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| 1 | Hairy Leaf 6, an AP2/ERF Transcription Factor, Interacts with OsWOX3B and Regulates Trichome Formation in Rice显示文摘毛状体形成广泛地在植物为表皮的房间区别和房间形态发生作为一个机械学的模型被学习了。然而,位于毛状体形成下面的基因、分子的机制(即,开始和延伸) 在米饭仍然保持大部分不清楚。这里,我们报导一个 AP2/ERF 抄写因素,毛乎乎的叶 6 (HL6 ) ,它在米饭控制毛状体形成。功能的分析表明 HL6 transcriptionally 在米饭调整毛状体延伸,它依赖于功能的 OsWOX3B,在毛状体充当一个关键管理者的包含 homeodomain 蛋白质开始。生物化学、分子的基因分析证明那 HL6 身体上交往与 OsWOX3B,和他们俩在毛状体形成, OsWOX3B 多半与它的直接目标基因之一在提高 HL6 的有约束力的能力期间调整一些植物生长素相关的基因的表达式, OsYUCCA5。人口基因分析显示 HL6 在米饭驯服期间在否定选择下面。一起拿,我们的调查结果提供新卓见进毛状体形成的分子的规章的网络在 ? 米饭。 | Wenqiang Sun Dawei Gao Yin Xiong Xinxin Tang Xiongfeng Xiao Chongrong Wang Sibin Yu | 2017 | Molecular Plant2017，10，11： | 20 |
| 2 | Analysis of bacterial community in bulking sludge using culture-dependent and -independent approaches显示文摘The bacterial community of a bulking sludge from a municipal wastewater treatment plant with anoxic-anaerobic-oxic process was investigated by combination of cultivation and 16S rRNA gene clone library analysis for understanding the causes of bulking.A total of 28 species were obtained from 63 isolates collected from six culture media.The most cultivable species belonged to γ-Proteobacteria including Klebsiella sp.,Pseudomonas sp.,Aeromonas sp.and Acinetobacter sp.Further analysis of these strains by repetitive sequence based on polymerase chain reaction (rep-PCR) technology showed that rep-PCR yielded discriminatory banding patterns within the same genus using REP and BOX primer sets.While the culture-independent assessment revealed that β-Proteobacteria was the dominant group in the bulking sample.Sequence analysis revealed that the highest proportion (14.7%) of operational taxonomic units was 98% similar to Candidatus Accumulibacter phosphatis,which is used to remove phosphorous from wastewater.Our results indicated that combining different approaches can produce complementary information,thus generate a more accurate view of microbial community in bulking sludge. | Decai Jin Ping Wang Zhihui Bai Xinxin Wang Hong Peng Rong Qi Zhisheng Yu Guoqiang Zhuang | 2011 | Journal of Environmental Sciences2011，23，11： | 11 |
| 3 | Establishment and Preliminary Application of a Rapid Fluorescent Focus Inhibition Test (RFFIT) for Rabies Virus显示文摘The World Health Organization (WHO) standard assay for determining levels of the rabies virus neutralization antibody (RVNA) is the rapid fluorescent focus inhibition test (RFFIT), which is used to evaluate the immunity effect after vaccination against rabies. For RFFIT, CVS-11 was used as the challenge virus, BSR cells as the adapted cells, and WHO rabies immunoglobulin (WHO STD) as the reference serum in this study. With reference to WHO and Pasteur RFFIT procedures, a micro-RFFIT procedure adapted to our laboratory was produced, and its specificity and reproducibility were tested. We tested levels of RVNA in human serum samples after immunization with different human rabies vaccines (domestic purified Vero cell rabies vaccine (PVRV) and imported purified chick embryo cell vaccine (PCECV)) using different regimens (Zagreb regimen and Essen regimen). We analyzed the levels of RVNA, and compared the immune efficacy of domestic PVRV and imported PCECV using different immunization regimens. The results showed that the immune efficacy of domestic PVRV using the Zagreb regimen was as good as that of the imported PCECV, but virus antibodies were generated more rapidly with the Zagreb regimen than with the Essen regimen. The RFFIT procedure established in our laboratory will enhance the comprehensive detection ability of institutions involved in rabies surveillance in China. | Pengcheng Yu Xinjun Lv Xinxin Shen Qing Tang Guodong Liang | 2013 | Virologica Sinica2013，28，4： | 11 |
| 4 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 5 | Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios显示文摘The coronavirus disease 2019(COVID-19)has become a life-threatening pandemic.The epidemic trends in different countries vary considerably due to different policy-making and resources mobilization.We calculated basic reproduction number(R0)and the time-varying estimate of the effective reproductive number(Rt)of COVID-19 by using the maximum likelihood method and the sequential Bayesian method,respectively.European and North American countries possessed higher (R0)and unsteady Rt fluctuations,whereas some heavily affected Asian countries showed relatively low (R0)and declining Rt now.The numbers of patients in Africa and Latin America are still low,but the potential risk of huge outbreaks cannot be ignored.Three scenarios were then simulated,generating distinct outcomes by using SEIR(susceptible,exposed,infectious,and removed)model.First,evidence-based prompt responses yield lower transmission rate followed by decreasing Rt.Second,implementation of effective control policies at a relatively late stage,in spite of huge casualties at early phase,can still achieve containment and mitigation.Third,wisely taking advantage of the time-window for developing countries in Africa and Latin America to adopt adequate measures can save more people’s life.Our mathematical modeling provides evidence for international communities to develop sound design of containment and mitigation policies for COVID-19. | Chen Xu Yinqiao Dong Xiaoyue Yu Huwen Wang Lhakpa Tsamlag Shuxian Zhang Ruijie Chang Zezhou Wang Yuelin Yu Rusi Long Ying Wang Gang Xu Tian Shen Suping Wang Xinxin Zhang Hui Wang Yong Cai | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 6 | Thermal Radiative Properties of Xonotlite Insulation Material显示文摘This paper presents experimental results of thermal radiative properties of xonotlite-type calcium silicate insulation material. Transmittance spectra were first taken using Fourier transform infrared spectrometer (FTIR) for the samples with ρ =234 kg/m3. Specific extinction coefficient spectra were then obtained by applying Beer’s law. Finally, by using the diffusion approximation, the specific Rossland mean extinction coefficients and radiative thermal conductivities were obtained for various temperatures. The results show that the specific spectral extinction coefficient of xonotlite is larger than 7 m2/kg in the whole measured spectra, and diffusion approximation equation is a reasonable description of radiative heat transfer in xonotlite insulation material. The specific Rossland mean extinction coefficient of xonotlite has a maximum value at 400 K and the radiative thermal conductivity is almost proportional to the cube of temperature. | Xinxin ZHANG Gaosheng WEI Fan YU | 2005 | Journal of Thermal Science2005，14，3： | 5 |
| 7 | Effective Thermal Conductivity Analysis of Xonotlite-aerogel Composite Insulation Material显示文摘A 3-dimensional unit cell model is developed for analyzing effective thermal conductivity of xonotlite-aerogelcomposite insulation material based on its microstructure features. Effective thermal conductivity comparisonsbetween xonotlite-type calcium silicate and aerogel as well as xonotlite-aerogel composite insulation material arepresented. It is shown that the density of xonotlite-type calcium silicate is the key factor affecting the effectivethermal conductivity of xonotlite-aerogel composite insulation material, and the density of aerogel has little influence.The effective thermal conductivity can be lowered greatly by composite of the two materials at an elevatedtemperature. | Gaosheng WEI Xinxin ZHANG Fan YU | 2009 | Journal of Thermal Science2009，18，2： | 5 |
| 8 | Control for a Class of Stochastic Mechanical Systems Based on the Discrete-Time Approximate Observer显示文摘This paper investigates the observer-based control problem of a class of stochastic mechanical systems. The system is modelled as a continuous-time It o stochastic differential equation with a discrete-time output. Euler-Maruyama approximation is used to design the discrete-time approximate observer, and an observer-based feedback controller is derived such that the closed-loop nonlinear system is exponentially stable in the mean-square sense. Also, the authors analyze the convergence of observer error when the discrete-time approximate observer servers as a state observer for the exact system. Finally, a simulation example is used to demonstrate the effectiveness of the proposed method. | FU Xinxin KANG Yu LI Pengfei YU Peilong | 2019 | Journal of Systems Science & Complexity2019，32，2： | 4 |
| 9 | Early assessment of the safety and immunogenicity of a third dose(booster)of COVID-19 immunization in Chinese adults显示文摘Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via vaccination is essential to combat the current pandemic of coronavirus disease 2019(COVID-19).It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time,which calls for an additional vaccination regime,as known as booster immunization,to restore immunity among previously vaccinated populations.Here we report a pilot open-label trial of a third dose of BBIBP-CorV,an inactivated SARS-CoV-2 vaccine(Vero cell),on 136 participants aged between 18 to 63 years.Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28.While systemic reactogenicity was either absent or mild,SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks,surpassing the peak antibody titers elicited by the initial two-dose immunization regime.Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination.Furthermore,in an exploratory study,a newly developed recombinant protein vaccine,NVSI-06-08(CHO Cells),was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals.Together,these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity,providing support for further trials of booster vaccination in larger populations. | Yuntao Zhang Yunkai Yang Niu Qiao Xuewei Wang Ling Ding Xiujuan Zhu Yu Liang Zibo Han Feng Liu Xinxin Zhang Xiaoming Yang | 2022 | Frontiers of Medicine2022，16，1： | 3 |
| 10 | Divergence, evolution and adaptation in ray-finned fish genomes显示文摘With the rapid development of next-generation sequencing technologies and bioinformatics, over 50 ray-finned fish genomes by far have been sequenced with high quality. The genomic work provides abundant genetic resources for deep understanding of divergence, evolution and adaptation in the fish genomes. They are also instructive for identification of candidate genes for functional verification, molecular breeding, and development of novel marine drugs. As an example of other omics data, the Fish-T1 K project generated a big database of fish transcriptomes to integrate with these published fish genomes for potential applications. In this review, we highlight the above-mentioned recent investigations and core topics on the ray-finned fish genome research, with a main goal to obtain a deeper understanding of fish biology for theoretical and practical applications. | Chao Bian Yu Huang Jia Li Xinxin You Yunhai Yi Wei Ge Qiong Shi | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 11 | B7-DC (PD-L2) costimulation of CD4^(+) T-helper 1 response via RGMb显示文摘The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo.In addition to interacting with the coinhibitory receptor PD-1,B7-DC has also been shown to bind repulsive guidance molecule b(RGMb).The functional consequences of the B7-DC/RGMb interaction,however,remain unclear.More than a decade ago,we reported that replacement of a murine B7-DC mutant lysine with serine(K113S)at positive 113 resulted in a loss of binding capacity to PD-1.Nevertheless,K113S remained costimulatory for T cells in vitro,implicating a dual functionality for B7-DC in T-cell responses.Here we show that recombinant K113S protein interacts with RGMb with a similar affinity to wild-type B7-DC.More importantly,K113S costimulates CD4^(+)T-cell responses via RGMb and promotes Th1 polarization.RGMb is expressed on the surface of naive mouse T cells,macrophages,neutrophils and dendritic cells.Finally,K113S/RGMb costimulation suppresses Th2-mediated asthma and ameliorates small airway inflammation and lung pathology in an experimental mouse model.Our findings indicate that RGMb is a costimulatory receptor for B7-DC.These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses,but also a novel approach to investigate the B7-DC/PD-1/RGMb axis.Recombinant K113S or its derivatives could potentially be developed as an agonist for RGMb to costimulate the Th1 response without triggering PD-1-mediated T-cell inhibition. | Xinxin Nie Wenni Chen Ying Zhu Baozhu Huang Weiwei Yu Zhanshuai Wu Sizheng Guo Yiping Zhu Liqun Luo Shengdian Wang Lieping Chen | 2018 | Cellular & Molecular Immunology2018，15，10： | 3 |
| 12 | Van der Waals epitaxy of ultrathin crystalline PbTe nanosheets with high near-infrared photoelectric response显示文摘Lead telluride(PbTe)is one of the reliable candidates for infrared(IR)optoelectronics with optimum band-gap as well as excellent photoelectric properties.Great interests had been paid on the growth and device applications with PbTe for the development of high-performance IR photodetectors especially those working in the near-infrared regime.Although a great deal of effort had been made to prepare PbTe nanostructures for miniaturized detectors,it is difficult to synthesize high-quality two-dimensional(2D)PbTe crystals due to its rock-salt non-layered structure.Herein,a facile strategy for controllable synthesis of ultrathin crystalline PbTe nanosheets by van der Waals epitaxy is reported.With an optimized growth temperature,which determines the morphology transit from triangular pyramid islands to regular square 2D planars,PbTe nanosheets in lateral size of tens of microns with thickness down to~7 nm are achieved.Meanwhile,ultrasensitive near-infrared detectors(NIRDs)based on the as-grown 2D PbTe nanosheets have been demonstrated with an ultrahigh responsivity exceeding 3,847 A/W at the wavelength of 1,550 nm under room temperature.Our approach demonstrates that 2D PbTe nanosheets have great latent capacity of developing high-performance miniaturized IR optoelectronic devices. | Xinxin Zhao Qing Yin Hao Huang Qiang Yu Bo Liu Jie Yang Zhuo Dong Zhenjiang Shen Benpeng Zhu Lei Liao Kai Zhang | 2021 | Nano Research2021，14，6： | 3 |
| 13 | Semi-Fragile Audio Watermarking Algorithm in DWT Domain显示文摘A novel semi-fragile audio watermarking algorithm in DWT domain is proposed in this paper.This method transforms the original audio into 3-layer wavelet domain and divides approximation wavelet coefficients into many groups.Through computing mean quantization of per group,this algorithm embeds the watermark signal into the average value of the wavelet coefficients.Experimental results show that our semi-fragile audio watermarking algorithm is not only inaudible and robust against various common images processing,but also fragile to malicious modification.Especially,it can detect the tampered regions effectively. | LEI Min YANG Yu LUO Shoushan NIU Xinxin | 2010 | China Communications2010，7，4： | 3 |
| 14 | Metabolic manifestations of insulin deficiency do not occur without glucagon action显示文摘 | Young Lee Eric D. Berglund May-yun Wang Xiaorong Fu Xinxin Yu Maureen J. Charron Shawn C. Burgess Roger H. Unger | 2012 | Proceedings of the National Academy of Sciences2012，，37： | 2 |
| 15 | Mathematical Model and Its Application of Radial Effective Thermal Conductivity for Coil Heat Transfer in HPH Furnace显示文摘Temperature uniformity of steel coils in High Performance Hydrogen bell-type annealing furnace has a significant effect on their quality and production. The hot rolled coil can be considered as a periodically laminated material composed of steel layers and interface layers in radial direction. A new formula for the radial effective thermal conductivity has been proposed, which is based on surface characteristic, strip thickness and compressive stress of the rolled coil. Furthermore, it has been used to develop a heat transfer mathematical model for steel coils in the HPH furnace. The calculated annealing curves using this mathematical model are in good agreement with the experimental data. | Wenfei Wu Fan Yu Xinxin Zhang Yi Zuo | 2002 | Journal of Thermal Science2002，11，2： | 2 |
| 16 | Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis显示文摘 | Wei Li Baoyang Hu XuepengWang Tianda Li Tongtong Cui Dawei Yu Chao Liu Liyuan Jiang Guihai Feng Lei wang Rui Fu Xinxin Zhang Jie Hao Yukai Wang Liu Wang Qi Zhou | 2018 | Cell Research2018，28，1： | 2 |
| 17 | Numerical investigation of airborne transmission of respiratory infections on the subway platform显示文摘Underground subway platforms are among the world’s busiest public transportation systems,but the airborne transmission mechanism of respiratory infections on these platforms has been rarely studied.Here,computational fluid dynamics(CFD)modeling is used to investigate the airflow patterns and infection risks in an island platform under two common ventilation modes:Mode 1-both sides have air inlets and outlets;Mode 2-air inlets are present at the two sides and outlets are present in the middle.Under the investigated scenario,airflow structure is characterized by the ventilation jet and human thermal plumes.Their interaction with the infector’s breathing jet imposes the front passenger under the highest exposure risk by short-range airborne route,with intake fractions up to 2.57%(oral breathing)or 0.63%(nasal breathing)under Mode 1;oral breathing of the infector may impose higher risks for the front passenger compared with nasal breathing.Pathogen are efficiently diluted as they travel further,in particular to adjacent crowds.The maximum and median value of intake fractions of passengers in adjacent crowds are respectively 0.093%and 0.016%(oral breathing),and 0.073%and 0.014%(nasal breathing)under Mode 1.Compared with Mode 1,the 2nd mode minimizes the interaction of ventilation jet and breathing jet,where the maximum intake fraction is only 0.34%,and the median value in the same crowd and other crowds are reduced by 23–63%.Combining published quanta generation rate data of COVID-19 and influenza infectors,the predicted maximum and median infection risks for passengers in the same crowds are respectively 1.46%–40.23%and 0.038%–1.67%during the 3–10 min waiting period,which are more sensitive to ventilation rate and exposure time compared with return air.This study can provide practical guidance for the prevention of respiratory infections in subway platforms. | Jianjian Wei Sirui Zhu Feiwu He Qianfang Guo Xinxin Huang Jianxiang Yu Lirong Zou Tao Jin Jie Wu | 2022 | Geoscience Frontiers2022，13，6： | 2 |
| 18 | Numerical and experimental study on coke size distribution in bell-type charging in the CDQ shaft显示文摘The mechanism of coke size segregation in the radial direction of pre-chamber in coke dry quenching(CDQ)shaft was investigated by experiment and numerical analysis.The experimental apparatus was a cold three-dimensional semicircle model for bell-type charging,which was used to study the influences of different kinds of bells and different stock line levels on the radial dis- tribution of coke size in the radial direction of a pre-chamber.A mathematical model was used,which is capable of estimating the radial average size distribution as well as the radial deposit distribution of each particle size for multiple size coke with a few fixed parameters.The calculated results agree well with the experimental data,which proves the reliability of both experimental study and numerical analysis. | Zhicheng Liu Yanhui Feng Xinxin Zhang Lie Xu Zhendong Yu | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 2 |
| 19 | Thermal conductivity measurements on xonotlite-type calcium silicate by the transient hot-strip method显示文摘The experimental results of the thermal conductivities of xonotlite-type calcium silicate insulation materials were pre-sented at different temperatures and pressures. Two appropriative surroundings, i.e. an elevated temperature surrounding from ambi-ent temperature to 1450 K and a vacuum surrounding from atmosphere pressure to 10-3 Pa, were designed for the transient hot-strip (THS) method. The thermal conductivities of xonotlite-type calcium silicate with four densities from ambient temperature to 1000 K and 0.045 Pa to atmospheric pressure were measured. The results show that the thermal conductivity of xonotlite-type calcium sili-cate decreases apparently with the fall of density, and decreases apparently with the drop of pressure, and reaches the least value at about 100 Pa. The thermal conductivity of xonotlite-type calcium silicate increases almost linearly with T3, and increases more abundantly with low density than with high density. The thermal conductivity measurement uncertainty is estimated to be approxi-mately 3% at ambient temperature, and 6% at 800 K. | Gaosheng Wei Xinxin Zhang Fan Yu | 2008 | Journal of University of Science and Technology Beijing2008，15，6： | 2 |
| 20 | Bright photon-pair source based on a silicon dual-Mach-Zehnder microring显示文摘Single photons and photon pairs are typically generated by spontaneous parametric down conversion or quantum dots;however,spontaneous four-wave mixing(SFWM)in silicon microring resonators[1]is also an appealing source of entangled photons,offering a strong cavity-enhanced nonlinear interactions while maintaining features,such as compact,simple to fabricate,and allowing for thermal tuning.However,silicon ring-resonators usually suffer from a trade-off between providing a high pair generation rate(PGR)and high extraction efficiency.To achieve high PGR,devices are generally operated with the signal and idler photons in the undercoupling regime and pump photons at the critical coupling point,while high extraction rates require the converted photons to be overcoupled.Therefore,the optimal conditions for achieving maximal output photon pair flux are critical coupling for the pump photons and overcoupling for the converted photons[2,3]. | Chao Wu YingWen Liu XiaoWen Gu XinXin Yu YueChan Kong Yang Wang XiaoGang Qiang JunJie Wu ZhiHong Zhu XueJun Yang Ping Xu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，2： | 2 |
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