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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Consolidation and dynamics of 3D unsaturated porous seabed under rigid caisson breakwater loaded by hydrostatic pressure and wave显示文摘In this study,based on the dynamic Biot's theory 'u-p' approximation,a 3D finite element method(FEM) numerical soil model is developed,in which the Generalized Newmark-β method is adopted to determine the time integration.The developed 3D FEM soil model is a part of the coupled model PORO-WSSI 3D for 3D wave-seabed-marine structures interaction problem,and is validated by the analytical solution proposed by Wang(2000) for a laterally infinite seabed loaded by a uniform force.By adopting the developed 3D soil model,the consolidation of seabed under a caisson breakwater and hydrostatic pressure is investigated.The numerical results show that the caisson breakwater built on seabed has very significant effect on the stresses/displacements fields in the seabed foundation after the transient deformation and primary consolidation are completed.The parametric study indicates that the Young's modulus E of seabed is the most important parameter to affect the settlement of breakwater,and the displacement fields in seabed foundation.Taking the consolidation status as the initial condition,the interaction between ocean wave,caisson breakwater and seabed foundation is briefly investigated.The 3D ocean wave is determined by solving the Navier-Stokes equations with finite volume method(FVM).The numerical results indicate that there is intensive interaction between | YE JianHong JENG DongSheng CHAN A H C | 2012 | Science China(Technological Sciences)2012，55，8： | 4 |
| 3 | Competition between radiation damping and transverse relaxation effects on NMR signal intensities 显示文摘 | Mao X A Guo J X Ye C H | 1994 | Chem Phys Lett1994，218，： | 2 |
| 4 | Effect of introducing Bacillus thuringiensis gene on nitrogen metabolism in cotton显示文摘 | CHEN D H Ye G Y Yang C Q | 2005 | Field Crops Research2005，92，： | 1 |
| 5 | An energy efficient clustering scheme in wireless sensor networks显示文摘 | M Ye C F Li G H Chen J Wu | 2007 | International Journal of Ad Hoc & Sensor Wireless Networks2007，3，2： | 1 |
| 6 | Analysis of marker or complex chromosomal rearrangements present in pre-and post-natal karyotypes utilizing a combination of G-banding,spectral karyotyping and fluorescence in situ hybridization 显示文摘 | Heng H H Ye C J Yang F | 2003 | Clin Genet2003，63，5： | 1 |
| 7 | An energy efficient clustering scheme in wireless sensor networks 显示文摘 | Ye M Li C F Chen G H | 2006 | Ad Hoc & Sensor Wireless Networks2006，3，： | 1 |
| 8 | Fluorescent carbon nanoparticles derived from candle soot 显示文摘 | Liu H Ye T Mao C | 2007 | Angew Chem Int Ed Engl2007，46，34： | 1 |
| 9 | Stability analysis of net- worked control systems显示文摘 | Walsh G C Ye H Bushnell L G | 2002 | IEEE Transactions on Control Sys- tems Technology2002，10，3： | 1 |
| 10 | Temperature- and duration- dependent rice straw-derived biochar: Characteristics and its effects on soil properties of an UltisoI in southern China显示文摘 | PENG X YE L L WANG C H | 2011 | Soil & Tillage Research2011，112，： | 1 |
| 11 | How increased VEGF induces glomerular hyperpermeability:a potential signaling pathway of Rac1 activation显示文摘 | Peng H Wang C Ye ZC | | 0，，1： | 1 |
| 12 | Ondansetron exhibits the properties of a local anesthetic显示文摘 | YE J H MUI W C REN J | 1997 | Anesth Analg1997，85，5： | 1 |
| 13 | Conferring polytetrafluoroethylene micropowders with hydrophilicity using dopamine chemistry and the application as water-based lubricant additive显示文摘 | Zhang H Hu H Y Ye W C | 2011 | Journal of Applied Polymer Science2011，122，5： | 1 |
| 14 | Transgenic rice with a synthetic crylAb gene from Bacillus thuringiensis is highly resistant to eight lepidopteran insects显示文摘 | Shu Q Y Ye G Y Cui H R Cheng X Xiang Y Wu D Gao M Xia Y Hu C Sardana R Altosaar I | 2000 | Mol Breed2000，，6： | 1 |
| 15 | Effect of heat treatment on the phenolic compounds and antioxidant capacity of citrus peel extract显示文摘 | Xu G H Ye X Q Chen J C | 2007 | Journal of Agricultural and Food Chemistry2007，55，2： | 1 |
| 16 | Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts 显示文摘 | Ye H Jeong S Y Ghosh M C | 2010 | J Clin Invest2010，120，5： | 1 |
| 17 | Reconstruction of integrin activation显示文摘 | YE F KIM C GINSBERG M H | 2012 | Blood2012，119，1： | 1 |
| 18 | High- solids mar resistant clearcoats prepared from an isophthalatebased oligoester and a melamine resin 显示文摘 | C D Diakoumakos F N Jones H Ye | 2002 | Journal of Applied Polymer Science2002，83，6： | 1 |
| 19 | Supercritical fluid synthesis and characterization of catalytic metal nanoparticles on carbon nanotubes显示文摘 | YE X R LIN Y H WANG C | 2004 | J Mater Chem2004，14，： | 1 |
| 20 | Effect of introducing Bacillus thuringiensis gene on nitrogen metabolism in cotton 显示文摘 | CHEN D H YE G Y YANG C Q | 2004 | Field Crops Research2004，87，： | 1 |
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