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| 1 | Carboniferous Post-collisional Rift Volcanism of the Tianshan Mountains, Northwestern China显示文摘The Tianshan Carboniferous post-collisional rift volcanic rocks occur in northwestern China as a large igneous province. Based on petrogeochemical data, the Tianshan Carboniferous post-collisional rift basic lavas can be classified into two major magma types: (1) the low-Ti/Y type situated in the eastern-central Tianshan area, which exhibits low Ti/Y (<500), Ce/Yb (<15) and SiO2 (43-55%), and relatively high Fe2O3T (6.4-11.5%); (2) the high-Ti/Y type situated in the western Tianshan area, which has high Ti/Y (>500), Ce/Yb (>11) and SiO2 (49-55%), and relatively low Fe2O3T (5.8-7.8%). Elemental data suggest that chemical variations of the low-Ti/Y and high-Ti/Y lavas cannot be explained by fractional crystallization from a common parental magma. The Tianshan Carboniferous basic lavas originated most likely from an OIB-like asthenospheric mantle source (87Sr/86Sr(t) ≈ 0.703-0.705, εNd(t) ≈ +4 to +7). The crustal contamination and continental lithospheric mantle have also contributed significantly to the formation of the basic lavas of the Tianshan Carboniferous post-collisional rift. The silicic lavas were probably generated by partial melting of the crust. The data of this study show that spatial petrogeochemical variations exist in the Carboniferous post-collisional rift volcanics province in the Tianshan region. Occurrence of the thickest volcanics dominated by tholeiitic lavas may imply that the center of the mantle-melting anomaly (mantle plume) was in the eastern Tianshan area at that time. The basic volcanic magmas in the eastern Tianshan area were generated by a relatively high degree of partial melting of the mantle source around the spinel-garnet transition zone, whereas the alkaline basaltic lavas are of the dominant magma type in the western Tianshan area, which were generated by a low degree of partial melting of the mantle source within the stable garnet region, thus the basic lavas of the western Tianshan area might have resulted from relatively thick lithosphere and low geothermal gradient. | XIA Linqi, XU Xueyi, XIA Zuchun, LI Xiangmin, MA Zhongping and WANG Lishe Xi’an Institute of Geology and Mineral Resources, China Geological Survey, Xi’an, Shaanxi 710054 E-mail: geologyx@pub.xaonline.com. Liu Shuchun and Liu Xinzhu | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 49 |
| 2 | Reassessment of petrogenesis of Carboniferous—Early Permian rift-related volcanic rocks in the Chinese Tianshan and its neighboring areas显示文摘The Carboniferous Early Permian rill-related volcanic successions.covering large areas in the Chinese Tianshan and its adjacent areas.make up a newly recognized important Phanerozoic large igneous province in the world.which can be further divided into two sub-provinces:Tianshan and Tarim. The regional unconformity of Lower Carboniferous upon basement or pre-Carboniferous rocks.the ages (360—351 Ma) of the youngest ophiolite and the peak of subduction metamorphism of high pressure-low temperature metamorphic belt and the occurrence of Ni-Cu-bearing mafic-ultramatic intrusion with age of—352 Ma and A-type granite with age of~358 Ma reveal that the final closure of the Paleo Asian Ocean might lake place in the Early Mississippian.Our summation shows that at least four criteria.being normally used to identify ancient asthenosphere upwelling(or mantle plumes),are met for this large igneous province:(1) surface uplift prior to magmatism:(2) being associated with continental ifting and breakup events:(3) chemical characteristics of asthenosphere(or plume) derived basalts;(4) close links to large-scale minerali/alion and the uncontaminaled basalts,being analogous to those of many 'ore-bearing' large igneous provinces.display Sr-Nd isotopic variations between plume and EMI geochemical signatures.These suggest that a Carboniferous asthenosphere upwelling and an Early Permian plume played the central role in the generation of the Tianshan—Tarim(central Asia) large igneous province. | Linqi Xia Xueyi Xu Xiangmin Li Zhongping Ma Zuchun Xia | 2012 | Geoscience Frontiers2012，3，4： | 30 |
| 3 | Mid—Late Neoproterozoic rift-related volcanic rocks in China:Geological records of rifting and break-up of Rodinia显示文摘Early Cambrian and Mid-Late Neoproterozoic volcanic rocks in China are widespread on several Precambrian continental blocks,which had aggregated to form part of the Rodinia supercontinent by ca.900 Ma.On the basis of petrogeochemical data,the basic lavas can be classified into two major magma types:HT(Ti/Y>500) and LT(Ti/Y<500) that can be further divided into HT1 (Nb/La>0.85) and HT2(Nb/La≤0.85),and LT1(Nb/La>0.85) and LT2(Nb/La≤0.85) subtypes, respectively.The geochemical variation of the HT2 and LT2 lavas can be accounted for by lithospheric contamination of asthenosphere-(or plume-) derived magmas,whereas the parental magmas of the HT1 and LT1 lavas did not undergo,during their ascent,pronounced lithospheric contamination.These volcanics exhibit at least three characteristics:(1) most have a compositional bimodality;(2) they were formed in an intracontinental rift setting;and(3) they are genetically linked with mantle plumes or a mantle surperplume.This rift-related volcanism at end of the MidNeoproterozoic and Early Cambrian coincided temporally with the separation between AustraliaEast Antarctica,South China and Laurentia and between Australia and Tarim,respectively. The Mid—Late Neoproterozoic volcanism in China is the geologic record of the rifting and break-up of the supercontinent Rodinia. | Linqi Xia Zuchun Xia Xueyi Xu Xiangmin Li Zhongping Ma | 2012 | Geoscience Frontiers2012，3，4： | 18 |
| 4 | Relationships between Basic and Silicic Magmatism in Continental Rift Settings:A Petrogeochemical Study of Carboniferous Post-collisional Rift Silicic Volcanics in Tianshan,NW China显示文摘Petrogeochemical data are reported for silicic volcanic rocks from the Tianshan Carboniferous rift, with the aim of discussing the petrogenesis of silicic magmas. Incompatible element vs. incompatible element diagrams display smooth positive trends for the Tianshan Carboniferous rift-related volcanic rocks; the isotope ratios of the silicic lavas [87Sr/86Sr(t)=0.69988–0.70532; εNd(t)=4.76–8.00; 206Pb/204Pb(t)=17.435–18.017; 207Pb/204Pb(t)=15.438–15.509; 208Pb/204Pb(t) = 37.075–37.723] encompass those of the basic lavas. These data suggest a genetic link between rhyolites and basalts, but are not definitive in establishing whether silicic rocks are related to basalts through fractional crystallization or partial melting. Geochemical modeling of incompatible vs. compatible elements excludes the possibility that silicic melts are generated by the melting of basaltic rocks, and indicates a derivation by fractional crystallization plus moderate assimilation of wall rocks (AFC) starting from intermediate rocks to silicic rocks. Continuous AFC from basalt to rhyolite, with small rates of crustal assimilation, best explains the geochemical data. The presence or absence of bimodal volcanism (the “Daly Gap”) might be related to cooling rates of magma chambers. In central and eastern Tianshan, the crust was thinner and the cooling rates of the magma chamber within the crust were greater. These conditions resulted in a rapid fall in temperature within the magma reservoir and caused a narrow temperature interval over which intermediate melts formed, effectively reducing the volume of the intermediate melts. | XIA Linqi XIA Zuchun XU Xueyi LI Xiangmin MA Zhongping WANG Lishe | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 14 |
| 5 | Forest Carbon Storage and Tree Carbon Pool Dynamics under Natural Forest Protection Program in Northeastern China显示文摘The Natural Forest Protection(NFP) program is one of the Six Key Forestry Projects which were adopted by the Chinese Government since the 1980s to address important natural issues in China. It advanced to protecting and restoring the structures and functions of the natural forests through sustainable forest management. However, the role of forest carbon storage and tree carbon pool dynamics since the adoption of the NFP remains unknown. To address this knowledge gap, this study calculated forest carbon storage(tree, understory, forest floor and soil) in the forest region of northeastern(NE) China based on National Forest Inventory databases and field investigated databases. For tree biomass, this study utilized an improved method for biomass estimation that converts timber volume to total forest biomass; while for understory, forest floor and soil carbon storage, this study utilized forest type-specific mean carbon densities multiplied by their areas in the region. Results showed that the tree carbon pool under the NFP in NE China functioned as a carbon sink from 1998 to 2008, with an increase of 6.3 Tg C/yr, which was mainly sequestrated by natural forests(5.1 Tg C/yr). At the same time, plantations also acted as a carbon sink, reflecting an increase of 1.2 Tg C/yr. In 2008, total carbon storage in forests covered by the NFP in NE China was 4603.8 Tg C, of which 4393.3 Tg C was stored in natural forests and 210.5 Tg C in planted forests. Soil was the largest carbon storage component, contributing 69.5%–77.8% of total carbon storage; followed by tree and forest floor, accounting for 16.3%–23.0% and 5.0%–6.5% of total carbon storage, respectively. Understory carbon pool ranged from 1.9 to 42.7 Tg C, accounting for only 0.9% of total carbon storage. | WEI Yawei YU Dapao Bernard Joseph LEWIS ZHOU Li ZHOU Wangming FANG Xiangmin ZHAO Wei WU Shengnan DAI Limin | 2014 | Chinese Geographical Science2014，24，4： | 9 |
| 6 | Parthenolide inhibits LPS-induced inflammatory cytokines through the toll-like receptor 4 signal pathway in THP-1 cells显示文摘Parthenolide (PTL ) 显示出反煽动性的有势力和反癌症活动。在现在的学习, PTL 的活动的分子的机制在导致的 lipopolysaccharide (LPS ) 被探索人的白血病 monocytic THP-1 房间和人的主要单核白血球。3-(4,5-dimethylthiazol-2-yl )-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 盐(山) 试金被用来在 THP-1 房间生存能力上分析 PTL 的效果。连接酶的 immunosorbent 试金被用来在导致 LPS 的煽动性的 cytokine 分泌物上决定 PTL 的效果。流动 cytometry 和量的即时聚合酶链反应被用来在导致 LPS 的像使用费的受体上估计 PTL 的效果 4 (TLR4 ) 表示。表明分子的 Phosphorylation 层次被西方的污点分析决定。结果显示出那 PTL < 12.5 M 显著地没影响 THP-1 房间生存能力。LPS 治疗导致了 interleukin (IL ) 的一条显著起来规定 -6, IL-1, IL-8, IL-12p40,肿瘤坏死因素 -- , IL-18,并且没有在里面 THP-1 房间。然而, PTL 以一种剂量依赖者方式禁止了这些 cytokines 的表示,与 1.0912.620 M 的 IC 50 价值。PTL 与由流动 cytometry 分析决定了的 1.373 M 的 IC 50 值堵住了 TLR4 表示,并且这堵住的效果在蛋白质和 mRNA 层次被验证。另外的分子的表情的细胞外的调整信号的 kinase 1/2 ,6月N终端 kinase , p38 ,原子因素 B ( NF-B ) p65 ,和 IB 和起来规定的 phosphorylation 层次的起来规定(可诱导的氮的氧化物 synthase , TLR4 ,并且 TNF 联系受体的因素 6 )由 LPS 导致了被 PTL 以一种剂量依赖者方式废除。PTL 的反煽动性的机制通过表明小径的调停 TLR4 的激活 mitogen 的蛋白质 kinase 和 NF-B 部分操作。因此, TLR4 可以是为反发炎治疗的一个新目标。 | Shuangshuang Li Xiangli Gao Xiaoxin Wu Zhigang Wu Linfang Cheng Lifen Zhu Dan Shen Xiangmin Tong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 5 |
| 7 | Geology and geochemistry of the Bingdaban ophiolitic mélange in the boundary fault zone on the northern Central Tianshan Belt,and its tectonic implications显示文摘The properties and tectonic significance of the fault bound zone on the northern margin of the Central Tianshan belt are key issues to understand the tectonic framework and evolutionary history of the Tianshan Orogenic Belt. Based on the geological and geochemical studies in the Tianshan orogenic belt, it is suggested that the ophiolitic slices found in the Bingdaban area represent the remaining oceanic crust of the Early Paleozoic ocean between the Hazakstan and Zhungaer blocks. Mainly com-posed of basalts, gabbros and diabases, the ophiolites were overthrust onto the boundary fault be-tween the Northern Tianshan and Central Tianshan belts. The major element geochemistry is charac-terized by high TiO2 (1.50%-2.25%) and MgO (6.64%-9.35%), low K2O (0.06%-0.41%) and P2O5 (0.1%-0.2%), and Na2O>K2O as well. Low ΣREE and depletion in LREE indicate that the original magma was derived from a depleted mantle source. Compared with a primitive mantle, the geochemistry of the basalts from the Bingdaban area is featureded by depletion in Th, U, Nb, La, Ce and Pr, and unfrac-tionated in HFS elements. The ratios of Zr/Nb, Nb/La, Hf/Ta, Th/Yb and Hf/Th are similar to those of the typical N-MORB. It can be interpreted that the basalts in the Bingdaban area were derived from a de-pleted mantle source, and formed in a matured mid-oceanic ridge setting during the matured evolu-tionary stage of the Northern Tianshan ocean. In comparison with the basalts, the diabases from the Bingdaban area show higher contents of Al2O3, ∑REE and HFS elements as well as unfractionated incompatible elements except Cs, Rb and Ba, and about 10 times the values of the primitive mantle. Thus, the diabases are thought to be derived from a primitive mantle and similar to the typical E-MORB. The diabases also have slight Nb depletion accompanying no apparent Th enrichment compared with N-MORB. From studies of the regional geology and all above evidence, it can be suggested that the diabases from the Bingdaban area were formed in the mid-oceanic ridge of the Northern Tianshan ocean during the initial spreading stage. | DONG YunPeng ZHANG GuoWei ZHOU DingWu LUO JinHai ZHANG ChengLi XIA LinQi XU XueYi LI XiangMin | 2007 | Science China Earth Sciences2007，50，1： | 5 |
| 8 | CD147 regulates antitumor CD8^(+)T-cell responses to facilitate tumor-immune escape显示文摘Negative regulation of antitumor T-cell-immune responses facilitates tumor-immune escape.Here,we show that deletion of CD147,a type I transmembrane molecule,in T cells,strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8^(+)T-cell-dependent manner.In mouse tumor models,CD147 expression was upregulated on CD8^(+)tumor-infiltrating lymphocytes(TILs),and CD147 was coexpressed with two immune-checkpoint molecules,Tim-3 and PD-1.Mining publicly available gene-profiling data for CD8^(+)TILs in tumor biopsies from metastatic melanoma patients showed a higher level of CD147 expression in exhausted CD8^(+)TILs than in other subsets of CD8^(+)TILs,along with expression of PD-1 and TIM-3.Additionally,CD147 deletion increased the abundance of TILs,cytotoxic effector function of CD8^(+)T cells,and frequency of PD-1^(+)CD8^(+)TILs,and partly reversed the dysfunctional status of PD-1^(+)Tim-3^(+)CD8^(+)TILs.The cytotoxic transcription factors Runx3 and T-bet mediation enhanced antitumor responses by CD147^(-/-)CD8^(+)T cells.Moreover,CD147 deletion in T cells increased the frequency of TRM-like cells and the expression of the T-cell chemokines CXCL9 and CXCL10 in the tumor microenvironment.Analysis of tumor tissue samples from patients with non-small-cell lung cancer showed negative correlations between CD147 expression on CD8^(+)TILs and the abundance of CD8^(+)TILs,histological grade of the tumor tissue samples,and survival of patients with advanced tumors.Altogether,we found a novel function of CD147 as a negative regulator of antitumor responses mediated by CD8^(+)TILs and identified CD147 as a potential target for cancer immunotherapy. | Yatong Chen Jing Xu Xiaodong Wu Hui Yao Zhou Yan Ting Guo Wenjing Wang Peixiao Wang Yu Li Xiangmin Yang Hao Li Huijie Bian Zhi-Nan Chen | 2021 | Cellular & Molecular Immunology2021，18，8： | 4 |
| 9 | A large-scale flight multi-objective assignment approach based on multi-island parallel evolution algorithm with cooperative coevolutionary显示文摘Due to the rapid increase of air traffic demand, the large-scale flight assignment plays a crucial role in reducing airspace congestion and economic losses via reasonably regulating the air traffic flow of China. In this paper, the large-scale flight assignment problem is formulated as a multi-objective model with consideration of the reduction of airspace congestion and flight delay. However, it is a large-scale combinatorial optimization problem with complex constraints and tightly coupled decision variables, which is difficult to deal with.Hence, an effective multi-objective optimization algorithm is proposed based on the multi-island parallel evolution framework(PEA) with a left-right probability migration topology. Multi-island PEA employs multiple evolution populations for solving the problem simultaneously, and the left-right probability migration topology for exchange individuals among populations to improve the efficiency of the cooperation of populations. Then the cooperative co-evolution(CC) algorithm is introduced for each population to further improve the searching capability. Simulation results using the real traffic data from the China air route network and daily flight plans demonstrate that the proposed approach can improve the solution quality effectively, showing superiority to the existing approaches such as the multi-objective genetic algorithm, the well-known multi-objective evolutionary algorithm based on decomposition, a CC-based multi-objective algorithm as well as other two parallel evolution algorithms with different migration topologies. | Renli LU Xiangmin GUAN Xueyuan LI Inseok HWANG | 2016 | Science China(Information Sciences)2016，59，7： | 4 |
| 10 | Geochemical Constrains on Petrogenesis and Tectonic Setting of Volcanic Rocks from the Baimianxia and Sanwan Formations in the Northern Margin of the Yangtze Plate显示文摘根据 petrogeochemical 数据, Baimianxia 形成的暴烈的熔岩能被分类进二个单位:高 TiO2 和低 TiO2。前者的 TiO2 集中通常比 1% 高,它与高级变态发生在更低的部分,但是后者是不到 1% 并且与低档变态在上面的部分外面收割。high-TiO2 单位被显示出高稀土元素元素(REE ) 内容的 tholeiitic 熔岩统治(REE = 83.4180.8 g/g ) ,高轻 / 重的 REE (LREE/HREE ) 比率(LREE/HREE=2.175.85 ) 和弱否定 Eu 异例(Eu=0.791.01 ) 。它的踪迹元素模式关于 Th 显示弱 Nb-Ta 异例, K, La, Ce,出现在内板暗岩亲密关系。相反, low-TiO2 单位被低 REE 内容,低 LREE/HREE 比率,和显著 Nb-Ta 异例描绘,显示典型的弧或大陆人弧签名。从 Sanwan 形成的暗岩和安山岩的使球粒状陨石正常化的 REE 模式是公寓或 LREE 弄空,它很类似于正常中间海洋的暗岩。因此,我们建议这些熔岩应该在一个背弧盆背景被形成。在更低的部分的暗岩的 Sr-Nd 同位素的数据建议岩石将在 1144 妈被形成。基于 geochemical 和暗岩的同位素的特征,我们建议在 Baimianxia 形成的低部分的这些岩石应该从 asthenospheric 发源海洋岛的像暗岩的披风来源,可以被石榴石 lherzolite 的部分融化生产,并且显著地经历了部分结晶化并且外壳或 lithospheric 披风污染在旅途中到表面。然而,激光脱离诱导地联合了从 Baimianxia 形成的上面的部分暗岩样品标明日期的锆石 U-Pb 给 437 妈的血浆团 spectrometry,显示早古生代的年龄。在这份报纸的 geochemical 分析建议他们可以响应水的液体从一条弧或大陆人弧发源或融化从一个 subducting 平板驱逐了,并且部分融化发生在石榴石稳定性域里。在 Sanwan 形成的暗岩和安山岩的样品证明他们从类似于正常中间海洋的暗岩的弄空的披风来源被导出。最后,我们能断定在 Baimianxia 形成的更低的部分的熔岩原生地在中间代表裂缝相关的火山作用的地质的记录,它通常被认为是大陆人决裂的先锋并且由海洋的盆从 Neoproterozoic 形成到列在后面早古生代。而,在 Baimianxia 形成和 Sanwan 形成的上面的部分的熔岩可能被产生了由海洋并且发生了在的大陆人变换早古生代。 | XU Xuey CHEN Junlu1 LI Xiangmin MA Zhongping WANG Hongliang LI Ping LI Ting | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 3 |
| 11 | Key Recovery Against 3DES in CPU Smart Card Based on Improved Correlation Power Analysis显示文摘The security of CPU smart cards,which are widely used throughout China,is currently being threatened by side-channel analysis.Typical countermeasures to side-channel analysis involve adding noise and filtering the power consumption signal.In this paper,we integrate appropriate preprocessing methods with an improved attack strategy to generate a key recovery solution to the shortcomings of these countermeasures.Our proposed attack strategy improves the attack result by combining information leaked from two adjacent clock cycles.Using our laboratory-based power analysis system,we verified the proposed key recovery solution by performing a successful correlation power analysis on a Triple Data Encryption Standard(3DES)hardware module in a real-life 32-bit CPU smart card.All 112 key bits of the 3DES were recovered with about 80 000 power traces. | Yanting Ren Liji Wu Hexin Li Xiangyu Li Xiangmin Zhang An Wang Hongyi Chen | 2016 | Tsinghua Science and Technology2016，21，2： | 3 |
| 12 | Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders显示文摘Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named 'amelin' or 'sheathlin') is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta(AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth. The vital role of Ambn in amelogenesis has been confirmed experimentally using mouse models. Only two cases have been reported of mutations of AMBN associated with non-syndromic human AI. However, no AMBN missense mutations have been reported to be associated with both human AI and dentin disorders.We recruited one kindred with autosomal-dominant amelogenesis imperfecta(ADAI) and dentinogenesis imperfecta/dysplasia characterized by generalized severe enamel and dentin defects. Whole exome sequencing of the proband identified a novel heterozygous C-T point mutation at nucleotide position 1069 of the AMBN gene, causing a Pro to Ser mutation at the conserved amino acid position 357 of the protein. Exfoliated third molar teeth from the affected family members were found to have enamel and dentin of lower mineral density than control teeth, with thinner and easily fractured enamel, short and thick roots, and pulp obliteration. This study demonstrates, for the first time, that an AMBN missense mutation causes non-syndromic human AI and dentin disorders. | Ting Lu Meiyi Li Xiangmin Xu Jun Xiong Cheng Huang Xuelian Zhang Aiqin Hu Ling Peng Decheng Cai Leitao Zhang Buling Wu Fu Xiong | 2018 | International Journal of Oral Science2018，10，4： | 3 |
| 13 | Geochemistry, geochronology and Hf isotope of granitoids in the Chinese Altai: Implications for Paleozoic tectonic evolution of the Central Asian Orogenic Belt显示文摘The Chinese Altai in northwestern Xinjiang has numerous outcrops of granitoids which provide critical information on accretionary orogenic processes and crustal growth of the Central Asian Orogenic Belt.Zircon U-Pb ages, Hf-isotopic compositions and whole-rock geochemistry of monzogranite and granodiorites in the Qinghe County are employed to elucidate Paleozoic tectonics of the Chinese Altai. Granodiorites have crystallization ages of 424.6 ± 3.1 Ma(MSWD = 0.23) and 404.0 ± 3.4 Ma(MSWD = 0.18);monzogranite was emplaced in the early Permian with a crystallization age of 293.7 ± 4.6 Ma(MSWD = 1.06). Both granodiorites and monzogranite are I-type granites with A/CNK ratios of 0.92 -0.97 and 1.03 -1.06, respectively. They also show similar geochemical features of high HREE and Y contents, low Sr contents and Sr/Y ratios, as well as enrichment of Cs, Rb, Th and U, and depletion of Nb, Ta, P and Ti.These geochemical features indicate that the monzogranite and granodiorites were formed in an arc setting related to subduction. The gneissic monzogranites display high SiO_2 and K_2 O contents, and belong to the high-K calc-alkaline series. In the chondrite normalized REE distribution pattern, the monzogranite samples exhibit enrichment of LREE with strong negative Eu anomalies(σE u =0.44 -0.53), zircon εHf(t) values from +7.24 to +12.63 and two-stage Hf model ages of 463 -740 Ma. This suggests that the monzogranite was generated from the mixing of pelitic and mantle material. The granodiorite samples are calc-alkaline granites with lower contents of Si O_2 and Na_2 O + K_2 O, higher contents of TiO_2, Fe_2O_3~t, MgO and CaO compared to the monzogranite samples. They also show enrichment of LREE and moderate negative Eu anomalies(σE u= 0.54 =0.81), as well as slightly higher differentiation of LREE than that of HREE. The425 Ma granodiorite has zircon εHf(t) values from -0.51 to +1.98 and two-stage Hf model ages of 1133 -1240 Ma, whereas the 404 Ma granodiorite displays those of +2.52 to +7.50 and 816 -1071 Ma.Geochemistry and zircon Hf isotopic compositions indicate that granodiorites were formed by partial melting of juvenile lower crust. Together with regional geology and previous data, the geochemical and geochronological data of the monzogranite and granodiorites from this study suggest long-lived subduction and accretion along the Altai Orogen during ca. 425 -294 Ma. | Dengfeng He Yunpeng Dong Xueyi Xu Junlu Chen Xiaoming Liu Wei Li Xiangmin Li | 2018 | Geoscience Frontiers2018，9，5： | 3 |
| 14 | Epstein-Barr 病毒的从潜伏的膜蛋白质 2 的重叠 epitopes (LMP2 ) 的空想地熔化的抗原富人作为一支潜在的疫苗和诊断代理人显示文摘Epstein-Barr 病毒(EBV ) 在全世界是流行的并且在人与几恶意的疾病被联系。(LMP2 ) 潜伏的膜蛋白质 2 在联系 EBV 的 tumors; 的致病 EBV 起一个关键作用;因此, LMP2 被认为是一个潜在的 immunodiagnostic 和 immunotherapeutic 目标。multi-epitope-based 抗原是为治疗学的疫苗的一种有希望的选择并且如此的恶意诊断。在这研究,我们系统地屏蔽了细胞毒素的 T 淋巴细胞(CTL ) ,助手 T 房间(Th ) 和在用生物信息学的 EBV-LMP2 以内的 B 房间 epitopes。基于屏幕,在 T 房间和 B 房间的重叠 epitopes 的二个肽富人被选择构造为叫作 EBV-LMP2m 的妄想的 multi-epitope 蛋白质包含顺序的 plasmid,它 LMP2aa195~232 和 LMP2aa419~436 是镇静的。EBV-LMP2m 蛋白质在 E 被表示。在原核生物的 codon 优化以后的 coli BL21 (DE3 ) 。在 BALB/c 老鼠的净化的妄想的抗原的接种在阴道粘液而且特定的 CTL 回答在浆液和能分泌的 IgA 导致了特定的 IgG 的高水平不仅。由把净化的 EBV-LMP2m 用作抗原,在 202 鼻咽的癌(NPC ) 的浆液标本的特定的 IgG 的存在病人们有效地与 52.84 % 被检测;敏感和 95.40 %特性,基于 VCA-IgA 在传统的察觉方法上代表改进, 60.53 %敏感和 76.86 %特性) 。上述结果显示 EBV-LMP2m 可以为 NPC 病人为联系 EBV 的肿瘤而且一个诊断代理人被用作潜在的目标抗原不仅。 | Xiaoyun Lin Shao Chen Xiangyang Xue Lijun Lu Shanli Zhu Wenshu Li Xiangmin Chen Xiaozhi Zhong Pengfei Jiang Torsoo Sophia Sename Yi Zheng Lifang Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 15 | The interface structure of nano-SiO2/PA66 composites and its influence on material mechanical and thermal properties 显示文摘 | Xu Xiangmin Li Binjie Lu Huimin | 2007 | Applied Surface Science2007，254，5： | 1 |
| 16 | A simple method for the assessment of crown rot disease severity in wheat seedlings inoculated with Fusarium pseduograminearun 显示文摘 | Li Xiangmin Liu Chunji Chakraborty Sukumar | 2008 | J Phytopathology2008，156，： | 1 |
| 17 | Down-regulation of miR-126 expression in colorectal cancer and its clinical significance 显示文摘 | XiangMin Li AiMin Wang Juan Zhang | 2011 | Med Oncol2011，28，： | 1 |
| 18 | Quantitative Risk Assess- ment on a Gaseous Hydrogen Refueling Station in Shanghai 显示文摘 | LI Zhiyong PAN Xiangmin MA Jimlxin | 2010 | International Journal of Hydrogen Energy2010，35，13： | 1 |
| 19 | The interface structure of nano-SiO2/PA66 composites and its influence on material' s mechanical and thermal properties 显示文摘 | Xu Xiangmin Li Binjie Lu Huimin | 2007 | Applied Surface Science2007，254，5： | 1 |
| 20 | Clinical Research of Head Acupoints Treatments for Cerebral Thrombosis 显示文摘 | Sun Huailing Li Xiangmin | 2001 | Chinese Acupuncture and Moxibustion2001，，5： | 1 |
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