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| 1 | Changes of Expressions of VEGF, bFGF, and Angiogenesis, and Effect of Benazepril, bFGF on Angiogenesis in Acute Myocardial Infarction Model of the Rabbits显示文摘Objective To explore the changes of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiogenesis, and the effects of bFGF, angiotensin converting enzyme inhibiter(ACEI) benazepril on the angiogenesis in acute myocardial infarction (AMI) model of rabbits, and to provide a probable evidence for the treatment of AMI. Methods AMI model was established by ligating anterior descending branch of coronary artery of Japan-Sino hybridization white rabbits. The postoperative rabbits were randomly divided into 6 groups and each group was treated with different drugs. Groups 1 and 2 were treated with normal saline (NS) for 28 and 14 days (d), group 3 and 4 with bFGF for 28 and 14 d, groups 5 with benazepril for 14 d, and group 6 with benazepril and bFGF for 14 d respectively. The rabbits were killed on the 14th or 28th d and their hearts were excised, sectioned and stained with HE, Masson trichrome to observe VEGF, bFGF and CD34 under a microscope, which were quantified with a computer-assisted morphometry. Results Compared with group 1, the granulation tissue of infarction zone (IZ) in group 2 freshened up, and the capillary density (CD) in IZ was increased (P=0.002). The CD in the IZ as well as VEGF and bFGF in groups 3 and 4 were increased respectively (P=0.011-0.037). In group 5 the changes of VEGF and bFGF were not found in the IZ and the border zone (BZ) while CD was significantly increased (35.4% and 25.6%, P=0.036 and 0.037). Compared with group 2, the CD in the IZ and BZ of group 6 was significantly increased (63.4% and 44.3% P=0.007 and 0.007), meanwhile VEGF and bFGF were increased. Compared with group 5, only VEGF was increased. Conclusion Intravenous bFGF may increase VEGF and bFGF significantly, thus promoting the angiogenesis in the IZ and BZ in cardiac infarction as VEGF and bFGF are the potent angiogenic growth factors. Benazepril may promote angiogenesis in the IZ and BZ in cardiac infarction, but its mechanism is irrelative to the expression of VEGF and bFGF. The combination of benazepril and bFGF may promote, to some extent, the expression of VEGF and bFGF, but their effect on angiogenesis has not been found. | DAN-YANGLI KUIZHAO JUN-FUZHOU PENGCHEN WEILI | 2004 | Biomedical and Environmental Sciences2004，17，4： | 12 |
| 2 | Using genomic data to improve the estimation of general combining ability based on sparse partial diallel cross designs in maize显示文摘Evaluation of general combining ability(GCA)is crucial to hybrid breeding in maize.Although the complete diallel cross design can provide an efficient estimation,sparse partial diallel cross(SPDC)is more flexible in breeding practice.Using real and simulated data sets of partial diallel crosses between 266 maize inbred lines,this study investigated the performance of SPDC designs for estimating the GCA.With different distributions of parental lines involved in crossing(called random,balanced and unbalanced samplings),different numbers of hybrids were sampled as the training sets to estimate the GCA of the 266 inbred lines.In this process,three statistical approaches were applied.One obtained estimations through the ordinary least square(OLS)method,and the other two utilized genomic prediction(GP)to estimate the GCA.It was found that the coefficient of determination of each approach was always higher than the heritability of a target trait,showing that the GCA for maize inbred lines could be accurately predicted with SPDC designs.Both the GP approaches were more accurate than the OLS,particularly in the scenario for a low-heritability trait with a small sample size.Additionally,prediction results demonstrated that a big sample of hybrids could greatly help improve the accuracy.The random sampling of parental lines had little influence on the average accuracy.However,the prediction for lines that never or seldom involved in crossing might suffer from much lower accuracy. | Xin Wang Zhenliang Zhang Yang Xu Pengchen Li Xuecai Zhang Chenwu Xu | 2020 | The Crop Journal2020，8，5： | 4 |
| 3 | Low-dimensional metal halide perovskites and related optoelectronic applications显示文摘Low-dimensional materials have pivotal significance in modern photonic,electronic,and optoelectronic areas due to their unique properties of the scale effect.Metal halide perovskites have revived in the optoelectronic fields recently,drawing intensive attention in photovoltaic devices,light-emitting diodes,lasers,photodetectors,and so on.Compared to their three-dimensional counterparts,the role of low-dimensional perovskites is becoming crucial,requiring a comprehensive understanding and exploration unceasingly.In this review,we examine low-dimensional perovskite of different forms and clarify various synthesis methods with morphological and dimensional control.Additionally,we also summarize potential optoelectronic applications based on their advantageous optical/electrical properties and enhanced mechanical integrity and stability.Finally,we propose a future perspective and possible developing directions in the exploration of novel perovskite-derived materials,new physics,and promising applications. | Pengchen Zhu Jia Zhu | 2020 | InfoMat2020，2，2： | 4 |
| 4 | The C-Terminal Portion of the Nucleocapsid Protein Demonstrates SARS-CoV Antigenicity显示文摘In order to develop clinical diagnostic tools for rapid detection of SARS-CoV (severe acute respiratory syndrome-associated coronavirus) and to identify candidate proteins for vaccine development, the C-terminal portion of the nucleocapsid (NC)gene was amplified using RT-PCR from the SARS-CoV genome, cloned into a yeast expression vector (pEGH), and expressed as a glutathione S-transferase (GST) and Hisx6 double-tagged fusion protein under the control of an inducible promoter.Western analysis on the purified protein confirmed the expression and purification of the NC fusion proteins from yeast. To determine its antigenicity, the fusion protein was challenged with serum samples from SARS patients and normal controls.The NC fusion protein demonstrated high antigenicity with high specificity, and therefore, it should have great potential in designing clinical diagnostic tools and provide useful information for vaccine development. | GuozhenLiu ShaohuiHu YongwuHu PengChen JianningYin JieWen JingqiangWang LiangLin JinxiuLiu BoYou YeYin ShutingLi HaoWang YanRen JiaJi XiaoqianZhao YongqiaoSun XiaoweiZhang JianqiuFang JianWang SiqiLiu JunYu HengZhu HuanmingYang | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 4 |
| 5 | Effects of copper-aspirin complex on platelet-neutrophil interactions显示文摘AIM: To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between plateletsand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawleyrats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregationstimulated by activated neutrophils were observed by rosette assay and Borns method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) dose-dependently prolonged the occlusion time; it signifi-cantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % ofinhibitory concentration (IC50) was (54.64.3) mol/L. Copper-aspirin complex markedly inhibited rat plateletaggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension.The values of IC50 were (224.516.2) mol/L and (820.521.4) mol/L, whereas aspirin had no influence.CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property fromaspirin and resulted in a more potent antithrombotic activity. | Zhi-qiangSHEN PengCHENt LingLI,PengCHEN Wei-pingLIU | 2004 | Acta Pharmacologica Sinica2004，25，5： | 3 |
| 6 | Transition from hepatic steatosis to steatohepatitis: Unique microRNA patterns and potential downstream functions and pathways显示文摘 | XiJin Yi‐pengChen MeiKong LinZheng Yi‐daYang You‐mingLi | 2012 | Journal of Gastroenterology and Hepatology2012，，2： | 1 |
| 7 | Research progress of low-dimensional perovskites:synthesis,properties and optoelectronic applications显示文摘The lead halide-based perovskites,for instance,CH_3NH_3PbX_3 and CsPbX_3(X = Cl,Br,I),have received a lot of attention.Compared with bulk materials,low-dimensional perovskites have demonstrated a range of unique optical,electrical and mechanical properties,which enable wide applications in solar cells,lasers and other optoelectronic devices.In this paper,we provide a summary of the research progress of the low-dimensional perovskites in recent years,from synthesis methods,basic properties to their optoelectronic applications. | Xinzhe Min Pengchen Zhu Shuai Gu Jia Zhu | 2017 | Journal of Semiconductors2017，38，1： | 1 |
| 8 | Three-dimensional finite element analysis of two kinds of extracoronal attachments in a new design to restore maxillary edentulous jaw显示文摘 | PengChen ShujuanYu BingLin etal | 2006 | World Journal of Modellig and Simulation2006，2，： | 1 |
| 9 | Enhanced Secretion of Heterologous Proteins in Pichia pastoris Following Overexpression of Saccharomyces cerevisiae Chaperone Proteins显示文摘 | WeiZhang Hong‐liangZhao ChongXue Xiang‐huaXiong Xue‐qinYao Xian‐yuLi Hui‐pengChen Zhi‐minLiu | 2008 | Biotechnol Progress2008，，4： | 1 |
| 10 | Two-dimensional bending vector sensing based on spatiM cascaded orthogonal long period fiber显示文摘 | Geng Pengchen Zhang Weigang Gao Shecheng | 2012 | Op- tics Express2012，20，28： | 1 |
| 11 | Effects of Seawater Acidification on Early Development of Clam Cyclina sinensis显示文摘Anthropogenic emission of atmospheric carbon dioxide (CO2) has led to a rapid increase in atmospheric CO2 concentra- tion. Increasing atmospheric CO2 can reduce seawater pH and carbonate ions, which may adversely affect the survival of the larvae of calcareous animals. Cyclina sinensis is a commercially and ecologically important species in several Asian countries. Living in coast shallow waters, this species has experienced the coastal environmental changes frequently throughout its life cycle. In this study, we simulated possible future seawater pH values including 8.2, 7.8 and 7.4 and examined the effects of ocean acidification on the early development of C. sinensis. Clam embryos were incubated for 48 h (2 d) in control and high-CO2 seawater to compare embryo- genesis, larval growth and swimming behavior. Fertilization rate was quite sensitive to pH, and moderate acidification could induce a significant decrease in fertilization rate. However, only extreme acidification could bring significant negative effect to hatching rate, body size, and average path velocity of trochophora. Moreover, with seawater acidification, C. sinensis needs much more time to reach the same developmental stage, which increases the risk of larva survival. Together with recent studies demonstrating negative impacts of high CO2 on fertilization and larva swimming behavior, the results imply a future decrease of C. sinensis populations in oceans if its acclimation to the predicted environmental alteration does not occur. | SUI Yanming ZHOU Kai LAI Qifang YAO Zongli GAO Pengchen | 2019 | Journal of Ocean University of China2019，18，4： | 1 |
| 12 | Model consisting of ultrasonographic and simple blood indexes accurately identify compensated hepatitis B cirrhosis显示文摘 | Yong‐PengChen LinDai Jing‐LinWang You‐FuZhu Xiao‐RongFeng Jin‐LinHou | 2008 | Journal of Gastroenterology and Hepatology . 2008 (8pt1)2008，，8： | 1 |
| 13 | 3-Thiomorpholin-8-oxo-8 H -acenaphtho [1,2- b ] pyrrole-9-carbonitrile ( S1 ) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-x L and Mcl-1显示文摘 | Ting Song Xiangqian Li Xilong Chang Xiaomeng Liang Yan Zhao Guiye Wu Shenghui Xie Pengchen Su Zhiyong Wu Yingang Feng Zhichao Zhang | 2013 | Bioorganic & Medicinal Chemistry2013，，1： | 1 |
| 14 | Broad - band high- power amplifier using spatial power - combining technique 显示文摘 | Jia Pengchen Chen Lee - Yin Alexanian A | 2003 | IEEE Transactions on Microwave Theory Tech-nology2003，51，12： | 1 |
| 15 | Expression and role of PTV1 lncRNA in glioma cells progression显示文摘Objective The aim of this study was to investigate the expression of PTV1 lncRNA in gliomas and themechanism of its interaction with miR-203a.Methods U87 and U251 cells were cultured stably and transfected with sh-PTV1 or ov-PTV1, respectively.The proliferative activity of U87 and U251 cells was detected and the transplanted tumor model nude micewere divided into U87 and U251 groups. U87-sh and u251-ov cells were injected into the armpit, thenmiR-203a mic and miR-203a inhibitors were administered to detect the changes in the expression of tumorrelatedproteins.Results The relative expression of PTV1 in gliomas was significantly higher than that in normal braintissues, while in GBM it was significantly higher than that in low-grade gliomas. Knockdown of PTV1significantly inhibited the proliferation of U87 cells, resulting in fewer cell clones;overexpression of rPTV1significantly promoted the proliferation of U251 cells, resulting in more cell colonies. The dual LuciferaseReporter assay showed that SP2 was a potential target of miR-203a. When U87 cells were treated with amiR-203a mimic, the expression of SP2 decreased;and when U251 cells were treated with a miR-203ainhibitor, the expression of SP2 increased significantly. SP2 was overexpressed in u87-sh cells and theproliferation, migration, and invasion of u87-sh cells were significantly enhanced. U251-ov cells showedthe opposite trend. Compared with the control group mice, the tumor volume in u87-sh group mice wassignificantly smaller and the positive rate of SP2 in tumor tissue was significantly lower. After administrationof the miR-203a inhibitor, the tumor volume increased gradually and the positive rate of SP2 increasedsignificantly, while u251-ov mice showed the opposite trend.Conclusion lncRNA PTV1 can be used as a molecule to interfere with miR-203a expression in order todownregulate SP2 and to promote the proliferation and invasion of glioma cells. lncRNA PTV1 may be anew biomarker and therapeutic target for glioma. | Yue Li Yuling Bai Yan Qi Chang Cai Ying Liao Xiuzhu Liu Pengchen He | 2021 | Oncology and Translational Medicine2021，7，2： | 0 |
| 16 | Mechanical Analysis for Two-layered Ultrahigh Pressure Apparatus with Interlayer Pressure显示文摘To improve the bearing pressure capacity of ultrahigh pressure apparatus,the internal autofrettaged cylinder with interlayer pressure(ACCIP)is introduced,and the analytical model for the ACCIP structure and its derivation are presented as well.Calculation showed that the ACCIP method enhance bearing pressure of the apparatus obviously;optimization results revealed that under the working pressure pw=1.07σs and different radius ratios,the ACCIP method can keep the apparatus in deformed-elastically state;And when the pw=1.07σs,the minimum radius ratio was approximate 3.29,in this case,no yielding happened.The above results demonstrate that the ACCIP method is a promising technique to improve the bearing pressure of ultrahigh pressure apparatus,and the analytical model for the ACCIP method is also reasonable.In addition,the minimum radius ratio ro/ri under randomly specified workload can be Fig.d out by the analytical model proposed in this work. | Mengjun ZHAO Pengchen ZHU Zan LIU Chao KANG | 2021 | Mechanical Engineering Science2021，3，1： | 0 |
| 17 | 三阴性乳腺癌基因组与转录组全景图:亚型及治疗策略显示文摘文章简介三阴性乳腺癌(triple-negative breast cancer,TNBC)是雌激素受体、孕激素受体和HER-2均为阴性的一群乳腺癌,缺乏有效靶向治疗,预后差,是乳腺癌学界的世界性难题。近年的研究表明TNBC是一个异质性很强的群体,为更全面而深入地认识这类疾病,寻找精准治疗的突破口,研究团队全面分析了465例原发性三阴性乳腺癌(TNBC)队列的临床、基因组学和转录组学数据。 | Yi-Zhou Jiang Ding Ma Chen Suo Jinxiu Shi Mengzhu Xue Xin Hu Yi Xiao Ke-Da Yu Yi-Rong Liu Ying Yu Yuanting Zheng Xiangnan Li Chenhui Zhang Pengchen Hu Jing Zhang Qi Hua Jiyang Zhang Wanwan Hou Luyao Ren Ding Bao Bingying Li Jingcheng Yang Ling Yao Wen-Jia Zuo Shen Zhao Yue Gong Yi-Xing Ren Ya-Xin Zhao Yun-Song Yang Zhenmin Niu Zhi-Gang Cao Daniel G.Stover Claire Verschraegen Virginia Kaklamani Anneleen Daemen John R.Benson Kazuaki Takabe Fan Bai Da-Qiang Li 王鹏 石乐明 黄薇 邵志敏 | 2020 | 科学新闻2020，，2： | 0 |
| 18 | Recent applications in dielectric barrier discharge and radio frequency plasmas‐engineered transition metal electrocatalysts for water splitting显示文摘Hydrogen generated by water electrolysis is considered as one of the most promising protocols to partly replace the roles of traditional fossil fuels.However,high‐performance electrocatalyst satisfied with the industrial requirement still faces significant challenges.Low‐temperature plasma contains numerous high‐energy ions,electrons and other reactive species,which can provide a highly reactive environment for tuning the physio‐chemical structures of catalysts through plasma milling,etching,doping and/or deposi-tion.It is well‐known that high‐temperature micro‐filaments contained in plasmas can cause some special modifications of the catalyst surface,thus effectively adjusting the physio‐chemical structure of latterly engineered compounds.Therefore,low‐temperature plasma technologies,especially the dielectric barrier discharge(DBD)and radio frequency(RF)plasmas,can be considered as a green and sustainable strategy for engineering high‐performance electrocatalysts for water splitting(hydrogen evolution reaction[HER];oxygen evolution reaction[OER]).Herein,recent progress of DBD and RF plasmas for fabricating and modifying transition metal‐based electrocatalysts(e.g.sulphide,phos-phide,selenide,oxide,hydroxide)for hydrogen evolution reaction or OER is compre-hensively reviewed,and the role of plasma is also discussed. | Guangliang Chen Bin He Yuxin Wang Pengchen He Liguang Dou Renwu Zhou Dongliang Chen Tao Shao | 2023 | High Voltage2023，8，6： | 0 |
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