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| 1 | 中国农村合作医疗的受益公平性显示文摘在中国的大多数地区所建立的合作医疗都属于“低保费、高共付率”的形式。虽然低保费更有利于贫困的农民参加合作医疗,但是,高共付率会阻碍他们实际利用医疗服务。利用2002年中国贵州省开阳县冯三镇的家庭入户调查资料,采用logistic回归模型和“四部模型”研究农民参加合作医疗的概率、合作医疗参加者对卫生服务的利用、以及农民从合作医疗获得的净收益,探索这种“低保费、高共付率”设计的合作医疗的受益公平性。结果表明,在“低保费、高共付率”模式下,合作医疗受益存在着不公平性。基于研究结果提出了政策性建议。 | 汪宏 Winnie Yip 张里程 王禄生 萧庆伦 | 2005 | 中国卫生经济2005，24，2： | 70 |
| 2 | APACHE system is better than Ranson system in the prediction of severity of acute pancreatitis显示文摘BACKGROUND: It has been suggested that addition of obesity score to the APACHE-Ⅱ system can lead to more accurate prediction of severity of acute pancreatitis. However there is scanty information on the usefulness of the combined APACHE-O scoring system in Asian patients. This study aimed to compare the accuracy of Ranson, APACHE-Ⅱ and APACHE-O systems in assessing severity of acute pancreatitis in a local Chinese population. METHODS: One hundred and one consecutive patients with acute pancreatitis were prospectively studied. Body mass index (BMI) was measured on admission. Ranson score, APACHE-Ⅱ and APACHE-O scores were recorded on admission and at 48 hours. By adopting the cut-off levels and definitions advocated in the Atlanta consensus for severe disease, the diagnostic accuracy of the three scoring systems was compared by the area under the curve (AUC) under the receiver operator characteristic curve. RESULTS: Of the 101 patients, 12 (11.9%) patients suffered from severe pancreatitis. Obesity was uncommon and only two patients (2.0%) had BMI >30. Eighty-two (81.2%) patients were normal weight (BMI≤25) whereas 17 (16.8%) were overweight ( BMI 25-30 ). Overweight or obesity (BMI >25) was not associated with severe pancreatitis (P= 0.40). The AUC for admission scores of Ranson, APACHE-Ⅱ, and APACHE-O systems was 0. 549, 0. 904 and 0. 904, respectively. The AUC for 48-hour scores of Ranson, APACHE-Ⅱ and APACHE-O systems was 0.808, 0.955 and 0.951, respectively. CONCLUSIONS: The APACHE-Ⅱ scoring system is more accurate than the Ranson scoring system of the prediction of severity in acute pancreatitis. Addition of obesity score does not significantly improve the predictive accuracy of the APACHE-Ⅱ system in our local population with a low prevalence of obesity. | Yuk Pang Yeung Billy Yeung Kit Lam Andrew Wai Chun Yip | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 41 |
| 3 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 4 | Incidence and mortality of female breast cancer in the AsiaPacific region显示文摘Objective: To provide an overview of the incidence and mortality of female breast cancer for countries in the Asia-Pacific region.Methods: Statistical information about breast cancer was obtained from publicly available cancer registry and mortality databases(such as GLOBOCAN), and supplemented with data requested from individual cancer registries. Rates were directly age-standardised to the Segi World Standard population and trends were analysed using joinpoint models.Results: Breast cancer was the most common type of cancer among females in the region, accounting for 18% of all cases in 2012, and was the fourth most common cause of cancer-related deaths(9%). Although incidence rates remain much higher in New Zealand and Australia, rapid rises in recent years were observed in several Asian countries. Large increases in breast cancer mortality rates also occurred in many areas, particularly Malaysia and Thailand, in contrast to stabilising trends in Hong Kong and Singapore, while decreases have been recorded in Australia and New Zealand. Mortality trends tended to be more favourable for women aged under 50 compared to those who were 50 years or older. Conclusion: It is anticipated that incidence rates of breast cancer in developing countries throughout the Asia-Pacific region will continue to increase. Early detection and access to optimal treatment are the keys to reducing breast cancerrelated mortality, but cultural and economic obstacles persist. Consequently, the challenge is to customise breast cancer control initiatives to the particular needs of each country to ensure the best possible outcomes. | Danny R.Youlden Susanna M.Cramb Cheng Har Yip Peter D.Baade | 2014 | Cancer Biology & Medicine2014，11，2： | 35 |
| 5 | 早产儿视网膜病变显示文摘早产儿视网膜病变(ROP)是特指发生于早产儿特别是过早产儿的以视网膜血管异常增生为病变特征的视网膜血管疾病,是发达国家儿童失明的主要病因。随着围产医学的不断发展,ROP的发病率也随之上升,而早期发现和及时合理的治疗无疑是现阶段拯救ROP患儿视功能的最重要措施。我们对近年来国内外有关ROP的研究进行综述,内容涵盖了ROP的发病、诊断、筛查、治疗以及随访等诸方面。 | 高磊 赵秀芹 Wilson Yip 林顺潮 | 2005 | 中华眼底病杂志2005，21，5： | 30 |
| 6 | 农村居民主观幸福感与健康的相关性显示文摘目的分析农村居民主观幸福感与健康之间的相关性。方法采用昨日重现法和EQ5D量表分别对主观幸福感和健康进行测量,并对二者进行相关分析。结果调查居民中有27%产生过不愉快情绪,平均有47%的时间处于不幸福状态;分别有31.9%和17.9%居民感到疼痛/不舒服、焦虑/沮丧。结论主观幸福感与健康呈正相关关系。 | 王健 孟庆跃 Winnie Yip 贾莉英 王丽娜 | 2008 | 山东大学学报(医学版)2008，46，9： | 22 |
| 7 | IEC 61850应用于分布式馈线自动化系统的模型显示文摘远传型故障指示器或功能模块可以检测配电线路各区段的故障并上传检测结果,从而为分布式馈线自动化(FA)进行故障区间定位提供判断依据。以IEC 61580-90-6技术报告所提出的故障指示功能为基础,构建基于IEC 61850的分布式馈线自动化的系统模型,提出了分布式故障区间定位、隔离和供电恢复的逻辑节点。扩展现有的IEC 61850系统配置语言(SCL)模型以描述配电网的一次拓扑和逻辑功能配置。给出IEC 61850应用于馈线自动化系统的通信服务映射。最后,提出了变电站自动化和馈线自动化系统进行数据交换的配置流程。通过应用示例表明,所提出的IEC 61850信息模型可以支持分布式馈线自动化功能和终端之间的互操作。 | 朱正谊 徐丙垠 Tony YIP 陈羽 于强强 李妍 | 2018 | 电力系统自动化2018，42，23： | 22 |
| 8 | 农村居民主观幸福感及其影响因素研究显示文摘和谐社会是社会发展目标和前进方向,我国有9亿农民,农民感觉幸福是和谐社会建设的关键。文章采用昨日重现法,对农村居民的主观幸福感及其影响因素进行了测量和分析。结果表明:被调查居民平均有12.79%的时间处于不幸福状态;有27.00%的居民U指数大于0,均数为47.03%,说明平均有47.03%的时间处于不幸福状态;不同特征人群的主观幸福感不同;Logistic回归分析发现调查县、文化程度、相对经济状况、失眠状况、心情抑郁和时间压力对主观幸福感有影响。 | 王健 孟庆跃 Winnie Yip 王丽娜 曲江斌 贾莉英 孙强 | 2009 | 中国卫生经济2009，28，3： | 20 |
| 9 | 基于换电和电池租赁模式的纯电动汽车运营成本评估及预测研究显示文摘在纯电动汽车示范运营中,动力电池运营价格测算是开展电池租赁模式的重要前提,目前尚无成熟方法并缺少可靠数据。本文运用成本加成定价法和年金法,在裸车销售,电池租赁模式下,在充换电站建设、运营和电池租赁由两个主体承担的条件下,对电池运营价格进行了测算;同时,应用影响因素敏感性分析方法,结合北京市纯电动公交车实际运营数据,分析了电池系统价格、贴现率、年人工成本、年充电量和充电基础设施初期投资等因素对动力电池运营价格的影响,得出电池价格和充电量是影响运营价格的最敏感因素。根据连续4年的小型成熟二次锂电池价格历史数据和燃油价格趋势,预测并比较了未来几个四年电动汽车和传统汽车的运营费用,最终提出了未来电动汽车产业发展的建议。 | 孙丙香 何婷婷 牛军龙 张维戈 姜久春 Tony Yip | 2014 | 电工技术学报2014，29，4： | 18 |
| 10 | Hepatocellular carcinoma in central Sydney :a 10yearreview of patients seen in a medical oncology department显示文摘AIM To report a single Australian oncology unit′s experience with the management of patients with hepatocellular carcinoma (HCC), in the context of a literature review of the current management issues. METHODS Retrospective case record review of 76 patients with diagnosis of HCC referred to the unit between 1984 and 1995. RESULTS Sixty three patients had adequate records for analysis. Thirty six (56%) were migrants with half from Southeast Asia. Twenty four patients had a documented viral aetiology. Nine (14%) of 51 patients with pathological confirmation of HCC had normal alpha fetoprotein levels. Median survival of the 20 patients managed palliatively was 5 weeks compared to 16 weeks for the cohort overall. Surgery in 16 patients rendered all initially disease free with a median survival of 88 weeks. Chemoembolisation induced tumor responses in 5 of the 11 patients so treated. Systemic chemotherapy and tamoxifen treatment caused tumor response in two of 12 and one of 25 respectively. CONCLUSION Prolonged survival of patients with HCC depends on early detection of small tumors suitable for surgical resection. Other active treatments are palliative in intent and have limited success. In addition to tumor response and survival duration, the toxicities of therapies and the overall quality of life of patients need to be considered as important outcomes. Viral hepatitis prevention and screening of individuals at risk are strategies that are important for HCC management in communities where the disease is endemic. | Desmond Yip 1, Michael Findlay 2, Michael Boyer 1 and Martin H. Tattersall 3 | 1999 | World Journal of Gastroenterology1999，5，6： | 17 |
| 11 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 12 | 替诺福韦可降低慢性HBV感染者发生肝细胞癌的风险显示文摘【据《Gastroenterology》2020 年1 月报道】题:在中国,替诺福韦与恩替卡韦相比,可降低慢性HBV 感染者发生肝细胞癌的风险(作者Yip TC 等)在慢性HBV 感染者中,用替诺福韦治疗与恩替卡韦治疗罹患肝细胞癌(HCC)风险的研究结果相互矛盾。 | 冯丽娜 金清龙 YIP TC WONG VW CHAN HL | 2020 | 临床肝胆病杂志2020，36，2： | 17 |
| 13 | Pathological mechanisms and therapeutic strategies for Alzheimer's disease显示文摘Alzheimer's disease is a rather complex neurodegenerative disease,which is attributed to a combination of multiple factors.Among the many pathological pathways,synaptic dysfunctions,such as synapses loss and deficits in synaptic plasticity,were thought to be strongly associated with cognitive decline.The deficiencies in various sorts of neurotransmissions are responsible for the multifarious neurodegenerative symptoms in Alzheimer's disease,for example,the cholinergic and glutamatergic deficits for cognitive decline,the excitatory and inhibitory neurotransmission dyshomeostasis for synaptic plasticity deficits and epileptiform symptoms,and the monoamine neurotransmission for neuropsychiatric symptoms.Amyloid cascade hypothesis is the most popular pathological theory to explain Alzheimer's disease pathogenesis and attracts considerable attention.Multiple lines of genetic and pathological evidence support the predominant role of amyloid beta in Alzheimer's disease pathology.Neurofibrillary tangles assembled by microtubule-associated protein tau are other important histopathological characteristics in Alzheimer's disease brains.Cascade of tau toxicity was proved to lead to neuron damage,neuroinflammation and oxidative stress in brain.Ageing is the main risk factor of neurodegenerative diseases,and is associated with inflammation,oxidative stress,reduced metabolism,endocrine insufficiencies and organ failures.These aging related risk factors were also proved to be some of the risk factors contributing to Alzheimer's disease.In Alzheimer's disease drug development,many good therapeutic strategies have been investigated in clinical evaluations.However,complex mechanism of Alzheimer's disease and the interplay among different pathological factors call for the come out of allpowerful therapies with multiple curing functions.This review seeks to summarize some of the representative treatments targeting different pathological pathways currently under clinical evaluations.Multi-target therapies as an emerging strategy for Alzheimer's disease treatment will be highlighted. | Yaojun Ju Kin Yip Tam | 2022 | Neural Regeneration Research2022，17，3： | 16 |
| 14 | UDP-glucose pyrophosphorylase2 (OsUgp2), a pollen-preferential gene in rice, plays a critical role in starch accumulation during pollen maturation显示文摘UDP-glucose pyrophosphorylase (UGPase) is predominantly present and plays significant role in carbohydrate metabolism in plants. Two homologous UGPase genes, OsUgp1 and OsUgp2, exist in rice genome. OsUgp1 has recently been reported to be essential for callose deposition during pollen mother cell and meiosis stages as well as for seed carbohydrate metabolism. In this study, a full-length cDNA of OsUgp2 was isolated from rice anther. Northern blot and RNA in situ hybridization indicated that the expression of OsUgp2 was preferentially in pollen and developmentally regulated. No transcripts were found in leaf, stem, lemma/palea, ripening grain and florets before the uninucleate microspore developmental stage, but a large quantity of OsUgp2 mRNA was found in pollen at the binucleate and mature stages. The immunolocalization of OsUgp2 showed a similar expression pattern to that by RNA in situ hybridization. The function of OsUgp2 was investigated by dsRNA-mediated transcriptional gene silencing. The pollen fertility of 16 independent transgenic rice plants was found between 25% and 90%, which was correlated with the amount of OsUgp2 mRNA. The results of morphological changes and starch variation during pollen development in transgenic rice showed that the abnormal feature of pollen development appeared after the uninucleate microspore stage. Starch failed to accumulate in pollen and thus led to sterile pollens. These results demonstrated that OsUgp2 is a pollen-preferential 'late gene' and plays a key role during pollen maturation, especially for starch accumulation. OsUgp2 complements OsUgp1 to fulfill the UGPase’s functions necessary for the full process of pollen development. | MU Hong KE JianHao LIU Wei ZHUANG ChuXiong YIP WingKin | 2009 | Chinese Science Bulletin2009，54，2： | 15 |
| 15 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 16 | Wafer-scale synthesis of monolayer WS2 for high-performance flexible photodetectors by enhanced chemical vapor deposition显示文摘 | Changyong Lan Ziyao Zhou Zhifei Zhou Chun Li Lei Shu Lifan Shen Dapan Li Ruoting Dong SenPo Yip Johnny C. Ho | 2018 | Nano Research2018，11，6： | 12 |
| 17 | Synthesis of an AIE-active fluorogen and its application in cell imaging显示文摘A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor. | LAM Jacky Wing Yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian | 2009 | Science China Chemistry2009，52，1： | 12 |
| 18 | 颈动脉狭窄:无创伤性检查的准确性——个体病人数据的Meta分析显示文摘目的评价临床相关的无创伤性影像学检查——US、CT血管成像、MR血管成像和MR增强血管成像对于诊断重度和中度有症状的颈动脉狭窄的准确性;确定先期各种特异性临床因素和临床表现对诊断准确性的影响:评估两种无创性检查的一致性。方法利用原始检查资料得到伦理委员会认可。所有的资料都是匿名的。利用个体病例无创性影像学检查的资料(IPDS)评估有症状的颈动脉狭窄的敏感度、特异度和一致性:比较同侧与对侧动脉:比较IPDs与文献的评估结果; | F.M. Chappell J.M. Wardlaw G.R. Young J.H. Gillard G.H. Roditi B. Yip 郑梅竹(译) 夏爽(校) | 2009 | 国际医学放射学杂志2009，32，4： | 12 |
| 19 | 多方共赢的政策设计案例:宁夏盐池县县级医院包干制显示文摘2009年以来,我国多个地区都开展了各具特色的卫生改革尝试。总结这些改革的经验对于深化我国医药卫生体制有着积极意义。文章以宁夏回族自治区盐池县县级医院支付制度改革为核心,系统阐述了这次改革的政策安排并对政策效果进行了初步的评价。通过剖析这些安排对医疗服务提供者的激励作用,着重分析了这次改革如何实现'医、患、保多方共赢'的政策目标。 | 简伟研 Winnie Yip William Hsiao 陈文 胡敏 | 2014 | 中国卫生经济2014，33，11： | 11 |
| 20 | 乳胶手套中总的可溶性蛋白质的测定——RRIM和ASTM测定法的对比显示文摘1摘要采用两种常用的测定法,即马来西亚橡胶研究所(RRIM)和美国材料试验学会(ASTM)各自修订的Lowry测定法[简称RRIM法(MS 1392:96P)和ASTM法(D5712-95)],测定了乳胶手套中总的可溶性蛋白质(EP),并研究了它们的相关性. | ESAH YIP 李普旺 | 2001 | 热带农业工程2001，26，2： | 10 |
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