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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Synthesis,characterization,and evaluation of[Ir(ppy) 2(vpy) C[J]as a polymer-bound oxygen sensor显示文摘 | Derosa M C Mosher P J Yap G P A | | 0，，16： | 1 |
| 3 | Size, leverage, concentration, and R&D investment in generating growth opportunities 显示文摘 | Ho Y K Tjahjapraata M Yap C M | 2006 | Journal of Business2006，79，2： | 1 |
| 4 | New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells显示文摘 | Yap S P Shen P Butler M S | 2005 | Planta Med2005，71，2： | 1 |
| 5 | Openroads : empowering research in mobile networks显示文摘 | YAP K K KOBAYASHI M SHERWOOD R | 2010 | SI- GCOMM Computer Commun Eev2010，40，1： | 1 |
| 6 | A general fast registration frame- work by learning deformation-appearance correlation 显示文摘 | KIM M WU G YAP piT | 2012 | IEEE Transactions on Image Processing2012，21，4： | 1 |
| 7 | Body mass index and percent body fat:a meta analysis among different ethnic groups显示文摘 | Deurenberg P Yap M van Staveren WA | 1998 | Int J Obes Relat Metab Disord1998，22，12： | 1 |
| 8 | The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma显示文摘 | Bose S Yap LF Fung M | 2009 | J Pathol2009，217，3： | 1 |
| 9 | Preclinical pharmacology,antitumor activity,and development of pharmacodynamic markers for the novel,potent AKT inhibitor CCT128930显示文摘 | YAP T A WALTON M I HUNTER L J | 2011 | Mol Cancer Ther2011，10，2： | 1 |
| 10 | R&D Investment and Systematic Risk 显示文摘 | Ho Y K Z Xu C M Yap | 2004 | Accounting & Fianance2004，44，3： | 1 |
| 11 | Evaluating FDG uptake changes between pre and post therapy respiratory gates PET scans 显示文摘 | Aristophanous M Yong Y Yap JT | 2012 | Radiother Oncol2012，102，3： | 1 |
| 12 | The assessment of obesity: methods for measuring body fat and global prevalence of obesity显示文摘 | Deurenberg P Yap M | 1995 | Baillieres Best Pract Res Clin Endocrinol Metab1995，13，： | 1 |
| 13 | Spatial distribution and sources of polycyclic aromatic hydrocarbons (PAHs) in green mussels (Perna viridis) from coastal areas of Peninsu- lar Malaysia: implications for source identification of pery- lene显示文摘 | Shahbazi A Zakaria M P Yap C K | 2010 | Int J EnvironAnal Chem2010，90，1： | 1 |
| 14 | Synthesis and reactivity of ruthenium(11) complexes containing hemilabile phosphine-thiophene ligands显示文摘 | Clot O Wolf M O Yap G P A | 2000 | Journal of the Chemical Society Dalton Transactions2000，16，： | 1 |
| 15 | Evaluation of the accuracy of volume determination on the orbit and eyeball using MRI 显示文摘 | CHAU A FUNG K YAP M | 2005 | Radiography2005，11，1： | 1 |
| 16 | Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii显示文摘 | Scharton-Kersten T M Yap G Magram J | 1997 | The Journal of Experimental Medicine1997，185，7： | 1 |
| 17 | Molecular characterization of a novel senescence-associated gene SPA15 induced during leaf senescence in sweet potato显示文摘 | Yap M N Lee R H Huang Y J Liao C J Chen S C G | | 0，，： | 1 |
| 18 | Comparison of Physicochemical and Antioxidant Properties of Egg-white Proteim and Fructose and Inulin Maillard Reaction Products显示文摘 | JING H YAP M WONG P Y | | 0，，： | 1 |
| 19 | Effects of surface finish on indentation modulus and hardness of dental composite restoratives 显示文摘 | M Chung AUJ Yap | 2005 | Dental Materials2005，21，： | 1 |
| 20 | A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction显示文摘 | Yap M W Nisole S Stoye J P | 2005 | Curr Biol2005，15，1： | 1 |
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