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| 1 | Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells显示文摘橡黄素是自然地发生之一饮食的黄酮醇混合物。它在植物富有地是在场的并且有 chemopreventive 和 anticancer 效果。调查它的 anticancer 机制,我们对尖锐白血病房间线检验了橡黄素的活动, HL-60。我们的结果证明橡黄素禁止了房间增长并且在一个时间依赖者和剂量依赖者举止导致了 apoptosis。而且,橡黄素下面调整 anti-apoptosis 蛋白质 Bcl-2 的表示并且起来调整 pro-apoptosis 蛋白质 Bax 的表示。Caspase-3 被橡黄素也激活,它开始了一条 caspase-3-depended mitochodrial 小径导致 apoptosis。橡黄素禁止了 cycloocygenase-2 (Cox-2 ) 的表示,这也被发现 mRNA 和 Cox-2 蛋白质。一起拿,这些调查结果建议橡黄素由禁止 Cox-2 表示在一条 caspase-3-dependent 小径导致 apoptosis 并且调整下游的 apoptotic 部件的表示,包括 Bcl-2 和 Bax。橡黄素能是可能安全地在白血病治疗被使用的一个有势力和有希望的药。 | Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 28 |
| 2 | Effect of contrast-enhanced ultrasound on differential diagnosis of intrahepatic cholangiocarcinoma and arterial phase enhanced hepatic inflammatory lesions显示文摘Objective: To investigate differential diagnosis between intrahepatic cholangiocarcinoma(ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound(CEUS).Methods: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve(TIC), including the arrival time, peak intensity(PI) in the lesions, the starting time for washout, and the intensity difference at 3 min(ΔI_3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions.Results: Twenty-five ICC and fifteen inflammatory patients were included in this study. Seventeen ICC(68.0%)and two inflammatory cases(13.3%) showed bile duct dilatation on conventional ultrasound. Using CEUS, three ICC cases(12.0%) were misdiagnosed as inflammatory lesions and three inflammatory lesions(20.0%) as ICC; two ICC(8.0%) and one inflammatory case(6.7%) could not be made definite diagnosis. Washout started at 34.5±3.5 s and 61.5±12.9 s for ICC and inflammatory lesions respectively(P<0.001). The intensity difference between lesion and liver parenchyma at 3 min after contrast agent injection was 10.8±3.1 dB in ICC and 4.2±2.3 dB in inflammatory group(P<0.001). The sensitivity and specificity differentiating ICC and inflammatory lesions were76% and 87% if the cut-off value of the intensity difference was 7.7 d B.Conclusions: Combined with TIC analysis, and particularly with the characteristic of the early-starting and obvious washout in ICC, CEUS can be useful in differential diagnosis between hepatic inflammatory lesions and ICC. | Shanshan Yin Qiuli Cui Kun Yan Wei Yang Wei Wu Liping Bao Minhua Chen | 2017 | Chinese Journal of Cancer Research2017，29，3： | 13 |
| 3 | Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China显示文摘To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency. | Song Chen Shaowen Liu Xi Zheng Min Yin Guang Chu Chunmei Xu Jinxiang Yan Liping Chen Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，6： | 13 |
| 4 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 5 | The long-term prediction of the oil-contaminated water from the Sanchi collision in the East China Sea显示文摘The condensate and bunker oil leaked from the Sanchi collision would cause a persistent impact on marine ecosystems in the surrounding areas. The long-term prediction for the distribution of the oil-polluted water and the information for the most affected regions would provide valuable information for the oceanic environment protection and pollution assessment. Based on the operational forecast system developed by the First Institute of Oceanography, State Oceanic Administration, we precisely predicted the drifting path of the oil tanker Sanchi after its collision. Trajectories of virtual oil particles show that the oil leaked from the Sanchi after it sank is mainly transported to the northeastern part of the sink location, and quickly goes to the open ocean along with the Kuroshio. Risk probability analysis based on the outcomes from the operational forecast system for years 2009 to2017 shows that the most affected area is at the northeast of the sink location. | YIN Liping ZHANG Min ZHANG Yuanling QIAO Fangli | 2018 | Acta Oceanologica Sinica2018，37，3： | 9 |
| 6 | Effects of AMF on soil enzyme activity and carbon sequestration capacity in reclaimed mine soil显示文摘A series of pot experiments and field trials were carried out to evaluate the effects of arbuscular mycorrhizal fungi(AMF) on activities of soil enzymes and carbon sequestration capacity in reclaimed mine soil.A complex substrate of coal gangue,fly ash and sludge was used as reclaimed mine soil,and ryegrass was planted with AMF inoculation to construct a plant-complex substrate-microbe ecological restoration system.The changes to the soil organic carbon(SOC),activities of soil enzymes and glomalin-related soil protein(GRSP) were measured and the effects of AMF on activities of soil enzymes and carbon sequestration capacity in reclaimed mine soil were analyzed.The results show that the contents of GRSP(total glomalin(TG) and easily extractable glomalin(EEG)),SOC and activities of enzymes increased,and the increments were higher in the AMF inoculation treated plant-complex substrate-microbe ecological restoration systems than those with no AMF inoculated treatments after 12 months of ryegrass growth.TG,EEG and soil enzyme activity have a significant positive correlation,and the correlative coefficient was 0.427-0.573;SOC and TG,EEG have a significant positive correlation(p < 0.01),indicating that AMF plays an important role in carbon sequestration of reclaimed mine soils. | Qian Kuimei Wang Liping Yin Ningning | 2012 | International Journal of Mining Science and Technology2012，22，4： | 9 |
| 7 | Overview of Relation between Mineral Nutrient Elements and Growth and Development of Fruit Trees显示文摘Mineral nutrition is the material basis for growth and development,yield and quality of fruit trees. It exerts a great effect on the growth and development,fruit quality,yield,and resistance of fruit trees. On the basis of reading a large number of references both at home and abroad,this paper elaborated the relationship between mineral nutrient elements and growth and fruit yield and quality of fruit trees,so as to make proper fertilizer mixing,balance the fertilizer application,promote growth and development of fruit trees,and increase the yield of fruit trees and improve the fruit quality. | Liping HUANG Qianru ZHANG Zheng ZHANG Rong YIN Jing ZHANG Ping YANG | 2017 | Asian Agricultural Research2017，9，10： | 7 |
| 8 | SKP2 siRNA inhibits the degradation of P27^kip1 and down-regulates the expression of MRP in HL-60/A cells显示文摘S 阶段联系 kinase 的蛋白质 2 (SKP2 ) 基因是肿瘤 suppressor 基因,并且涉及 P27kip1 的调停 ubiquitin 的降级。SKP2 和 P27kip1 影响通过调整白血病房间的增长, apoptosis 和区别继续和白血病的预后。在这研究,我们探索了通过 SKP2 下面规定 HL-60/A 药抵抗逆行的机制。HL-60/A 房间是由有 SKP2 siRNA 的 Amaxa Nucleofector 系统的 nucleofected。Skp2, P27kip1,和多药抵抗的基因和蛋白质表示层次联系了蛋白质(MRP ) 被反向的抄写聚合酶链反应和西方的污点分析分别地决定。房间周期被流动 cytometry 分析。50% 禁止的集中价值在 chemotherapeutics 的不同集中下面根据这些二种房间的死亡率用细胞毒素的分析被计算比较房间的敏感。HL-60/A 房间显示出由抗力移转特征的多药抵抗显型到 adriamycin, daunorubicin,和 arabinosylcytosine,由于 MRP 的表示。我们发现 SKP2 的表示比在 HL-60 房间在 HL-60/A 房间是更高的,但是 P27kip1 的表示更低。而 P27kip1 的蛋白质水平是起来调整的,在由 SKP2 siRNA 的 HL-60/A 房间 nucleofected 的 SKP2 的表示是下面调整的。与在控制组(由控制 siRNA 的 nucleofected ) 的 MRP 表达式水平相比, mRNA 和蛋白质表达式由 SKP2 siRNA 在 HL-60/A 房间 nucleofected MRP 铺平更低,并且后者房间对 adriamycin, daunorubicin,和 arabinosylcytosine 更敏感。下面调整在 G0/G1 阶段的 SKP2 表示和逮捕房间与下面调整的 MRP 改进白血病房间的药敏感表示。 | Jie Xiao Songmei Yin Yiqing Li Shuangfeng Xie Danian Nie Liping Ma Xiuju Wang Yudan Wu Jianhong Feng | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 7 |
| 9 | Hepatoprotective and antioxidant effects of dietary Glycyrrhiza polysaccharide against TCDD-induced hepatic injury and RT-PCR quantification of AHR2,ARNT2,CYPIA mRNA in Jian Carp(Cyprinus carpio var.Jian)显示文摘To evaluate the protective effects of Glycyrrhiza polysaccharide(GPS) against 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced hepatotoxicity in Jian carp,the fish were fed diets containing GPS at doses of 0.1,0.5 and 1.0 g/kg for 60 days before an intraperitoneal injection of 0.6 μg/kg TCDD at a volume of 0.05 mL/10 g body weight.At 72 hr post-injection,blood and liver samples were taken for biochemical analysis and the fish liver samples were used for the preparation of pathological slices.The results showed that increases in alanine aminotransferase(GPT),aspartate aminotransferase(GOT),lactate dehydrogenase(LDH),and alkaline phosphatase(AKP) in serum induced by TCDD were significantly inhibited by pre-treatment with 1.0 g/kg GPS.Following the 1.0 g/kg GPS pre-treatment,total protein(TP),albumin(Alb),catalase(CAT),glutathione peroxidase(GPx),total antioxidant capacity(T-AOC) and superoxide dismutase(SOD) activities in liver tissue increased significantly,malondialdehyde(MDA) formation(P < 0.05 or P < 0.01) was significantly inhibited,and the expression of cytochrome P4501A(CYP1A),aryl hydrocarbon receptor 2(AHR2) and aryl hydrocarbon receptor nuclear translocator 2(ARNT2) mRNA(P < 0.05) was significantly enhanced.Histological observations on fish liver were obtained by preparing paraffin tissue sections via HE staining,and the results showed that histological changes were obviously reduced by 0.5 and 1.0 g/kg GPS.GPS significantly reduced liver tissue damage caused by TCDD.Overall,these results proved the hepatoprotective effect of GPS in protecting against fish liver injury induced by TCDD,and supported the use of GPS(1.0 g/kg) as a hepatoprotective and antioxidant agent in fish. | Jinliang Du Liping Cao Rui Jia Guojun Yin | 2017 | Journal of Environmental Sciences2017，29，1： | 7 |
| 10 | NECK LEAF 1, a GATA type transcription factor, modulates organogenesis by regulating the expression of multiple regulatory genes during reproductive development in rice显示文摘在 monocot 米饭种类 Oryza sativa L. ,最惹人注目的词法过程之一在繁殖开发期间是有上面的 internodes (合众国际社) 的顺序的延伸的圆锥花序开发的同时发生。阐明内在的分子的机制,我们克隆米饭基因颈叶 1 (NL1 ) ,什么时候变异,它在 flowering 时间,有簇叶丛生的苞的更小的圆锥花序和反常合众国际社延伸模式导致延期。NL1 基因与一个单个锌手指领域,和它的抄本编码一个 GATA 类型抄写因素在苞 primordia 主要被检测,它通常在野类型的植物堕落。在转基因的植物的 NL1 的 Overexpression 经常产生严重生长延迟,不太植物的 phytomers 和更小的叶子,建议 NL1 起在器官区别的一个重要作用。PLASTOCHRON1 (PLA1 ) 的新奇变异的等位基因,知道在调整叶开始起一个关键作用的基因,在这研究被识别。基因分析表明了在 nl1 和 pla1 之间的一个相互作用,与 PLA1 在上游的代理的 NL1。表示水平和 PLA1 的空间模式被发现在 nl1 被改变变异。而且, flowering, Hd3a 和 OsMADS1 的二个管理者的表示,也在 nl1 异种被影响。根据这些调查结果,我们建议 NL1 是通过在米饭在繁殖开发期间调整 PLA1 和另外的规章的基因的表示调制并且协调 organogenesis 的一个内在的因素。 | Liping Wang Hengfu Yin Qian Qian Jun Yang Chaofeng Huang Xiaohe Hu Da Luo | 2009 | Cell Research2009，19，5： | 6 |
| 11 | Development of a disease-specific health-related quality of life questionnaire for patients with post-stroke spasticity显示文摘OBJECTIVE:This study was designed to develop a disease-specific health-related quality of life(HR-QOL) measure for patients with post-stroke spasticity.METHODS:Based on responses from 20 patients with post-stroke spasticity and an extensive literature search,items potentially used to measure these patients' recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire(ASPQ) was formed.A sample of 106 patients was then tested twice using the ASPQ,the Self-rating Depression Scale(SDS) and the Stroke-specific Quality of Life(SS-QOL).Clinicians also examined all the patients using the Ashworth Scale(AS).Internal reliability was assessed using Cronbach's coefficient α,while construct validity was determined using principal component analysis(PCA).Empirical validity was evaluated between patients with depression and those without depression by single factor analysis.Sensitivity was examined by calculating the Spearman correlation coefficient between the changes in scores of the ASPQ,the AS and the SS-QOL.RESULTS:The ASPQ had adequate internal consistency reliability(α=0.874) and sensitivity,with significant correlations between the changes in scores of the AS,the SS-QOL and the ASPQ,with three domains.In a construct validity test,six factors were extracted;the overall variance explained by all factors was 72.6%.For empirical validity,mean values of 19 items and 3 domains were all higher in the depressive patients than in the non-depressive patients.CONCLUSION:The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in patients with post-stroke spasticity. | Yanhong Zhang Baoyan Liu Zhishun Liu Yin Wang Hong Zhao Mingjie Zi Liping Wang Hong Liu Zhen Chen Ying Xie | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 5 |
| 12 | Dynamic temperature prediction of electronic equipment under high altitude long endurance conditions显示文摘Unmanned Aerial Vehicle(UAV) is developing towards the direction of High Altitude Long Endurance(HALE). This will have an important influence on the stability of its airborne electronic equipment using passive thermal management. In this paper, a multi-node transient thermal model for airborne electronic equipment is set up based on the thermal network method to predict their dynamic temperature responses under high altitude and long flight time conditions. Some relevant factors are considered into this temperature prediction model including flight environment,radiation, convection, heat conduction, etc. An experimental chamber simulating a high altitude flight environment was set up to survey the dynamic thermal responses of airborne electronic equipment in a UAV. According to the experimental measurement results, the multi-node transient thermal model is verified without consideration of the effects of flight speed. Then, a modified way about outside flight speed is added into the model to improve the temperature prediction performance. Finally, the corresponding simulation code is developed based on the proposed model. It can realize the dynamic temperature prediction of airborne electronic equipment under HALE conditions. | Liping PANG Miao ZHAO Kun LUO Yongli YIN Zhou YUE | 2018 | Chinese Journal of Aeronautics2018，31，6： | 4 |
| 13 | Construction of cDNA library from iron-deficiency induced maize roots and screening and identification of iron-stress gene Fdr3显示文摘To isolate Fe-deficient related (Fdr) genes, an expression cDNA library of 4.5×105 pfu/μg has been constructed from maize roots in iron-stress. 6 clones have been screened from the cDNA library by differential hybridization screening. It is proved that an Fdr3 cDNA clone expressed stronger under iron-deficient condition than under iron-sufficient one by Northern blot and Western blot. | YIN Liping QI Xiaoting LIU Xianglin HUO Chunyan BAI Yanxia QIU Zesheng ZHANG Fusuo | 2000 | Chinese Science Bulletin2000，45，12： | 4 |
| 14 | Rotifer community structure and its response to environmental factors in the Backshore Wetland of Expo Garden,Shanghai显示文摘We investigated rotifer community structure in the Backshore Wetland of the Expo Garden in Shanghai from September 2009 to August 2010.We identified 116 rotifer species,determined the dominant species and their relationships with environmental factors,and community diversity indices.Polyarthra trigla was the most common species over the four seasons and proportionally most dominant in spring and autumn,whereas Cephalodella exigua and Keratella cochlearis were the most dominant species in winter and summer,respectively.There was seasonal variability in species numbers,with the highest numbers in summer,followed by autumn and winter.The mean annual density was 815±1346 ind./L and the biomass was 0.3649±0.4940 mg/L.There were significant differences between months:the highest density(2723±2926 ind./L)and biomass(0.7938±0.8197 mg/L)occurred in June,while the lowest density(238±271 ind./L)and biomass(0.0476±0.0429 mg/L)occurred in May.Canonical correspondence analysis(CCA)indicated that temperature,pH,nitrite nitrogen(NO2-N),and total phosphorus(TP)were the most important abiotic factors affecting rotifer distribution.Our research showed that the adaptability of the rotifers to temperature was the important factor. | Liping Yin Yu Ji Yinjiang Zhang Linxuan Chong Lijing Chen | 2018 | Aquaculture and Fisheries2018，3，2： | 4 |
| 15 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 16 | Safety and efficacy of Compound Huangdai Tablets combined with all-trans retinoic acid for treatment of acute promyelocytic leukemia:Clinical evidence and potential mechanisms显示文摘Objective:To evaluate the safety and efficacy of Compound Huangdai Tablets(Realgar-Indigo Naturalis formula,RIF)combined with all-trans retinoic acid(ATRA)to treat acute promyelocytic leukemia(APL).Methods:This study was registered in PROSPERO(CRD42018108118).The relevant literatures on RIF treatment of APL were systematically searched in the following databases:China National Knowledge Infrastructure,Wanfang,VIP Medical Information System,Chinese Biomedical Database,EMBASE,Cochrane Library,and PubMed.The quality of the included studies was evaluated and Review Manager 5.3 software and Stata 13.0 software were used to perform the Meta-analysis.In addition,this study used the method of network pharmacology to conduct a preliminary exploration of the mechanism of RIF on APL.Results:The study included 12 studies involving 775 APL patients.The Meta-analysis showed that there was no significant difference(P>0.05)between the RIF group and the arsenic trioxide(ATO)group for primary outcomes,secondary outcomes apart from liver dysfunction.The incidence of liver dysfunction(P=0.006)in the RIF group were significantly lower than those in the ATO group.In addition,the cost of maintenance therapy in the RIF group was significantly lower(P<0.05)than the ATO group.Besides,the active ingredients in RIF mainly act on targets proteins such as ACHE,NCOA2,RXRA,and then play a role in the treatment of APL through regulating multiple molecular mechanisms,such as TP53 regulates transcription of cell cycle genes,nuclear receptor transcription pathway.Conclusion:There was no significant difference in efficacy of oral RIF combined with ATRA compared with intravenous ATO combined with ATRA for the treatment of APL.The oral RIF exposed patients to less risk,offered more convenience and had lower prices.RIF can treat APL by multi-target and multipathway interventions that inducing apoptosis of APL cells and inhibiting the proliferation of APL cells,and so on.Therefore,oral RIF in the treatment of APL is worthy of further research and development. | Qianqian Huang Tao Wang Yan Xiong Liping Qu Qiaozhi Yin Wenjun Zou | 2022 | Chinese Herbal Medicines2022，14，1： | 3 |
| 17 | Evolution and protein interactions of AP2 proteins in Brassicaceae: Evidence linking development and environmental responses显示文摘Plants have evolved a large number of transcription factors(TF), which are enriched among duplicate genes,highlighting their roles in complex regulatory networks. The APETALA2/EREBP-like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes,we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of representative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition,the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 A.thaliana AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP-interacting proteins,with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an antherdefective mutant, providing a possible link to developmental regulation. The putative AP2-interacting proteins participate in many functions in development and stress responses,including photomorphogenesis, flower development, pathogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study. | Liping Zeng Yue Yin Chenjiang You Qianli Pan Duo Xu Taijie Jin Bailong Zhang Hong Ma | 2016 | Journal of Integrative Plant Biology2016，58，6： | 3 |
| 18 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 19 | Vesicle-related OsSEC27P enhances H^+ secretion in the iron deficient transgenic tobacco root显示文摘Iron is an essential micronutritional element for plants.In addition to the iron uptake mechanism Strategy Ⅰ and Strategy Ⅱ,the vesicle transport process was also found to participate in iron uptake and homeostasis.Herein,a new iron deficiency induced OsSEC27P gene was isolated and investigated in both its localization and its function in transgenic plants.The vesicle-related protein OsSEC27P may play a potential role in enhancing H+ secretion in roots under the iron deficiency conditions. | YANG Guang MA Feng WANG Yi FENG ChangGeng LI Peng XU Yue ZHAO WeiZhong YIN LiPing | 2010 | Chinese Science Bulletin2010，55，29： | 2 |
| 20 | Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population显示文摘Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 singlenucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I. | Bo Xiang Zhenxing Yang Yin Lin Lijie Guan Xuan Li Wei Deng Zeyu Jiang Guohui Lao Qiang Wang Xiaoyu Hao Xiang Liu Yingcheng Wang Liansheng Zhao Xiaohong Ma Tao Li Liping Cao Xun Hu | 2014 | Neuroscience Bulletin2014，30，1： | 2 |
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