|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Peptide mass maps: a highly informative approach to protein identification 显示文摘 | YATES J R SPEICHER S GRIFFIN P R | 1993 | Anal Biochem1993，214，2： | 1 |
| 3 | Reproducible electrochemical etching of tungsten probe tips显示文摘 | GUISE O L AHNER J W JUNG M C GOUGHNOUR P C YATES J | 2002 | Nano Letters2002，2，3： | 1 |
| 4 | A catalytic loop within Pseudomonas aerugi nosa exotoxin A modulates its transferase activity显示文摘 | Yates S P Merrill A R | 2001 | J Biol Chem2001，276，35： | 1 |
| 5 | Honeycomb monoliths of activated carbons for effluent gas purification 显示文摘 | YATES M BLANCO J AVILA P | 2000 | Microporoas and Mesoporous Materials2000，37，1： | 1 |
| 6 | Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women显示文摘 | ROSCHGER P RINNERTHALER S YATES J | 2001 | Bone2001，29，2： | 1 |
| 7 | Use of pseudo-cross variograms and eokriging to improve estimates of soil solute concentrations显示文摘 | Zhang R Shouse P Yates S | 1997 | Soil Science Society of America Journal1997，61，5： | 1 |
| 8 | X-ray analysis of fluidized beds and other multiphase systems显示文摘 | YATES J CHEESMAN D LETTIERI P | 2005 | Chemical Engineering Science2005，，2： | 1 |
| 9 | Effects of systematic oral care in critically ill patients: a multicenter study 显示文摘 | Ames N J Sulima P Yates JM | 2011 | American Journal of Critical Care2011，20，5： | 1 |
| 10 | Intra-and interrater variation in the evaluation of videoflourographic swallowing studies显示文摘 | Kuhlemeier KV Yates P Palmer JB | 1998 | Dysphagia1998，13，3： | 1 |
| 11 | Using the Precede - proceed model of health program planning in breast cancer nursing re- search显示文摘 | Tramm R McCarthy A Yates P | 2012 | J Adv Nuts2012，68，8： | 1 |
| 12 | Honeycomb monoliths of activated carbons for effluent gas purification 显示文摘 | Yates M Blanco J Avila P | 2000 | Micro- porous and Mesoporous Materials2000，37，： | 1 |
| 13 | Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial):randomised placebo-controlled trial显示文摘 | ROBERTS I YATES D SANDERCOCK P | 2004 | Lancet2004，364，9442： | 1 |
| 14 | IR spectroscopic detection of Lewis acid sites on alumina using adsorbed carbon monoxide: Correlation with aluminum-hydroxyl group removal 显示文摘 | P allinger T H Yates J T | 1991 | Langmuir1991，7，12： | 1 |
| 15 | Dietary reference intakes for energy,carbohydrate,fiber,fat,fatty acids,cholesterol,protein and amino acids显示文摘 | Trumbo P Schlicker S Yates A A | 2002 | Journal of the American Dietetic Association2002，102，11： | 1 |
| 16 | Estimates of soil nitrate distributions using cokriging with pseudo-cross variograms显示文摘 | Zhang R Shouse P Yates S | 1999 | Journal of Environmental Quality1999，28，2： | 1 |
| 17 | Mutations conferring zanamivir resistance in human influenza virus N2neuraminidases compromise virus fitness and are not stably maintained in vitro显示文摘 | Zürcher T Yates P J Daly J | 2006 | J Antimicrob Chemoth2006，58，4： | 1 |
| 18 | Bistatic SAR image formation显示文摘 | Yates G Home A M Blake A P | 2006 | IET Radar Sonar and Navigation2006，153，3： | 1 |
| 19 | Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring显示文摘 | Yates C C Krishna P Whaley P | 2010 | Am J Pathol2010，176，4： | 1 |
| 20 | Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomona aerug/nosa exotoxin A 显示文摘 | Yates S P and Merrill A R | 2004 | The Biochemical Journal2004，379，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员