guo-Gang Xing You Wan | 2012 | Neuroscience Bulletin2012，28，2： | 19 |
| 4 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 5 | Modeling and Operation of the Power-to-Gas System for Renewables Integration: A Review显示文摘Power-to-Gas(P2G)plays an important role in enhancing large-scale renewable energy integration in power systems.As an emerging inter-disciplinary subject,P2G technology requires knowledge in electrochemistry,electrical engineering,thermodynamic engineering,chemical engineering and system engineering.Aiming at P2G modeling and operational problems concerning the research field of power systems and the energy internet,this paper briefly reviews the main technologies and application potentials of the P2G system,and makes systematic summaries of major progresses related to P2G’s integration into the power grid in a bottom-top manner,including the modeling of high/room-temperature electrolysis cells,steady-state/dynamic optimization control of the P2G system,P2G’s integrated model and operational strategies at the grid level.In the final part of this paper,suggestions are put forward on future research directions of P2G systems from the aspects of modeling and operational optimization. | Xuetao Xing Jin Lin Yonghua Song You Zhou Shujun Mu Qiang Hu | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 15 |
| 6 | Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces显示文摘 | Jian-feng XING Hai-sheng YOU Ya-lin DONG Jun LU Si-ying CHEN Hui-fang ZHU Qian DONG Mao-yi WANG Wei-hua DONG | 2011 | Acta Pharmacologica Sinica2011，32，5： | 11 |
| 7 | Time Trends of Cancer Incidence in Urban Beijing,1998-2007显示文摘Objective:To report the time trends of cancer incidence in urban Beijing from 1998 to 2007.Methods:All data were obtained from Beijing Cancer Registry from 1998-2007 in urban Beijing.Time trends of incidence rate of cancer were assessed by annual percentage change(APC) of age-standardized incidence rate(ASR) of world standard population during this 10-year period.Results:For all 156851 cancer cases combined,the incidence rate rose in both males and females,with an APC of 2.23% and 3.74%,respectively.The incidence rate of upper gastrointestinal cancers declined significantly,with an APC of-2.83% in esophageal cancer and-1.37% in male gastric cancer,while lower gastrointestinal cancer,such as colorectal cancer,increased with an APC of 4.08%.The rates of kidney and bladder cancer increased with an APC of 7.93% and 5.57%,respectively.For women,the APC continued to rise in breast cancer(4.98%),ovary cancer(6.16%),cervix uteri cancer(11.74%),corpus uteri cancer(6.96%) and thyroid gland cancer(13.39%).The rate of prostate cancer among men increased with an APC of 8.58%;the rate of lymphoma and leukemia increased with APC of 5.48% and 5.44%,respectively.Conclusion:Because of population aging and urban modernization,the cancer burden in Beijing has become more and more severe and similar to the western developed countries. | Ning Wang Wei-xing Zhu Xiu-mei Xing Lei Yang Ping-ping Li Wei-cheng You | 2011 | Chinese Journal of Cancer Research2011，23，1： | 9 |
| 8 | Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea显示文摘iridoid scyphiphin A1 (1a ) 的二新 epimeric 对, A2 (1b ) 和 scyphiphin B1 (2a ) , B2 (2b ) 从 Scyphiphora hydrophyllacea Gaertn 被孤立。F。他们的结构被分光镜的方法阐明。scyphiphin B1 和 scyphiphin B2 的混合由 MTT 方法在 vitro 对人的 hepatoma SMMC-7721 房间线显示出中等 cytotoxicity。 | Yan Bo Zeng Wen Li Mei You Xing Zhao Ling Zhuang Kui Hong Hao Fu Dai | 2007 | Chinese Chemical Letters2007，18，12： | 8 |
| 9 | System modeling based measurement error analysis of digital sun sensors显示文摘Stringent attitude determination accuracy is required for the development of the advanced space technologies and thus the accuracy improvement of digital sun sensors is necessary.In this paper,we presented a proposal for measurement error analysis of a digital sun sensor.A system modeling including three different error sources was built and employed for system error analysis.Numerical simulations were also conducted to study the measurement error introduced by different sources of error.Based on our model and study,the system errors from different error sources are coupled and the system calibration should be elaborately designed to realize a digital sun sensor with extra-high accuracy. | WEI M insong XING Fei WANG Geng YOU Zheng | 2015 | Instrumentation2015，2，1： | 7 |
| 10 | A cooperative interference resource allocation method based on improved firefly algorithm显示文摘To deal with the radio frequency threat posed by modern complex radar networks to aircraft,we researched the unmanned aerial vehicle(UAV)formations radar countermeasures,aiming at the solution of radar jamming resource allocation under system countermeasures.A jamming resource allocation method based on an improved firefly algorithm(FA)is proposed.Firstly,the comprehensive factors affecting the level of threat and interference efficiency of radiation source are quantified by a fuzzy comprehensive evaluation.Besides,the interference efficiency matrix and the objective function of the allocation model are determined to establish the interference resource allocation model.Finally,A mutation operator and an adaptive heuristic are integtated into the FA algorithm,which searches an interference resource allocation scheme.The simulation results show that the improved FA algorithm can compensate for the deficiencies of the FA algorithm.The improved FA algorithm provides a more scientific and reasonable decision-making plan for aircraft mission allocation and can effectively deal with the battlefield threats of the enemy radar network.Moreover,in terms of convergence accuracy and speed as well as algorithm stability,the improved FA algorithm is superior to the simulated annealing algorithm(SA),the niche genetic algorithm(NGA),the improved discrete cuckoo algorithm(IDCS),the mutant firefly algorithm(MFA),the cuckoo search and fireflies algorithm(CSFA),and the best neighbor firefly algorithm(BNFA). | Huai-xi Xing Hua Wu You Chen Kun Wang | 2021 | Defence Technology(防务技术)2021，17，4： | 7 |
| 11 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 12 | Tunable and multichannel terahertz perfect absorber due to Tamm surface plasmons with graphene显示文摘In this paper, we have shown that perfect absorption at terahertz frequencies can be achieved by using a composite structure where graphene is coated on one-dimensional photonic crystal(1 DPC) separated by a dielectric. Due to the excitation of optical Tamm states(OTSs) at the interface between the graphene and 1 DPC, a strong absorption phenomenon occurs induced by the coupling of the incident light and OTSs. Although the perfect absorption produced by a metal–distributed Bragg reflector structure has been researched extensively, it is generally at a fixed frequency and not tunable. Here, we show that the perfect absorption at terahertz frequency not only can be tuned to different frequencies but also exhibits a high absorption over a wide angle range. In addition,the absorption of the proposed structure is insensitive to the polarization, and multichannel absorption can berealized by controlling the thickness of the top layer. | XI WANG XING JIANG QI YOU JUN GUO XIAOYU DAI YUANJIANG XIANG | 2017 | Photonics Research2017，5，6： | 7 |
| 13 | A New Genus of Psittacosauridae (Dinosauria: Ornithopoda) and the Origin and Early Evolution of Marginocephalian Dinosaurs显示文摘An almost complete juvenile dinosaur skull with lower jaw was discovered from the Early Cretaceous Yixian Formation in Beipiao, Liaoning Province, China. Here, the specimen is described and a cladistic analysis is performed in order to find its phylogenetic relationships. The result shows that this specimen represents a new genus of Psittacosauridae, Hongshanosaurus houi, gen. et sp. nov., and confirms the monophyletic status for Ceratopsia and Marginocephalia. However, Heterodontosaurus is found to be the sister taxon to Marginocephalia, rather than a basal Omithopoda. | YOU Hailu Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037XU Xing and WANG XiaolinInstitute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences, Beijing 100044 | 2003 | Acta Geologica Sinica(English Edition)2003，77，1： | 6 |
| 14 | Study of high-precision earth sensor with triple-FOV显示文摘Earth sensors are widely used in spacecraft for attitude determination. They need to have a very large field of view(FOV)( > 120°) and relatively low accuracy while being used in the aircrafts around orbit. A triple-FOV infrared earth sensor is proposed in this paper. It uses three pieces of standard infrared detectors with a wavelength range of 14;16μm,to sense the horizontal circle by detecting the infrared light emitted from the earth. From which,the geocentric vector can be obtained. A mathematic model is established and a validation model is set up to provide input parameters for the mathematic model. The simulation results of the two models show that the output of the mathematic model coincides with the known parameters. Based on the above analysis,a prototype has been built and tested. The test results show that the angle measurement error is about 0. 002° and hence such a triple-FOV earth sensor is capable to provide high-precision position information for autonomous navigation. | WANG Hongjian XING Fei YOU Zheng CHU Daping ZHENG Lungui | 2014 | Instrumentation2014，1，2： | 6 |
| 15 | Research on dynamic performance of star tracker显示文摘This manuscript briefly summarizes the development trends and recent research focus of the star tracker.And the relevant technologies about dynamic performance of the star tracker are analyzed and discussed.These can provide reference for the star tracker and attitude measurement device researchers. | SUN Ting XING Fei YOU Zheng | 2015 | Instrumentation2015，2，1： | 6 |
| 16 | A real-time detection and positioning method for small and weak targets using a 1D morphology-based approach in 2D images显示文摘A small and weak target detection method is proposed in this work that outperforms all other methods in terms of real-time capability.It is the first time that two-dimensional(2D)images are processed using only one-dimensional1D structuring elements in a morphology-based approach,enabling the real-time hardware implementation of the whole image processing method.A parallel image readout and processing structure is introduced to achieve an ultra-low latency time on the order of nanoseconds,and a hyper-frame resolution in the time domain can be achieved by combining the row-by-row structure and the electrical rolling shutter technique.Experimental results suggest that the expected target can be successfully detected under various interferences with an accuracy of 0.1 pixels(1σ)under the worst sky night test condition and that a centroiding precision of better than 0.03 pixels(1σ)can be reached for static tests.The real-time detection method with high robustness and accuracy is attractive for application to all types of real-time small target detection systems,such as medical imaging,infrared surveillance,and target measurement and tracking,where an ultra-high processing speed is required. | Min-Song Wei Fei Xing Zheng You | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 17 | Structure,Orientation and Finite Element Analysis of the Tail Club of Mamenchisaurus hochuanensis显示文摘The structure and orientation of the posterior extremity (tail club) of the caudal vertebrae of Mamenchisaurus hochuanensis Young and Chao, 1972 from the Upper Jurassic Shangshaximiao Formation has been analyzed to determine the tail club function using Finite Element Analysis. Of the four caudal vertebrae composing the tail club, the second largest (C'1') was probably the most proximal, and is fixed with the preceding sequence of the caudal vertebrae, whereas the smallest (C'4') is free and forms the termination of the tail club. Our analysis also suggests that the tail club is more efficient in lateral swinging rather than up-and-down motion, and that the best region for the tail club to impact is at the spine of the largest of the four caudals (C'2'), with a maximum load for impact at about 450 N. The tail club of Mamenchisaurus hochuanensis probably also had limitations as a defense weapon and was more possibly a sensory organ to improve nerve conduction velocity to enhance the capacity for sensory perception of its surroundings. | XING Lida YE Yong SHU Chunkang PENG Guangzhao YOU Hailu | 2009 | Acta Geologica Sinica(English Edition)2009，83，6： | 5 |
| 18 | Space high-accuracy intelligence payload system with integrated attitude and position determination显示文摘recently,the requirements for space high resolution and high accuracy earth observation payloads are more urgent in many fields.However,traditional satellites mainly use the separation model of platform and payload.The precision of platform was unable to fulfill the requirements of high-precision imaging of payload.In addition,because traditional satellites mainly use the rigid connection between platform and payload,the precision of payload strongly depends on platform.They make satellite development and requirements increasingly difficult.To solve these disadvantages,in this paper,we introduce a Space High-accuracy integrated Intelligence Payload(SHIP) system with real-time attitude and position determination.SHIP can complete real time autonomous high accuracy attitude and position determination,high resolution remote sensing imaging,high-accuracy target position based on image,multi-mode motion imaging and target identification,tracking,self-recovery function of on orbit image,self-determination function of attitude and position,and so on. | LI Jin XING Fei SUN Ting LIU Zengyi YOU Zheng | 2015 | Instrumentation2015，2，1： | 5 |
| 19 | Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels显示文摘在高集中的客观甲醛是一个贡献者让污染通风。它也是在房间的一个内长的新陈代谢的产品,并且什么时候在生理的集中以外,在神经原上有病理学的效果。甲醛在癌症疼痛模型导致外部 nociceptive 神经原的记忆功能,以及刺激的 neuronal 字形物蛋白质,海马趾的 neuronal apoptosis,认知缺陷和损失的合拢 mis 和聚集。细胞内部的钙([Ca2+] 我) 是一个重要细胞内部的送信人,并且在许多病理学的过程起一个关键作用。现在的学习试图调查甲醛的效果在上[Ca2+] i 和 N-methyl-D-aspartate 受体(NMDAR ) 和房间膜上的 T 类型 Ca2+ 隧道的可能的参与。把主要有教养的海马趾的神经原用作一个模型,的方法变化[Ca2+] 我被共焦的激光扫描面对在低集中的甲醛检测显微镜学。在近似加倍的 1 mmol/L 的结果甲醛[Ca2+] 我。( 2R ) -amino-5-phosphonopentanoate ( AP5 , 25 mol/L ,一个 NMDAR 对手)并且 mibefradil ( MIB , 1 mol/L ,T类型Ca2+隧道 blocker ),在甲醛灌注以后给 5 min ,部分各禁止了导致甲醛的增加[Ca2+]我,并且这禁止的效果被 AP5 和 MIB 的联合申请增强。什么时候在甲醛灌注前使用了 3 min, AP5 (甚至在 50 mol/L ) 没禁止导致甲醛的增加[Ca2+] 我,而是 MIB (1 mol/L ) 显著地在 70% 禁止了这增加。这些结果在低集中建议那甲醛的结论增加[Ca2+] 在有教养的海马趾的神经原的 i;NMDAR 和 T 类型 Ca2+ 隧道可以涉及这个过程。 | Ye-Nan Chi Xu Zhang Jie Cai Feng-Yu Liu Guo-Gang Xing You Wan | 2012 | Neuroscience Bulletin2012，28，6： | 4 |
| 20 | Lipid-associated membrane proteins of Mycoplasma penetrans induce production of proinflammatory cytokines in human monocytic cells显示文摘The aim of this study is to explore potential pathogenicity of Mycoplasma penetrans, and to investigate whether M.penetrans lipid-associated membrane proteins (LAMPs) could induce human monocytic cell line (THP-1) to produce some proinflammatory cytokines in vitro, including interleukin-1β(IL-1β) , tumor necrosis factor alpha (TNF-α) , and IL-8. THP-1 was stimulated with different concentrations of M .penetrans LAMPs and at different time to analyze the production of human IL-1β, TNF-αand IL-8. The protein levels of human IL-1β, TNF-αand IL-8 were measured by enzyme-linked immunoadsorbent assay (ELISA) and the mRNA levels of these proinflamrnatory cytokines were detected by reverse transcriptase -PCR (RT-PCR). It was demonstrated in the present study that the production of IL-1β, TNF-αand IL-8 increased in dose- and time-dependent manner after stimulation with M. penetrans LAMPs in THP-1 cells. M.penetrans LAMPs also induced the expression of IL-1β, TNF-αand IL-8 mRNA. The production of IL-1β, TNF-αand IL-8 and the expression of mRNA were down-regulated by pyrrolidine dithiocarbamate (PDTC). This study demonstrated that M. penetrans LAMPs can induce the production of proinflammatory cytokines in human monocytic cells in vitro, thus suggesting that it may be an important etiological factor. | YI MOU WU MIN JUN YU LI ZHI TAN XIAO XING YOU | 2006 | Journal of Microbiology and Immunology2006，4，4： | 3 |
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