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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Investigation of Chinese skin colour and appearance for skin colour reproduction显示文摘A Chinese skin colour database is established based on measurements taken from nine bodies areas of 202 Chinese individuals to move towards accurate skin colour reproduction. The colour appearance of each skin point is predicted, and a comprehensive colour gamut for Chinese skin is determined. A consistent colour shift between facial and arm colours is identified, in which facial colour tends to be more reddish, more colourful, and darker than arm colour. Moreover, Chinese females are found to have lighter, paler, and more yellowish skin than Chinese males. Variations in Chinese skin colour are quantified, and body area differences and gender differences are shown to have significant effects on Chinese skin colour. | Kaida Xiao 廖宁放 Faraedon Zardawi 刘浩学 Richard Van Noort 杨智雄 黄敏 Julian M Yates | 2012 | Chinese Optics Letters2012，10，8： | 2 |
| 3 | The biological impact of mass-spectrometry-based proteomics 显示文摘 | Cravatt B F Simon G M Yates J R 3rd | 2007 | Nature2007，450，7172： | 1 |
| 4 | Atmospheric Pressure MOCVD Growth of Crystalline InP in Opals显示文摘 | Yates H M Pemble M E | 1998 | Journal of Crystal Growth1998，193，： | 1 |
| 5 | Parlay X Web Services显示文摘 | LOFTHOUSE H YATES M J STRETCH R | 2004 | BT Technology Journal2004，22，1： | 1 |
| 6 | Reproducible electrochemical etching of tungsten probe tips显示文摘 | GUISE O L AHNER J W JUNG M C GOUGHNOUR P C YATES J | 2002 | Nano Letters2002，2，3： | 1 |
| 7 | Relativistic nuclear magnetic resonance chemical shifts of heavy nuclei with pseudopotentials and the zeroth-order regular approximation显示文摘 | Yates J R Pickard C J Payne M C | 2003 | J Chem Phys2003，118，13： | 1 |
| 8 | The thermal conductivity of carbon fibre-reinforced composites显示文摘 | Pilling M W Yates B Black M A | 1979 | Journal of Materials Science1979，14，6： | 1 |
| 9 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 10 | Honeycomb monoliths of activated carbons for effluent gas purification 显示文摘 | YATES M BLANCO J AVILA P | 2000 | Microporoas and Mesoporous Materials2000，37，1： | 1 |
| 11 | Persistence of maternal antibodies against Mycoplasma agassizii in desert tortoise hatchlings显示文摘 | SCHUMACHER I M ROSTAL D C YATES R A | 1999 | Am J Vet Res1999，60，： | 1 |
| 12 | Compensatory mutations in E1,p7,NS2,and NS3 enhance yields of cell culture-infectious intergeno-typic chimeric hepatitis C virus显示文摘 | Yi M Ma Y Yates J | 2007 | J Virol2007，81，2： | 1 |
| 13 | The role of nitrogen doping on the development of visible light induced photocatalytic activi ty in thin TiO2 films grown on glass by chemical vapour deposition显示文摘 | Yates H M Nolan | 2006 | J Photochem Photobiolo A Chem2006，179，12： | 1 |
| 14 | A 'high-pressure' electron spectrometer for surface studies 显示文摘 | Joyner R W Roberts M W Yates K | 1979 | Surface Science1979，87，： | 1 |
| 15 | Quantifying crack tip displacement fields with DIC显示文摘 | YATES J R ZANGANEH M TAI Y H | 2010 | Engineering Fracture Mechanics2010，77，11： | 1 |
| 16 | Formation of Rod-shaped Calcite Crystals by Microemulsion-based Synthesis显示文摘 | Liu D Yates M Z | 2006 | Langmuir2006，22，： | 1 |
| 17 | Honeycomb monoliths of activated carbons for effluent gas purification 显示文摘 | Yates M Blanco J Avila P | 2000 | Micro- porous and Mesoporous Materials2000，37，： | 1 |
| 18 | Microemul- sion-directed synthesis of molecular sieve fibers显示文摘 | LIN J C DIPRE J T YATES M Z | 2003 | Chem Mater2003，15，14： | 1 |
| 19 | Contemporary issues sur- rounding folic acid fortification initiatives 显示文摘 | Choi JH Yates Z Veysey M | 2014 | Prev Nutr Food Sci2014，19，4： | 1 |
| 20 | A comparison of the performance of microsatcllite and methylation urine analysis for predicting the recurrence of urothelial cell carcinoma and definition of a set of markers by Bayesian network analysis 显示文摘 | Roupret M Hupertan V Yates DR | 2008 | BJU Int2008，101，11： | 1 |
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