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| 1 | Solid-state additive manufacturing and repairing by cold spraying:A review显示文摘High-performance metal additive manufacturing(AM) has been extensively investigated in recent year because of its unique advantages over traditional manufacturing processes. AM has been applied to form complex components of Ti, Fe or Ni alloys. However, for other nonferrous alloys such as Al alloys, Mg alloys and Cu alloys, AM may not be appropriate because of its melting nature during processing by laser electron beam, and/or arc. Cold spraying(CS) has been widely accepted as a promising solid-state coating technique in last decade for its mass production of high-quality metals and alloys, and/or metal matrix composites coatings. It is now recognized as a useful and powerful tool for AM, but the related research work has just started. This review summarized the literature on the state-of-the-art and problems for C as an AM and repairing technique. | Wenya Li Kang Yang Shuo Yin Xiawei Yang Yaxin Xu Rocco Lupoi | 2018 | Journal of Materials Science & Technology2018，34，3： | 35 |
| 2 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 3 | Research progress and mechanism of nanomaterials-mediated in-situ remediation of cadmium-contaminated soil:A critical review显示文摘Cadmium contamination of soil is a global issue and in-situ remediation technology as a promising mitigation strategy has attracted more and more attention.Many nanomaterials have been applied for the in-situ remediation of cadmium-contaminated soil due to their excellent properties of the nano-scale size effect.In this work,recent research progress of various nanomaterials,including carbon nanomaterials,metal-based nanomaterials and nano mineral materials,in the removal of cadmium and in-situ remediation of cadmiumcontaminated soil were systematically discussed.Additional emphases were particularly laid on both laboratory and field restoration effects.Moreover,the factors which can affect the stability of cadmium,main interaction mechanisms between nanomaterials and cadmium in the soil,and potential future research direction were also provided.Therefore,it is believed that this work will ultimately contribute to the myriad of environmental cleanup advances,and further improve human health and sustainable development. | Yuenan Zhang Yujie Zhang Ozioma Udochukwu Akakuru Xiawei Xu Aiguo Wu | 2021 | Journal of Environmental Sciences2021，33，6： | 15 |
| 4 | CCL5/CCR5 axis in human diseases and related treatments显示文摘To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among them, chemokines act as crucial regulators in defense systems. CCL5/CCR5 combination is known for facilitating inflammatory responses, as well as inducing the adhesion and migration of different T cell subsets in immune responses. In addition, recent studies have shown that the interaction between CCL5 and CCR5 is involved in various pathological processes including inflammation, chronic diseases, cancers as well as the infection of COVID-19. This review focuses on how CCL5/CCR5 axis participates in the pathological processes of different diseases and their relevant signaling pathways for the regulation of the axis. Moreover, we highlighted the gene therapy and chemotherapy studies for treating CCR5-related diseases, including the ongoing clinical trials. The barriers and perspectives for future application and translational research were also summarized. | Zhen Zeng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Genes & Diseases2022，9，1： | 12 |
| 5 | Mitochondrial DNA in the regulation of innate immune responses显示文摘线粒体作为房间的精力工厂被知道,它也是一个唯一的哺乳动物的细胞器并且考虑超过 10 亿年以前从氧气的初核质被发展。Mitochondrial DNA,类似于它的细菌的祖先,由一个圆形的环组成并且作为 CpG 岛包含 unmethylated DNA 的重要数字。天生的免疫系统在哺乳动物的有免疫力的反应起一个重要作用。最近的研究证明了 mitochondrial DNA (mtDNA ) 激活包含发信号的 TLR9, NLRP3 和圈套的几条天生的有免疫力的小径,它在受动器回答贡献发信号的平台和结果。除了便于抗菌剂豁免并且调整抗病毒的发信号,装证据建议 mtDNA 贡献跟随细胞的损坏和应力的煽动性的疾病。除了它在细胞的新陈代谢和精力生产的欣赏得好的角色,因此, mtDNA 看起来在天生的免疫系统作为一个关键成员工作。这里,我们在天生的免疫加亮 mtDNA 的新兴的角色。 | Chunju Fang Xiawei Wei Yuquan Wei | 2016 | Protein & Cell2016，7，1： | 12 |
| 6 | JMJD3 in the regulation of human diseases显示文摘In recent years,many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases.The Jumonji domain-containing protein D3(JMJD3),specifically demethylate di-and trimethyllysine 27 on histone H3(H3K27me2/3),has been widely studied in immune diseases,infectious diseases,cancer,developmental diseases,and aging related diseases.We will focus on the recent advances of JMJD3 function in human diseases,and looks ahead to the future of JMJD3 gene research in this review. | Xiangxian Zhang Li Liu Xia Yuan Yuquan Wei Xiawei | 2019 | Protein & Cell2019，10，12： | 10 |
| 7 | Epigenetic regulation of macrophages: from homeostasis maintenance to host defense显示文摘Macrophages are crucial members of the innate immune response and important regulators.The differentiation and activation of macrophages require the timely regulation of gene expression,which depends on the interaction of a variety of factors,including transcription factors and epigenetic modifications.Epigenetic changes also give macrophages the ability to switch rapidly between cellular programs,indicating the ability of epigenetic mechanisms to affect phenotype plasticity.In this review,we focus on key epigenetic events associated with macrophage fate,highlighting events related to the maintenance of tissue homeostasis,responses to different stimuli and the formation of innate immune memory.Further understanding of the epigenetic regulation of macrophages will be helpful for maintaining tissue integrity,preventing chronic inflammatory diseases and developing therapies to enhance host defense. | Siyuan Chen Jing Yang Yuquan Wei Xiawei Wei | 2020 | Cellular & Molecular Immunology2020，17，1： | 8 |
| 8 | Molecular mechanisms and clinical management of cancer bone metastasis显示文摘As one of the most common metastatic sites of malignancies,bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish.The fenestrated capillaries in the bone,bone matrix,and bone cells,including osteoblasts and osteoclasts,together maintain the homeostasis of the bone microenvironment.In contrast,tumor-derived factors act on bone components,leading to subsequent bone resorption or excessive bone formation.The various pathways involved also provide multiple targets for therapeutic strategies against bone metastases.In this review,we summarize the current understanding of the mechanism of bone metastases.Based on the general process of bone metastases,we specifically highlight the complex crosstalk between tumor cells and the bone microenvironment and the current management of cancer bone metastases. | Manni Wang Fan Xia Yuquan Wei Xiawei Wei | 2020 | Bone Research2020，8，3： | 7 |
| 9 | Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine显示文摘Mesenchymal stem cell(MSC)-mediated immunomodulation has been harnessed for the treatment of human diseases,but its underlying mechanism has not been fully understood.Dead cells,including apoptotic cells have immunomodulatory properties.It has been repeatedly reported that the proportion of nonviable MSCs in a MSC therapeutic preparation varied from 5-50%in the ongoing clinical trials.It is conceivable that the nonviable cells in a MSC therapeutic preparation may play a role in the therapeutic effects of MSCs.We found that the MSC therapeutic preparation in the present study had about 5%dead MSCs(DMSCs),characterized by apoptotic cells.Namely,1×10^(6) MSCs in the preparation contained about 5×10^(4) DMSCs.We found that the treatment with even 5×10^(4) DMSCs alone had the equal therapeutic effects as with 1×10^(6) MSCs.This protective effect of the dead MSCs alone was confirmed in four mouse models,including concanavalin A(ConA)-and carbon tetrachloride(CCI4)-induced acute liver injury,LPS-induced lung injury and spinal cord injury.We also found that the infused MSCs died by apoptosis in vivo.Furthermore,the therapeutic effect was attributed to the elevated level of phosphatidylserine(PS)upon the injection of MSCs or DMSCs.The direct administration of PS liposomes(PSLs)mimic apoptotic cell fragments also exerted the protective effects as MSCs and DMSCs.The Mer tyrosine kinase(MerTK)deficiency or the knockout of chemokine receptor C-C motif chemokine receptor 2(CCR2)reversed these protective effects of MSCs or DMSCs.These results revealed that DMSCs alone in the therapeutic stem cell preparation or the apoptotic cells induced in vivo may exert the same immunomodulatory property as the'living MSCs preparation'through releasing PS,which was further recognized by MerTK and participated in modulating immune cells. | Xuemei He Weiqi Hong Jingyun Yang Hong Lei Tianqi Lu Cai He Zhenfei Bi Xiangyu Pan Yu Liu Lunzhi Dai Wei Wang Canhua Huang Hongxin Deng Xiawei Wei | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 6 |
| 10 | Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment显示文摘Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of Salmonella in immunocompetent and immunodeficient mice bearing melanoma allografts.Since flagella are key inducers of the host immune response during bacterial infection,flagella were genetically disrupted to analyse their involvement in Salmonella-mediated cancer therapy.The results showed that flagellum-deficient strains failed to induce significant anti-tumor effects,even when more bacteria were administered to offset the difference in invasion efficiency.Flagella mainly activate immune cells via Flagellin/Toll-like receptor 5(TLR5)signalling pathway.Indeed,we showed that exogenous activation of TLR5 signalling by recombinant Flagellin and exogenous expression of TLR5 both enhanced the therapeutic efficacy of flagellum-deficient Salmonella against melanoma.Our study highlighted the therapeutic value of the interaction between Salmonella and the host immune response through Flagellin/TLR5 signalling pathway during Salmonella-mediated cancer therapy,thereby suggesting the potential application of TLR5 agonists in the cancer immune therapy. | Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 11 | Effects of Annealing on Microstructure, Mechanical and Electrical Properties of AlCrCuFeMnTi High Entropy Alloy显示文摘The multi-component AlCrCuFeMnTi high entropy alloy was prepared using a vacuum arc melting process. Serial annealing processes were subsequently performed at 590 ℃, 750 ℃, 955 ℃ and 1 100 ℃ respectively with a holding time of 4 h at each temperature. The effects of annealing on microstructure, mechanical and electrical properties of as-cast alloy were investigated by using differential thermal analysis(DTA), X-ray diffraction(XRD), scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The experimental results show that two C14 hexagonal structures remain unchanged after annealing the as-cast AlCrCuFeMnTi alloy specimens being heated to 1 100 ℃. Both annealed and as-cast microstructures show typical cast-dendrite morphology and similar elemental segregation. The hardness of alloys declines as the annealing temperature increases while the strength of as-cast alloy improves obviously by the annealing treatment. The electrical conductivities of annealed and as-cast alloys are influenced by the distribution of interdendrite regions which is rich in Cu element. | NONG Zldsheng NONG Zldsheng ZHU Jingchuan YANG Xiawei YU Hailing LAI Zhonghong | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 5 |
| 12 | Characterizations and anisotropy of cold-spraying additive-manufactured copper bulk显示文摘In this study, thick copper coatings were deposited by cold spraying(CS) as an additive manufacturing(AM) method. The interfacial microstructure evolution and mechanical behavior were investigated for the as-sprayed and annealed conditions. In addition, experiments together with numerical simulations were employed to study the recrystallization in different stages. Finally, the mechanical anisotropy of the CSed deposit was tested for the first time, being important to the applications of CS-AM. Results show that there exist two stages of recrystallization in the spraying and annealing processes. Heat treatment has a significant effect on mechanical properties, i.e., the tensile strength increases by 34.2% while microhardness decreases by 43.6%. The mechanical anisotropy analysis shows that the tensile strengths of different directions are completely different and show some regular changes. | Kang Yang Wenya Li Xueping Guo Xiawei Yang Yaxin Xu | 2018 | Journal of Materials Science & Technology2018，34，9： | 5 |
| 13 | The effects of vegetation restoration strategies and seasons on soil enzyme activities in the Karst landscapes of Yunnan, southwest China显示文摘Soil enzymes play a vital role in biogeochemical cycling and ecosystem functions.In this study,we examined the response of six soil enzymes to changes in physicochemical properties resulting from changes in season and vegetation and geological conditions.Catalase,urease,acid phosphatase,invertase,amylase,and cellulase not only promote carbon,nitrogen,and phosphorus cycling,but also participate in the decomposition of harmful substances.Thirty-six soil samples were collected from karst and non-karst areas in two different seasons and from three different types of vegetation in Yunnan province,southwest China.Both vegetation types and season had significant effects on soil physicochemical properties and enzyme activities.In the same plot,soil water content,electrical conductivity,organic carbon,total nitrogen,and total phosphorus increased in the rainy season,indicating enhanced microbial metabolic activity.With the exception of urease activity,the remaining five enzymes showed higher activity in the rainy season.Changes in activities between the two seasons were significant in all samples.In the same season,activity levels of soil enzymes were higher in karst areas than in non-karst areas,and higher in natural forest than in artificial forests.The transformative abilities of soil elements are higher in karst areas than in non-karst areas,and higher in natural forests than in artificial forests.Correlation analysis showed that the activities of the six enzymes correlated significantly;however,soil physical and chemical indices,such as organic matter,pH,and moisture,which are essential for enzyme activity,differed by season.Redundancy analysis also revealed that the main factors influencing enzyme activity differed between the two seasons.The results from this study provide a theoretical basis for further research on the restoration of natural ecological systems in karst landscapes. | Zhouzhou Fan Shuyu Lu Shuang Liu Zhaorong Li Jiaxin Hong Jinxing Zhou Xiawei Peng | 2020 | Journal of Forestry Research2020，31，5： | 5 |
| 14 | Multifunctional regulatory protein connective tissue growth factor (CTGF):A potential therapeutic target for diverse diseases显示文摘Connective tissue growth factor(CTGF),a multifunctional protein of the CCN family,regulates cell proliferation,differentiation,adhesion,and a variety of other biological processes.It is involved in the disease-related pathways such as the Hippo pathway,p53 and nuclear factor kappa-B(NF-κB)pathways and thus contributes to the developments of inflammation,fibrosis,cancer and other diseases as a downstream effector.Therefore,CTGF might be a potential therapeutic target for treating various diseases.In recent years,the research on the potential of CTGF in the treatment of diseases has also been paid more attention.Several drugs targeting CTGF(monoclonal antibodies FG3149 and FG3019)are being assessed by clinical or preclinical trials and have shown promising outcomes.In this review,the cellular events regulated by CTGF,and the relationships between CTGF and pathogenesis of diseases are systematically summarized.In addition,we highlight the current researches,focusing on the preclinical and clinical trials concerned with CTGF as the therapeutic target. | Minyang Fu Dandan Peng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 5 |
| 15 | Acidity of Aerosols during Winter Heavy Haze Events in Beijing and Gucheng, China显示文摘We investigated the acidity and concentrations of water-soluble ions in PM_(2.5) aerosol samples collected from an urban site in Beijing and a rural site in Gucheng, Hebei Province from November 2016 to January 2017 to gain an insight into the formation of secondary inorganic species. The average SO_4^(2–), NO_3~–, and NH_4^+ concentrations were 8.3,12.5, and 14.1 μg m^(–3), respectively, at the urban site and 14.0, 14.2, and 24.2 μg m^(–3), respectively, at the rural site.The nitrogen and sulfur oxidation ratios in urban Beijing were correlated with relative humidity(with correlation coefficient r = 0.79 and 0.67, respectively) and the aerosol loadings. Based on a parameterization model, we found that the rate constant of the heterogeneous reactions for SO_2 on polluted days was about 10 times higher than that on clear days, suggesting that the heterogeneous reactions in the aerosol water played an essential role in haze events.The ISORROPIA II model was used to predict the aerosol pH, which had a mean(range) of 5.0(4.9–5.2) and 5.3(4.6–6.3) at the urban and rural site, respectively. Under the conditions with this predicted pH value, oxidation by dissolved NO_2 and the hydrolysis of N_2O_5 may be the major heterogeneous reactions forming SO_4^(2–) and NO_3~– in haze.We also analyzed the sensitivity of the aerosol p H to changes in the concentrations of SO_4^(2–), NO_3~–, and NH_4^+ under haze conditions. The aerosol p H was more sensitive to the SO_4^(2–) and NH_4^+ concentrations with opposing trends, than to the NO_3~– concentrations. The sensitivity of the p H was relatively weak overall, which was attributed to the buffering effect of NH_3 partitioning. | Xiyuan CHI Pengzhen HE Zhuang JIANG Xiawei YU Fange YUE Longquan WANG Bokun LI Hui KANG Cheng LIU Zhouqing XIE | 2018 | Journal of Meteorological Research2018，32，1： | 4 |
| 16 | Targeting folate receptorβpositive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex显示文摘Tumor-associated macrophages(TAMs)facilitate cancer progression by promoting tumor invasion,angiogenesis,metastasis,inflammatory responses,and immunosuppression.Folate receptorβ(FRβ)is overexpressed in TAMs.However,the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood.In this study,we verified that FRβoverexpression in lung cancer TAMs was associated with poor prognosis.We utilized a folate-modified lipoplex comprising a folatemodified liposome(F-PLP)delivering a BIM-S plasmid to target both lung cancer cells and FRβ-positive macrophages in the tumor microenvironment.Transfection of LL/2 cells and MH-S cells with F-PLP/pBIM induced cell apoptosis.Injection of F-PLP/pBIM into LL/2 and A549 lung cancer models significantly depleted FRβ-positive macrophages and reduced tumor growth.Treatment of tumor-bearing mice with F-PLP/pBIM significantly inhibited tumor growth in vivo by inducing tumor cell and macrophage apoptosis,reducing tumor proliferation,and inhibiting tumor angiogenesis.In addition,a preliminary safety evaluation demonstrated a good safety profile of F-PLP/pBIM as a gene therapy administered intravenously.This work describes a novel application of lipoplexes in lung cancer targeted therapy that influences the tumor microenvironment by targeting TAMs. | Yan Tie Heng Zheng Zhiyao He Jingyun Yang Bin Shao Li Liu Min Luo Xia Yuan Yu Liu Xiangxian Zhang Hongyi Li Min Wu Xiawei Wei | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 17 | Hot deformation behavior and microstructure evolution of the laser solid formed TC4 titanium alloy显示文摘Hot compressive experiments of the laser solid formed(LSFed)TC4 titanium alloy were conducted at a wide temperature range of 650-950℃and strain rate of 0.01-10 s^(-1).The Arrheniustype constitutive models of the LSFed TC4 alloy were established at the temperature range of 800-950℃and of 650-800℃,respectively.The average relative error between the predicted stresses and experimental values in those two temperature ranges are 10.4%and 8.3%,respectively,indicating that the prediction models constructed in this paper are in a good agreement with experimental data.Processing maps were established by the principle of dynamic materials modeling on the basis of the data achieved from the hot compression experiments.The processing parameters corresponding to the stable and unstable regions of material deformation can be determined from the processing maps.The microstructure evolution of the stable and unstable regions of the samples after tests were observed.Finally,the effect of hot compressive parameters on the microstructure were investigated to research the dynamic recrystallization and the texture of the deformed LSFed TC4 alloy. | Xiawei YANG Yanying WANG Xiurong DONG Chong PENG Baijin JI Yaxin XU Wenya LI | 2021 | Chinese Journal of Aeronautics2021，34，5： | 3 |
| 18 | Optimization of cold-sprayed AA2024/Al_2O_3 metal matrix composites via friction stir processing: Effect of rotation speeds显示文摘In this study, friction stir processing(FSP) was employed to modify cold-sprayed(CSed) AA2024/Al_2 O_3 metal matrix composites(MMCs). Three different rotation speeds with a constant traverse speed were used for FSP. Microstructural analysis of the FSPed specimens reveals significant Al_2 O_3 particle refinement and improved particle distribution over the as-sprayed deposits. After FSP, a microstructural and mechanical gradient MMC through the thickness direction was obtained. Therefore, a hybrid technique combining these two solid-state processes, i.e. CS and FSP, was proposed to produce functionally gradient deposits. The Guinier-Preston-Bagaryatskii zone was dissolved during FSP, while the amounts at different rotation speeds were approximately the same, which is possibly due to the excellent thermal conductivity of the used Cu substrate. Mechanical property tests confirm that FSP can effectively improve the tensile performance and Vickers hardness of CSed AA2024/Al_2 O_3 MMCs. The properties can be further enhanced with a larger rotation speed with a maximum increase of 25.9% in ultimate tensile strength and27.4% in elongation at 1500 rpm. Friction tests show that FSP decreases the wear resistance of CSed MMCs deposits due to the breakup of Al_2 O_3 particles. The average values and fluctuations of friction coefficients at different rotation speeds vary significantly. | Kang Yang Wenya Li Chunjie Huang Xiawei Yang Yaxin Xu | 2018 | Journal of Materials Science & Technology2018，34，11： | 3 |
| 19 | Nucleic acids and analogs for bone regeneration显示文摘With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials. Bone tissue engineering has also been considered as a promising strategy to repair various bone defects. Therefore, different biological materials that can promote stem cell proliferation, migration, and osteoblastic differentiation to accelerate bone tissue regeneration and repair have also become the focus of research in multiple fields. Stem cell therapy, biomaterial scaffolds, and biological growth factors have shown potential for bone tissue engineering; however, off-target effects and cytotoxicity have limited their clinical use. The application of nucleic acids(deoxyribonucleic acid or ribonucleic acid)and nucleic acid analogs(peptide nucleic acids or locked nucleic acids), which are designed based on foreign genes or with special structures, can be taken up by target cells to exert different effects such as modulating protein expression, replacing a missing gene, or targeting specific gens or proteins. Due to some drawbacks, nucleic acids and nucleic acid analogs are combined with various delivery systems to exert enhanced effects, but current studies of these molecules have not yet satisfied clinical requirements. In-depth studies of nucleic acid or nucleic acid analog delivery systems have been performed, with a particular focus on bone tissue regeneration and repair. In this review, we mainly introduce delivery systems for nucleic acids and nucleic acid analogs and their applications in bone repair and regeneration. At the same time, the application of conventional scaffold materials for the delivery of nucleic acids and nucleic acid analogs is also discussed. | Yuxin Zhang Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Xueping Xie Xiawei Wei Yunfeng Lin | 2018 | Bone Research2018，6，4： | 3 |
| 20 | Author correction to‘Multifunctional regulatory protein connective tissue growth factor(CTGF):A potential therapeutic target for diverse diseases’[Acta pharmaceutica sinica B 12(2022)1740-1760]显示文摘The authors regret that there was an error in 7.Conclusion and prospect section of the article.The last paragraph of this section‘Under particular external…integrins interact with CT domain’is supposed to be the content of the figure legend(Fig.1).It is superfluous in this part and should be deleted.The revision does not affect any conclusions of this work. | Minyang Fu Dandan Peng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 3 |
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