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| 1 | 改进随机森林的集成分类方法预测结直肠癌存活性显示文摘癌症是人类死亡的主要原因之一,许多国家在癌症方面的支出占医疗总支出的很大比例。癌症存活性预测作为癌症预后的一项重要工作,可以辅助医生做出更精准的诊疗决策,进而降低癌症治疗成本。近年来,基于数据驱动的癌症存活性预测方法逐渐得到应用,而预测的准确性是评价预测方法性能的主要指标,因此提高癌症存活性预测方法的准确性一直是一个活跃的研究领域。结直肠癌是一种具有高发病率和高死亡率的癌症,为了提高结直肠癌存活性预测的准确性,利用遗传算法对随机森林进行改进,提出基于GA-RF的集成分类方法。该方法通过遗传算法对随机森林中的决策树实行进化搜索,以提高集成分类准确率为目标选出决策树的满意集成。实验分别使用基于GA-RF的集成分类方法、决策树和参数优化的随机森林训练预测模型预测结直肠癌患者的存活性,利用SEER数据库的结直肠癌数据集对3种方法分别进行10折交叉验证,然后用准确性、敏感性和特异性3个指标对它们进行评价。实验结果显示,基于GA-RF的集成分类方法的预测精度最高(88.2%),参数优化的随机森林的预测精度次之(86.4%),但集成复杂度远高于基于GA-RF的集成分类方法,决策树的预测精度最差(74.2%),而基于GA-RF的集成分类方法还表现出了最好的泛化性能。该集成分类方法对随机森林进行了有效的改进,能以更高的运算效率和更好的准确性预测结直肠癌存活性,可以为结直肠癌的预后提供决策参考,弥补经验预测的不足,该方法的提出对节约医疗资源、降低医疗成本、提高患者满意度具有实际意义。 | 王宇燕 王杜娟 王延章 Yaochu Jin | 2017 | 管理科学2017，30，1： | 15 |
| 2 | Variability of the Kuroshio in the East China Sea in 1993 and 1994显示文摘 | Liu Yonggang and Yuan Yaochu | 1999 | Acta Oceanologica Sinica1999，18，1： | 11 |
| 3 | 基于GMM-RBF神经网络的前列腺癌诊断方法显示文摘前列腺癌是近年来发病率上升速度最快的男性癌症,严重威胁着患者的身体健康,准确地判断癌症患者的患病情况对于节约医疗资源、提高患者满意度起着至关重要的作用。近年来,基于数据挖掘的癌症诊断方法逐渐成为疾病诊断领域的研究热点,在提高诊断准确性上显示出极大优势。针对现有前列腺癌早期诊断方法准确性不高的问题,提出一种基于高斯混合模型改进径向基函数神经网络的前列腺癌诊断方法——GMM-RBF神经网络方法。该方法通过使用高斯混合模型对径向基函数神经网络中径向基函数的参数进行预训练,使模型避免陷入局部最优,之后采用改进的粒子群优化算法对神经网络进行训练。采用国家临床医学科学数据中心提供的数据进行前列腺癌诊断实验,将所提出的方法与径向基神经网络、分类回归树、支持向量机和逻辑回归等主流的机器学习算法进行对比,并使用准确性、特异性、敏感性和AUC值对模型的性能进行评价。研究结果表明,与改进前的神经网络模型相比,GMM-RBF神经网络模型收敛速度更快、初始准确度更高;与其它机器学习算法相比,GMM-RBF神经网络模型在10折交叉验证中取得了较高的准确性、敏感性、特异性和AUC值。GMM-RBF神经网络方法在模型预测精度上比传统的径向基函数神经网络模型有很大提升,能够得到更为可靠的前列腺癌诊断结果,为医疗工作者初步诊断前列腺癌和穿刺活检操作提供有效的辅助决策支持,该方法的提出对于减少患者痛苦、提高患者满意度和节约医疗资源具有实际意义。 | 崔少泽 王杜娟 王苏桐 夏江南 王延章 JIN Yaochu | 2018 | 管理科学2018，31，1： | 9 |
| 4 | Circulation in the South China Sea in summer of 1998显示文摘Based on the CTD and meteorological data obtained by R/V Xiangyanghong No. 14 in the South China Sea (SCS) in the summer of 1998, both current velocity and volume transport are calculated by using a modified inverse model. Circulation in the SCS is analyzed by combining the calculated results with ADCP data. The following results are obtained, (i) The most important feature of the circulation in the northeastern SCS is that a branch of the Kuroshio intrudes into the SCS with a small volume transport. It flows anticyclonically through the Bashi Strait and towards the southwest off the Taiwan Island, and it does not intrude into the inner SCS. (ii) The northern SCS is dominated mainly by a cyclonic circulation system with two cold eddies, (iii) The central and southwestern SCSs are mainly occupied by anticyclonic circulation systems, including three anticyclonic and one stronger cyclonic eddies, (iv) In the southeastern SCS, there is a large scope of cyclonic circulation extending in the SW-NE direction, | LIU Yonggang YUAN Yaochu SU Jilan JIANG Jingzhong | 2000 | Chinese Science Bulletin2000，45，18： | 9 |
| 5 | A Survey of Evolutionary Algorithms for Multi-Objective Optimization Problems With Irregular Pareto Fronts显示文摘Evolutionary algorithms have been shown to be very successful in solving multi-objective optimization problems(MOPs).However,their performance often deteriorates when solving MOPs with irregular Pareto fronts.To remedy this issue,a large body of research has been performed in recent years and many new algorithms have been proposed.This paper provides a comprehensive survey of the research on MOPs with irregular Pareto fronts.We start with a brief introduction to the basic concepts,followed by a summary of the benchmark test problems with irregular problems,an analysis of the causes of the irregularity,and real-world optimization problems with irregular Pareto fronts.Then,a taxonomy of the existing methodologies for handling irregular problems is given and representative algorithms are reviewed with a discussion of their strengths and weaknesses.Finally,open challenges are pointed out and a few promising future directions are suggested. | Yicun Hua Qiqi Liu Kuangrong Hao Yaochu Jin | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 8 |
| 6 | Circulations east of Taiwan and in East China Sea and east of Ryukyu Islands during early summer 1985显示文摘Circulations east of Taiwan and in East China Sea and east of Ryukyu Islands during early summer 1985YuanYaochu;Cho-tengLiu;P... | Yuan Yaochu Cho-teng Liu Pan Ziqin and Shi-pei Zhend | 1996 | Acta Oceanologica Sinica1996，15，4： | 8 |
| 7 | The study of the Kuroshio in the East China Sea and the currents east of the Ryukyu Islands显示文摘In this study, the inverse method is used to compute the Kuroshio in the East China Sea and southeast of Kyushu and the currents east of the Ryukyu Islands, on the basis of hydrographic data obtained during September-October, 1987 by R/V Chofu Maru. The results show that: (1)A part of the Taiwan Warm Current has a tendency to converge to the shelf break; (2) the Kuroshio flows across the section C3 (PN) with a reduced current width, and the velocity of the Kuroshio at the section C3 increases and its maximum current speed is about 158 cm/s, and its volume transport here is about 26×106m3/s; (3) the Kuroshio has two current cores at the sections C3 (PN) and B2 (at the Tokara Strait); (4) the currents east of the Ryukyu Islands are found to flow northward over the Ryukyu Trench during September-October, 1987. The velocities of the currents are not strong throughout the depths. At the section C2 east of the Ryukyu Islands, the maximum current speed is at the 699 m levei and its magnitude is 25 cm/s, and | Yuan Yaochu, Endoh Masahiro and Ishizaki Hiroshi The Second Institute of Oceanography, State Oceanic Administration, Hangzhou, 310012, ChinaMeteorological Research Institute, JMA, Tsukuba 305, Japan | 1991 | Acta Oceanologica Sinica1991，10，3： | 7 |
| 8 | 基于多目标神经网络的前列腺癌诊断方法显示文摘前列腺癌是男性恶性肿瘤中发病率最高的肿瘤之一.通过对前列腺癌的有效诊断,可以尽早治疗,降低前列腺癌的死亡率.针对前列腺癌早期筛查的准确度不足,病理检查给病人身体带来严重负担的现状,以及现有基于数据挖掘的癌症诊断方法只关注诊断结果准确性或者只关注可解释性的问题,本文提出一种基于多目标神经网络的诊断方法,通过特征选择提取对诊断结果最具有解释性的特征子集,以提高模型的可解释性和准确度;通过采用进化计算的方式进行神经网络的结构和权重学习,从而构建有效的能够充分体现临床信息与前列腺癌之间关联的多目标神经网络模型进行前列腺癌诊断;并通过Pareto优化方法对模型训练过程中的结构和参数进行优化,从而提供多个有效的诊断模型以满足医务工作者不同的决策偏好. | 孔倩 王杜娟 王延章 JIN Yaochu 江彬 | 2018 | 系统工程理论与实践2018，38，2： | 7 |
| 9 | 基于结构自适应模糊神经网络的前列腺癌诊断方法显示文摘前列腺癌是近年来严重危害男性健康的疾病.利用模糊神经网络方法可以实现前列腺癌诊断,并将诊断模型表示为模糊规则集合.针对模糊神经网络所提取规则解释性差的问题,提出结构自适应模糊神经网络方法,通过改进损失函数,在训练中控制相似隶属度函数的合并,实现模糊神经网络模型结构自适应调整,减少模糊规则数量,在保证诊断准确性情况下,提取出容易理解的可解释性规则.同时该方法在模型的训练过程中引入粒子群优化(PSO)算法进行结构和参数学习,有效减少计算量,提高训练效率.最后,使用临床医学科学数据中心提供的前列腺疾病检查数据进行数值实验,验证了所提出方法在前列腺癌诊断和可解释性规则提取中的有效性. | 夏江南 王杜娟 王延章 Yaochu Jin 江彬 | 2018 | 系统工程理论与实践2018，38，5： | 7 |
| 10 | A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population显示文摘Objective:Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility togastric cancer in a Chinese population. Methods: Two variations in the 5'-flanking region of TLR4 (rs1927914 T>C and rs10759932 T>C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population. Results: Individuals carrying the C allele of rs10759932 had a significantly reduced risk of gastric cancer (adjusted OR=0.81; 95%CI=0.67-0.96), compared with the wild-type homozygote (TT), and the protective effect was not significantly different among subgroups stratified by age, sex, smoking, drinking and H.pylori infection status (P for heterogeneity >0.05). No significant association was observed between rs1927914 and gastric cancer risk in this study population. Conclusion: The T to C allele substitution of rs10759932 may play a protective role in gastric carcinogenesis in a Chinese population. Large studies with different ethnic populations are warranted to confirm these findings. | Hua Huang Juan Wu Guangfu Jin Hanze Zhang Yanbing Ding Zhaolai Hua Yan Zhou Yan Xue Yan Lu Zhibin Hu Yaochu Xu Hongbing Shen | 2010 | The Journal of Biomedical Research2010，24，2： | 5 |
| 11 | Analysis of internal tidal characteristics in the layer above 450 m from acoustic Doppler current profiler observations in the Luzon Strait显示文摘The characteristics of internal tides in the upper layer of the Luzon Strait are investigated on the basis of direct-observation current data recorded on April 25 and September 26, 2008 by an acoustic Doppler current profiler. Spectral analysis and energy estimation show that the diurnals and semidiurnals carry most of the energy of internal tides. Values of the depth-integrated total energy E for the three frequency bands of diurnal, semidiurnal, and high frequencies are 31, 6.9, and 3.4 kJ·m, respectively. Near-inertial peaks are only present in the baroclinic component. The behavior of typical tidal frequencies (i.e., O1, K1, M2, MK3, and M4) and the near-inertial frequency is basically consistent with linear internal wave theory, which predicts E + (ω)/E (ω)=(ω f) 2 /(ω+f) 2 at depths above 66 m, while not all prominent tidal components coincide well with the relation of the linear internal wave field at other depths. Examinations of depth structures of the baroclinic tides and temporal variations show that the surface tides and internal tides are both of mixed type, having diurnal inequality and spring-neap fortnight periods. The K1 and O1 tides have comparable cross-and along-shelf components, while the M2 and S2 tides propagate toward the shelf in the northern South China Sea as wave beams. The amplitude and phase of internal tides vary with time, but M2 and S2 tides appear to have structures dominated by the first mode, while the K1 and O1 tides resemble second-mode structures. The minor to major axis ratios are close to expected values of f/ω in the thermocline. | LIAO GuangHong YUAN YaoChu Kaneko ARATA YANG ChengHao CHEN Hong Taniguchi NAOKAZU Gohda NORIAKI | 2011 | Science China Earth Sciences2011，54，7： | 4 |
| 12 | Effects of mesoscale eddies on the internal solitary wave propagation显示文摘The mesoscale eddy and internal wave both are phenomena commonly observed in oceans. It is aimed to investigate how the presence of a mesoscale eddy in the ocean affects wave form deformation of the internal solitary wave propagation. An ocean eddy is produced by a quasi-geostrophic model in f-plane, and the one-dimensional nonlinear variable-coefficient extended Korteweg-de Vries (eKdV) equation is used to simulate an internal solitary wave passing through the mesoscale eddy field. The results suggest that the mode structures of the linear internal wave are modified due to the presence of the mesoscale eddy field. A cyclonic eddy and an anticyclonic eddy have different influences on the background environment of the internal solitary wave propagation. The existence of a mesoscale eddy field has almost no prominent impact on the propagation of a smallamplitude internal solitary wave only based on the first mode vertical structure, but the mesoscale eddy background field exerts a considerable influence on the solitary wave propagation if considering high-mode vertical structures. Furthermore, whether an internal solitary wave first passes through anticyclonic eddy or cyclonic eddy, the deformation of wave profiles is different. Many observations of solitary internal waves in the real oceans suggest the formation of the waves. Apart from topography effect, it is shown that the mesoscale eddy background field is also a considerable factor which influences the internal solitary wave propagation and deformation. | LIAO Guanghong YANG Chenghao XU Xiaohua SHI Xingang YUAN Yaochu HUANG Weigen | 2012 | Acta Oceanologica Sinica2012，31，5： | 4 |
| 13 | Variability of the currents in the Luzon Strait during spring of 2002 obtained from observations and satellite geostrophic currents and spectral analyses显示文摘The structure and variability of the currents in the Luzon Strait during spring of 2002 are studied, based on the current measurements at the average position of the mooring station (20°49′57'N, 120°48′12'E) from March 17 to April 15, 2002, satellite geostrophic currents in the Luzon Strait, and the spectral analyses, using the maximum entropy method. The subtidal currents at the mooring station show de-creased amplitudes downward with an anti-cyclonic rotation, suggesting that the currents enter and exit the South China Sea in the upper and intermediate layers, respectively. The vertical structure of the currents in the Luzon Strait suggests strongly the sandwiched structure of the LST, even though the bottom part of the profile is not resolved by the observational grid. The spectral analyses show the following periods of significant spectral peaks: (1) the tidal currents variability in the vertical direction; (2) the period about 4-6 d for the two cases of frequency f >0 and f<0 at the 200 and 500 m levels, but at the 800 m level only for the case of f >0; (3) The fluctuation in the period range is about 2-3 days for the two cases of f >0 and f<0 at the 200, 500 and 800 m levels, namely the Luzon Strait currents exhibit significant synoptical variability throughout the water column up to 800 m deep. Both direct current measurements and in situ hydrographic and satellite survey suggest no Kuroshio loop current in the Luzon Strait during the spring of 2002. | YUAN YaoChu LIAO GuangHong WANG HuiQun LOU RuYun CHEN Hong | 2009 | Science China Earth Sciences2009，52，4： | 3 |
| 14 | Three dimensional diagnostic,semidiagnostic and prognostic calculations of current in the East China Sea in April of 1994显示文摘Three dimensional diagnostic,semidiagnostic and prognostic models in the σ coordinate are used to compute the current in the East China Sea with wind and hydrographic data obtained from the investigation of ocean fluxes in the East China Sea during the cruise of April 1994.The computed results show that:the density and velocity fields and so on have been adjusted when time t ≈ 23 d, i.e.,the solution of semidiagnostic calculation has been obtained.The quasi steady state solution also has been reached after about 60 d.Comparing the results of diagnostic calculation with those of semidiagnostic and prognostic calculations,it is found that they agree qualitatively.For example,they all show that:(1)The Kuroshio flows along the shelf break of 200~1 000 m isobaths;(2)In the southeastern part of the computational region there is a stronger counter current with an anticyclonic eddy;(3)The volume transport through Section PN is about 30×10 6m 3/s and so on.However there are some quantitative differences between them.For example,(1)For the semidiagnostic results the Kuroshio current is stronger and clearer than that for diagnostic results and the Kuroshio width is more narrow than that for diagnostic results.This shows that the semidiagnostic calculation can better reflect the topography effect;(2)In most computed region the vertical component of velocity intensifies for semidiagnostic result,especially on the shelf break.Comparing the results of semidiagnostic calculation with those of prognostic calculation,they agree qualitatively,and also agree quantitatively in the middle of computed region. | Wang Huiqun 1,2 ,Yuan Yaochu 1,21 .KeyLaboratoryofOceanDynamicProcessesandSatelliteOceanography ,StateOceanicAdministration ,China 2 .SecondInstituteofOceanography ,StateOceanicAdministration ,POBox .12 0 7,Hangzhou 310 0 12 ,China | 2001 | Acta Oceanologica Sinica2001，20，1： | 3 |
| 15 | Progress of studies in China from July 2010 to May 2015 on the influence of the Kuroshio on neighboring Chinese seas and the Ryukyu Current显示文摘The influence of the Kuroshio on neighboring Chinese seas and the Ryukyu Current is a very important subject of interest in physical oceanography. To deeply explain the research progress made by Chinese scientists from July2010 to May 2015, the following three aspects are reviewed in this paper. The first concerns the Kuroshio intrusion into the South China Sea(SCS) and its circulation around the Luzon Strait. There are two very important points to be explained: the seasonal and inter-annual variation of the Kuroshio intrusion and the mechanisms of the Kuroshio intrusion and the influence of the Kuroshio on currents in the Luzon Strait and circulation in the northern SCS. The second concerns the variability of the Kuroshio and its interaction with the East China Sea(ECS). There are following four interesting topics to be explained: an overview of studies on the Kuroshio in the ECS; the Kuroshio intrusion into the ECS, water exchange, and dynamic impacts; the downstream increase of nutrient transport by the Kuroshio; and the application of satellite remote sensing on terrestrial material transport by the Kuroshio intrusion into the ECS. Third, the interaction between the Ryukyu Current and Kuroshio in the ECS are also discussed. Finally, the main results are summarized and areas of further study are simply discussed. | YUAN Yaochu ZHU Xiaohua ZHOU Feng | 2015 | Acta Oceanologica Sinica2015，34，12： | 2 |
| 16 | The diel vertical migration of sound scatterers observed by an acoustic Doppler current profiler in the Luzon Strait from July 2009 to April 2011显示文摘Acoustic Doppler current profiler(ADCP)receives echoes from sound scatterers,then their speed is calculated by the Doppler effect.In the open ocean,most of these backscatterers are from the plankton.The sound scatterers descend down to depth at around dawn,their mean speed is 2.9 cm/s,then they ascend up to the surface layer at around dusk with a mean speed of 2.1 cm/s,in the Luzon Strait.The descending speed is faster,which suggests that this zooplankton population may accelerate its downward migration under the action of the gravity.The vertical distribution of a mean volume backscattering strength(MVBS)in the nighttime has two peaks,which locate near the upper and lower boundary layers of halocline,respectively.However,the backscatterers only aggregate near the surface layer in the daytime.The diel vertical migration(DVM)of sound scatterers has several characteristic patterns,it is stronger in summer,but weaker in winter,and the maximum peak occurs in September.The DVM occurrence is synchronous with the seawater temperature increasing at around dawn and dusk,it may affect the ocean mixing and water stratification. | YANG Chenghao LIAO Guanghong YUAN Yaochu CHEN Hong ZHU Xiaohua | 2013 | Acta Oceanologica Sinica2013，32，11： | 2 |
| 17 | A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population显示文摘MET tyrosine kinase and its ligand,hepatocyte growth factor(HGF),play a pivotal role in the activties of tumor cells.A germline missense variant in exon 2 of the MET gene,N375S(rs33917957 A>G),may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis.In this study,we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls.Logistic regression analysis was applied to estimate crude and adjusted odds ratios(ORs) and 95% confidence intervals(CIs) for the associations between genotypes and gastric cancer risk.We found that MET N375S variant genotypes(NS/SS) were associated with a significantly decreased risk of gastric cancer(OR = 0.78,95% CI = 0.63-0.96,P = 0.021) compared with the wildtype homozygote(NN).The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese. | Yao Liu Qin Zhang Chuanli Ren Yanbing Drag Guangfu Jin Zhibin Hu Yaochu Xu Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，5： | 2 |
| 18 | RM-MEDA: A Regularity Model Based Multiobjective Estimation of Distri bution Algorithm显示文摘 | Zhang Qingfu Zhou Aimin Jin Yaochu | 2008 | IEEE Transactions on Evolutionary Computation2008，12，1： | 1 |
| 19 | Lamarckian memetic algorithms:local optimum and connectivity structure analysis显示文摘 | MINH NGHIA LE YEW-SOON ONG YAOCHU JIN | | 0，，01： | 1 |
| 20 | Surrogate-assisted evolutionary computation: Recent advances and future challenges 显示文摘 | Yaochu J | 2011 | Swarm and Evolutionary Computation2011，1，2： | 1 |
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