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| 1 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Notes on Extended-Range Atmospheric Prediction in the Northern Hemisphere Winter显示文摘NotesonExtended-RangeAtmosphericPredictionintheNorthernHemisphereWinterShingoYamadaForecastDivision,JapanMeteorologicalAgency... | Shingo Yamada Forecast Division, Japan Meteorological Agency, Tokyo, 100, Japan Shuhei Maeda Administration Division, Climate and Marine Department, Japan Meteorological Agency, Tokyo, 100, Japan K. Gambo c/o Department of Earth and Planetary Physi | 1997 | Advances in Atmospheric Sciences1997，14，1： | 3 |
| 4 | Processing of biocompatible porous Ti and Mg显示文摘 | WEN C E MABUCHI M Yamada Y | 2001 | Scripta Materialia2001，45，10： | 1 |
| 5 | Analysis of laminate strength and its distribution显示文摘 | Yamada S E Sun C T | 1978 | J Compos Mater1978，12，： | 1 |
| 6 | Ectopic expression of Oct4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues显示文摘 | Hochedlinger K Yamada Y Beard C | 2005 | Cell2005，121，3： | 1 |
| 7 | Identification of KIF21A mutations as a rare cause of congenital fibrosis of the extraocular muscles type 3 ( CFEOM3 ) 显示文摘 | Yamada K Chan WM Andrews C Bosley TM Sener EC Zwaan JT | 2004 | Invest Ophthalmol Vis Sci2004，45，7： | 1 |
| 8 | Predictors of progression from prehypertension to hypertension in Japanese men 显示文摘 | Tomiyama H Matsumoto C Yamada J | 2009 | Am J Hypertens2009，22，11： | 1 |
| 9 | Expression of basic fibroblast growth factor and fibroblast growth factor receptor 1 in the experimental retinal vein occlusion model显示文摘 | Matsushima M Yamada H Yamamoto C | 1997 | Nippon Ganka Gakkai Zasshi1997，101，： | 1 |
| 10 | Pilots with non-insulin-dependent diabetes mellitus can self-monitor their blood glucose显示文摘 | Tajima N Yamada C Asukata I | 1989 | Aviat Space Environ Med1989，60，： | 1 |
| 11 | Processing of biocompatible porous Ti and Mg显示文摘 | WEN C E MABUCHI M YAMADA Y SHIMOJIMA K CHINO Y ASAHINA T | 2001 | Scripta Materialia2001，45，10： | 1 |
| 12 | Optimized LiFeP04 for lithiumbattery cathodes 显示文摘 | YAMADA A CHUNGS C | 2001 | J Electrochem Soc2001，148，3： | 1 |
| 13 | Processing and mechanical properties of autogenous titanium implant materials 显示文摘 | WEN C E YAMADA ~ SHIMOJIMA K CHINO Y ASAHINA T MABUCHI M | 2002 | Journal of Materials Science: Materials in Medicine2002，13，4： | 1 |
| 14 | 查看详情显示文摘 | Yamada C Hirota E | | 0，，： | 1 |
| 15 | Ectopic expression of Oct-4 blocks progenitor-cel differentiation and causes dysplasia in epithelial tissues显示文摘 | Hochedlinger K Yamada Y Beard C | | 0，，03： | 1 |
| 16 | Interferongamma production by neutrophils during bacterial pneumonia in mice显示文摘 | Yamada M Gomez J C Chugh P E | 2011 | Am J Respir Crit Care Med2011，183，10： | 1 |
| 17 | The murine glucagon-like peptide-1 receptor is essential for control of bone resorption显示文摘 | Yamada C Yamada Y Tsukiyama K | 2008 | Endocrinology2008，149，2： | 1 |
| 18 | Optimized LiFePO4 for lithium battery cathodes 显示文摘 | Yamada A Chung S C Hinokuma K | 2001 | Electrochem Soc2001，148，3： | 1 |
| 19 | Bilateral lobectomy excluding the caudate lobe for giant mesenchymal hamartoma of the liver显示文摘 | Shuto T Kinoshita H Yamada C | 1993 | Surgery1993，113，2： | 1 |
| 20 | Processing of biocompatible porous Ti and Mg 显示文摘 | WEN C E MABUCHI M YAMADA Y SHIMOJIMA K CHINO Y ASAHINA T | 2001 | Scripta Materialia2001，45，10： | 1 |
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