|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene显示文摘瞄准:在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度,以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法:95 个 GS 盒子和 95 正常控制被选择。肝工作,另外的测试被做。倡导者和 UGT1A1 基因的所有 5 前 ons 被重新定序。对新奇 trinucleotide 插入的功能的评价被做由在 silico 分析并且由估计 UGT1A1,倡导者活动在 Hep G2 由适当构造的酶记者试金执行了房间线。结果:在 GS 病人之中, 80% 为 TA 插入是同型结合的,它比从另外的种族组的报告高好几倍。吝啬的 UCB 水平与仅仅这插入的一个拷贝在个人之中被提高,它不与有二个拷贝的那些显著地不同。在 UGT1A1 基因的许多新 DNA 变体被发现,包括在倡导者的插入在 GS 病人的一个子集(10%) 发现了的 trinucleotide (猫) ,然而并非在正常之中控制。In-silico 分析证明在倡导者和功能的分析的合拢 DNA 的显著变化在 UGT1A1 基因源于这插入的抄写效率显示出 20 褶层减小,显著地从而提高 UCB 水平。结论:GS 的基因传染病学越过种族组是可变的,在 UGT1A1 倡导者变体之中的上位相互作用调制胆红素 glucuronidation。 | Shabana Farheen Sanghamitra Sengupta Amal Santra Suparna Pal Gopal Krishna Dhali Meenakshi Chakravorty Partha P Majumder Abhijit Chowdhury | 2006 | World Journal of Gastroenterology2006，12，14： | 29 |
| 2 | KOH activated carbon derived from biomass-banana fibers as an efficient negative electrode in high performance asymmetric supercapacitor显示文摘Here we demonstrate the fabrication, electrochemical performance and application of an asymmetric supercapacitor(AS) device constructed with β–Ni(OH)_2/MWCNTs as positive electrode and KOH activated honeycomb-like porous carbon(K-PC) derived from banana fibers as negative electrode. Initially,the electrochemical performance of hydrothermally synthesized β–Ni(OH)_2/MWCNTs nanocomposite and K-PC was studied in a three-electrode system using 1 M KOH. These materials exhibited a specific capacitance(Cs) of 1327 F/g and 324 F/g respectively at a scan rate of 10 m V/s. Further, the AS device i.e.,β–Ni(OH)_2/MWCNTs//K-PC in 1 M KOH solution, demonstrated a Cs of 156 F/g at scan rate of 10 m V/s in a broad cell voltage of 0–2.2 V. The device demonstrated a good rate capability by maintaining a Cs of 59 F/g even at high current density(25 A/g). The device also offered high energy density of 63 Wh/kg with maximum power density of 5.2 kW/kg. The AS device exhibited excellent cycle life with 100% capacitance retention at 5000 th cycle at a high current density of 25 A/g. Two AS devices connected in series were employed for powering a pair of LEDs of different colors and also a mini fan. | ChaitraK Vinny R T Sivaraman P Narendra Reddy Chunyan Hu Krishna Venkatesh Vivek C S Nagaraju N Kathyayini N | 2017 | Journal of Energy Chemistry2017，26，1： | 4 |
| 3 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 4 | Evaluation of sampling strategies to estimate crown biomass显示文摘Background:Depending on tree and site characteristics crown biomass accounts for a significant portion of the total aboveground biomass in the tree.Crown biomass estimation is useful for different purposes including evaluating the economic feasibility of crown utilization for energy production or forest products,fuel load assessments and fire management strategies,and wildfire modeling.However,crown biomass is difficult to predict because of the variability within and among species and sites.Thus the allometric equations used for predicting crown biomass should be based on data collected with precise and unbiased sampling strategies.In this study,we evaluate the performance different sampling strategies to estimate crown biomass and to evaluate the effect of sample size in estimating crown biomass.Methods:Using data collected from 20 destructively sampled trees,we evaluated 11 different sampling strategies using six evaluation statistics:bias,relative bias,root mean square error(RMSE),relative RMSE,amount of biomass sampled,and relative biomass sampled.We also evaluated the performance of the selected sampling strategies when different numbers of branches(3,6,9,and 12)are selected from each tree.Tree specific log linear model with branch diameter and branch length as covariates was used to obtain individual branch biomass.Results:Compared to all other methods stratified sampling with probability proportional to size estimation technique produced better results when three or six branches per tree were sampled.However,the systematic sampling with ratio estimation technique was the best when at least nine branches per tree were sampled.Under the stratified sampling strategy,selecting unequal number of branches per stratum produced approximately similar results to simple random sampling,but it further decreased RMSE when information on branch diameter is used in the design and estimation phases.Conclusions:Use of auxiliary information in design or estimation phase reduces the RMSE produced by a sampling strategy.However,this is attained by having to sample larger amount of biomass.Based on our finding we would recommend sampling nine branches per tree to be reasonably efficient and limit the amount of fieldwork. | Krishna P Poudel Hailemariam Temesgen Andrew N Gray | 2015 | Forest Ecosystems2015，2，1： | 2 |
| 5 | The influence of mass transfer and mixing on the performance of a tray column for reactive distillation 显示文摘 | Higlera P Taylor R Krishna R | 1999 | Chemical Engineering Science1999，54，1314： | 1 |
| 6 | Mufti-signal flow graphs:a novel approach for system testability analysis and fault diagnosis显示文摘 | Somnath Deb Krishna R P Vijay R | 1995 | IEEE Aerospace and Electronics Magazine1995，10，5： | 1 |
| 7 | Filamentous bulking sludge-a critical review显示文摘 | ANTONIO M KRISHNA P JOSEPH H | 2004 | Wat Res2004，38，4： | 1 |
| 8 | Treatment of low- strength soluble wastewater using an anaerobic baffled reactor (ABR) 显示文摘 | Gopala Krishna G V T Kumarb P Kumarb P | 2009 | Journal of Environmental Management2009，90，1： | 1 |
| 9 | Assessment of heavy metal contamination in soils around Manali industrial area, Chennai, Southern India 显示文摘 | Krishna A K Govil P K | 2008 | Environmental Geology2008，54，7： | 1 |
| 10 | Honey bee behavior inspired load balancing of tasks in cloud computing environments显示文摘 | KRISHNA P V | | Applied Soft Computing0，13，5： | 1 |
| 11 | Clustering Web Transactions Using Rough Approximation 显示文摘 | Supriya K D Krishna P R | 2004 | Fuzzy Sets and Systems2004，，148： | 1 |
| 12 | Plant responses to heat stress 显示文摘 | KRISHNA P | 2003 | Topics in Current Genetics2003，4，： | 1 |
| 13 | Test sequencing problems arising in test planning and design for testability显示文摘 | Vijaya R Mojdeh S Krishna R P | 1999 | IEEE Transactions on Systems Man and Cybernetics-Part A:Syatems and Humans1999，29，2： | 1 |
| 14 | Heavy metal contamination of soil around Pali Industrial Area,Rajasthan,India显示文摘 | Krishna A K Govil P K | 2004 | Environmental Geology2004，47，： | 1 |
| 15 | Effect of micro arc oxidation coatings on eorrosion resistance of 6061-al alloy 显示文摘 | WASEKAR N P JYOTHIRMAYI A KRISHNA L R | 2008 | Journal of Materials Engineering and Performance2008，17，5： | 1 |
| 16 | LACAV:An Energy-Effi- cient Channel Assignment Mechanism for Vehicular Ad hoc Net- works显示文摘 | Misra S Venkata Krishna P Saritha V | 2012 | J Supercomput2012，62，5： | 1 |
| 17 | Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 P13K-PKB/Akt-dependent pathway 显示文摘 | Nair P Somasundaram K Krishna S | 2003 | J Virol2003，77，12： | 1 |
| 18 | Effect of different extraction agents on metal and organic contaminant removal from a field soil显示文摘 | AMID P K KRISHNA R R KRANTI M | 2005 | Journal of Hazardous Materials2005，，117： | 1 |
| 19 | Counter-current operation of a structured catalytically packed-bed reactor:liquid phase mixing and mass transfer显示文摘 | Higler A P Krishna R Ellenberger J Taylor R | 1999 | Chem Eng Sci1999，54，21： | 1 |
| 20 | Fluorescence spectroscopy for noninvasive early diagnosis of oral mucosal malignant and potentially malignant lesions 显示文摘 | Chaturvedi P Majumder SK Krishna H | 2010 | J Cancer Res Ther2010，6，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员