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| 1 | Reductive damage induced autophagy inhibition for tumor therapy显示文摘Numerous therapeutic anti-tumor strategies have been developed in recent decades.However,their therapeutic efficacy is reduced by the intrinsic protective autophagy of tumors.Autophagy plays a key role in tumorigenesis and tumor treatment,in which the overproduction of reactive oxygen species(ROS)is recognized as the direct cause of protective autophagy.Only a few molecules have been employed as autophagy inhibitors in tumor therapy to reduce protective autophagy.Among them,hydroxychloroquine is the most commonly used autophagy inhibitor in clinics,but it is severely limited by its high therapeutic dose,significant toxicity,poor reversal efficacy,and nonspecific action.Herein,we demonstrate a reductive-damage strategy to enable tumor therapy by the inhibition of protective autophagy via the catalytic scavenging of ROS using porous nanorods of ceria(PN-CeO_(2))nanozymes as autophagy inhibitor.The antineoplastic effects of PN-CeO_(2)were mediated by its high reductive activity for intratumoral ROS degradation,thereby inhibiting protective autophagy and activating apoptosis by suppressing the activities of phosphatidylinositide 3-kinase/protein kinase B and p38 mitogen-activated protein kinase pathways in human cutaneous squamous cell carcinoma.Further investigation highlighted PN-CeO_(2)as a safe and efficient anti-tumor autophagy inhibitor.Overall,this study presents a reductive-damage strategy as a promising anti-tumor approach that catalytically inhibits autophagy and activates the intrinsic antioxidant pathways of tumor cells and also shows its potential for the therapy of other autophagy-related diseases. | Yuqian Wang Yingjian Huang Yu Fu Zhixiong Guo Da Chen Fangxian Cao Qi Ye Qiqi Duan Meng Liu Ning Wang Dan Han Chaoyi Qu Zhimin Tian Yongquan Qu Yan Zheng | 2023 | Nano Research2023，16，4： | 1 |
| 2 | 2-4 First Isochronous Mass Measurement in Neutron-rich Region at CSRe显示文摘Mass is one of the fundamental properties of atomic nuclei. Isochronous mass spectrometry (IMS), using astorage ring combined with an in-flight separator, has been shown to be a powerful tool for mass measurementof exotic nuclei[1]. Recently, masses of many proton-rich nuclides were accurately determined at the HIRFL-CSRfacility[2]. In this paper, we described the first isochronous mass measurement of neutron-rich nuclides at CSRe.This experiment was performed at the end of 2011. In the experiment, the primary beam of 86Kr28+ ions wasaccumulated and accelerated to an energy of 460.65 MeV/u in the synchrotron CSRm. The 86Kr28+ ions were fastextracted and focused on a 15 mm thick beryllium target which was placed at the entrance of the RIBLL2 (anin-flight fragment separator). | Xu Xing Wang Meng Zhang Yuhu Xu Hushan Tu Xiaolin Yu.A.Litvinov Zhou Xiaohong Sun Baohua Yuan Youjin Xia Jiawen Yang Jiancheng K.Blaum Chen Ruijiu Chen Xiangchen Fu Chaoyi Ge Zhuang Hu Zhengguo Huang Wenjia Liu Dawei Y.H.Lam Ma Xinwen Mao Ruishi T.Uesaka Xiao Guoqing Xing Yuanming T.Yamaguchi Y.Yamaguchi Zeng Qi Yan Xinliang Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 3 | 2-6 First Isochronous Mass Measurements with Two Time-of-Flight Detectors at CSRe显示文摘In conventional isochronous mass spectrometry (IMS), single time-of-flight (TOF) method is adopted to measurethe ions' revolution times in a storage ring which can then be used to calculate the ions' masses. However, themass-to-charge ratio (m=q) is only related to the revolution time (T) under the condition that is equal to taccording to the following equation: | Xing Yuanming Zhang Yuhu Wang Meng Xu Hushan Shuai Peng Xu Xing Chen Ruijiu Yan Xinliang Tu Xiaolin Zhang Wei Fu Chaoyi Zeng Qi Yu.A.Litvinov K.Blaum Chen Xiangcheng Ge Zhuang Gao Bingshui Huang Wenjia S.A.Litvinov Liu Dawei Ma Xinwen Mao Ruishi Xiao Guoqing Yang Jiancheng Yuan Youjin Zhou Xiaohong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 4 | 2-8 SimCSR Program for the Simulation of the Isochronous Mass Spectrometry at the HIRFL-CSR显示文摘Until now, several isochronous mass spectrometry (IMS) experiments have been successfully performed usingvarious primary beams at the HIRFL-CSR and masses of both proton-rich and proton-deficient exotic nuclei havebeen measured. In order to improve the performance of the IMS experiments and to provide a reliable tool fordesigning and preparing the future experiments, a simulation code, named SimCSR is developed.Presently, six-dimension phase-space linear transmission theory is applied to simulate the transmission of ionsin the experimental storage ring (CSRe). The basic algorithm is Bf = MBi. The Bi and Bf are six-dimensionphase-space vectors of ions at the entrance and exit of each element of the CSRe lattice, respectively. M is a6-by-6-dimension first-order transfer matrix of each element. M is calculated using formulas described in Ref.[1]. Inthe simulations, the ring lattice is considered in detail, and the same magnetic setting as in our previous experimentwith 58Ni projectile fragments[2] is considered. The ions are assumed to circulate 300 turns inside the CSRe. | Chen Ruijiu Yuan Youjin Wang Meng Xu Xing Shuai Peng Zhang Yuhu Yan Xinliang Xing Yuanming Xu Hushan Zhou Xiaohong Litvinov Yuri Litvinov Sergy Chen Xiangcheng Fu Chaoyi Ge Wenwen Ge Zhuang Hu Xuejing Huang Wenjia Liu Dawei Zeng Qi Zhang Wei | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 5 | 2-9 Half-life Measurement of 94mRu44+ at CSRe显示文摘A radioactive nucleus is characterized with an intrinsic half-life. However, for a nuclear species, the half-lives inneutral atoms could be very different from that in highly charged ions. The half-lives of some highly charged ionshave been directly measured at GSI for multiple motivations[1]. In the same case, the nuclear state(i:e the isomer)may be in the range of several tens of microseconds and their half-live can be measured using isochronous massspectrometry. The J = 8+ isomeric state in 94Ru was chosen to test this method. The half-life of this isomer is71 s [2] in neutral atoms, and the excitation energy is 2.64 MeV. The internal conversion coefficient of this decayin neutral atom is 0.335. So its half-life in the bare nucleus would be modified to be 94.78 s when the internalconversion channel is blocked. | Zeng Qi Zhang Yuhu Wang Meng Xu Hushan Tu Xiaolin Zhou Xiaohong Yan Xinliang Chen Ruijiu Huang Wenjia Ge Zhuang Liu Dawei Fu Chaoyi Sun Mingze Mei Bo Xu Xing Xing Yuanming Shuai Peng Zang Yongdong Zhang Wei Xiao Guoqing Yu.A.Litvinov Isao.Tanihata | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 6 | 重离子存储环等时性质谱术中的粒子鉴别和回旋周期修正显示文摘In the isochronous mass spectrometry(IMS)[1]performed at storage rings,masses of short-lived nuclides are determined through precision measurements of their revolution time which has a relationship with the mass-tocharge ratio,m=q as following。 | Xing Yaunming Zhang Yuhu Wang Meng Yu.A.Litvinov Chen Ruijiu Chen Xiangcheng Fu Chaoyi Shuai Peng Si Min Sun Mingze Tu Xiaolin Xu Hushan Xu Xing Yan Xinliang Yuan Youjin Zhang Min Zhou Xu Zhou Xiaohong | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 7 | 5 - 20 Isochronous Mass Spectrometry with Two Time-of-Flight Detectors at CSRe显示文摘 | Wang Meng Xu Hushan Zhang Yuhu Shuai Peng Zhang Wei Tu Xiaolin Xu Xing Yu. A. Litvinov K. Blaum Chen Ruijiu Chen Xiangcheng Fu Chaoyi Ge Zhuang Gao Bingshui Hu Zhengguo Huang Wenjia S. A. Litvinov Liu Dawei Ma Xinwen Mao Ruishi Mei Bo Sun Baohua Xia Jiawen Xiao Guoqing Xing Yuanming T. Yarnaguchi Yan Xinliang Yang Jiancheng Yuan Youjin Zeng Qi Zhang Xueying Zhao Hongwei Zhao Tieeheng Zhou Xiaohong | 2013 | IMP & HIRFL Annual Report2013，，1： | 0 |
| 8 | Precision Velocity Measurement of Stored Ions for IMS at the CSRe显示文摘Isochronous mass spectrometry(IMS)at heavy-ion rings is a powerful tool for precision mass measurements of short-lived nuclei.In the conventional IMS,the masses are determined through precision measurements of revolution times. | Zhou Xu Wang Meng Zhang Yuhu Fu Chaoyi Zeng Qi Xing Yuanming Zhang Min | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 9 | CSRe二极磁铁电源稳定性测试显示文摘The distance between two identical Time-Of-Flight(TOF)detectors,which are installed inside 10−11 mbar vacumm beam pipe in the straight section of the storage ring CSRe,is measured by a laser range-finder Leica Nova MS60 MultiStation[1].The objects of the measurement are the two carbon-foils of the detectors with their centres aligned to the ion beam trajectory.The diameter and thickness of the foils are 40 mm and90 nm respectively.Schematic view and picture of the TOF-detector[2]are shown in the left and middle panels of Fig.1.The TOFdetectors are moveable in x direction so that the carbon foil can be placed in and out of the beam line. | Yan Xinliang Chen Ruijiu Ma Hui Yuan Jiandong Wang Shaoming Cai Guozhu Zhang Min Lu Ziwei Fu Chaoyi Zhou Xu Wang Meng Zhang Yuhu | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 10 | 2-5 Mass Measurements of Neutron-defcient Nuclides 79Y,81,82Zr,83,84Nb显示文摘The masses of neutron-defcient nuclides play a critical role in the calculation of astrophysical rapid proton-capture processes[1].Neutron-defcient nuclides with mass number∧around 80 are the last set of nuclides with unknown masses on the pathway of vp-process[2].The mass measurement of nuclides would be very useful.In 2016,masses of neutron-defcient nuclides 79Y,81Zr,82Zr,83Nb and 84Nb nuclei were precisely measured directly by the experimental storage-ring CSRe at Lanzhou. | Xing Yuanming Zhang Yuhu Wang Meng Xu Hushan Chen Ruijiu Shuai Peng Yan Xinliang Fu Chaoyi Xu Xing Tu Xiaolin Zhang Wei Zeng Qi Yu.A.Litvinov K.Blaum Chen Xiangcheng Ge Zhuang Gao Bingshui Huang Wenjia S.A.Litvinov Ma Xinwen Mao Ruishi Xiao Guoqing Yang Jiancheng Yuan Youjin Zhou Xiaohong | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 11 | 2-6 Mass Prediction of Neutron-defcient N=Z Nuclides 78Y,80Zr,82Nb and 84Mo显示文摘We have reported the mass measurements of neutron-deficient nuclides 79Y,81;82Zr,83;84Nb in this year’s Annual Report.However,for the N=Z nuclides close to A=80,the yield is much lower and even if they can be produced,there is still great difficult to identify them because of their quite similar mass-to-charge ratio and revolution times.However,their mass are extremely important for rapid proton capture process,for example,80Zr and 84Mo are waiting points of rp-process.Their masses can greatly effect the reaction flow of proton capture on them and then the abundance of the heavier nuclides.In addition,the separation energy of 84Mo(determined by the mass of 80Zr and 84Mo)has a strong impact on the 83Nb(p,α)reaction rate and plays a key role in the formation of Zr-Nb Fig. | Xing Yuanming Zhang Yuhu Wang Meng Xu Hushan Chen Ruijiu Chen Xiangcheng Fu Chaoyi Ge Zhuang Gao Bingshui Huang Wenjia Ma Xinwen Mao Ruishi S.A.Litvinov Shuai Peng Tu Xiaolin Xiao Guoqing Xu Xing Yan Xinliang Yu.A.Litvinov Yang Jiancheng Yuan Youjin Zhang Wei Zeng Qi Zhou Xiaohong | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 12 | 2-7 Study of Zr-Nb Cycle in Astrophysical rp-process显示文摘At a certain high temperature,this cycle will be dominant and end the rp-process to heavier region[2].It provides an upper temperature limit for rp-process along the proton drip line to produce nuclides beyond A=84,including the light p nuclides of 92;94Mo,96;94Ru.The existence of Zr-Nb cycle is an important question in rp-process[2].α-separation energy(Sα)of 84Mo plays an important role in the formation of this cycle.A strong enhancement of 83Nb(p,α)reaction rate is due to a very low Sαof 84Mo[1]. | Xing Yuanming Zhang Yuhu Wang Meng Li Kuoang Tang Xiaodong Xu Hushan Chen Ruijiu Chen Xiangcheng Fu Chaoyi Ge Zhuang Gao Bingshui Huang Wenjia Ma Xinwen Mao Ruishi S.A.Litvinov Shuai Peng Tu Xiaolin Xiao Guoqing Xu Xing Yan Xinliang Yu.A.Litvinov Yang Jiancheng Yuan Youjin Zhang Wei Zeng Qi Zhou Xiaohong | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 13 | 2-8 Direct Mass Measurements of Short-Lived A=2Z+3 Nuclides at CSRe显示文摘Nuclear mass is one of the fundamental quantity of atomic nucleus.The total binding energy of a nucleus derived from the related mass values reflects all the interactions among the constituting nucleons.Masses of short-lived A=2Z+3 nuclei of 112Sn projectile fragments have been measured at the experimental cooler storage ring CSRe,employing the Isochronous mass spectrometry(IMS).The experiment was conducted at the Heavy Ion Research Facility in Lanzhou at the beginning of 2016.The primary beam of 112Sn35+was accumulated in the synchrotron CSRm and accelerated to 467.91 MeV/u.Secondary beam were produced by impinging the high intensity 112Sn35+beam onto a 10 mm beryllium target which was located at the entrance of the radioactive beam line RIBLL2.The projectile fragments of 112Sn emerged from the target were then transmitted,separated in flight through RIBLL2 and finally injected into CSRe. | Liu Junhao Xing Yuanming Yan Xinliang Xu Xing Chen Ruijiu Zeng Qi Zhang Peng Shuai Peng Li Hongfu Zhang Yuhu Wang Meng Yuan Youjin Fu Chaoyi Sun Mingze Chen Xiangchen Bao Tong Lam Yihua | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 14 | 2-4 Principle of Isochronous Mass Spectrometry Using Two Time-of-flight Detectors显示文摘Isochronous mass spectrometry (IMS) in storage rings is a powerful tool for mass measurements of exotic nucle with very short half-lives down to several tens of microseconds, using a multicomponent secondary beam separated in-ight without cooling. However, the inevitable momentum spread of secondary ions limits the precision of nuclear masses determined by using IMS. | Xu Xing Shuai Peng Zhang Yuhu Wang Meng Tu Xiaolin Xu Hushan Yuan Youjin Chen Xiangchen Chen Ruijiu Yan Xinliang Bao Tong Fu Chaoyi Ge Zhuang Huang Wenjia Sun Mingze Xing Yuanming Zeng Qi Zhang Peng Zhou Xu | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | 2-5 Efforts toward World Best Storage-ring-based Mass Spectrometry显示文摘Nuclear mass measurements provide valuable information on the nuclear binding energy which reflects the summed result of all interactions among its constituent protons and neutrons. The systematic and accurate knowledge of nuclear masses have wide application in many areas of subatomic physics ranging from nuclear structure and astrophysics to the fundamental interactions and symmetries depending on the achieved mass precision[1]. | Xu Xing Zhang Peng Shuai Peng Zhang Yuhu Wang Meng Tu Xiaolin Xu Hushan Yuan Youjin Chen Xiangchen Bao Tong Chen Ruijiu Yan Xinliang Chen Han Fu Chaoyi Ge Zhuang Huang Wenjia Lam Yihua Sun Mingze Xing Yuanming Zeng Qi Zhou Xu | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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