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| 1 | The active surveillance management approach for patients with low risk papillary thyroid microcarcinomas: is China ready?显示文摘Due to exponential increases in incidences,low risk papillary thyroid microcarcinoma(PTMC)has become a clinical and social issue in recent years.An active surveillance(AS)management approach is an alternative to immediate surgery for patients with low risk PTMC.With decreased doubts about the safety and validity due to evidence from a large number of studies,the AS approach has become increasingly popular worldwide.However,Chinese thyroid surgeons still lag behind other countries in their knowledge of clinical practices and research related to AS.To promote the implementation of AS in China,thyroid surgeons should understand the implications,advantages,and disadvantages of management approaches for AS,and should also consider the willingness of Chinese patients,the impact on the medical billing system,and the enthusiasm of doctors.Thus,a management approach for AS based on the Chinese population should be developed to reduce the risk of disease progression and enhance patient adherence.Herein,we summarize the recent research achievements and deficiencies in AS approaches,and describe the initial experiences regarding AS in the Chinese population,in order to assist Chinese thyroid surgeons in preparing for AS management in the era of PTMC precision medicine. | Wen Liu Xuejing Yan Ruochuan Cheng | 2022 | Cancer Biology & Medicine2022，19，5： | 4 |
| 2 | Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups显示文摘Graphene quantum dots(GQDs) possess great potential in various applications due to their superior physicochemical properties and wide array of available surface modifications.However, the toxicity of GQDs has not been systematically assessed, thus hindered their further development; especially, the risk of surface modifications of GQDs is largely unknown. In this study, we employed a lung carcinoma A549 cells as the model to investigate the cytotoxicity and autophagy induction of three types GQDs, including cGQDs(COOH-GQDs), hGQDs(OH-GQDs), and aGQDs(NH_2-GQDs). The results showed hGQDs was the most toxic, as significant cell death was induced at the concentration of 100 μg/mL,determining by WST-1 assay as well as Annexin-V-FITC/PI apoptosis analysis, whereas cGQDs and aGQDs were non-cytotoxic within the measured concentration. Autophagy detection was performed by TEM examination, LC3 fluorescence tracking, and Westernblot. Both aGQDs and hGQDs induced cellular autophagy to various degrees except for cGQDs. Further analysis on autophagy pathways indicated all GQDs significantly activated p-p38 MAPK; p-ERK1/2 was inhibited by aGQDs and hGQDs but activated by c GQDs. p-JNK was inhibited by aGQDs and c GQDs, while activated by hGQDs. Simultaneously, Akt was activated by hGQDs but inhibited by aGQDs. Inhibition of autophagy by 3-MA significantly increased the cytotoxicity of GQDs, suggesting that autophagy played a protective role against the toxicity of GQDs. In conclusion, c GQDs showed excellent biocompatibility and may be considered for biological applications. Autophagy induction may be included in the health risk assessment of GQDs as it reflects the stress status which may eventually lead to diseases. | Yichun Xie Bin Wan Yu Yang Xuejing Cui Yan Xin Liang-Hong Guo | 2019 | Journal of Environmental Sciences2019，31，3： | 4 |
| 3 | Effect of adjuvant therapy with electroacupuncture on bone turnover markers and interleukin 17 in patients with rheumatoid arthritis显示文摘OBJECTIVE: To evaluate the effect of electroacupuncture as an adjuvant treatment with first-line medications on bone metabolism biomarkers and interleukin-17(IL-17) in the peripheral blood of patients with rheumatoid arthritis(RA).METHODS: Sixty RA patients were randomized into three groups. The control group was treated with methotrexate plus leflunomide(MTX + LEF),the acupuncture group was treated with simple needling plus MTX + LEF, and the patients in the electroacupuncture(EA) group were treated with EA plus MTX + LEF. EA or acupuncture was applied every other day for a total of 10 times over a treatment period of 8 weeks.RESULTS: In all three treatment groups, serum levels of the bone metabolism markers PICP, N-MID,and B-ALP were elevated and the concentrations of the inflammatory markers β-CTx, IL-17, CRP, and TRACP-5b were reduced after treatment. These differences were significant for the EA group but not the other groups(P < 0.05).CONCLUSION: EA could effectively reduce the suffering and improve the quality of life of RA patients. It is a promising adjuvant therapy for enhancing the effectiveness of clinical therapeutics. | Zeng Chuang Bai Xuejing Qin Heping Wang Hong Rong Xiaofeng Yan Jin | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 2 |
| 4 | Cellulose extraction from wood chip in an ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl)显示文摘 | Xuejing Wang Huiquan Li Yan Cao Qing Tang | 2011 | Bioresource Technology2011，，17： | 1 |
| 5 | Advances in the study of submarine groundwater discharge(SGD)in China显示文摘Submarine groundwater discharge(SGD)is a critical land-ocean process in coastal areas and an essential component of the global hydrological cycle.Thus,hydrologists and oceanographers are paying more attention to SGD.SGD transports large amounts of materials into the ocean,including nutrients,carbon,and metals,and thus plays a vital role in the cycling of marine materials and affects the ecological environments of nearshore areas.This study examined the research status of SGD and its environmental effects in China,including a systematic analysis of radium activities and nutrient contents in groundwater,SGD rates,and the contribution of SGD to nutrients in various coastal ecosystems(bays,estuaries,continental shelves,and lagoons).The results showed the median concentrations of groundwater nutrients(dissolved inorganic nitrogen DIN,dissolved inorganic phosphorus DIP,and dissolved inorganic silicon DSi),SGD rates,and SGD-derived DIN and DIP in estuarine areas far exceeded those in the other three ecosystems studied.This result could be attributed to the complex hydrodynamic conditions of estuary areas as well as the considerable influence of human activities.Conversely,the lowest SGD rates and three inorganic nutrient species via SGD were observed in large scale continental shelves.SGD-derived nutrient fluxes were comparable to riverine inputs along the entire coast of China,which significantly affected the nutrient budget,nutrient composition,and primary productivity of coastal waters.Finally,this review suggests further research of SGD in three aspects:(1)accurate assessment,(2)its environmental effects,and(3)its regulatory strategies. | Yan ZHANG Xuejing WANG Yan XUE Changpei ZOU Manhua LUO Gang LI Lei LI Laitong CUI Hailong LI | 2022 | Science China Earth Sciences2022，65，10： | 1 |
| 6 | Submarine groundwater discharge and associated nutrient fluxes in the Greater Bay Area, China revealed by radium and stable isotopes显示文摘The estuary-bay system is a common and complex coastal environment.However,quantifying submarine groundwater discharge(SGD)and associated nutrient fluxes in the complex coastal environment is challenging due to more dynamic and complicated riverine discharge,ocean processes and human activities.In this study,SGD and SFGD(submarine fresh groundwater discharge)fluxes were evaluated by combining stable and radium isotopes in the Guangdong-Hong Kong-Macao Greater Bay Area(GBA),a typical estuary-bay system.We first built a spatially distributed radium mass balance model to quantify SGD fluxes in coastal areas of GBA integrating the Pearl River Estuary(PRE),bays and shelf.We then used the stable water isotope(d2 H and d18O)end-member mixing model to distinguish submarine fresh groundwater discharge(SFGD)from SGD.Based on the 228Ra mass balance,the estimated SGD fluxes in the PRE,adjacent bay,and shelf areas were(6.14±2.74)×10^(8) m^(3) d^(-1),(3.00±1.11)×10^(7) m^(3) d^(-1),and(5.00±5.64)×10^(8) m^(3) d^(-1),respectively.Results showed that the largest area-averaged SGD was in the PRE,followed by that in the adjacent shelf and the bay.These differences may be mainly influenced by ocean forces,urbanization and benthic topographies controlling the variability of groundwater pathways.Further,the three end-member mixing model of ^(228)Ra and salinity was developed to confirm the validity of the estimated SGD using the Ra mass balance model.In the two models,groundwater endmember and water apparent age estimation were the main sources of uncertainty in SGD.The estimated SFGD flux was(1.39±0.76)108 m^(3) d^(-1),which accounted for approximately 12%of the total SGD.Combining stable and radium isotopes was a useful method to estimate groundwater discharge.Moreover,the estimated SGD associated dissolved inorganic nitrogen(DIN)flux was one order of magnitude higher than other DIN sources.SGD was considered to be a significant contributor to the DIN loading to the GBA.The findings of this study are expected to provide valuable information on coastal groundwater management and environmental protection of the GBA and similar coastal areas elsewhere. | Qianqian Wang Xuejing Wang Kai Xiao Yan Zhang Manhua Luo Chunmiao Zheng Hailong Li | 2021 | Geoscience Frontiers2021，12，5： | 1 |
| 7 | Usable values for Chinese standard reference samples of stream sediments, soils, and rocks: GSD 9-12, GSS 1-8 and GSR 1-6显示文摘 | Xie Xuejing Yan Mingcai Li Lianzhong Shen Huijun | 1985 | Geostandard Newslett1985，9，2： | 1 |
| 8 | Geochemical standard reference samples GSD 9-12, GSS 1-8 and GSR 1-6显示文摘 | Xie Xuejing Yan Mingcai Wang Chunshu Li Lianzhong Shen Huijun | 1989 | Geostandard Newslett1989，13，1： | 1 |
| 9 | Immune Response, Safety, and Survival and Quality of Life Outcomes for Advanced Colorectal Cancer Patients Treated with Dendritic Cell Vaccine and Cytokine-Induced Killer Cell Therapy显示文摘 | Hui Zhu Xuejing Yang Jiali Li Yanjie Ren Tianyu Zhang Chunze Zhang Jintai Zhang Jing Li Yan Pang Shiwu Zhang | 2014 | BioMed Research International2014，，： | 1 |
| 10 | Immune response, clinical outcome and safety of dendritic cell vaccinein combination with cytokine?induced killer cell therapy in cancer patients显示文摘 | Yu Cui Xuejing Yang Wei Zhu Jiali Li Xiaojing Wu Yan Pang | 2013 | Oncology Letters2013，，2： | 1 |
| 11 | Cyclopropanation of active methylene compounds with β-alkoxycarbonyl vinylsulfonium salts显示文摘An efficient synthesis of β-alkoxycarbonyl vinylsulfonium salts had been developed. Their reaction with indene-1,3-diones and other active methylene compounds provided cyclopropane carboxylates in good yields. A tentative reaction mechanism was proposed. | Shenquan Guo Niuniu Zhang Xiangzheng Tang Zhifeng Mao Xuejing Zhang Ming Yan Yining Xuan | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
| 12 | 2-8 SimCSR Program for the Simulation of the Isochronous Mass Spectrometry at the HIRFL-CSR显示文摘Until now, several isochronous mass spectrometry (IMS) experiments have been successfully performed usingvarious primary beams at the HIRFL-CSR and masses of both proton-rich and proton-deficient exotic nuclei havebeen measured. In order to improve the performance of the IMS experiments and to provide a reliable tool fordesigning and preparing the future experiments, a simulation code, named SimCSR is developed.Presently, six-dimension phase-space linear transmission theory is applied to simulate the transmission of ionsin the experimental storage ring (CSRe). The basic algorithm is Bf = MBi. The Bi and Bf are six-dimensionphase-space vectors of ions at the entrance and exit of each element of the CSRe lattice, respectively. M is a6-by-6-dimension first-order transfer matrix of each element. M is calculated using formulas described in Ref.[1]. Inthe simulations, the ring lattice is considered in detail, and the same magnetic setting as in our previous experimentwith 58Ni projectile fragments[2] is considered. The ions are assumed to circulate 300 turns inside the CSRe. | Chen Ruijiu Yuan Youjin Wang Meng Xu Xing Shuai Peng Zhang Yuhu Yan Xinliang Xing Yuanming Xu Hushan Zhou Xiaohong Litvinov Yuri Litvinov Sergy Chen Xiangcheng Fu Chaoyi Ge Wenwen Ge Zhuang Hu Xuejing Huang Wenjia Liu Dawei Zeng Qi Zhang Wei | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | Influence of Pr-Al-Co alloy diffusion source on magnetic properties and microstructure of sintered Nd-Fe-B magnets processed by grain boundary diffusion显示文摘In this study,the influence of the content of Al and Co in the diffusion source on the magnetic performance and microstructure of the diffused magnet was studied by grain boundary diffusion treatment with Pr_(70)Al_(30-x)Co_(x)(x=0 at%,10 at%,15 at%,20 at%,30 at%)alloys.When the Co content in the diffusion source increases from 0 at%to 10 at%,the coercivity enhancement in the Pr_(70)Al_(20)Co_(10)diffused magnet is the highest,increased from 1.62 to 2.24 T,higher than 2.01 T of the Pr_(70)Al_(30)diffused magnet.With further increase of Co content in the diffused source,the coercivity of the diffused magnet decreases gradually,the coercivity of Pr_(70)Al_(15)Co_(15),Pr_(70)Al_(20)Co_(10)and Pr_(70)Co_(30)diffused magnet is 2.15,1.99 and1.81 T,respectively.Microstructural analysis shows that plenty of continuous grain boundary phases(CGBPs)can be formed in the Pr_(70)Al_(20)Co_(10)diffused magnet under the synergistic effect of Al and Co,which leads to the enhancement of magnetic isolation between more adjacent grains.However,the amount of CGBP in the diffused magnets gradually decreases with the further increase of Co content in the diffusion source. | Lei Jin Jinhao Zhu Guangfei Ding Zhehuan Jin Bo Zheng Xuejing Cao Shuai Guo Renjie Chen Aru Yan | 2022 | Journal of Rare Earths2022，40，12： | 0 |
| 14 | Efficient production of 2′-fucosyllactose in unconventional yeast Yarrowia lipolytica显示文摘2′-Fucosyllactose(2′-FL)has great application value as a nutritional component and the whole cell biosynthesis of 2′-FL has become the focus of current research.Yarrowia lipolytica has great potential in oligosaccharide synthesis and large-scale fermentation.In this study,systematic engineering of Y.lipolytica for efficient 2′-FL production was performed.By fusing different protein tags,the synthesis of 2′-FL was optimized and the ubiquitin tag was demonstrated to be the best choice to increase the 2′-FL production.By iterative integration of the related genes,increasing the precursor supply,and promoting NADPH regeneration,the 2′-FL synthesis was further improved.The final 2′-FL titer,41.10 g/L,was obtained in the strain F5-1.Our work reports the highest 2′-FL production in Y.lipolytica,and demonstrates that Y.lipolytica is an efficient microbial chassis for the synthesis of oligosaccharides. | Yan Zhang Xuejing Zhang Haiyan Liu Jin Hou Mengmeng Liu Qingsheng Qi | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 15 | Cycloaddition of hydrazones and 1,2-diarylalkynes promoted by t-BuOK/DMF:A convenient synthesis of tetraarylpyrazoles显示文摘A facile synthesis of tetraarylpyrazoles has been developed via t-BuOK/DMF promoted intermolecular cycloaddition of hydrazones and 1,2-diarylalkynes. A possible reaction pathway via a hydrazone radical is proposed. | Lang Tong Zhifeng Mao Xiangzheng Tang Xuejing Zhang Ming Yan | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
| 16 | An improved coverage-oriented retrieval algorithm for large-area remote sensing data显示文摘With the rapid development of satellite technology,the amount of remote sensing data and demand for remote sensing data analysis over large areas are greatly increasing.Hence,it is necessary to quickly filter out an optimal dataset from massive dataset to support various remote sensing applications.However,with the improvements in temporal and spatial resolution,remote sensing data have become fragmented,which brings challenges to data retrieval.At present,most data service platforms rely on the query engines to retrieve data.Retrieval results still have a large amount of data with a high degree of overlap,which must be manually selected for further processing.This process is very labour-intensive and time-consuming.This paper proposes an improved coverage-oriented retrieval algorithm that aims to retrieve an optimal image combination with the minimum number of images closest to the imaging time of interest while maximized covering the target area.The retrieval efficiency of this algorithm was analysed by applying different implementation practices:Arcpy,PyQGIS,and GeoPandas.The experimental results confirm the effectiveness of the algorithm and suggest that the GeoPandas-based approach is most advantageous when processing large-area data. | Xuejing Yan Shibin Liu Wei Liu Qin Dai | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
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