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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | Predicting hepatitis B viruspositive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning显示文摘 | Ye QH Qin LX F orgues M | 2003 | Nat Med2003，9，4： | 3 |
| 3 | Development of a reverse transcription quantitative polymerase chain reaction-based assay for broad coverage detection of African and Asian Zika virus lineages显示文摘The Zika virus(ZIKV) is an arbovirus that has spread rapidly worldwide within recent times. There is accumulating evidence that associates ZIKV infections with Guillain-Barré Syndrome(GBS) and microcephaly in humans. The ZIKV is genetically diverse and can be separated into Asian and African lineages. A rapid, sensitive, and specific assay is needed for the detection of ZIKV across various pandemic regions. So far, the available primers and probes do not cover the genetic diversity and geographic distribution of all ZIKV strains. To this end, we have developed a one-step quantitative reverse transcription polymerase chain reaction(qRT-PCR) assay based on conserved sequences in the ZIKV envelope(E) gene. The detection limit of the assay was determined to be five RNA transcript copies and 2.94 × 10^(–3) 50% tissue culture infectious doses(TCID50) of live ZIKV per reaction. The assay was highly specific and able to detect five different ZIKV strains covering the Asian and African lineages without nonspecific amplification, when tested against other flaviviruses. The assay was also successful in testing for ZIKV in clinical samples. Our assay represents an improvement over the current methods available for the detection ZIKV and would be valuable as a diagnostic tool in various pandemic regions. | Yang Yang Gary Wong Baoguo Ye Shihua Li Shanqin Li Haixia Zheng Qiang Wang Mifang Liang George F Gao Lei Liu Yingxia Liu Yuhai Bi | 2017 | Virologica Sinica2017，32，3： | 3 |
| 4 | Synthesis and Characterization of Mixed Al+AlN Nanoparticles显示文摘Mixed Al+AlN nanoparticles were synthesized by an active plasma-metal reaction method. Mean particle size of the mixed Al+AlN nanoparticles is about 30-50 nm. Defects were found in some AlN particles. Moreover, the AlN ratio and its particle size in mixed Al+AIN nanoparticles obtained in different atmospheres (N2+Ar) increase with increasing N2 particle pressure, and the specific sudece areas of the mixed Al+AlN nanoparticles increase with the AlN ratio. The surface degradation of the Al+AlN exposed to air is estimated by the infrared absorption | Sun, XC Yang, MC Ye, F Sun, XK Wei, WD Yu, YD Ping, DH | 1997 | Journal of Materials Science & Technology1997，13，4： | 2 |
| 5 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 6 | GRAdient broabcast: A Robust Data Delivery Protoeol for Large Scale Sensor Networks显示文摘 | YE F ZHONG G LU S | 2005 | ACM Wireless Networks2005，11，3： | 1 |
| 7 | 8-Bromo-2-methylquinoline显示文摘 | YANG L T SHEN F YE J | 2009 | Acta Cryst2009，65，： | 1 |
| 8 | Haemolytic activity and adjuvant effect of Notoginsenoside K from the roots of Panax notoginseng显示文摘 | Sun HX Ye YP | 2006 | Chemistry & Biodiversity2006，3，10： | 1 |
| 9 | Analysis on the weld defects of AZ91D magnesium alloy joints显示文摘 | YE H YAN Z L SHEN B XUE Z F | 2009 | Materials Science Forum2009，610，： | 1 |
| 10 | Fluorescent microsphere-based readout technology for multiplexed human single nueleotide polymorphism analysis and bacterial identification 显示文摘 | Ye F Li M S Taylor J D | 2001 | Hum Murat2001，17，4： | 1 |
| 11 | A peptide targeted contrast specific to Fibrin-Fibronectin complexes for cancer molecular imaging with MRI显示文摘 | Ye F Jeong EK Jia Z | 2008 | Bioconjugate Chem2008，19，： | 1 |
| 12 | Effect of sludge retention time in sludge holding tank on excess sludge production in the oxic - settling - anoxic ( OSA ) activated sludge process 显示文摘 | Ye F X Zhu R F Li Y | 2008 | J Chem Technol Biotechnol2008，83，： | 1 |
| 13 | Raman scattering spectra of coupled LO-phonon-plasmon modes in N-In codoped p-type ZnO thin films显示文摘 | KONG J F CHEN H YE H B | 2007 | Appl Phys Lett2007，90，04： | 1 |
| 14 | An energy efficient clustering scheme in wireless sensor networks显示文摘 | M Ye C F Li G H Chen J Wu | 2007 | International Journal of Ad Hoc & Sensor Wireless Networks2007，3，2： | 1 |
| 15 | The effect of temperature onthe interfacial tension between crude oil and gemini sur-factant solution显示文摘 | Ye Z Zhang F Han L | 2008 | Colloids and Surfaces A2008，322，： | 1 |
| 16 | Utilization of fluorescence tracer in hyperinsulinemic-euglycemic clamp test in mice 显示文摘 | Ye F Tao R Cong W | 2008 | J Biochem Biophys Methods2008，70，6： | 1 |
| 17 | Involvenment of calcitonin gene-related peptide the depressor effects of losartan and period in rats显示文摘 | Qin xP Ye F Liao DF | 2003 | Eur J Pharmao12003，464，1： | 1 |
| 18 | Analysis of marker or complex chromosomal rearrangements present in pre-and post-natal karyotypes utilizing a combination of G-banding,spectral karyotyping and fluorescence in situ hybridization 显示文摘 | Heng H H Ye C J Yang F | 2003 | Clin Genet2003，63，5： | 1 |
| 19 | Study on microhardness of bulk nanocrystalline copper 显示文摘 | YANG M C YE F SUN X K | 1997 | Nanostruetured Materials1997，9，48： | 1 |
| 20 | Relationship between molecular structures and tribological properties of phosphazene lubricants显示文摘 | Liu W M Ye C F | 2002 | Wear2002，252，4： | 1 |
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