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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | Interaction between the atmospheric boundary layer and a standalone wind turbine in Gansu—Part I: Field measurement显示文摘 | De Shun Li Tao Guo Yin Ran Li Jin Sen Hu Zhi Zheng Ye Li Yu Jia Di WenRui Hu RenNian Li | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，9： | 6 |
| 3 | Effects of land use change on the spatiotemporal variability of soil organic carbon in an urban-rural ecotone of Beijing,China显示文摘Understanding the effects of land use changes on the spatiotemporal variation of soil organic carbon(SOC)can provide guidance for low carbon and sustainable agriculture.In this paper,based on the large-scale datasets of soil surveys in 1982 and 2009 for Pinggu District—an urban-rural ecotone of Beijing,China,the effects of land use and land use changes on both temporal variation and spatial variation of SOC were analyzed.Results showed that from 1982 to 2009in Pinggu District,the following land use change mainly occurred:Grain cropland converted to orchard or vegetable land,and grassland converted to forestland.The SOC content decreased in region where the land use type changed to grain cropland(e.g.,vegetable land to grain cropland decreased by 0.7 g kg^(-1);orchard to grain cropland decreased by 0.2 g kg^(-1)).In contrast,the SOC content increased in region where the land use type changed to either orchard(excluding forestland)or forestland(e.g.,grain cropland to orchard and forestland increased by 2.7 and 2.4 g kg^(-1),respectively;grassland to orchard and forestland increased by 4.8 and 4.9 g kg^(-1),respectively).The organic carbon accumulation capacity per unit mass of the soil increased in the following order:grain cropland soikvegetable land/grassland soikorchard soikforestland soil.Therefore,to both secure supply of agricultural products and develop low carbon agriculture in a modern city,orchard has proven to be a good choice for land using. | YE Hui-chun HUANG Yuan-fang CHEN Peng-fei HUANG Wen-jiang ZHANG Shi-wen HUANGShan-yu HOU Sen | 2016 | Journal of Integrative Agriculture2016，15，4： | 4 |
| 4 | Late Mesozoic Tectonic Evolution of Southwestern Fujian Province,South China:Constraints from Magnetic Fabric,Zircon U-Pb Geochronology and Structural Deformation显示文摘A combined study of magnetic fabrics, zircon U-Pb geochronology and structural deformation was carried out for Late Paleozoic sedimentary and Mesozoic magmatic rocks in the southwestern Fujian rift basin, South China, aiming at deciphering the tectonic evolution during Late Mesozoic. Field observations showed that the Late Mesozoic structure deformations in southwestern Fujian were categorized into four phases: NW-SE compression, ENE-WSW extension, NNE-SSW compression and NNW-SSE extension, sequentially. Zircons picked out from Juzhou granite and WNW-trending diabase dykes showed complete crystal shapes and clear oscillatory zonings on their edges, and the U-Pb dating yielded ages of 132 and 141 Ma, respectively. The susceptibility ellipsoid magnitude parameters of the Juzhou granite are characterized by flaser type strain ellipsoid, with pole density center of K3 falling into the first and the third quadrants, these features revealed that the Juzhou granite formed in ENE-WSW compressional stress field, indicating the early stage of Early Cretaceous extrusion in southwestern Fujian. The late stage of Early Cretaceous NNE-SSW extension was limited by the widespread WNW-trending diabase dykes, which were usually regarded as important indications for a regional extensional setting. On the basic of the previous researches, structural deformation studies, and the deductions above, it can be concluded that southwestern Fujian experienced five main tectonic stages during Late Mesozoic: Early Jurassic extension, Middle–Late Jurassic thrusting, early stage of Early Cretaceous extension, late stage of Early Cretaceous compression and Late Cretaceous extension. | Sen Wang Da Zhang Ganguo Wu Xingjian Li Xiaoqiao Gao Absai Vatuva Yuan Yuan Tengda Yu Yu Bai Ye Fang | 2018 | Journal of Earth Science2018，29，2： | 4 |
| 5 | Improved production of docosahexaenoic acid in batch fermentation by newly-isolated strains of Schizochytrium sp.and Thraustochytriidae sp.through bioprocess optimization显示文摘Thraustochytrids,rich in docosahexaenoic acid(DHA,C22:6u3),represent a potential source of dietary fatty acids.Yet,the effect of culture conditions on growth and fatty acid composition vary widely among different thraustochytrid strains.Two different thraustochytrid strains,Schizochytrium sp.PKU#Mn4 and Thraustochytriidae sp.PKU#Mn16 were studied for their growth and DHA production characteristics under various culture conditions.Although they exhibited similar fatty acid profiles,PKU#Mn4 seemed a good candidate for industrial DHA fermentation while PKU#Mn16 displayed growth tolerance to a wide range of process conditions.Relative DHA content of 48.5%and 49.2%(relative to total fatty acids),respectively,were achieved on glycerol under their optimal flask culture conditions.Maximum DHA yield(Yp/x)of 21.0%and 18.9%and productivity of 27.6 mg/L-h and 31.9 mg/L-h were obtained,respectively,in 5-L bioreactor fermentation operated with optimal conditions and dual oxygen control strategy.A 3.4-and 2.8-fold improvement of DHA production(g/L),respectively,was achieved in this study.Overall,our study provides the potential of two thraustochytrid strains and their culture conditions for efficient production of DHA-rich oil. | Qiuzhen Wang Huike Ye Biswarup Sen Yunxuan Xie Yaodong He Sunghoon Park Guangyi Wang | 2018 | Synthetic and Systems Biotechnology2018，3，2： | 4 |
| 6 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 7 | Real-time recognition of human lower-limb locomotion based on exponential coordinates of relative rotations显示文摘This paper proposes a data-driven method using a parametric representation of relative rotations to classify human lower-limb locomotion, which is designed for wearable robots. Three Inertial measurement units(IMUs) are mounted on the subject's waist,left knee, and right knee, respectively. Features for classification comprise relative rotations, angular velocities, and waist acceleration. Those relative rotations are represented by the exponential coordinates. The rotation matrices are normalized by Karcher mean and then the Support Vector Machine(SVM) method is used to train the data. Experiments are conducted with a time-window size of less than 40 ms. Three SVM classifiers telling 3, 5 and 6 rough lower-limb locomotion types respectively are trained, and the average accuracies are all over 98%. With the combination of those rough SVM classifiers, an easy SVMbased ensembled-system is proposed to classify 16 fine locomotion types, achieving the average accuracy of 98.22%, and its latency is 18 ms when deployed to an onboard computer. | XU Sen DING Ye | 2021 | Science China(Technological Sciences)2021，64，7： | 3 |
| 8 | Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation显示文摘Neogenin is a transmembrane receptor critical for multiple cellular processes,including neurogenesis,astrogliogenesis,endochondral bone formation,and iron homeostasis.Here we present evidence that loss of neogenin contributes to pathogenesis of persistent hyperplastic primary vitreous(PHPV)formation,a genetic disorder accounting for^5% of blindness in the USA.Selective loss of neogenin in neural crest cells(as observed in Wntl-Cre;Neofff mice),but not neural stem cells(as observed in GFAP-Cre and Nestin-Cre;Neo^f/f mice),resulted in a dysregulation of neural crest cell migration or delamination,exhibiting features of PHPV-like pathology(e.g.elevated retrolental mass),unclosed retinal fissure,and microphthalmia.These results demonstrate an unrecognized function of neogenin in preventing PHPV pathogenesis,implicating neogenin regulation of neural crest cell delamination/migration and retinal fissure formation as potential underlying mechanisms of PHPV. | Sen Lin Wei Liu Chun-Lin Chen Dong Sun Jin-Xia Hu Lei Li Jian Ye Lin Mei Wen-Cheng Xiong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 3 |
| 9 | Influence of Protective Coating at High Temperature on Surface Quality of Stainless Steel显示文摘A ceramic matrix coating for minimizing steel loss of stainless steel at high temperatures was prepared by handled air-spraying technique,and the influence of coating on surface quality of stainless steel was mainly investigated in laboratory.Experimental results showed that the protective coating reduced the oxidation of stainless steel by more than 91%and minimized high-temperature scaling and also enhanced steel surface quality.The scales of coated specimen were removed completely and the scales of uncoated specimen were partly residual on the surface after cooling process.Mn-rich and Fe-rich zones were found in the oxides.The Cr2O3found in scales came from the underlying stainless steel and formed a Cr-rich layer along the spalled surface. | Xiao-meng ZHANG Lian-qi WEI Peng LIU Sen WANG Shu-feng YE Yun-fa CHEN | 2014 | Journal of Iron and Steel Research(International)2014，21，2： | 3 |
| 10 | Interactions between dislocations and twins in deformed titanium aluminide crystals显示文摘Using scanning, transmission electron microscopy and aberration-corrected scanning transmission electron microscopy, we have studied the interactions between dislocations and twins in impact deformed polysynthetic twinned TiAl crystal. The 1/3 < 111] and 1/6 < 211] step dislocations on coherent twin boundaries reveal the interactions of glissile 1/2 < 101> dislocations with the coherent twin boundaries.An abnormal stacking fault was found adjacent to the coherent twin boundary. It has the same stacking sequence but different atom species in the [110] direction with an additional displacement of 1/4[110]in two neighboring {111} layers, and is likely induced by the slip of a 1/12[112](i.e. 1/4[110] + 1/6[211])dislocation. | Guang Yang Shang-Yi Ma Kui Du Dong-Sheng Xu Sen Chen Yang Qi Heng-Qiang Ye | 2019 | Journal of Materials Science & Technology2019，35，3： | 2 |
| 11 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 12 | A Study of the Key Techniques of High-Speed Optical Time Division Multiplexing Systems显示文摘 | LIU Xian bing directed by YE Pei da, ZHAO Zi sen | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，4： | 1 |
| 13 | Induction of Innate immune response genes by Nombre Hantavirus does not require viral replication显示文摘 | Prescoot J Ye C Sen G | 2005 | J Virol2005，79，15： | 1 |
| 14 | POLAR SUBSTITUENT EFFECTS OF ORGANOPHOSPHORUS ESTERS IN STRUCTURE-REACTIVITY STUDIES显示文摘In order to study the polar substituent effect almost with no steric effect in organophosphoruschemistry,a series of 4-substituted-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxides(1)and p-substitutedphenylphosphonates(2)and corresponding mono hexyl esters(3)as model were synthesized.31P-NMR chemicalshifts of compounds(1)in methanol and deuterioacetone were determined.The Δδ values reflect 4-sbstituent po-lar effect.The 31P-NMR of compounds(2)and(3)and the pKa of compounds(3)were also measured.Theresults showed that the trend of polar effects of substituents in both carboxylic and organophosphates chemistryare similar,and the change of polar effects in variation with the alkyl groups is not significant. | Wen Xiang HU Cheng Ye YUAN Shu Sen LI Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032 Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850. | 1992 | Chinese Chemical Letters1992，3，8： | 1 |
| 15 | A full-bridge resonant inverter with modified phase-shift modulation for high-frequency AC power distribution systems显示文摘 | Ye Zhongming Jain P K Sen P C | 2007 | IEEE Transactions on Industry Electronics2007，54，5： | 1 |
| 16 | Phasor-domain modeling of resonant inverters for high-frequency AC power distribution systems显示文摘 | Ye Zhongming Jain P K Sen P C | 2009 | IEEE Transactions on Power Electronics2009，24，4： | 1 |
| 17 | 显示文摘 | Jin Ye Qin Wei Ping Zhang Ji Sen | 2008 | Journal of Fluoride Chemistry2008，129，： | 1 |
| 18 | Analysis and design of full bridge resonant inverter for high frequency AC distributed power system application显示文摘 | Ye Z M Jain P K Sen P C | 2005 | IEEE Trans2005，，： | 1 |
| 19 | Circulating current minimization inhigh-frequency AC power distribution architecture with multipleinverter modules operated in parallel 显示文摘 | YE Z JAIN P K SEN P C | 2007 | IEEE Trans onIndustry Electronics2007，54，5： | 1 |
| 20 | The Phytophthora effector Avh241 interacts with host NDR1-like proteins to manipulate plant immunity显示文摘Plant pathogens rely on effector proteins to suppress host innate immune responses and facilitate colonization.Although the Phytophthora sojae RxLR effector Avh241 promotes Phytophthora infection,the molecular basis of Avh241 virulence remains poorly understood.Here we identified non-race specific disease resistance 1(NDR1)-like proteins,the critical components in plant effector-triggered immunity(ETI)responses,as host targets of Avh241.Avh241 interacts with NDR1 in the plasma membrane and suppresses NDR1-participated ETI responses.Silencing of GmNDR1s increases the susceptibility of soybean to P.sojae infection,and overexpression of GmNDR1s reduces infection,which supports its positive role in plant immunity against P.sojae.Furthermore,we demonstrate that GmNDR1 interacts with itself,and Avh241 probably disrupts the self-association of GmNDR1.These data highlight an effective counter-defense mechanism by which a Phytophthora effector suppresses plant immune responses,likely by disturbing the function of NDR1 during infection. | Bo Yang Sen Yang Baodian Guo Yuyin Wang Wenyue Zheng Mengjun Tian Kaixin Dai Zehan Liu Haonan Wang Zhenchuan Ma Yan Wang Wenwu Ye Suomeng Dong Yuanchao Wang | 2021 | Journal of Integrative Plant Biology2021，63，7： | 1 |
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