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| 1 | Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common human cancers,and its incidence is still increasing in many countries.The prognosis of HCC patients remains poor,and identification of useful molecular prognostic markers is required.Many recent studies have shown that functional alterations of cell-cycle regulators can be observed in HCC.Among the various types of cell-cycle regulators,p16 and p27 are frequently inactivated in HCC and are considered to be potent tumor suppressors.p16,a G1-specific cell-cycle inhibitor that prevents the association of cyclindependent kinase(CDK)4 and CDK6 with cyclin D1,is frequently inactivated in HCC via CpG methylation of its promoter region.p16 may be involved in the early steps of hepatocarcinogenesis,since p16 gene methylation has been detected in subsets of pre-neoplastic liver cirrhosis patients.p27,a negative regulator of the G1-S phase transition through inhibition of the kinase activities of Cdk2/cyclin A and Cdk2/cyclin E complexes,is now considered to be an adverse prognostic factor in HCC.In some cases of HCC with increased cell proliferation,p27 is overexpressed but inactivated by sequestration into cyclin D1-CDK4-containing complexes.Since loss of p16 is closely related to functional inactivation of p27 in HCC, investigating both p16 and p27 may be useful for precise prognostic predictions in individuals with HCC. | Yasunobu Matsuda | 2008 | World Journal of Gastroenterology2008，14，11： | 20 |
| 2 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 3 | Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy显示文摘A well-known tumor suppressor, p21, acts parado-xically by promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinogenesis. The molecular behavior of p21 depends on its subcellular localization. Nuclear p21 may inhibit cell proliferation and be proapoptotic, while cytoplasmic p21 may have oncogenic and anti-apoptotic functions. Because most typical tumor suppressive proteins also have different effects according to subcellular localization, elucidating the regulatory mechanisms underlying nucleo-cytoplasmic transport of these proteins would be significant and may lead to a new strategy for anti-hepatocellular carcinoma(HCC) therapy. Chromosome region maintenance 1(CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cytoplasm. Expression of CRM1 is enhanced in a variety of malignancies and in vitro studies have shown the efficacy of specific inhibition of CRM1 against cancer cell lines. Interestingly, interferon may keep p21 in the nucleus; this is one of the mechanisms of its anti-hepatocarcinogenic function. Here we review the oncogenic property of p21, which depends on its subcellular localization, and discuss the rationale underlying a new strategy for HCC treatment and prevention. | Shogo Ohkoshi Masahiko Yano Yasunobu Matsuda | 2015 | World Journal of Gastroenterology2015，21，42： | 6 |
| 4 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 5 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 6 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 7 | Early colon cancer within a diverticulum treated by magnifying chromoendoscopy and laparoscopy显示文摘We report a unique case of intramucosal carcinoma in a tubulovillous adenoma arising from a single diverticulum.Endoscopic mucosal resection(EMR)was carried out successfully and completely with the assistance of laparoscopy.A 71-year-old man was admitted to our hospital because of melena and anemia.Emergent colonoscopy showed diverticulosis in the right-sided colon.However,endoscopy could not exactly detect the bleeding site.A flat elevated polyp was found within a single diverticulum located in the descending colon and diagnosed as an intramucosal carcinoma,as magnifying chromoendoscopy revealed a type Ⅳ pit pattern.As his diverticular bleeding repeated,a rightsided hemicolectomy was decided for treatment,the polyp within the diverticulum was also completely removed by EMR with the assistance of laparoscopy.Although a colonic perforation was detected immediately after EMR,the perforation was closed with endoclips intraluminally and also repaired laparoscopically from the serosal side.Histologically,the resected lesion was an intramucosal well-differentiated adenocarcinoma and the surgical margin was free of tumor. | Kuang I Fu Yukihiro Hamahata Yasunobu Tsujinaka | 2010 | World Journal of Gastroenterology2010，16，12： | 3 |
| 8 | BALLOON-BORNE MEASUREMENTS OF AEROSOL VERTICAL DISTRIBUTIONS OVER BEIJING DURING THE SUMMER AND AUTUMN OF 1993显示文摘The results of two balloon soundings during the summer and autumn of 1993 from the Xianghe Observation Stationare being utilized in a study of the temporal and spatial distribution of the atmospheric aerosols.The balloon,gondola,instrumentation and atmospheric conditions during the observation period are described.The temporal and spatialcharacteristics of aerosol concentration,size ratio,mixing ratio,and size distribution for both troposphere and strato-sphere are presented and analyzed. | 周军 谭锟 邵石生 龚知本 石广玉 郭建东 王标 张豹武 孙宝来 Yasunobu Iwasaka Masahiko Hayashi Masahiro Hase | 1994 | Acta meteorologica Sinica1994，8，4： | 3 |
| 9 | Analysis software for upper atmospheric data developed by the IUGONET project and its application to polar science显示文摘To comprehensively understand the Arctic and Antarctic upper atmosphere,it is often crucial to analyze various data that are obtained from many regions.Infrastructure that promotes such interdisciplinary studies on the upper atmosphere has been developed by a Japanese inter-university project called the Inter-university Upper atmosphere Global Observation Network(IUGONET).The objective of this paper is to describe the infrastructure and tools developed by IUGONET.We focus on the data analysis software.It is written in Interactive Data Language(IDL)and is a plug-in for the THEMIS Data Analysis Software suite(TDAS),which is a set of IDL libraries used to visualize and analyze satellite-and ground-based data.We present plots of upper atmospheric data provided by IUGONET as examples of applications,and verify the usefulness of the software in the study of polar science.We discuss IUGONET’s new and unique developments,i.e.,an executable file of TDAS that can run on the IDL Virtual Machine,IDL routines to retrieve metadata from the IUGONET database,and an archive of 3-D simulation data that uses the Common Data Format so that it can easily be used with TDAS. | Yoshimasa Tanaka Atsuki Shinbori Tomoaki Hori Yukinobu Koyama Shuji Abe No-rio Umemura Yuka Sato Manabu Yagi Satoru UeNo Akiyo Yatagai Yasunobu Ogawa Yoshizumi Miyoshi | 2013 | Advances in Polar Science2013，24，4： | 2 |
| 10 | 持续性细胞皱缩在人上皮细胞凋亡过程中的必要性(英文)显示文摘持续性细胞皱缩是凋亡发生的一个主要标志。近期研究发现细胞皱缩在细胞凋亡过程中并不是一个被动的次要事件。在各种细胞中,包括人上皮细胞,凋亡因子(apoptogen)刺激后马上发生全细胞皱缩,又称为凋亡性容积减小(apoptotic volume decrease,AVD),继而发生caspase激活、DNA片段化、细胞破裂死亡。K^+和Cl^-通道的激活导致KCl外流,诱导AVD发生。抑制AVD发生可以抑制细胞凋亡。AVD与调节性容积增加(regulatory volume increase,RVI)异常相伴发生时,人上皮性HeLa细胞发生持续性细胞皱缩。RVI功能受损时,高渗本身就能诱导HeLa细胞持续性细胞皱缩,继而凋亡。即使在正常渗透压、无凋亡因子刺激的情况下,将HeLa细胞置于缺乏Na^+或Cl^-的溶液也会导致细胞持续性皱缩,继而凋亡。因此,AVD诱导和RVI异常所导致的持续性细胞皱缩是人上皮细胞发生凋亡的首要条件。 | SHIMIZU Takahiro MAENO Emi OKADA Yasunobu | 2007 | 生理学报2007，59，4： | 2 |
| 11 | Undifferentiated spindle-cell carcinoma of the gallbladder: an immunohistochemical study显示文摘 | Kensuke Kubota Yukio Kakuta Shunji Kawamura Yasunobu Abe Masahiko Inamori Harunobu Kawamura Hiroyuki Kirikoshi Noritoshi Kobayashi Satoru Saito Atushi Nakajima | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，5： | 2 |
| 12 | Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture显示文摘在现在的学习,我们试图评估在低亚硫酸钠期间从老鼠星形细胞贡献 ATP 版本的小径渗透的应力。我们首先为组成在过去的几年被建议了的可能的释放 ATP 小径的蛋白质检验了 mRNAs 的表示。在用控制和渗透的联盟者的 RT-PCR 分析肿的星形细胞,期望的尺寸的 cDNA 碎片的扩大为 connexins 被看见(Cx32, Cx37, Cx43 ) , pannexin 1 (Px1 ) , P2X7 受体, MRP1 和 MDR1,然而并非 CFTR。巨大的 ATP 上的重要效果都不免除星形细胞的小囊的版本,差距连接半隧道, CFTR, MRP1, MDR1, P2X7 受体,和卷敏感的表面地修正的氯化物隧道有的 exocytotic 的禁止者。相反,从星形细胞的导致张力减退的 ATP 版本被金轧(50 妈妈) 最有效地禁止,迷嬉装阴离子隧道的一个禁止者,它最近被显示了从几种另外的房间类型为 ATP 版本用作一条小径。因此,我们建议迷嬉装阴离子隧道也从有教养的老鼠星形细胞为膨胀导致 ATP 版本组成一条主要小径。 | Hong-Tao Liu Abduqodir H Toychiev Nobuyuki Takahashi Ravshan Z Sabirov Yasunobu Okada | 2008 | Cell Research2008，18，5： | 2 |
| 13 | Aerosol optical properties derived from simultaneous sunphotometer and aureolemeter measurements in Lhasa显示文摘In order to obtain some aerosol properties in Tibetan Plateau atmosphere, simultaneous measurements of aerosols by use of a sunphotometer and an aureolementer were performed in the summer of 1998 in Lhasa(29.65°N, 91.13°E). Optical depth, volume size distribution and phase\|function of aerosols were obtained from the measurements. Religious activities can have an effect on optical depth in Lhasa. The daily average aerosol optical depth( λ =500 nm) is less than 0.2. The diurnal variations of aerosol optical depth are relatively small during the period of summer. The maximal value of the mode radius in the volume size distribution are about 0.4, 2.0 and 4.0μm. | BAI Yu\|bo\+1, SHI Guang\|yu\+\{1*\}, Koichi Tamura\+2, Takashi Shibata\+2, Yasunobu Iwasaka\+2, Kaneta Shin′ichi\+3, Takamura Tamio\+3 (1. State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute | 2000 | Journal of Environmental Sciences2000，12，4： | 2 |
| 14 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 15 | Miniaturization of Bubbles by Shock Waves in Gas-Liquid Two-phase Flow in the Venturi Tube显示文摘Fine bubbles have been widely applied in many fields such as industry,medical engineering and agricultures.Therefore,many attentions have been paid to the study of fine bubble generations in order to increase the yield while decrease the cost.However,the generation process of fine bubbles is a quite complicated process in which multiple hydrodynamic forces are interacted in the gas-liquid two-phase flow.Many studies focus on the techniques of the converging-diverging nozzle(venturi tube)generator,which is famous for its simple and cheap features,and generates fine bubbles by using the miniaturization phenomenon of bubbles occurring in the venturi tube.However,the impact conditions on the amount and size of bubbles such as nozzle geometry and bleed air haven’t been investigated clearly.In this work,we implement many experiments on the venturi tube fine bubble generators with different geometries and generating conditions,and evaluate different factors impacting the production components such as the volume and the bubble size.The experimental results show that the supersonic flow filed in the venturi tube promotes the miniaturization of the bubbles,and the convergent angle of the nozzle and air bleed have a great impact on the size and volume of bubbles. | JIANG Xin YASUNOBU Tsuyoshi NAKAMURA Arisa SHIMAZU Masaki | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 16 | Effects of chemical composi tion and oxidation temperature on the adhesion of scale in plain carbon steels 显示文摘 | Taro Kizu Yasunobu Nagataki | 2001 | ISIJ International2001，41，12： | 1 |
| 17 | A General Practical Design Methodfor Fuzzy PID Control from Conventional PID Control显示文摘 | Huang-Yongli Yasunobu Seiji | 2005 | FuzzySystems2005，，2： | 1 |
| 18 | In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage显示文摘 | Haruo Mitani Nobukazu Ishizaka Toru Aizawa Minoru Ohno Shin-ichi Usui Toru Suzuki Toshihiro Amaki Ichiro Mori Yasushi Nakamura Misako Sato Masaomi Nangaku Yasunobu Hirata Ryozo Nagai | 2002 | Hypertension: Journal of the American Heart Association2002，，4： | 1 |
| 19 | Numerical Study for Hysteresis Phenomena of Shock Wave Reflection in Overexpanded Axisymmetric Supersonic Jet显示文摘当高压的气体对从超声的嘴的真空房间精疲力尽时, overexpanded 超声的喷气以特定的状况被形成。在二维的超声的喷气,而且,为流动地里的冲击波的思考类型的磁滞现象现象在伪稳定的流动下面并且例如被发生,这被知道,在常规思考( RR )和马赫思考(先生)之间的过渡压力比率被这现象影响。许多报纸为 underexpanded 描述了磁滞现象现象在 overexpanded axisymmetric 喷气下面的超声的喷气,而是这现象没在过去的报纸被详细说明。这研究的目的是用 TVD 方法在 overexpanded axisymmetric 喷气为冲击波的思考类型清除磁滞现象现象并且讨论磁滞现象现象的特征。 | Tsuyoshi Yasunobu Ken Matsuoka Hideo Kashimura ShigeruMatsuo ToshiakiSetoguchi | 2006 | Journal of Thermal Science2006，15，3： | 1 |
| 20 | Diffuse large B-cell lymphoma solely involving bilateral adrenal glands and stomach:report of an extremely rare case with review of the literature显示文摘 | Mutsumi Wakabayashi Yasunobu Sekiguchi Asami Shimada | 2014 | Int J Clin Exp Pathol2014，7，11： | 1 |
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