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| 1 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 2 | Isolation and characterisation of collagens from the skin, scale and hone of deep - sea redfish (Sehastes mentella) 显示文摘 | Wang Lin An Xinxin Yang Fangmei | 2008 | Food Chemistry2008，108，2： | 1 |
| 3 | Isolation and characterisation of collagens from the skin,scale and bone of deepsea redfish(Sebastes mentella)显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food chemistry2008，108，： | 1 |
| 4 | Isolation and characteri- sation of collagens from the skin, scale and bone of deep sea redfish (Sebastes mentella)显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food Chemistry2008，，108： | 1 |
| 5 | Isolation and characterisation of collagens from the skin, scale and bone of deep sea redfish (Sebastes mentella)显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food Chemistry2008，，108： | 1 |
| 6 | Isolation and Characteviantion of collagen from the skin,scale and bone of deep-sea redfish(Sebastes mentella ) 显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food chemistry2008，108，： | 1 |
| 7 | Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish ( Sebastes mentella )显示文摘 | Lin Wang Xinxin An Fangmei Yang Zhihong Xin Liyan Zhao Qiuhui Hu | 2007 | Food Chemistry2007，，2： | 1 |
| 8 | Silibinin induced the apoptosis of Hep-2 cells via oxidative stress and down-regulating survivin expression显示文摘 | Xinxin Yang Xiaoyu Li Liangxiang An Bo Bai Jing Chen | 2013 | European Archives of Oto-Rhino-Laryngology2013，，： | 1 |
| 9 | Isolation and chamcterisation of collagens from the skin,scale and bone of deep sea redfish(Sebastes rnentella)显示文摘 | Lin Wang Xinxin An Fangmei Yang | | 0，，02： | 1 |
| 10 | Isolation and characterisation of collagens from the skin, scale and bone of deep - sea redfish ( Sebastes mentella) 显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food Chemistry2008，，108： | 1 |
| 11 | Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella)显示文摘 | WANG Lin AN Xinxin YANG Fangmei | 2008 | Food Chemistry2008，108，： | 1 |
| 12 | Regulation of gastric hormones by systemic rapamycin显示文摘 | Geyang Xu Yin Li Wenjiao An Jing Zhao Xinxin Xiang Li Ding Ziru Li Youfei Guan Xian Wang Chaoshu Tang Yi Zhu Nanping Wang Xiaoying Li Michael Mulholland Weizhen Zhang | 2010 | Peptides2010，，12： | 1 |
| 13 | Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella)显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food Chemistry2008，108，： | 1 |
| 14 | Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella ) 显示文摘 | Wang Lin An Xinxin Yang Fengmei | 2008 | Food Chemistry2008，108，： | 1 |
| 15 | Structure and prop-erties of miktoarm star-shaped styrene-butadiene copolymers显示文摘 | Zhang Haiyan Li An Kong Xinxin | 2010 | Journal of Beijing University of Chemistry Technology:Natural Science Edition2010，37，1： | 1 |
| 16 | Isolation and characterisation of collagens from the skin, scale and bone of deep - sea redfish ( Sebastes mentella) 显示文摘 | Wang Lin An Xinxin Yang Fengmei | 2008 | Food Chemistry2008，108，： | 1 |
| 17 | Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella)显示文摘 | Wang Lin An Xinxin Yang Fangmei | 2008 | Food Chemistry2008，108，： | 1 |
| 18 | Isolation and characterisation of collagens from the skin,scale and bone of deep-sea redfish(Sebastes mentella)显示文摘 | Lin Wang Xinxin An Fangmei Yang | 2008 | Food Chemistry2008，，108： | 1 |
| 19 | Isolation and characterization of collagens from the skin, scale and bone of deep sea redfish:Sebastes mentella显示文摘 | Wang Lin An Xinxin Yang Fangmei | 2008 | Food Chemistry2008，，108： | 1 |
| 20 | Over-expression of pcvA involved in vesicle - vacuolar fusion affects the conidiation and penicillin production in Penicillium chrysogenum显示文摘 | Xinxin Xu Jing Yang Yang An | 2012 | Biotechnology Letters2012，，3： | 1 |
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